Published December 15 (EPO); December 9 (WO); December 15 (GB)
Actinova GB 2 338 237
Peptide expression library
Cambridge, UK
In vitro peptide expression library in which the peptides are covalently linked to the DNA encoding them.
Adv. Res. & Technol. Inst. WO 99/62548
Neurofibril formation disease
Indianapolis
Diagnosis, modeling, and treatment of tau protein-related pathologies that involve neurofibrillary formation.
AEA Technology GB 2 338 236
Plasmid DNA isolation
Didcot, UK
Isolation of plasmid DNA using a vortex mixer and an alkaline lysis reagent.
Airaksinen, M.S., et al. WO 99/62332
Neuropathy transgenics
Helsinki, Finland
Transgenics and derived cells lacking a functional GFRa2 receptor; for studying nervous system diseases.
American Cyanamid WO 99/63064
Attenuated RNA viruses
Madison, N.J.
Production of non-segmented negative-sense single-stranded RNA viruses; for making attenuated viruses.
Amgen WO 99/63089
Cyclin E2 proteins
Thousand Oaks, Calif.
Cyclin E2 proteins, encoding genes, production methods; for diagnostics and therapeutics.
Azur Environmental WO 99/63107
Bioluminescence reagent
Wokingham, UK
Cell-derived assay reagent that retains signal-generating metabolic activity and is derived from killed cells.
Biomolecular Res. Inst. WO 99/62955
EGF receptor modulators
Parkville, Australia
Designing modulators of EGF family receptor function using three-dimensional information from EGF protein crystals.
Biotech. & Biol. Sci. Res. Counc. WO 99/63061
Embryonic cell production
Swindon, UK
Animal embryonic stem cells made by nuclear transfer and subsequent killing of differentiated cells.
British Defense Ministry WO 99/63098
Encephalitis vaccines
Farnborough, UK
Recombinant vaccinia virus expressing Venezuelan equine encephalitis structural proteins; for vaccines.
Cadus Pharma WO 99/63099
Adenosine receptor modulators
Tarrytown, N.Y.
Adenosine receptors functionally integrated into the yeast pheromonal response pathway; for screening modulators.
Calgene WO 99/63096
Producing sterol esters
Davis, Calif.
Acyl CoA:cholesterol acyltransferase-related proteins, encoding gene sequences; for sterol ester production.
California, Univ. of WO 99/62547
Multidrug resistance therapy
Oakland, Calif.
Human minor vault protein, variants, encoding gene sequence; for diagnosing and treating multidrug resistant cancer.
California, Univ. of WO 99/62931
Connective tissue therapeutics
Oakland, Calif.
Cell density protein produced by fibroblasts, encoding gene sequence, antibodies; for connective tissue therapeutics.
Celtrix Pharma WO 99/63086
IGF binding protein-3 variants
San Jose, Calif.
Insulin-like growth factor (IGF) binding protein-3 variants; for hydrolysis resistance.
CDC (Ctr. Disease Control) WO 99/63095
Flavivirus vaccines
Atlanta
Nucleic acid sequences encoding flavivirus M and E protein antigens; for flavivirus vaccines and infection prevention.
Children's Hosp. WO 99/62944
Endostatin oligomers
Boston
Endostatin protein oligomers including metal ions; for inhibition of tumorigenesis.
Columbia Univ. WO 99/63073
Serine-threonine kinase
New York
Serine-threonine kinase gene, encoded protein, fusions, fragments, antibodies; for function modulation.
CSIRO (Comm. Sci. & Ind. Res. Org.) WO 99/63062
Entomopoxvirus production vectors
Campbell, Australia
Recombinant entomopoxviruses in which heterologous genes are located between the fusolin and p68 genes; for production.
Diversa WO 99/62847
Low copy gene libraries
San Diego
Catalogued gene sequence libraries containing enriched populations of low copy and difficult to isolate genes.
Effector Cell Inst. WO 99/62556
Eosinophil chemotactic factor
Tokyo
Eosinophil chemotactic factor of the galectin family, encoding gene; for screens and immunotherapy.
Fujisawa Pharma WO 99/63102
Diabetes therapeutic
Osaka, Japan
Gluconeogenesis inhibitors, bacterial production methods; for treating diabetes and obesity.
Genentech WO 99/63088
Membrane-bound proteins
S. San Francisco
Membrane-bound proteins, encoding genes, chimeric proteins, fusions, antibodies; for diagnostics and therapeutics.
Genetronics WO 99/62592
Gene therapy electroporation
San Diego
Flow-through electroporation system for ex vivo gene therapy at selected temperatures.
Glaxo WO 99/62561
Egr-1 transcription factor
Greenford, UK
Egr-1 transcription factor, active fragments, encoding gene sequence; for wound therapeutics.
Harvard Univ. WO 99/63052
Differentiation transgenics
Cambridge, Mass.
Transgenics with genes for under-regulation of transcription signals; for bigenic strains to study differentiation.
Human Genome Sciences WO 99/62927
Connective tissue growth factor-4
Rockville, Md.
Connective tissue growth factor-4, encoding gene sequences, antibodies; for diagnostics and therapeutics.
Human Genome Sciences WO 99/62934
Interferon receptor
Rockville, Md.
Interferon receptor, encoding gene sequences, production methods; for modulator screens and immunotherapeutics.
Hunt-Wesson WO 99/63112
Detecting microbial contaminants
Fullerton, Calif.
PCR-based amplification methods for detecting microbial and viral contaminants.
Immune Response WO 99/63076
Plamid DNA purification
Carlsbad, Calif.
Methods for purifying pharmaceutical grade plasmid DNA using anion exchange and a stringent ethanol wash.
Imperial Coll. Innovations WO 99/63110
Bladder cancer diagnosis
London
Determination of Pax 5 gene and protein levels in urothelium; for bladder cancer diagnosis and therapy.
Imtox WO 99/62933
Autoantibody binding peptides
Berlin
Computer-assisted methods for designing peptides and variants that bind autoantibodies.
Incyte Pharma WO 99/63067
Carbamoyl phosphate synthase homolog
Palo Alto, Calif.
Carbamoyl phosphate synthase homolog, encoding gene, antibodies, modulators; for diagnostics and therapeutics.
Infectech WO 99/63056
Apoptosis induction
Sharon, Penn.
Induction of apoptosis in cells immobilized on an impenetrable and nonmetabolizable material.
Isis Pharma WO 99/63114
Cancer antisense therapy
Carlsbad, Calif.
Antisense oligonucleotide modulation of human thymidylate synthase expression; for cancer therapy.
Janssen Pharma WO 99/63080
Cell behaviour modulators
Beerse, Belgium
Human homologs of the UNC-53 protein from C. elegans; for finding cell behaviour modulators.
Krebs Res. Ctr. WO 99/63071
Tumor cell apoptosis
Heidelberg, Germany
Triggering tumor cell apoptosis by inducing overexpression of the C1D gene.
Kyowa WO 99/63085
Nephropathy-associated gene
Tokyo
Gene whose expression varies in leukocytes from patients with Ig-A nephropathy, antibodies; for diagnostics.
Lilly WO 99/62925 & 62956
Angiopoietin-related genes
Indianapolis
Angiopoietin-related scarface-1 and -3 genes, encoded proteins, production methods; for finding modulators.
Lilly WO 99/63070
Truncated protein C
Indianapolis
Human protein C having a truncated heavy chain; for treating thrombotic disorders.
Maryland, Univ. of WO 99/63055
Carotenoid biosynthesis
College Park, Md.
Genes for carotenoid biosynthesis and metabolism; for producing carotenoids and screening modulators.
Mayo Clinic WO 99/62526
Multiple myeloma antibodies
Rochester, Minn.
Genetically engineered antibodies to CD38, fragments, fusions; for treating multiple myeloma.
MRC (Med. Res. Counc.) WO 99/62494
Cell uptake enhancement
London
Membrane permeable molecule that inhibits dynamin-mediated endocytosis; for enhancing cell uptake of substances.
Millennium Pharma WO 99/62943
AIP-related proteins
Cambridge, Mass.
AIP-related family proteins, encoding genes, antibodies, transgenics; for diagnostics and therapeutics.
Millennium Pharma WO 99/63087
G-protein coupled receptor
Cambridge, Mass.
G-protein coupled receptor, encoding gene sequences, modulators; for treating receptor-related disorders.
Mt. Sinai Sch. Med. WO 99/63094
GPR1 proteins
New York
GPR1 proteins, encoding gene sequences, fragments, derivatives, analogs; for finding modulators.
North Carolina State Univ. WO 99/63059
Transcription activation
Raleigh, N.C.
Transactivation of transcription of viral RNA; for activating cellular transcription.
Northwestern Univ. WO 99/63063
Herpesvirus entry proteins
Evanston, Ill.
Herpesvirus entry proteins, mutants, homologs, derivatives, variants; for inhibiting viral entry.
Norwegian Radium Hosp. WO 99/63066
Modified ribozymes
Oslo
Ribozymes with pyrimidines modified at the 2' position with amino groups; for improved stability.
Organogenesis WO 99/63051
Bioengineered graft protheses
Canton, Mass.
Bioengineered flat sheet graft protheses having chemically bonded tissue material layers; for implantation and repair.
Peptide Solutions WO 99/62945
HIV antigen peptides
Columbia, Md.
Immunologically cross-reactive peptides derived from HIV antigens; for diagnostics and therapeutics.
Queensland, Univ. of WO 99/63068
Translation regulation
St. Lucia, Australia
Phenotype-modifying genetic sequences; for regulating translation of mRNAs.
Reprogen WO 99/63115
Endometriosis therapy
Irvine, Calif.
Determination of cathepsin S expression as an indicator of endometriosis; for diagnosis and therapy.
Rockefeller Univ. WO 99/62537
Immunoresponse modulation
New York
Dendritic cell migration agents that modulate p-glycoprotein and tissue factor activity; for modulating immunoresponses.
Roos, J.C., et al. WO 99/63082
Drosophila GDNF homolog
Esbo, Finland
Drosophila homolog to mammalian glial-derived neurotrophic factor (GDNF), encoding gene sequences.
Scios WO 99/63090
Protease inhibitors
Mountain View, Calif.
Analogs of the Kunitz Protease Inhibitor domain of amyloid precursor protein; for inhibiting proteases.
Shanghai Second Med. Univ. WO 99/62947-62950
Ubiquinone oxidoreductase homologs
Shanghai, China
Human ubiquinone oxidoreductase subunit homolog genes, encoded proteins; for diagnostics and therapeutics.
Shanghai Second Med. Univ. WO 99/62951 & 62952
Zinc finger protein
Shanghai, China
Human zinc finger protein, encoding gene, recombinant production methods; for diagnostics and therapeutics.
Shanghai Second Med. Univ. WO 99/62953
Leucine finger protein
Shanghai, China
Human leucine finger protein, encoding gene, recombinant production methods; for diagnostics and therapeutics.
Shanghai Second Med. Univ. WO 99/62954
Human MAGO gene
Shanghai, China
Human MAGO gene, encoding gene sequences, production methods; for diagnostics and therapeutics.
Shanghai Second Med. Univ. WO 99/63065
RNA cyclase gene
Shanghai, China
Human hematopoietic cell-derived RNA cyclase gene, encoded protein; for diagnostics and therapeutics.
Shanghai Second Med. Univ. WO 99/63069
Mitochondrial processing protease homolog
Shanghai, China
Human mitochondrial processing protease _ subunit homolog gene, encoded protein; for diagnostics and therapeutics.
SmithKline Beecham WO 99/62527
Antibacterial screens
Philadelphia
Bacterial nrdE polypeptides, encoding gene sequences, production methods; for antibacterial screens.
SmithKline Beecham WO 99/62946
Antibacterial screens
Philadelphia
Bacterial nrdF polypeptides, encoding gene sequences, production methods; for antibacterial screens.
SmithKline Beecham WO 99/63093
Moraxella antigens
Rixensart, Belgium
Moraxella catarrhalis antigens, encoding gene sequences, antibodies; for diagnostics and therapeutics.
Starzinski-Powitz, A. WO 99/63079
Endometriosis-associated gene
Frankfurt, Germany
Gene associated with invasive endometriosis, encoded protein, antibodies; for diagnostics and therapeutics.
Taisho Pharma WO 99/63083
Hair growth regulator
Tokyo
Hair growth regulating protein, encoding gene sequences; for developing hair growth promoting agents.
Teikoku Hormone WO 99/63075
FDP assay
Tokyo
Monoclonal antibodies not reacting with specific fractions in human fibrinogen degradation products (FDP).
TM Technologies WO 99/63074
Relative gene expression
Woburn, Mass.
Methods for altering the relative expression level of genes of interest.
TM Technologies WO 99/63077 & 63117
DNA ligand binding alteration
Woburn, Mass.
DNA sequences conferring relative binding affinity to DNA ligands whose binding site is adjacently placed.
Torii Pharma WO 99/63084
Arthrosis deformans antigens
Tokyo
T cell antigen receptor peptides that accumulate in the synovial membranes of arthrosis deformans patients.
Tosoh EPO 964 057
DNA purification
Shinnanyo, Japan
Separation of nucleic acids using hydrophobic interaction chromatography; for purification.
Toyo Kohan WO 99/63072
Gene diagnostics
Tokyo
Apparatus for constructing an immobilized DNA library that can be amplified; for diagnostics.
Univ. College WO 99/63081
Cation channels
London
Acid-sensitive cation channels, encoding gene sequences, fragments, antibodies; for screening analgesics.
Univ. Technol. Intl. WO 99/63078
Retinal calcium channel
Calgary, Alberta
Retinal calcium channel subunit gene associated with X-linked congenital stationary night blindness; for diagnosis.
Urogenesys WO 99/62941
Prostate cancer diagnostics
Santa Monica, Calif.
Serpentine transmembrane antigens that are highly expressed in prostate cancers; for diagnostics and therapeutics.
Urogenesys WO 99/62942
Prostate cancer diagnostics
Santa Monica, Calif.
Prostate-specific cell surface serine protease tumor antigen, encoding gene; for diagnostics and therapeutics.
Vanderbilt Univ. WO 99/62932
Viral infection inhibition
Nashville, Tenn.
Peptides, mimics, and antibodies to the viral fusion protein binding domain of Rho A; for inhibiting viral infection.
Vertex Pharma WO 99/63097
Caspase-9 apoptosis
Cambridge, Mass.
Caspase-9 deficient transgenics; for modeling cell death and preventing apoptosis associated with caspase-9 activation.
Visible Genetics WO 99/63118
HPV genotyping
Toronto
Amplification of the L1 open reading frame of human papillomavirus (HPV); for viral genotyping.
Washington, Univ. of WO 99/62562
Therapeutic secreting implants
Seattle
Prosthetic cell implant for use in delivering recombinant therapeutics to the digestive tract.
Washington, Univ. of WO 99/63101
Diabetes implants
Seattle
Cells having proinsulin and glucose-regulatable cleavage protease genes; for implantation into diabetics.
Yale Univ. WO 99/62926
Fluorescent in situ hybridization
New Haven, Conn.
In situ hybridization involving oligonucleotides labeled with distinguishable fluorescent tags.
Zeneca GB 2 338 301
DNA target detection
London
Detection of target nucleic acid sequences using signalling systems that respond to hybridization.
Zymogenetics WO 99/63091
Serine proteinase inhibitors
Seattle
Disulfide core protein, encoding gene sequences, antibodies; for inhibiting serine proteinases.