Published July 30 & August 6 (EPO); July 24 & 31 (WO)

Abbott Labs WO 97/26320 Inhibiting Haemophilus attachment Abbott Park, Ill. Inhibition of Haemophilus influenzae attachment to human cells using phosphorylated recombinant human ß-casein.

Alabama, Univ. of EPO 786 521 Pneumococcal surface protein A Birmingham, Ala. Gene for pneumococcal surface protein A, probes, vectors, production method.

Allegheny Univ. Hlth. Sci. WO 97/25860 Cancer vaccine immunogens Philadelphia, Penn. Cellular immunogens prepared from proteins expressed from proto-oncogenes; for cancer vaccines.

Amoco EPO 787 805 Chromosomal probes Downers Grove, Ill. Multiple DNA probes that covalently bind fluorophores and are specific for chromosomes and chromosomal regions.

Avigen WO 97/26336 & 26337 Anemia gene therapy Alameda, Calif. Adeno-associated viral vectors for expressing erythropoietin in muscle cells; for treating anemia.

Boehringer Mannheim EPO 786 520 NGF production method Mannheim, Germany Method for producing biologically active nerve growth factor (NGF) using oxidation-reduction steps [in German].

Boehringer Mannheim WO 97/26326 Bone stem cell isolation Indianapolis, Ind. Antibodies to CD34; for isolating bone and cartilage precursors from hematopoietic cells.

British Columbia, Univ. of WO 97/26358 Cell growth control Vancouver, B.C. In vitro cell proliferation control in growth chambers containing growth factor-polysaccharide fusion proteins.

California, Univ. of WO 97/26273 Lyme disease therapeutics Oakland, Calif. Borrelia burgdorferi outer membrane proteins, encoding genes, antibodies; for treating Lyme disease.

Carelli, C.M.H. et al. WO 97/27298 Growth hormone potentiators Suresnes, France Growth hormone peptide that has a potentiating effect on the biological action of the intact hormone.

Cheil Jedang WO 97/27302 Hemorrhagic fever vaccine Seoul, S. Korea Human-origin Hantaan virus nucleocapsid protein, encoding gene, E. coli production system; for making vaccines.

Columbia Univ. WO 97/27208 Kaposi's-associated herpes New York Herpes virus associated with Kaposi's, encoded proteins, antibodies, antisense; for diagnosis and treatment.

Eberhard Karls Univ. EPO 787 743 SCF receptor antibodies Tubingen, Germany Monoclonal antibodies specific for human stem cell factor (SCF) receptor, hybridomas [in German].

Flinders Univ. WO 97/26324 Solid phase cell enrichment Bedford Park, Australia Cell enrichment using solid phase separation techniques and ligands for intracellular constituents.

Florida, Univ. of WO 97/26333 Humanized green fluorescent protein Gainesville, Fla. Humanized versions of green fluorescent protein, encoding genes; for efficient expression in human-derived cells.

Fraunhofer Res. Inst. EPO 787 804 Soluble proteins from bacteria Munich, Germany Process for the synthesis of soluble proteins from bacterial host expression systems [in German].

Fred Hutchinson Cancer Res. Ctr. WO 97/26327 Cell cycle enhancement Seattle, Wash. Inhibitors of cyclin-dependent kinase inhibitor protein; for making transgenics and increasing growth rate.

Genelabs Technol. WO 97/27284 RAD50/septin-2 Redwood City, Calif. Genes for human RAD50 and septin-2, genomic sequences, encoded proteins.

Genentech EPO 786 257 tPA glycosylation variants S. San Francisco Tissue plasminogen activators (tPA) with variations in glycosylation; for improved circulatory half-life.

Genentech EPO 787 802 Tissue Factor variants S. San Francisco Genes for Tissue Factor protein and its variants, encoded proteins; for treating coagulation disorders.

Genetic Engin. & Biotech. Ctr. WO 97/26359 E. coli production system Havana, Cuba E. coli production system using stabilizing DNA sequences and fusion proteins; for high expression.

Georgetown Univ. WO 97/27216 Increased vector expression Washington, D.C. Vaccinia vectors with sequences for signal and anchor peptides; for amplified response to encoded proteins.

Hoechst EPO 787 795 Scleroderma topoisomerase Tokyo Muteins of human DNA topoisomerase I that react with scleroderma patient serum; for use as a diagnostic reagent.

Hoffmann-La Roche EPO 787 806 ABO polymorphic site Basel, Switzerland Nucleotide probes for an ABO locus polymorphic site on blood cells; for tissue typing and individual identification.

HSC Res. & Devlop. WO 97/27296 Familial Alzheimer's-related genes Toronto, Ont. Genes whose products interact with presenilins; for determining mutations present in familial Alzheimer's.

Human Genome Sciences EPO 786 519 Staphylococcus aureus genome sequences Rockville, Md. Staphylococcus aureus nucleic acid sequences, vectors, hosts, computer readable data storage system.

Innogenetics WO 97/27300 Toxoplasma antigens Ghent, Belgium Antigens from Toxoplasma gondii, encoding genes, primers, probes; for diagnosing and preventing infection.

Innogenetics WO 97/27332 HIV drug resistance analysis Ghent, Belgium Detection of drug-induced reverse transcriptase gene mutations from HIV isolates; for analyzing drug resistance.

INRA (Natl. Inst. Agron. Res.) WO 97/27309 Adenoviral gene therapy vector Paris Expression vectors derived from the adenovirus VA RNA I gene; for heterologous gene insertion and gene therapy.

Iowa, Univ. of WO 97/26371 Macular degeneration diagnostics Iowa City, Iowa Diagnostics and therapeutics based on the mapping of the gene responsible for age-related macular degeneration.

McGill Univ. WO 97/26903 Disease treating bacteria Montreal, Que. Oral administration of microencapsulated genetically modified microorganisms; for disease-induced chemical removal.

MRC (Med. Res. Coun.) WO 97/26904 Herpes cancer treatment London Mutant herpes virus modified within the long terminal repeat; for treating non-neuronal cancer.

Michigan, Univ. of WO 97/26373 Kaposi's herpes virus Ann Arbor, Mich. Isolation of a herpes virus from AIDS-associated Kaposi's sarcoma; for diagnosis, vaccines, and antiviral screens.

Mitotix WO 97/27297 Cell growth inhibitors Cambridge, Mass. Chimeric proteins that inhibit cyclin-dependent kinases and complexes with cyclin; for controlling cell growth.

Mitsui Toatsu Chemicals EPO 787 742 VEGF monoclonal antibodies Tokyo Vascular endothelial growth factor (VEGF) monoclonal antibodies, hybridomas; for inhibiting vascularization.

Muller, M.W. WO 97/26368 Nucleic acid amplification method Klosterneuburg, Austria Nucleic acid amplification method in which the target molecule is lengthened at its 3' end.

New York Univ. WO 97/26790 Apoptotic gene therapy New York Gene for Shigella IpaB protein, encoded protein; for binding interleukin-1ß; converting enzyme and inducing apoptosis.

NeXstar Pharma EPO 786 469 Triplex nucleic acid ligands Boulder, Colo. Non-naturally occurring triplex nucleic acid having specific binding or catalytic properties.

Northwestern Univ. WO 97/26001 Male contraceptives Evanston, Ill. Sperm- and testes-specific proteins, encoding genes; for diagnosing infertility and making contraceptives.

Novo Nordisk Biotech WO 97/26361 Bacteriocidal inhibition Davis, Calif. Bacterial donor cell useful in conjugation; for reduction in the ability to produce bacteriocidal agents.

Ortho Pharma WO 97/25861 H2-Ma genes Raritan, N. J. Altered H2-Ma genes producing altered proteins; for making transgenics not producing functional H2-M proteins.

Otsuka Pharma EPO 787 798 Cancer treatment gene Tokyo Gene associated with cell growth arrest and DNA damage induction, encoded protein; for cancer treatment.

Ottawa, Univ. of WO 97/26331 Neuronal apoptosis inhibiting protein Ottawa, Ont. Gene for neuronal apoptosis inhibiting protein, encoded protein; for apoptosis modulation.

Oxford Biomedica WO 97/27310 Gene therapy retroviral vectors Oxford, U.K. DNA sequences that create replication-deficient retroviral vectors that cannot make structural proteins in cells.

Pasteur Inst. EPO 787 796 Bortedella antibodies Paris Bortedella species adenylate cyclase hemolysin epitopes, antibodies; for infection prevention [in French].

Pharmacia EPO 786 474 Factor VIII truncation Stockholm, Sweden Recombinant human Factor VIII truncated derivative, expression system, production methods.

Praxis Biologics EPO 786 472 Haemophilus antigens Rochester, N.Y. Proteins from Haemophilus influenzae outer membrane, encoding genes; for vaccines and diagnostics.

Progenics Pharma WO 97/26009 Anti-HIV antibodies Tarrytown, N.Y. Antibodies inhibiting HIV infected cells fusion with CD4⁺ cells without reacting to HIV envelope glycoprotein or CD4.

Progenitor WO 97/26272, 26370 & 26523 Leptin receptor variants Columbus, Ohio Leptin receptor variants; for identifying individuals with these receptors and regulating obesity.

Progenitor WO 97/27286 Leptin-induced hematopoiesis Columbus, Ohio Leptin receptor variants on hematopoietic stem cells; for stimulating their long-term repopulating potential.

Res. Corp. Technol. WO 97/26537 Alzheimer's diagnosis Tucson, Ariz. Band 3 protein antibodies, assaying differential phosphorylation of this protein; for detecting Alzheimer's.

Ribozyme Pharma EPO 786 522 Restenosis ribozyme Boulder, Colo. Enzymatic RNA for cleaving mRNA associated with development or maintenance of restenosis.

Rigel Pharma WO 97/27212 Intracellular transdominant effectors Sunnyvale, Calif. Methods for screening for intracellular transdominant effector peptides and RNA from inside living cells.

Rockefeller Univ. WO 97/26335 Leptin receptors New York Leptin receptors, encoding genes; for antagonist identification and gene therapy.

RPMS Technol. WO 97/26328 CTLs for immunotherapy London Cytotoxic T lymphocytes (CTLs) having disease-associated molecules presented on their surfaces; for immunotherapy.

St. Jude's Hosp. WO 97/27311 Vaccinia HIV vaccines Memphis, Tenn. Recombinant vaccinia virus vectors expressing different HIV envelope proteins; for HIV vaccines.

Sandoz WO 97/26329 Herpes antibodies E. Hanover, N.J. Monoclonal antibodies to herpes simplex virus, hybridoma; for diagnosis and treatment.

Schering WO 97/26332 IL-5 receptor antagonist screen Kenilworth, N.J. Baculovirus system for the over-expression of human interleukin (IL)-5 receptor; for screening antagonists.

Schering WO 97/27299 CX₃C chemokine genes Kenilworth, N.J. Genes for mammalian CX₃C chemokines, encoded proteins, antibodies; for diagnostic kits.

SmithKline Beecham EPO 787 799 & WO 97/26338-26356 Staphylococcus proteins Brentford, U.K. Genes for Staphylococcus aureus proteins, encoded proteins; for bacterial infection protection.

SmithKline Beecham WO 97/26010 Coagulation factor antibodies King of Prussia, Penn. Monoclonal antibodies to coagulation factors; for inhibiting thrombosis.

SRL WO 97/26902 Cells treating dementia Tokyo Human amniotic epithelial cells producing choline acetyltransferase; for transplanting to brains to treat dementia.

Stanford Univ. WO 97/26325 Inflammation down-regulation Palo Alto, Calif. Genes encoding down-regulatory molecules are transfected into cells mediating the inflammatory response.

Synaptic Pharma EPO 787 797 5-HT_1D serotonin receptors Paramus, N.J. Human 5-HT_1D serotonin receptors, encoding genes, antibodies; for finding antagonists and making transgenics.

Synaptic Pharma WO 97/26853 Galanin receptors Paramus, N.J. Gene for galanin receptors, mutated genes, encoded protein, muteins, antibodies, antisense, transgenics.

Texas, Univ. of WO 97/26321 & 26334 Therapeutics from secretory cells Austin, Tex. Heterologous protein production using secretory cell lines; for high expression levels and large-scale production.

Texas A&M Univ. WO 97/27301 Lyme disease antigens College Station, Tex. Genes for Borrelia burgdorferi decorin-binding proteins, encoded proteins, antibodies; for treating Lyme disease.

Thomas Jefferson Univ. WO 97/26372 Smooth muscle cancer detection Philadelphia, Penn. Detection of the expression of gamma-smooth muscle isoactin; for determining smooth muscle tumor malignancy.

Virginia Mason Res. Ctr. WO 97/26538 Rubella vaccine strategy Seattle, Wash. HLA allele-specific peptide epitope strategy for developing Rubella vaccines.