Published December 15 (EPO); December 9 (WO); December 15 (GB)

Actinova GB 2 338 237

Peptide expression library

Cambridge, UK

In vitro peptide expression library in which the peptides are covalently linked to the DNA encoding them.

Adv. Res. & Technol. Inst. WO 99/62548

Neurofibril formation disease

Indianapolis

Diagnosis, modeling, and treatment of tau protein-related pathologies that involve neurofibrillary formation.

AEA Technology GB 2 338 236

Plasmid DNA isolation

Didcot, UK

Isolation of plasmid DNA using a vortex mixer and an alkaline lysis reagent.

Airaksinen, M.S., et al. WO 99/62332

Neuropathy transgenics

Helsinki, Finland

Transgenics and derived cells lacking a functional GFRa2 receptor; for studying nervous system diseases.

American Cyanamid WO 99/63064

Attenuated RNA viruses

Madison, N.J.

Production of non-segmented negative-sense single-stranded RNA viruses; for making attenuated viruses.

Amgen WO 99/63089

Cyclin E2 proteins

Thousand Oaks, Calif.

Cyclin E2 proteins, encoding genes, production methods; for diagnostics and therapeutics.

Azur Environmental WO 99/63107

Bioluminescence reagent

Wokingham, UK

Cell-derived assay reagent that retains signal-generating metabolic activity and is derived from killed cells.

Biomolecular Res. Inst. WO 99/62955

EGF receptor modulators

Parkville, Australia

Designing modulators of EGF family receptor function using three-dimensional information from EGF protein crystals.

Biotech. & Biol. Sci. Res. Counc. WO 99/63061

Embryonic cell production

Swindon, UK

Animal embryonic stem cells made by nuclear transfer and subsequent killing of differentiated cells.

British Defense Ministry WO 99/63098

Encephalitis vaccines

Farnborough, UK

Recombinant vaccinia virus expressing Venezuelan equine encephalitis structural proteins; for vaccines.

Cadus Pharma WO 99/63099

Adenosine receptor modulators

Tarrytown, N.Y.

Adenosine receptors functionally integrated into the yeast pheromonal response pathway; for screening modulators.

Calgene WO 99/63096

Producing sterol esters

Davis, Calif.

Acyl CoA:cholesterol acyltransferase-related proteins, encoding gene sequences; for sterol ester production.

California, Univ. of WO 99/62547

Multidrug resistance therapy

Oakland, Calif.

Human minor vault protein, variants, encoding gene sequence; for diagnosing and treating multidrug resistant cancer.

California, Univ. of WO 99/62931

Connective tissue therapeutics

Oakland, Calif.

Cell density protein produced by fibroblasts, encoding gene sequence, antibodies; for connective tissue therapeutics.

Celtrix Pharma WO 99/63086

IGF binding protein-3 variants

San Jose, Calif.

Insulin-like growth factor (IGF) binding protein-3 variants; for hydrolysis resistance.

CDC (Ctr. Disease Control) WO 99/63095

Flavivirus vaccines

Atlanta

Nucleic acid sequences encoding flavivirus M and E protein antigens; for flavivirus vaccines and infection prevention.

Children's Hosp. WO 99/62944

Endostatin oligomers

Boston

Endostatin protein oligomers including metal ions; for inhibition of tumorigenesis.

Columbia Univ. WO 99/63073

Serine-threonine kinase

New York

Serine-threonine kinase gene, encoded protein, fusions, fragments, antibodies; for function modulation.

CSIRO (Comm. Sci. & Ind. Res. Org.) WO 99/63062

Entomopoxvirus production vectors

Campbell, Australia

Recombinant entomopoxviruses in which heterologous genes are located between the fusolin and p68 genes; for production.

Diversa WO 99/62847

Low copy gene libraries

San Diego

Catalogued gene sequence libraries containing enriched populations of low copy and difficult to isolate genes.

Effector Cell Inst. WO 99/62556

Eosinophil chemotactic factor

Tokyo

Eosinophil chemotactic factor of the galectin family, encoding gene; for screens and immunotherapy.

Fujisawa Pharma WO 99/63102

Diabetes therapeutic

Osaka, Japan

Gluconeogenesis inhibitors, bacterial production methods; for treating diabetes and obesity.

Genentech WO 99/63088

Membrane-bound proteins

S. San Francisco

Membrane-bound proteins, encoding genes, chimeric proteins, fusions, antibodies; for diagnostics and therapeutics.

Genetronics WO 99/62592

Gene therapy electroporation

San Diego

Flow-through electroporation system for ex vivo gene therapy at selected temperatures.

Glaxo WO 99/62561

Egr-1 transcription factor

Greenford, UK

Egr-1 transcription factor, active fragments, encoding gene sequence; for wound therapeutics.

Harvard Univ. WO 99/63052

Differentiation transgenics

Cambridge, Mass.

Transgenics with genes for under-regulation of transcription signals; for bigenic strains to study differentiation.

Human Genome Sciences WO 99/62927

Connective tissue growth factor-4

Rockville, Md.

Connective tissue growth factor-4, encoding gene sequences, antibodies; for diagnostics and therapeutics.

Human Genome Sciences WO 99/62934

Interferon receptor

Rockville, Md.

Interferon receptor, encoding gene sequences, production methods; for modulator screens and immunotherapeutics.

Hunt-Wesson WO 99/63112

Detecting microbial contaminants

Fullerton, Calif.

PCR-based amplification methods for detecting microbial and viral contaminants.

Immune Response WO 99/63076

Plamid DNA purification

Carlsbad, Calif.

Methods for purifying pharmaceutical grade plasmid DNA using anion exchange and a stringent ethanol wash.

Imperial Coll. Innovations WO 99/63110

Bladder cancer diagnosis

London

Determination of Pax 5 gene and protein levels in urothelium; for bladder cancer diagnosis and therapy.

Imtox WO 99/62933

Autoantibody binding peptides

Berlin

Computer-assisted methods for designing peptides and variants that bind autoantibodies.

Incyte Pharma WO 99/63067

Carbamoyl phosphate synthase homolog

Palo Alto, Calif.

Carbamoyl phosphate synthase homolog, encoding gene, antibodies, modulators; for diagnostics and therapeutics.

Infectech WO 99/63056

Apoptosis induction

Sharon, Penn.

Induction of apoptosis in cells immobilized on an impenetrable and nonmetabolizable material.

Isis Pharma WO 99/63114

Cancer antisense therapy

Carlsbad, Calif.

Antisense oligonucleotide modulation of human thymidylate synthase expression; for cancer therapy.

Janssen Pharma WO 99/63080

Cell behaviour modulators

Beerse, Belgium

Human homologs of the UNC-53 protein from C. elegans; for finding cell behaviour modulators.

Krebs Res. Ctr. WO 99/63071

Tumor cell apoptosis

Heidelberg, Germany

Triggering tumor cell apoptosis by inducing overexpression of the C1D gene.

Kyowa WO 99/63085

Nephropathy-associated gene

Tokyo

Gene whose expression varies in leukocytes from patients with Ig-A nephropathy, antibodies; for diagnostics.

Lilly WO 99/62925 & 62956

Angiopoietin-related genes

Indianapolis

Angiopoietin-related scarface-1 and -3 genes, encoded proteins, production methods; for finding modulators.

Lilly WO 99/63070

Truncated protein C

Indianapolis

Human protein C having a truncated heavy chain; for treating thrombotic disorders.

Maryland, Univ. of WO 99/63055

Carotenoid biosynthesis

College Park, Md.

Genes for carotenoid biosynthesis and metabolism; for producing carotenoids and screening modulators.

Mayo Clinic WO 99/62526

Multiple myeloma antibodies

Rochester, Minn.

Genetically engineered antibodies to CD38, fragments, fusions; for treating multiple myeloma.

MRC (Med. Res. Counc.) WO 99/62494

Cell uptake enhancement

London

Membrane permeable molecule that inhibits dynamin-mediated endocytosis; for enhancing cell uptake of substances.

Millennium Pharma WO 99/62943

AIP-related proteins

Cambridge, Mass.

AIP-related family proteins, encoding genes, antibodies, transgenics; for diagnostics and therapeutics.

Millennium Pharma WO 99/63087

G-protein coupled receptor

Cambridge, Mass.

G-protein coupled receptor, encoding gene sequences, modulators; for treating receptor-related disorders.

Mt. Sinai Sch. Med. WO 99/63094

GPR1 proteins

New York

GPR1 proteins, encoding gene sequences, fragments, derivatives, analogs; for finding modulators.

North Carolina State Univ. WO 99/63059

Transcription activation

Raleigh, N.C.

Transactivation of transcription of viral RNA; for activating cellular transcription.

Northwestern Univ. WO 99/63063

Herpesvirus entry proteins

Evanston, Ill.

Herpesvirus entry proteins, mutants, homologs, derivatives, variants; for inhibiting viral entry.

Norwegian Radium Hosp. WO 99/63066

Modified ribozymes

Oslo

Ribozymes with pyrimidines modified at the 2' position with amino groups; for improved stability.

Organogenesis WO 99/63051

Bioengineered graft protheses

Canton, Mass.

Bioengineered flat sheet graft protheses having chemically bonded tissue material layers; for implantation and repair.

Peptide Solutions WO 99/62945

HIV antigen peptides

Columbia, Md.

Immunologically cross-reactive peptides derived from HIV antigens; for diagnostics and therapeutics.

Queensland, Univ. of WO 99/63068

Translation regulation

St. Lucia, Australia

Phenotype-modifying genetic sequences; for regulating translation of mRNAs.

Reprogen WO 99/63115

Endometriosis therapy

Irvine, Calif.

Determination of cathepsin S expression as an indicator of endometriosis; for diagnosis and therapy.

Rockefeller Univ. WO 99/62537

Immunoresponse modulation

New York

Dendritic cell migration agents that modulate p-glycoprotein and tissue factor activity; for modulating immunoresponses.

Roos, J.C., et al. WO 99/63082

Drosophila GDNF homolog

Esbo, Finland

Drosophila homolog to mammalian glial-derived neurotrophic factor (GDNF), encoding gene sequences.

Scios WO 99/63090

Protease inhibitors

Mountain View, Calif.

Analogs of the Kunitz Protease Inhibitor domain of amyloid precursor protein; for inhibiting proteases.

Shanghai Second Med. Univ. WO 99/62947-62950

Ubiquinone oxidoreductase homologs

Shanghai, China

Human ubiquinone oxidoreductase subunit homolog genes, encoded proteins; for diagnostics and therapeutics.

Shanghai Second Med. Univ. WO 99/62951 & 62952

Zinc finger protein

Shanghai, China

Human zinc finger protein, encoding gene, recombinant production methods; for diagnostics and therapeutics.

Shanghai Second Med. Univ. WO 99/62953

Leucine finger protein

Shanghai, China

Human leucine finger protein, encoding gene, recombinant production methods; for diagnostics and therapeutics.

Shanghai Second Med. Univ. WO 99/62954

Human MAGO gene

Shanghai, China

Human MAGO gene, encoding gene sequences, production methods; for diagnostics and therapeutics.

Shanghai Second Med. Univ. WO 99/63065

RNA cyclase gene

Shanghai, China

Human hematopoietic cell-derived RNA cyclase gene, encoded protein; for diagnostics and therapeutics.

Shanghai Second Med. Univ. WO 99/63069

Mitochondrial processing protease homolog

Shanghai, China

Human mitochondrial processing protease _ subunit homolog gene, encoded protein; for diagnostics and therapeutics.

SmithKline Beecham WO 99/62527

Antibacterial screens

Philadelphia

Bacterial nrdE polypeptides, encoding gene sequences, production methods; for antibacterial screens.

SmithKline Beecham WO 99/62946

Antibacterial screens

Philadelphia

Bacterial nrdF polypeptides, encoding gene sequences, production methods; for antibacterial screens.

SmithKline Beecham WO 99/63093

Moraxella antigens

Rixensart, Belgium

Moraxella catarrhalis antigens, encoding gene sequences, antibodies; for diagnostics and therapeutics.

Starzinski-Powitz, A. WO 99/63079

Endometriosis-associated gene

Frankfurt, Germany

Gene associated with invasive endometriosis, encoded protein, antibodies; for diagnostics and therapeutics.

Taisho Pharma WO 99/63083

Hair growth regulator

Tokyo

Hair growth regulating protein, encoding gene sequences; for developing hair growth promoting agents.

Teikoku Hormone WO 99/63075

FDP assay

Tokyo

Monoclonal antibodies not reacting with specific fractions in human fibrinogen degradation products (FDP).

TM Technologies WO 99/63074

Relative gene expression

Woburn, Mass.

Methods for altering the relative expression level of genes of interest.

TM Technologies WO 99/63077 & 63117

DNA ligand binding alteration

Woburn, Mass.

DNA sequences conferring relative binding affinity to DNA ligands whose binding site is adjacently placed.

Torii Pharma WO 99/63084

Arthrosis deformans antigens

Tokyo

T cell antigen receptor peptides that accumulate in the synovial membranes of arthrosis deformans patients.

Tosoh EPO 964 057

DNA purification

Shinnanyo, Japan

Separation of nucleic acids using hydrophobic interaction chromatography; for purification.

Toyo Kohan WO 99/63072

Gene diagnostics

Tokyo

Apparatus for constructing an immobilized DNA library that can be amplified; for diagnostics.

Univ. College WO 99/63081

Cation channels

London

Acid-sensitive cation channels, encoding gene sequences, fragments, antibodies; for screening analgesics.

Univ. Technol. Intl. WO 99/63078

Retinal calcium channel

Calgary, Alberta

Retinal calcium channel subunit gene associated with X-linked congenital stationary night blindness; for diagnosis.

Urogenesys WO 99/62941

Prostate cancer diagnostics

Santa Monica, Calif.

Serpentine transmembrane antigens that are highly expressed in prostate cancers; for diagnostics and therapeutics.

Urogenesys WO 99/62942

Prostate cancer diagnostics

Santa Monica, Calif.

Prostate-specific cell surface serine protease tumor antigen, encoding gene; for diagnostics and therapeutics.

Vanderbilt Univ. WO 99/62932

Viral infection inhibition

Nashville, Tenn.

Peptides, mimics, and antibodies to the viral fusion protein binding domain of Rho A; for inhibiting viral infection.

Vertex Pharma WO 99/63097

Caspase-9 apoptosis

Cambridge, Mass.

Caspase-9 deficient transgenics; for modeling cell death and preventing apoptosis associated with caspase-9 activation.

Visible Genetics WO 99/63118

HPV genotyping

Toronto

Amplification of the L1 open reading frame of human papillomavirus (HPV); for viral genotyping.

Washington, Univ. of WO 99/62562

Therapeutic secreting implants

Seattle

Prosthetic cell implant for use in delivering recombinant therapeutics to the digestive tract.

Washington, Univ. of WO 99/63101

Diabetes implants

Seattle

Cells having proinsulin and glucose-regulatable cleavage protease genes; for implantation into diabetics.

Yale Univ. WO 99/62926

Fluorescent in situ hybridization

New Haven, Conn.

In situ hybridization involving oligonucleotides labeled with distinguishable fluorescent tags.

Zeneca GB 2 338 301

DNA target detection

London

Detection of target nucleic acid sequences using signalling systems that respond to hybridization.

Zymogenetics WO 99/63091

Serine proteinase inhibitors

Seattle

Disulfide core protein, encoding gene sequences, antibodies; for inhibiting serine proteinases.