Published November 5 & 12 (EPO); October 30 & November 6 (WO); November 12 (GB)

Abbott Labs WO 97/41256 Solid state DNA detection Abbott Park, Ill. Solid support hybridization platform having a defined array of immobilized capture probes; for DNA detection.

Akzo Nobel WO 97/40149 Systemic autoantigen tolerance Arnhem, Netherlands Autoantigens that cause articular cartilage destruction in autoimmune disease; for inducing systemic tolerance.

Amcell WO 97/41224 Hematopoietic stem cell antigen Sunnyvale, Calif. Hematopoietic progenitor cell antigen, antibodies; for isolating stem cells.

Amgen GB 2 312 899 Osteoprotegerin Thousand Oaks, Calif. Gene for osteoprotegerin, encoded protein, antibodies, expression system; for treating bone disease.

Amgen WO 97/40152 GDNF receptor Thousand Oaks, Calif. Gene for glial dell line-derived neurotrophic factor (GDNF) receptor, encoded protein.

Becton Dickinson EPO 805 213 Mycobacterial diagnostics Franklin Lakes, N.J. Primers for mycobacterial 16S rDNA; for strand displacement amplification to detect infections.

Beth Israel Deaconess Med. Ctr. WO 97/41232 IL-15 muteins Boston, Mass. Mutant interleukin (IL)-15 peptides; for use as antagonists to modify immune responses.

Biotechnol. Res. Ctr. EPO 805 207 & WO 97/41241 Tumor rejection gene therapy Braunschweig, Germany Polycistronic expression plasmid having tumor rejection antigen and cytokine genes; for DNA immunization.

Biotechnol. Res. Ctr. WO 97/41252 Mycobacterial detection Braunschweig, Germany Gene for a protein that is useful in detecting mycobacterial infection, corresponding RNAs, encoded protein.

Cadus Pharma WO 97/40170 Adenylyl cyclase inhibitor assay Tarrytown, N.Y. Functional expression of heterologous adenylyl cyclases in yeast cells; for assaying inhibitors.

Cangene WO 97/41233 HIV toxins Winnipeg, Manitoba Two ricin-like toxin domains linked by a peptide with HIV protease recognition sites; for HIV therapy.

Case Western Res. Univ. WO 97/41208 Multilayer skin equivalent Cleveland, Ohio Multilayer skin equivalent having scaffolding and mesenchymal stem cells; for skin regeneration.

Chiron WO 97/40173 Insulin resistance therapy Emeryville, Calif. Genes for phosphoinositol 3-kinase mutants; for finding inhibitors and overcoming insulin resistance.

Cold Spr. Harbor Labs WO 97/41153 DNA replication-regulating genes Cold Spr. Harbor, N.Y. Genes for proteins regulating DNA replication and entry into mitosis, homologs, encoded proteins, antibodies.

Cytokine Sciences WO 97/40159 Conserved transfer factor peptides Denver, Colo. Gene sequences for the conserved portion of transfer factors, corresponding peptides; for diagnosis and therapy.

Denver Immunol. Assoc. WO 97/41261 RNA transcript quantitation Denver, Colo. Gene expression quantitation without co-amplification of added template or endogenous constitutive transcript use.

Duke Univ. WO 97/41210 Transfected antigen-presenting cells Durham, N.C. Antigen-presenting cells loaded with RNA from tumors or pathogens; for generating immune responses.

Forssmann, W.-G. WO 97/41230 Linked CC cytokine genes Hannover, Germany Tandem linked genes for CC-type cytokines, encoded proteins; for antiviral therapy.

Fred Hutchinson Cancer Res. Ctr. WO 97/40060 Ribosome RNA vectors Seattle, Wash. Use of ribosomal RNA sequences as vectors for introducing heterologous RNA sequences into cells.

French Lab Fractionation WO 97/41220 von Willebrand Factor variants Les Ulis, France Peptide derivatives of mature von Willebrand Factor; for coagulation and inhibiting Factor VIII binding.

Fujirebio EPO 805 160 Agglutination immunoassays Tokyo Nucleic acid-bound polypeptide, method of binding; for agglutination immunoassays.

Gelman, I., et al. WO 97/40059 Tumor suppressor gene New York Gene for tumor suppressor whose product is a protein kinase C substrate, encoded protein.

Genelabs Technol. WO 97/40168 Hepatitis G protease Redwood City, Calif. Gene for hepatitis G virus protease, encoded protein, truncated and altered proteases; for making antivirals.

Genentech WO 97/40134 DNase II S. San Francisco Gene for human DNase II, encoded protein, production methods; for diagnostic and therapeutic uses.

Genentech WO 97/40153 AL-2 neurotrophic factor S. San Francisco Gene for AL-2 neurotrophic factor, encoded protein; for diagnosing and treating neuronal disorders.

Genentech WO 97/40154 Endocytic type C lectins S. San Francisco Genes for endocytic type C lectins, encoded proteins, expression system, production methods.

Genescape WO 97/41260 Subtractive amplification Mississagua, Ont. Preferential amplification of target RNA in the presence of a mixture of non-target RNAs; for gene detection.

Genetic Therapy WO 97/39629 Parkinson's gene therapy Gaithersburg, Md. Viral vectors with neurotrophic factor genes; for treating amyelotrophic lateral sclerosis and Parkinson's.

Genetics Inst. WO 97/40069 & 40151 Secreted protein screen Cambridge, Mass. Genes for proteins secreted from neural tissue, encoded proteins, screening methods.

Genetics Inst. WO 97/40146 Secreted mammalian proteins Cambridge, Mass. Isolation of secreted mammalian proteins using secretory leader sequences and a yeast invertase reporter system.

Genitope WO 97/41244 Leukemia/lymphoma vaccines Menlo Park, Calif. Expression system with amplifiable and selectable genes; for treating leukemias and lymphomas.

German Ministry of Health WO 97/41231 Modified IL-16 gene Bonn, Germany Modified gene for expressing a protein with interleukin (IL)-16 activity in prokaryotic or eukaryotic cells.

Geron WO 97/41242 Senescence transcriptional element Menlo Park, Calif. Expression vector with cell senescence-responsive transcriptional element; for gene expression in apoptotic cells.

Groningen, St. Univ. of WO 97/40160 Prokaryotic multidrug resistance homolog Groningen, Netherlands Prokaryotic homolog of the human P-glycoprotein encoded by the multidrug resistance gene, encoding gene.

Harvard Univ. WO 97/39721 Regulating T cell cytokines Cambridge, Mass. Modulation of T cell-associated cytokine expression using transcription factors.

Health Res. EPO 806 478 Synthetic p53as protein Buffalo, N.Y. Synthetic p53as protein, antibodies; for use as a p53 antagonist and agonist.

Henry Jackson Fdn. WO 97/40161 &40177 Tagged bacterial intimin Rockville, Md. Histidine-tagged antigenic bacterial intimin, fusions; for protecting epithelial cells from bacterial adhesion.

Hoechst EPO 805 209 Intracellular transport vector Frankfurt, Germany Expression system having intracellular transport signals; for foreign gene expression [in German].

Hoechst WO 97/41250 Mature BMP Tokyo, Japan Production of mature bone morphogenetic protein (BMP) by co-expression of a processing enzyme.

Hungarian Acad. Sci. WO 97/40183 Artificial chromosomes Szaged, Hungary Preparation, transfection, and purification of artificial chromosomes with heterologous DNA; for gene therapy.

Immuno WO 97/41206 von Wllibrand Factor protease Vienna, Austria Purified multimerase that proteolytically converts von Willebrand Factor, preparation methods.

Incyte Pharma WO 97/41143 Synaptogyrin Palo Alto, Calif. Gene for a synaptogyrin homolog isolated from colon cDNA, encoded protein, antibodies, antisense, antagonists.

Incyte Pharma WO 97/41225 Mixed lymphocyte receptors Palo Alto, Calif. Genes for mammalian mixed lymphocyte receptors, encoded proteins, antibodies, antisense, antagonists.

Inst. Hormone Res. EPO 805 204 Infertility diagnostic Hamburg, Germany Gene for epididymis-specific protein, encoded protein; for infertility diagnosis [in German].

Japanese Fdn. Cancer Res. WO 97/40143 Apoptosis-inducing protein Tokyo Gene for apoptosis-inducing protein kinase-like protein, encoded protein; for cancer treatment.

Johns Hopkins Univ. WO 97/40855 RNA transcript degradation Baltimore, Md. Genes for proteins mediating the degradation of nonsense RNA transcripts having premature translation signals.

Johns Hopkins Univ. WO 97/41136 p53 gene suppressor mutations Baltimore, Md. Yeast selection system for identifying suppressor mutations of the p53 gene; for cancer therapy.

Kirin Beer EPO 805 208 Yeast expression system Tokyo Promoter/terminator of yeast formate dehydrogenase gene; for expressing foreign proteins in yeast host cells.

Krebs Res. Inst. WO 97/40185 Cellular DNA analysis Heidelberg, Germany PCR-based in situ hybridization methods; for identifying changes in amounts of specific cellular DNA.

Landegren, U. WO 97/41254 Circularizable probe detection Uppsala, Sweden Probes that are circularizable by target-dependent reactions; for detecting specific nucleic acid sequences.

Laval Univ. EPO 805 476 Leishmania vaccines Sainte-Foy, Que. Attenuated strains of Leishmania with disabled virulence genes; for vaccines.

Leukosite WO 97/40174 Hyaluronan synthetase Cambridge, Mass. Gene for mammalian hyaluronan synthetase, encoded protein, expression system, production method.

Leuven Res. & Develop. WO 97/41209 Rabbit embryonic stem cells Leuven, Belgium Methods for generating and cultivating rabbit embryonic stem cells; for making transgenic rabbits.

Mass. Inst. Technol. WO 97/41255 Three-hybrid screening assay Cambridge, Mass. Hybrid ligand molecule with a targeting sequence whose binding is detected by a reporter gene.

Merck WO 97/41154 Eosinophil eotaxin receptor Rahway, N.J. Gene for the eosinophil eotaxin receptor, encoded protein, for ligand screening and allergy treatment.

Miami, Univ. of WO 97/41223 Calcitonin-associated gene Miami, Fla. Gene for the calcitonin gene related peptide receptor component protein; for antagonist screens.

Michigan, Univ. of WO 97/40145 Modified Factor VIII Ann Arbor, Mich. Factor VIII that has been modified to be inactivation-resistant, encoding genes; for treating hemophilia.

Montreal, Univ. of WO 97/40148 G protein receptor antagonists Montreal, Que. Transmembrane domain peptides from G protein-coupled receptors; for use as antagonists.

Murex Diagnostics WO 97/40164 Hepatitis B antibodies Bridgetown, Barbados Monoclonal antibodies to wild type and mutant forms of hepatitis B antigens; for immunoassays.

NIH (Natl. Inst. Hlth.) EPO 805 203 Tumor metastases treatment Bethesda, Md. HGF/SF and Met variants and antagonists, antibodies against these proteins; for preventing metastases.

NIH (Natl. Inst. Hlth.) WO 97/40147 Hepatitis A vaccines Bethesda, Md. Antigenic regions of hepatitis A proteins, antibodies; for detection and vaccination.

NIH (Natl. Inst. Hlth.) WO 97/40156 Mutant ras vaccinated patients Bethesda, Md. Mutant ras gene peptides; for specific anti-ras cellular immune responses in vaccinated patients.

NIH (Natl. Inst. Hlth.) WO 97/40166 Chimeric hepatitis A Bethesda, Md. Chimeric human-simian hepatitis A genomes, chimeric 2C protein; for use as vaccines.

NIH (Natl. Inst. Hlth.) WO 97/41226 EGF receptor promoter repressor Bethesda, Md. Genes for the transcriptional repressor of the epidermal growth factor (EGF) receptor promoter, antibodies.

NIH (Natl. Inst. Hlth.) WO 97/41245 Ribonucleoprotein complex transfection Bethesda, Md. Transfection with synthetic ribonucleoprotein complexes; for generating viral transfectants.

Neurotech WO 97/40139 Immortalized retinal cells Paris Retinal cell lines immortalized with viral oncogene fragments; for eye-delivered therapeutics.

Newcastle, Univ. of WO 97/40169 Non-antibiotic resistance vaccines Newcastle upon Tyne, U.K. Selectable marker genes that do not encode antibiotic resistance; for live vaccines.

Newcastle, Univ. of WO 97/41150 Mitochondrial gene therapy Newcastle upon Tyne, U.K. Targeting of peptide nucleic acids to mitochondria; for gene therapy.

Novartis WO 97/41221 Metastasis-associated antigen Basel, Switzerland Membrane-associated polypeptides that are antigens associated with metastases; for assessing metastatic potential.

Novopharm Biotech WO 97/39774 Melanoma antibodies San Diego, Calif. Human monoclonal antibody for melanoma-associated antigen; for diagnosing and treating melanomas.

Ortho Pharma WO 97/40138 Modified thrombin transgenic Raritan, N.J. Transgenic animals with modified thrombin gene that does not produce a functional protein; for disease modeling.

Otsuko Pharma WO 97/41217 Obese protein receptor Tokyo Obese protein receptor, encoding gene, variants, for making animal model systems.

Pasteur Inst. EPO 806 484 HIV/SIV primer diagnostics Paris Genes from HIV and SIV; for use with PCR diagnostics techniques [in French].

Pecher, G. WO 97/40182 Dendritic cell cancer vaccines Berlin, Germany Dendritic cells transfected with genes presenting tumor-associated epitopes on cell surfaces; for cancer vaccines.

Pennsylvania, Univ. of WO 97/41249 Simplified directional cloning Philadelphia, Penn. Simplified methods of directional cloning and cDNA library construction using 5' ends of RNAs.

Persson, M.A., et al. WO 97/40176 Hepatitis C antibodies Stockholm, Sweden Human monoclonal antibodies to hepatitis C virus E2 antigen, encoding genes; for therapy.

Pharmacia & Upjohn WO 97/41238 Catalytic domains of cdc25B Kalamazoo, Mich. Modified catalytic domains of cdc25B, a cell cycle-specific phosphatase; for making therapeutics.

Pittsburgh, Univ. of WO 97/41243 Cytoplasmic expression system Pittsburgh, Penn. Eukaryotic cytoplasmic gene expression system that uses prokaryotic RNA polymerase autogenes.

Princeton Univ. WO 97/41262 Telomere maintenance Princeton, N.J. Production of telomere tails; for making telomere replication intermediates and maintaining telomeres.

Rhone-Poulenc Rorer WO 97/40172 Transcription enhancement Antony, France Derived sequences of the first intron of the tyrosine hydrolase gene; for transcription enhancement in gene therapy.

Rockefeller Univ. WO 97/40155 CNS neuronal antigen New York CNS neuronal antigen mediating neuronal-glial interactions, encoded protein, antibodies, antisense, ribozymes.

Rockefeller Univ. WO 97/41151 Anti-pneumococcal vaccines New York Choline-binding proteins, fragments, antibodies; for anti-pneumococcal vaccines.

Schering WO 97/41207 Thioredoxin fusion expression Kenilworth, N.J. Methods for producing soluble, properly folded, biologically active proteins coexpressed with thioredoxin in bacteria.

Scientific Generics WO 97/41219 Nucleic acid electrode capture Cambridge, U.K. Capture of undamaged nucleic acids from crude samples by using an electrode; for PCR amplification.

Sheffield, Univ. of WO 97/40072 Reprolysin proteins Sheffield, U.K. Reprolysin proteins, variants, mutants, derivatives, and fragments; for diagnostics and therapeutics.

Sheffield, Univ. of WO 97/40186 H2 receptor primers Sheffield, U.K. Oligos specific for human H2 receptors; for diagnosis and treatment of neurological disorders.

SmithKline Beecham EPO 805 206 Cartilage remodeling protein Philadelphia, Penn. Gene for human cartilage glycoprotein, encoded protein; for tissue remodeling disorder treatment.

SmithKline Beecham WO 97/41135-41137 & 41156 Antibacterial screen Philadelphia, Penn. Genes for response regulator proteins and histidine kinase, encoded proteins; for screening antibacterial compounds.

SmithKline Beecham WO 97/41222 P2x4 receptor variants Brentford, U.K. Genes for human brain P2x4 receptor splice variants, encoded proteins, production methods; for antagonist screens.

Sumitomo Electric WO 97/40158 Epimorphin antagonist Osaka, Japan Part of the functional domain of epimorphin; for antagonizing epithelial cell morphogenesis.

Sumitomo Pharma WO 97/40150 Osteogenesis-inducing proteins Osaka, Japan Genes for osteogenesis-inducing proteins, encoded proteins; for screening inhibitors.

T Cell Sciences WO 97/41227 Atherosclerosis vaccine Needham, Mass. Plasmid-based vaccine with genes for B and T cell epitopes; for treating atherosclerosis.

Takeda WO 97/40157 Fibrotic disease metalloprotease Osaka, Japan Gene for a matrix metalloprotease, encoded protein, vectors; for diagnosing and treating fibrotic diseases.

Thomas Jefferson Univ. WO 97/41141 Repair oligos Philadelphia, Penn. Oligos having based-paired DNA and RNA, for targeting and repairing genes during gene therapy.

Udine Univ. EPO 805 214 Listeria infection diagnostic Udine, Italy Primer for identifying Listeria monocytogenes in biological samples; for infection detection.

Vessel Res. Lab EPO 806 477 Arteriosclerosis gene therapy Tokyo Recombinant vector with smooth muscle-type myosin heavy chain SM1 isoform protein gene; for arteriosclerosis.

Visible Genetics WO 97/41257-41259 Microorganismal DNA detection Toronto, Ont. Primers for detection of microorganismal DNA sequences in complex mixtures by thermal cycling amplification.

Vlaamse Inst. Technol. Res. WO 97/41251 Mutagenicity assay Mol, Belgium Reporter system having a DNA repair gene promoter linked to a fluorescent protein gene; for assaying mutagenicity.

Wakunaga Seiyaku EPO 805 212 Complementary strand exchange PCR Osaka, Japan PCR using complementary strand-exchange reaction in competitive hybridization; for nucleic acid discrimination.

Wistar Inst. WO 97/40140 Anti-tumor anti-idiotypes Philadelphia, Penn. Mouse monoclonal anti-idiotypic antibodies that mimic GD2; for inducing a CD4 T cell anti-tumor response.

Wistar Inst. WO 97/40165 Cytomegalovirus DNA vaccines Philadelphia, Penn. Human cytomegalovirus genes for protein antigens, expression vectors; for immunization.

Yeda Res. & Develop. WO 97/41229 Interferon /ß receptor antibodies Rehovot, Israel Antibodies to the interferon /ß receptor; for modulating type-I interferon activity.