Published January 5 (EPO); December 29 (WO)

Alabama, Univ. of WO 99/67429

HIV drug sensitivity assay

Birmingham, Ala.

Cell line that can be infected by HIV that also contains a reporter gene; for determining HIV drug sensitivity.

Antibioticos EPO 969 088

Cephalosporin preparation

Leon, Spain

Using a modified bacterial D-amino acid oxidase for preparing cephalosporin derivatives.

Arkansas, Univ. of WO 99/67372

Mutated herpes thymidine kinases

Little Rock, Ark.

Herpes simplex virus thymidine kinases with site-specific mutations, encoding genes; for improved analog metabolism.

Biosearch Italia WO 99/67374

Drug discovery methods

Gerenzano, Italy

Transferring enzymes producing natural products from one group of bacteria to another; for drug discovery.

California, Univ. of WO 99/67267

Drug abuse gene expression

Oakland, Calif.

Identification of genes whose expression levels are altered by chronic exposure to abused drugs using ESTs.

California, Univ. of WO 99/67268 & 67403

Triacylglycerol modulators

Oakland, Calif.

Diacylglycerol O-acyltransferase, encoding gene; for assays for modulators of triacylglycerol production.

California, Univ. of WO 99/67368

Cholesterol acyltransferase

Oakland, Calif.

Acyl CoA:cholesterol acyltransferase, encoding gene sequences; for diagnostics and therapeutics.

California, Univ. of WO 99/67634

Chromosomal cancer deletions

Oakland, Calif.

Detection of deletions in the chromosome 9p21 locus; for early diagnosis and prognosis determination in cancer.

Cambridge Univ. Tech. Serv. WO 99/67407

Obesity-related gene

Cambridge, UK

Use of Peg3 gene in assays and therapeutics relating to obesity and thermoregulation.

Canadian Agriculture Ministry WO 99/67401

Edible therapeutics

London, Ont.

Production of heterologous proteins in non-food crop plants; for oral administration of therapeutics.

Case Western Reserve Univ. WO 99/66956

Prion disease diagnostics


Monoclonal antibodies to mouse prion protein; for studying disease and making human diagnostics.

Case Western Reserve Univ. WO 99/67361

Gene function determination


DNA modifying agents used to produce an allelic series of genomic modifications; for determining gene function.

CNRS (Natl. Ctr. Sci. Res.) WO 99/67282

Olfactory receptors


Olfactory receptors, encoding genes; for detecting aromas and toxic substances.

Chiron WO 99/67386

Pancreatic cancer genes

Emeryville, Calif.

Genes that are differentially expressed in pancreatic cancer and dysplasia; for diagnostics and therapeutics.

Chugai WO 99/67369

Cell cycle regulators


Human cell cycle regulatory factors, encoding gene sequences; for diagnostics and therapeutics.

Chugai WO 99/67394

RNA virus therapeutics


Vector containing a cDNA that encodes a complete RNA virus gene; for developing therapeutics.

Chugai Res. Inst. Molec. Med. WO 99/67290

Hemopoietin receptor

Ibaraki, Japan

Hemopoietin receptor proteins, modifications, encoding gene sequences; for diagnostics and therapeutics.

Combact Diagnostic Systems EPO 969 018

Antibacterial antibodies

Herzilya, Israel

Monoclonal antibodies to specific bacterial species, hybridomas; for infection diagnostics and therapeutics.

Compugen WO 99/67382

Angiopoietin-like growth factor

Tel-Aviv, Israel

Angiopoietin-like growth factor gene sequences, encoded protein, antibodies; for therapeutics.

DSM WO 99/67390

b-lactam production

Heerlen, Netherlands

Genes encoding sulphate permease obtained from b-lactam producing microorganisms; for improved production.

DSM Fine Chemicals EPO 969 095

Hydroxynitrile lyases

Linz, Austria

Hydroxynitrile lyases, muteins, derivatives, encoding gene sequences [in German].

Gist-Brocades WO 99/67356

Bacterial production system

Delft, Netherlands

Endogenous plasmid from propionibacterium; for making expression vectors to produce heterologous proteins.

Hemosol WO 99/67360

Hemoglobin production

Etobicoke, Ont.

Serum-free medium that promotes growth and differentiation of erythroid cells; for the production of hemoglobin.

Hisamitsu Pharma WO 99/67388

IL-10 antisense

Saga, Japan

Antisense oligonucleotides that inhibit the expression of interleukin (IL)-10; for atopic and allergic dermatitis.

Hoechst Marion Roussel WO 99/67408

Diabetes therapeutic

Frankfurt, Germany

Glucose-6-phosphate translocase inhibitor mumbaistatin; for the treatment of diabetes.

Hoechst Roussel WO 99/66953

Coccidiosis vaccines

Wiesbaden, Germany

Inactivated, immunogenic sporocysts of pathogenic Eimeria species; for coccidiosis vaccines.

HSP Res. Inst. EPO 969 100

Heat shock protein modulators

Osaka, Japan

Cell lines transfected with heat shock protein genes; for screening modulators of expression.

Immunomedics WO 99/66951

Bispecific diagnostic antibodies

Morris Plains, N.J.

Bispecific antibodies and fragments that bind a targetable conjugate; for diagnostics and therapeutics.

Incyte Pharma WO 99/67377

Human ARF-related proteins

Palo Alto, Calif.

Human ARF-related proteins, encoding gene sequences, antibodies, modulators; for diagnostics and therapeutics.

Incyte Pharma WO 99/67384

Prostate cancer-associated genes

Palo Alto, Calif.

Prostate cancer-associated genes, encoded proteins, antibodies, modulators; for diagnostics and therapeutics.

Innogenetics EPO 968 648

Endonexin II transgenics

Ghent, Belgium

Transgenics expressing human endonexin II, muteins, or fragments; for testing potential drugs.

Innogenetics WO 99/67285

Hepatitis C vaccine

Ghent, Belgium

Use of particles formed from hepatitis C virus envelope proteins for vaccination.

Innogenetics WO 99/67428

HIV protease gene mutations

Ghent, Belgium

Rapid and reliable detection of drug-selected HIV protease gene mutations; for predicting susceptibility to therapy.

INSERM (Natl. Inst. Hlth. & Med. Res.) WO 99/67362

In vitro HCV replication


Cell culture medium for the in vitro replication of hepatitis C virus (HCV) in primary mammalian liver cells.

INSERM (Natl. Inst. Hlth. & Med. Res.) WO 99/67395

Partial retroviral motifs


Nucleic acid sequences for partial human endogenous retroviral motifs, deduced proteins; for diagnostics.

Iowa, Univ. of WO 99/67359

Prostate cancer antibody

Iowa City, Iowa

Bispecific antibodies that bind a prostste cell marker and CD3; for retargeting anti-cancer cytotoxic lymphocytes.

Japan Tobacco WO 99/67383

G protein-coupled receptor


G protein-coupled receptor protein whose ligand is lysophosphatidic acid, encoding gene, antibodies.

Japanese Agency Ind. Sci. & Technol. EPO 969 099

Ammonia elimination


Thermo-resistant isocitrate dehydrogenase; for elimination of ammonia in liquids.

Keygene EPO 969 102

Polymorphism fingerprinting

Wageningen, Netherlands

Controlled and selective restriction fragment amplification; for DNA fingerprinting to identify polymorphisms.

Korea Green Cross WO 99/67366

Hepatitis virus protein expression

Yongin-shi, S. Korea

Expressing hepatitis B virus surface antigen and hepatitis C virus core antigen using ice nucleation protein.

Luminis WO 99/67364

In vitro fertilization

Adelaide, Australia

Medium for the propagation of early stage embryos to the blastocyst stage; for in vitro fertilization.

Mass. Gen. Hosp. WO 99/67397

Cancer diagnostics


De novo DNA cytosine methyltransferase genes, encoded proteins; for cancer diagnostics and therapeutics.

McGill Univ. WO 99/67378

Protein synthesis inhibition

Montreal, Que.

Antisense oligonucleotides based on b-arabinfuranose and its analogs; for selective inhibition of protein biosynthesis.

Medi-Cult WO 99/67365

In vitro gamete maturation

Jylinge, Denmark

In vitro maturation of human gametes in a chemically defined cell culture medium.

MRC (Med. Res. Counc.) WO 99/67283

Protein kinases


Two kinase domain protein kinases, variants, fusions, fragments, encoding genes; for screening drugs.

MRC (Med. Res. Counc.) WO 99/67292

Modified GnRH receptors


Modified gonadotropin releasing hormone (GnRH) receptors, encoding genes; for inducing increased receptor expression.

MRC (Med. Res. Counc.) WO 99/67379

Structured antisense


Structured antisense nucleic acid molecules in which various regions are alternately masked; for increased specificity.

Medigene WO 99/67393

Increased AAV infectivity

Martinsried, Germany

Adeno-associated virus (AAV) scleroprotein containing at least one mutation that increases viral infectivity.

Millennium Biotherapeutics WO 99/67418

T110-related proteins

Cambridge, Mass.

T110-related family proteins, encoding gene sequences, antibodies, transgenics; for diagnostics and therapeutics.

Millennium Pharma WO 99/67385

Cardiac function proteins

Cambridge, Mass.

MSP-5 proteins involved in cardiac function, encoding genes, antisense, antibodies, fusions, peptides.

Millennium Pharma WO 99/67387

MP-7 proteins

Cambridge, Mass.

MP-7 proteins, encoding gene sequences, antisense, antibodies, fusions, transgenics; for therapeutics.

Netherlands Koninkiljke Acad. EPO 968 724

Vectors for injured nerves


Adenoviral and adeno-associated viral vectors; for treating injured nervous tissue.

Neuronova WO 99/67363

CNS stem cells


Ependymal central nervous system (CNS) stem cells, isolation methods; for use in therapeutic preparations.

Olympus Optical EPO 969 083

Nucleic acid detection


Cylindrical glass capillaries having multiple independent probe regions; for nucleic acid detection.

Pasteur Inst. WO 99/67376

Interacting viral peptides


Analysis of viral protein-protein interactions using a yeast two-hybrid system; for defining minimal peptides.

Paysan, J., et al. EPO 969 284

Cell molecule interactions

Stuttgart, Germany

Investigation of the interaction between cellular molecules using fluorescent localization in cells [in German].

Pennsylvania, Univ. of WO 99/66946

Apoptosis induction in cancer


Compositions and methods for inducing apoptosis in cells expressing the E6 oncogene; for cancer treatment.

Pharmacia Biotech EPO 969 103

Nucleic acid sequencing

Uppsala, Sweden

Consecutive oligonucleotide primers for parallel primer extension nucleic acid sequence analysis.

Promega WO 99/67371

Polymerase stabilization

Madison, Wis.

Stabilization of polymerases and other enzymes in aqueous solutions using cationic surfactants.

Qiagen EPO 969 090

Plasmid isolation

Hilden, Germany

Rapid and simple process for isolating circular nucleic acids using alkaline conditions and silica matrices.

Sagami Chem. Res. Ctr. WO 99/67399

Glycoprotease-like proteins

Sagamihara, Japan

Human glycoprotease-like proteins, encoding gene sequences; recombinant production methods; for sugar protein studies.

Selective Genetics WO 99/66959

Neuronal gene therapy

San Diego

Devices for delivering DNA encoding neurotrophic agents; for promoting neuronal survival and regeneration.

SmithKline Beecham EPO 969 091

Leptin receptor gene-related protein

Brentford, UK

Leptin receptor gene-related protein, encoding gene sequences; for diagnostics and therapeutics.

SmithKline Beecham EPO 969 093

Drug binding proteins


Cytokine suppressive anti-inflammatory drug binding proteins, encoding gene sequences; for drug screens.

SmithKline Beecham WO 99/67391

Antibacterial screen


Origin of replication (oriC) polypeptides, encoding genes, recombinant production methods; for antibacterial screens.

SmithKline Beecham WO 99/67422

RNA transcript mapping


Fine array RNA transcript mapping; for differential expression and identifying gene functions.

South Carolina, Med. Univ. of WO 99/67400

Tissue-specific ribozymes

Charleston, S.C.

Tissue-specific and target RNA-specific ribozymes; for the treatment of cancer and infectious diseases.

Stanford Univ. WO 99/66947

Asthma therapy

Palo Alto, Calif.

Adjuvant for redirecting a Th2-type cytokine response into a Th1-type response for a selected antigen; for asthma

Sumitomo Chemical EPO 969 094

Thermostable esterase

Osaka, Japan

Thermostable esterase, encoding gene sequences; for manufacturing therapeutics.

Temple Univ. WO 99/67380

Reversing cancer


Vector causing overexpression of the c-Cbl proto-oncogene; for suppressing or reversing neoplastic transformation.

Texas, Univ. of WO 99/67426

Absorptive hypercalciuria gene

Austin, Texas

Absorptive hypercalciuria-associated gene locus on human chromosome 1; for diagnostics and therapeutics.

Thomas Jefferson Univ. WO 99/67269

Apoptosis regulation


Gene sequence encoding an ankyrin repeat TVL-1 protein, encoded protein, antibodies; for apoptosis regulation.

Tosoh EPO 969 101

Single-stranded RNA assay

Shinnanyo, Japan

Assay methods for specific sequence single-stranded RNA at constant temperature.

Toyoda, T., et al. WO 99/67396

Hepatitis C polymerase

Fukuoka, Japan

Hepatitis C virus-derived RNA polymerase gene; for detecting viral growth inhibitors.

United Biomedical WO 99/66950

Somatostatin antibodies

Hauppauge, N.Y.

Synthetic somatostatin linked to a helper T cell epitope; for making high titer somatostatin antibodies.

United Biomedical WO 99/66952

LHRH antibodies

Hauppauge, N.Y.

Luteinizing hormone releasing hormone (LHRH)linked to a helper T cell epitope; for making LHRH antibodies.

United Biomedical WO 99/66954

FMDV vaccines

Hauppauge, N.Y.

VP1 capsid protein of Foot-and-Mouth Disease virus (FMDV) linked to a helper T cell epitope; for making vaccines.

United Biomedical WO 99/66957

Immunoresponse stimulators

Hauppauge, N.Y.

Artificial helper T cell epitopes; for use as stimulators for synthetic peptide immunogens.

United Biomedical WO 99/67293

Allergy therapeutic

Hauppauge, N.Y.

Third constant domain of the epsilon heavy chain of IgE linked to a helper T cell epitope; for treating allergies.

United Biomedical WO 99/67294

HIV therapeutic

Hauppauge, N.Y.

CDR-2 like domain of CD4 linked to a helper T cell epitope; for treating HIV infection and immune disorders.

Vermont, Univ. of WO 99/67381

Anti-staphylococcal proteins

Burlington, Vt.

Genes encoding anti-staphylococcal proteins; for delivery to cells and transgenics in gene therapy.

Virologic WO 99/67427

Monitoring retroviral therapy

S. San Francisco

Phenotypic susceptibility and genotypic assays to monitor reverse transcriptase inhibitor antiretroviral therapy.

Zurich Univ. WO 99/67375

Modulator screens

Zurich, Switzerland

Transfection of DNA libraries into host cells; for screening modulator peptides by their interaction profiles.

Compiled by Chester A. Bisbee