Published December 29 (EPO); December 23 (WO); December 29 (GB)

Ajinomoto EPO 967 282

Bacterial cytochrome

Tokyo

Bacterial cytochrome bd type quinol oxidase, encoding gene sequences, amplification probes; for diagnostics.

Beth Israel Deaconess Hosp. WO 99/65940

Anti-angiogenic proteins

Boston

Anti-angiogenic proteins, encoding gene sequences; for inhibiting angiogenesis.

Bio Merieux WO 99/65926

Marking RNA fragments

Marcy l'Etoile, France

Marking natural or synthetic RNA fragments; for medical diagnosis.

Biogen WO 99/65948

Cell growth disorders

Cambridge, Mass.

Variant type II TGF-b receptor fused to an immunoglobulin constant chain; for treating cell growth disorders.

California, Univ. of WO 99/65929

Transcription regulator modulators

Oakland, Calif.

Exon 4 and 7 domains of ESX, an ETS transcription regulator family member; for screening modulators.

Chiron EPO 967 279

Ulcer vaccine

Siena, Italy

Helicobacter pylori cytotoxin and heat shock protein, encoding genes; for vaccines and diagnostics.

Ciba-Geigy EPO 967 285

Prolylendopeptidase

Hyogo, Japan

Bacterial prolylendopeptidase, encoding gene sequences; for producing a C-terminal amidated peptide.

Cohesion Technol. EPO 967 226

Fibrillar collagen production

Palo Alto, Calif.

Recombinant production of fibrillar collagen using gene sequences encoding collagen monomers lacking propeptides.

Constantine, T., et al. WO 99/66070

Individual identification

Carlton, Australia

Unique sequences of DNA hypervariable regions; for biometric identification and authentication of an individual.

Curagen WO 99/65939

Cancer therapy

New Haven, Conn.

Interaction between p27(Kip1) and FKBP-12, formed complex, fragments, derivatives; for treating cancer.

DNAVec Res. WO 99/66061

Gene therapy phage

Ibaraki, Japan

Phage expressing a bifunctional protein with a nuclear transport and cell adhesion activity; for gene therapy.

Du Pont EPO 967 281

Antibiotic identification

Wilmington, Del.

3,4-dihydroxy-2-butanone 4-phosphate synthase, encoding gene sequences; for identifying antibiotics and fungicides.

Genzyme WO 99/66036

Myocardial scar transplants

Cambridge, Mass.

Cardiomyocytes, fibroblasts, endothelial cells, smooth muscle cells and skeletal myoblasts for myocardial scars.

Genzyme WO 99/66303

Differentially expressed genes

Framingham, Mass.

Differentially expressed gene sequences; for preferential expression of foreign genes in antigen presenting cells.

Genzyme Transgenics WO 99/66054

EPO analog fusion

Framingham, Mass.

Fusion of an erythropoietin (EPO) analog with human serum albumin; for diagnostics and therapeutics.

Guelph, Univ. of WO 99/66049

Antibacterial screen

Guelph, Ont.

Bacterial gene involved in heptose modification of membrane lipopolysaccharides; for finding antibacterials.

Hoechst Marion Roussel EPO 967 288

Histone-based transfection

Frankfurt, Germany

Histone-based transfection system; for transfection and gene therapy.

Hoechst Marion Roussel WO 99/66060

Osteogenetic gene promoter

Tokyo

Promoter from a human gene having osteogenetic activity; for finding modulators of the encoded protein.

Human Genome Sciences WO 99/66041

94 secreted proteins

Rockville, Md.

94 human secreted proteins, encoding genes, production methods, antibodies; for diagnostics and therapeutics.

Iconex Pharma WO 99/66035

Vector construction

Mountain View, Calif.

Vector construction by host cell-mediated recombination using gap repair mechanisms.

Inst. Phys. & Chem. Res. EPO 967 219

Fluorescent nucleotide terminators

Wako, Japan

Nucleotides with fluorescent donor and acceptor groups used in chain termination methods; for DNA sequencing.

Isis Pharma WO 99/65502

Protein kinase C oligos

Carlsbad, Calif.

Oligonucleotides derived from the protein kinase C gene; for expression modulation.

JCR Pharma EPO 967 225

Insulin deficient transgenics

Ashiya, Japan

ATP-sensitive potassium channel-deficient transgenics; for studying pancreatic b-cell insulin secretion.

Kaneka EPO 967 271

Carbonyl reductase

Osaka, Japan

Carbonyl reductase, encoding gene sequences; for making optically active alcohols.

Kikkoman EPO 967 286

Leucine aminopeptidase

Chiba, Japan

Fungal leucine aminopeptidase, encoding gene sequences, variants, production methods.

Kim, D.-S. EPO 967 276

Anti-tumor agent

Seoul, S. Korea

Anti-tumor agent salmosin, homologs, fragments; for treating various cancers.

Kirin Beer EPO 967 275

Promoter activity enhancers

Tokyo

DNA sequences enhancing promoter activity; for use in expression vectors having inserted heterologous genes.

Lausanne Polytech. WO 99/66032

Fluorescent response signaling

Lausanne, Switzerland

Cells that are transfected with genes encoding fluorescent proteins; for optical signaling of responses.

LeSaffre EPO 967 280

Stress resistant yeast

Paris

Yeast strain with fil phenotype that is stress resistant under conditions of growth and fermentation [in French].

Maryland, Univ. of WO 99/66074

Vibrio vaccines

Baltimore

Oligonucleotide probes for virulent strains of Vibrio, encoded proteins, antibodies; for vaccines.

Max Planck Inst. GB 2 338 711

Interacting molecules

Berlin

Identification and characterization of interacting molecules using a yeast two-hybrid system; for high-throughput assays.

Millennium Pharma WO 99/66025

MTbx proteins

Cambridge, Mass.

MTbx protein, encoding gene sequences, fusions, antigenic peptides, antibodies; for diagnostics and therapeutics.

Mitokor WO 99/66075

Extramitochondrial DNA assay

San Diego

Quantification of extramitochondrial DNA; for determining mitochondria-related disease risk and finding therapeutics.

Mologen EPO 967 274

Purifying expression vectors

Berlin

Method for purifying covalently closed expression vector plasmid DNA [in German].

Mosaic Technol. WO 99/66079

Non-viral organism detection

Boston

SRP RNA nucleic acid probes; for the detection and identification of non-viral microorganisms.

NIH (Natl. Inst. Hlth.) WO 99/66033

Hepatitis C diagnostics

Bethesda, Md.

Truncated hepatitis C virus envelope proteins targeted to plasma membranes; for modulator screens and diagnostics.

New York, State Univ. of WO 99/66027

Tumor metastasis antibodies

Stony Brook, N.Y.

Monoclonal antibodies to a tumor metastasis-associated antigen; for metastatic cancer diagnostics and therapeutics.

Novartis WO 99/66028

Anti-cancer epithilones

Vienna, Austria

Genes encoding the enzymes necessary for the biosynthesis of epithilones; for their production as cancer therapy agents.

Parenz Med. Res. & Develop. WO 99/66037

Anti-inflammatory oligos

Westmount, Que.

Antisense oligos to the CCR3 receptor and cytokine receptors; for inhibiting inflammation.

Pasteur Merieux WO 99/66046

HIV antigen mimotopes

Lyon, France

HIV virus mimotopes that react with antibodies to the viral envelope; for diagnostics and therapeutics.

Pfizer EPO 967 284

Phosphodiesterase

Sandwich, UK

Phosphodiesterase, encoding gene sequences, variants, homologs, fragments, derivatives.

Pharmacia & Upjohn WO 99/66038

Angiostatin receptor

Stockholm

Angiostatin-binding protein, encoding gene sequences; for screening anti-angiogenic agents.

Rhone-Poulenc Rorer WO 99/65947

G3BP protein antibodies

Antony, France

Monoclonal antibodies to G3BP protein, production methods; for diagnostics and therapeutics.

RMF Dictagene WO 99/66053

One-step purification

Prilly, Switzerland

Expression vector encoding a fusion of a desired protein with a lectin; for one-step purification.

Singapore, Republic of WO 99/66047 & 66048

Hepatitis B viral strains

Singapore

Vaccine-induced hepatitis B viral strains, mutated major surface antigen, encoding gene sequences; for therapeutics.

SmithKline Beecham WO 99/65299

Hematopoietic cell expansion

Philadelphia

Use of various agents for the in vitro, ex vivo, and in vivo expansion of hematopoietic cells.

SmithKline Beecham WO 99/66043

Toxoplasma SAG1 antigen

Rixensart, Belgium

Toxoplasma SAG1 antigen, fragments, truncated forms, recombinant production methods; for vaccines.

South Carolina, Med. Univ. of WO 99/66302

Finding coding regions

Charleston, S.C.

Systematic sampling of genomic sequences using a recurrent neural network program; for finding protein coding regions.

Stanford Univ. EPO 967 291

Allelic variation screen

Palo Alto, Calif.

Parallel hybridization analysis for the detection of allelic variation between closely related sequences.

Stichting Labs WO 99/66045

Newcastle disease vaccines

Wageningen, Netherlands

Infectious mutated Newcastle disease virus clones; for vaccines and diagnostics.

Sugen WO 99/66051

Kinase-related diseases

S. San Francisco

NEK and BUB1-related protein kinases, encoding gene sequences; for diagnostics and therapeutics.

Sydney, Univ. of WO 99/66069

Hypertension polymorphisms

Sydney, Australia

Polymorphisms in the inducible nitric oxide synthase gene; for predicting susceptibility to hypertension.

Tensei Suisan EPO 967 224

Apoptosis protein

Saga, Japan

Cell death inducing protein, encoding gene sequences, fragments; for inducing apoptosis and treating cancer.

Transgene EPO 967 289

Transfection complexes

Strasbourg, France

Transfection complexes of nucleic acids and nuclease inhibitors; for gene therapy.

Vlaams Inst. Biotech WO 99/66059

Triplet repeat flanking sequences

Zwijnaarde, Belgium

Yeast artificial chromosome fragmentation vectors; for isolating flanking sequences of short triplet repeats.

Xoma EPO 967 277

Tumor antigen antibodies

Berkeley, Calif.

Production of chimeric mouse-human antibodies having human constant regions and specificity to human tumor antigens.

Xoma WO 99/66044

BPI deletion analogs

Berkeley, Calif.

Bactericidal/permeability-increasing protein (BPI) deletion analogs, fusions, encoding gene sequences; for therapeutics.

Yamanouchi Pharma WO 99/66073

Diabetes therapeutics

Tokyo

Modulator screens for potentiating Pax4 gene expression in pancreatic b-cells; for diabetes therapeutics.

Yeda Res. & Develop. WO 99/66030

Apoptosis regulation

Rehovot, Israel

DAP kinase homolog, encoding gene sequences; for regulating calmodulin-dependent apoptosis.

Zeneca WO 99/66039

Apoptosis modulator screen

London

Tumor necrosis factor receptor-like protein having a death domain, encoding gene; for finding apoptosis modulators.

Ziekenhuis Acad. EPO 967 218

DNA isolation

Amsterdam

Isolation of DNA using silica-guanidiniumthiocyanate and casein; for removal of DNA processing enzyme inhibitors.

Zymogenetics Immunoglobulin- WO 99/66040

Seattle like protein

Immunoglobulin superfamily protein, encoding gene sequence from chromosome 6, antibodies; for therapeutics.