Published September 10 & 17 (EPO); September 4 & 12 (WO); September 17 (GB)

Alabama, Univ. of WO 97/32978 Transgenic hemoglobin production Birmingham, Ala. Production of human hemoglobin in transgenics that do not produce their own hemoglobin.

Amba Biosciences WO 97/32992 Transplantation stem cells Gaithersburg, Md. Stromal cell lines for the in vitro maintenance of pluripotent hematopoietic stem cells; for transplantation.

Amgen WO 97/32022 Transgenic obesity model Thousand Oaks, Calif. Gene for dog OB protein, encoded protein, vectors, production methods; for making transgenic models.

Avigen WO 97/32991 Solid tumor viral vectors Alameda, Calif. Recombinant adeno-associated virus vectors for delivery of drug-sensitivity genes to solid tumors.

Bayer WO 97/32029 Parapoxvirus vector vaccines Leverkusen, Germany Parapoxviruses containing deletions and substituted foreign genes; for use as vaccines.

Becton Dickinson EPO 795 602 Nucleic acid isolation Franklin Lakes, N.J. Heat-based cellular lysis in the presence of particles; for isolating nucleic acids.

California, Univ. of WO 97/32481 Adenoviral gene therapy vectors Oakland, Calif. Production of totally defective, helper-free adenovirus; for making gene therapy vectors.

California, Univ. of WO 97/32602 Double-stranded DNA antibodies Los Angeles, Calif. Monoclonal antibodies to double-stranded DNA, functional fragments; for studying autoimmunity.

California, Univ. of WO 97/32994 Cellular AMP depletion Oakland, Calif. In vivo method for depleting cells of adenosine 5'-monophosphate (AMP); for treating cancers.

Cancer Res. Camp. Technol. WO 97/32021 Anti-tumor antibodies London Monoclonal antibodies and fragments that generate an immune response against tumor-associated antigens, encoding genes.

Chugai WO 97/32601 Apoptosis screen Tokyo Myelocytic cells that express integrin-associated protein; for assaying for apoptosis-inducing substances.

Connaught Labs WO 97/32980 Moraxella infection treatment N. York, Ontario Genes for Moraxella transferrin receptors, encoded proteins, fragments; for diagnosis and treatment of infection.

DNAVec Res. WO 97/32971 Growth-promoting fusion Ibaraki, Japan Gene for a fusion protein having growth-promoting and binding domains; for targeting cells for growth.

Eisai WO 97/32982 Occludin Tokyo Gene for human tight junction adhesion protein occludin, encoded protein.

Euroscreen WO 97/32019 Chemokine genes Brussels, Belgium Genes for chemokines and chemokine receptors, encoded proteins, expression vectors, host cells, transgenics.

Genetics Inst. WO 97/31946 IL-13 receptor and fragments Cambridge, Mass. Genes for interleukin (IL)-13 receptor and its fragments; encoded proteins; for identifying inhibitors.

Gustave-Roussy Inst. WO 97/32997 Malignant transformation detection Villejuif, France Detection of malignant human cell transformation by measuring overexpression of chorionic gonadotropin ß subunits.

Hoechst EPO 794 196 Bile salt immunoassay Frankfurt, Germany Antibodies for the selective immunoassay of bile salts in biological samples [in German].

Human Genome Sciences WO 97/32993 Chemotactic cytokine III Rockville, Md. Genes for human chemotactic cytokine III, encoded protein, antagonists; for treating cancer and autoimmune disease.

Immusol WO 97/32018 Hepatitis C ribozymes San Diego, Calif. Ribozymes effective in the treatment and prevention of hepatitis C infection, vectors, host cells.

Imutran WO 97/32981 Modified C3 convertase Cambridge, U.K. Modified human C3 protein, encoding gene; for making a down-regulation-resistant complement C3 convertase.

Inst. Applied Biochem. EPO 795 325 Multilamellar liposomes for transfection Gifu, Japan Multilamellar liposomes containing specific lipids in defined ratios; for entrapping plasmids for transfection.

INSERM (Natl. Inst. Hlth. Med. Res.) WO 97/32996 Friedreich ataxia gene Paris Gene for a protein involved in Friedreich ataxia, encoded protein; for diagnosis and therapy.

Isis Innovation WO 97/32998 Autoimmune disease susceptibility Oxford, U.K. Detection of the TaqI vitamin D receptor gene polymorphism; for diagnosing susceptibility to autoimmune disease.

Mass. Inst. Technol. WO 97/32605 Cytomegalovirus autoimmunity vaccine Cambridge, Mass. Human cytomegalovirus vector having proteins that bind Class I MHC antigens; for vaccines and treating autoimmunity.

Medigene WO 97/32988 & 32989 Adeno-associated virus vector Martinsried, Germany Recombinant adeno-associated virus vector, cell transduction system; for boosting immunogenicity.

Merck GB 2 311 068 Cytomegalovirus helicase Rahway, N.J. Gene for helicase from human cytomegalovirus, encoded enzyme; for identifying inhibitors.

Merck GB 2 311 069 Cytomegalovirus primase Rahway, N.J. Gene for primase from human cytomegalovirus, encoded enzyme; for identifying inhibitors.

Minnesota, Univ. of WO 97/32025 Selective stem cell engraftment Minneapolis, Minn. Engraftment of drug-resistant hematopoietic stem cells using transfection and toxic drug selection of cells.

Mississippi, Univ. Med. Ctr. WO 97/31945 Human imidazole receptor Jackson, Miss. Gene for the human imidazole receptor, encoded protein, host cells; for identifying drugs that bind the receptor.

Morphosys WO 97/32017 Identifying interacting peptides Munich, Germany Identification of nucleic acid sequences that encode specific interacting peptides using a phage display system.

Mt. Sinai Hosp. WO 97/32020 Src homology protein genes Toronto Genes for Src homology proteins (SHC), encoded proteins; for mediating signaling from tyrosine kinases in the CNS.

New York Univ. WO 97/31612 Mammalian endonuclease II New York Gene for mammalian endonuclease II, encoded protein, fusion proteins; for diagnosis and therapy relating to DNA repair.

Nippon Chemiphar EPO 795 605 Low-density lipoprotein receptor Tokyo Gene for a mammalian vascular endothelial receptor for modified low-density lipoprotein, encoded protein.

Oxford Biomedica WO 97/32026 Retroviral particle targeting Oxford, U.K. Adapter molecules that bind specific cells and viral particles; for targeting retroviral vectors to cells.

Procter & Gamble WO 97/31931 Disintegrin metalloprotease Cincinnati Gene for disintegrin metalloprotease, encoded protein; for identifying antagonists and treating osteoarthritis.

Retro-Tech WO 97/32995 Reverse transcriptase assay Unterschleissheim, Germany Non-radioactive, enzymatic detection of reverse transcriptase using magnetic particles and immobilized primers.

Rhode Island Hosp. WO 97/32972 Immortalized hepatocytes Providence, R.I. Non-tumorigenic, virally immortalized hepatocytes from normal liver with hepatocyte-specific metabolic activity.

Scripps Res. Inst. WO 97/32603 T cell tumor receptors La Jolla, Calif. Genes for T cell receptors specific for human HLA-restricted tumor-associated antigens; for diagnosis and therapy.

Suntory EPO 794 254 Kex2 protease chimeric proteins Osaka, Japan Kex2 protease and derivatives obtained by culturing methanol metabolizing bacteria; for making chimeric proteins.

Suntory EPO 794 255 Chimeric protein processing Osaka, Japan Method for cleaving a chimeric protein made up of target and protective moieties by using a processing enzyme.

Takara Shuzo EPO 795 606 Injection transformation of cells Kyoto, Japan Injection of foreign genes into cells in the presence of a cell adhesion-active substance; for transforming cells.

Targeted Genetics WO 97/32970 In vitro expanded T cells Seattle Modified, rapid expansion methods for in vitro clonal expansion of T cells.

Targeted Genetics WO 97/32990 Viral vectors for angiogenesis Seattle Recombinant adeno-associated virus vectors; for gene therapy in blood vessels to support angiogenesis.

Toronto, Univ. of WO 97/32987 Vaccination vectors Toronto Vectors encoding antigens and costimulatory molecules; for vaccination/therapy of infectious/neoplastic diseases.

Trinity College WO 97/32024 Allelic expression suppression Dublin, Ireland Suppression of expression of one allele of an endogenous gene by binding antigens or antisense; for gene therapy.

Tubingen Univ. Clinic EPO 794 195 Flt3/Flk2 antibodies Tubingen, Germany Monoclonal antibodies against human Flt3/Flk2 receptors, hybridoma cell line [in German].

Unisearch WO 97/32979 Cell growth inhibition Kensington, Australia Inhibition of cell growth by decreasing Egr-1 expression or its nuclear accumulation; for treating restenosis.

Vanderbilt Univ. WO 97/32033 Embryonic stem cell production Nashville Methods of making embryonic stem cells; for cell growth and differentiation and male reproduction control.

Washington Univ. WO 97/32473 Human MytI kinase St. Louis, Mo. Gene for human MytI kinase, encoded protein, production methods; for measuring expression in cancer cells.

Yamanouchi GB 2 311 067 Proline-rich anti-inflammatories W. Byfleet, U.K. Proline-rich proteins from an Epstein-Barr transformed B cell line; for treating inflammatory diseases.

Zymogenetics WO 97/32984 Diabetes autoantigen Seattle Pancreatic islet cell autoantigen related to tyrosine phosphatase and involved in insulin-dependent diabetes.

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