Published January 5 (EPO); December 29 (WO)
Alabama, Univ. of WO 99/67429
HIV drug sensitivity assay
Cell line that can be infected by HIV that also contains a reporter gene; for determining HIV drug sensitivity.
Antibioticos EPO 969 088
Using a modified bacterial D-amino acid oxidase for preparing cephalosporin derivatives.
Arkansas, Univ. of WO 99/67372
Mutated herpes thymidine kinases
Little Rock, Ark.
Herpes simplex virus thymidine kinases with site-specific mutations, encoding genes; for improved analog metabolism.
Biosearch Italia WO 99/67374
Drug discovery methods
Transferring enzymes producing natural products from one group of bacteria to another; for drug discovery.
California, Univ. of WO 99/67267
Drug abuse gene expression
Identification of genes whose expression levels are altered by chronic exposure to abused drugs using ESTs.
California, Univ. of WO 99/67268 & 67403
Diacylglycerol O-acyltransferase, encoding gene; for assays for modulators of triacylglycerol production.
California, Univ. of WO 99/67368
Acyl CoA:cholesterol acyltransferase, encoding gene sequences; for diagnostics and therapeutics.
California, Univ. of WO 99/67634
Chromosomal cancer deletions
Detection of deletions in the chromosome 9p21 locus; for early diagnosis and prognosis determination in cancer.
Cambridge Univ. Tech. Serv. WO 99/67407
Use of Peg3 gene in assays and therapeutics relating to obesity and thermoregulation.
Canadian Agriculture Ministry WO 99/67401
Production of heterologous proteins in non-food crop plants; for oral administration of therapeutics.
Case Western Reserve Univ. WO 99/66956
Prion disease diagnostics
Monoclonal antibodies to mouse prion protein; for studying disease and making human diagnostics.
Case Western Reserve Univ. WO 99/67361
Gene function determination
DNA modifying agents used to produce an allelic series of genomic modifications; for determining gene function.
CNRS (Natl. Ctr. Sci. Res.) WO 99/67282
Olfactory receptors, encoding genes; for detecting aromas and toxic substances.
Chiron WO 99/67386
Pancreatic cancer genes
Genes that are differentially expressed in pancreatic cancer and dysplasia; for diagnostics and therapeutics.
Chugai WO 99/67369
Cell cycle regulators
Human cell cycle regulatory factors, encoding gene sequences; for diagnostics and therapeutics.
Chugai WO 99/67394
RNA virus therapeutics
Vector containing a cDNA that encodes a complete RNA virus gene; for developing therapeutics.
Chugai Res. Inst. Molec. Med. WO 99/67290
Hemopoietin receptor proteins, modifications, encoding gene sequences; for diagnostics and therapeutics.
Combact Diagnostic Systems EPO 969 018
Monoclonal antibodies to specific bacterial species, hybridomas; for infection diagnostics and therapeutics.
Compugen WO 99/67382
Angiopoietin-like growth factor
Angiopoietin-like growth factor gene sequences, encoded protein, antibodies; for therapeutics.
DSM WO 99/67390
Genes encoding sulphate permease obtained from b-lactam producing microorganisms; for improved production.
DSM Fine Chemicals EPO 969 095
Hydroxynitrile lyases, muteins, derivatives, encoding gene sequences [in German].
Gist-Brocades WO 99/67356
Bacterial production system
Endogenous plasmid from propionibacterium; for making expression vectors to produce heterologous proteins.
Hemosol WO 99/67360
Serum-free medium that promotes growth and differentiation of erythroid cells; for the production of hemoglobin.
Hisamitsu Pharma WO 99/67388
Antisense oligonucleotides that inhibit the expression of interleukin (IL)-10; for atopic and allergic dermatitis.
Hoechst Marion Roussel WO 99/67408
Glucose-6-phosphate translocase inhibitor mumbaistatin; for the treatment of diabetes.
Hoechst Roussel WO 99/66953
Inactivated, immunogenic sporocysts of pathogenic Eimeria species; for coccidiosis vaccines.
HSP Res. Inst. EPO 969 100
Heat shock protein modulators
Cell lines transfected with heat shock protein genes; for screening modulators of expression.
Immunomedics WO 99/66951
Bispecific diagnostic antibodies
Morris Plains, N.J.
Bispecific antibodies and fragments that bind a targetable conjugate; for diagnostics and therapeutics.
Incyte Pharma WO 99/67377
Human ARF-related proteins
Palo Alto, Calif.
Human ARF-related proteins, encoding gene sequences, antibodies, modulators; for diagnostics and therapeutics.
Incyte Pharma WO 99/67384
Prostate cancer-associated genes
Palo Alto, Calif.
Prostate cancer-associated genes, encoded proteins, antibodies, modulators; for diagnostics and therapeutics.
Innogenetics EPO 968 648
Endonexin II transgenics
Transgenics expressing human endonexin II, muteins, or fragments; for testing potential drugs.
Innogenetics WO 99/67285
Hepatitis C vaccine
Use of particles formed from hepatitis C virus envelope proteins for vaccination.
Innogenetics WO 99/67428
HIV protease gene mutations
Rapid and reliable detection of drug-selected HIV protease gene mutations; for predicting susceptibility to therapy.
INSERM (Natl. Inst. Hlth. & Med. Res.) WO 99/67362
In vitro HCV replication
Cell culture medium for the in vitro replication of hepatitis C virus (HCV) in primary mammalian liver cells.
INSERM (Natl. Inst. Hlth. & Med. Res.) WO 99/67395
Partial retroviral motifs
Nucleic acid sequences for partial human endogenous retroviral motifs, deduced proteins; for diagnostics.
Iowa, Univ. of WO 99/67359
Prostate cancer antibody
Iowa City, Iowa
Bispecific antibodies that bind a prostste cell marker and CD3; for retargeting anti-cancer cytotoxic lymphocytes.
Japan Tobacco WO 99/67383
G protein-coupled receptor
G protein-coupled receptor protein whose ligand is lysophosphatidic acid, encoding gene, antibodies.
Japanese Agency Ind. Sci. & Technol. EPO 969 099
Thermo-resistant isocitrate dehydrogenase; for elimination of ammonia in liquids.
Keygene EPO 969 102
Controlled and selective restriction fragment amplification; for DNA fingerprinting to identify polymorphisms.
Korea Green Cross WO 99/67366
Hepatitis virus protein expression
Yongin-shi, S. Korea
Expressing hepatitis B virus surface antigen and hepatitis C virus core antigen using ice nucleation protein.
Luminis WO 99/67364
In vitro fertilization
Medium for the propagation of early stage embryos to the blastocyst stage; for in vitro fertilization.
Mass. Gen. Hosp. WO 99/67397
De novo DNA cytosine methyltransferase genes, encoded proteins; for cancer diagnostics and therapeutics.
McGill Univ. WO 99/67378
Protein synthesis inhibition
Antisense oligonucleotides based on b-arabinfuranose and its analogs; for selective inhibition of protein biosynthesis.
Medi-Cult WO 99/67365
In vitro gamete maturation
In vitro maturation of human gametes in a chemically defined cell culture medium.
MRC (Med. Res. Counc.) WO 99/67283
Two kinase domain protein kinases, variants, fusions, fragments, encoding genes; for screening drugs.
MRC (Med. Res. Counc.) WO 99/67292
Modified GnRH receptors
Modified gonadotropin releasing hormone (GnRH) receptors, encoding genes; for inducing increased receptor expression.
MRC (Med. Res. Counc.) WO 99/67379
Structured antisense nucleic acid molecules in which various regions are alternately masked; for increased specificity.
Medigene WO 99/67393
Increased AAV infectivity
Adeno-associated virus (AAV) scleroprotein containing at least one mutation that increases viral infectivity.
Millennium Biotherapeutics WO 99/67418
T110-related family proteins, encoding gene sequences, antibodies, transgenics; for diagnostics and therapeutics.
Millennium Pharma WO 99/67385
Cardiac function proteins
MSP-5 proteins involved in cardiac function, encoding genes, antisense, antibodies, fusions, peptides.
Millennium Pharma WO 99/67387
MP-7 proteins, encoding gene sequences, antisense, antibodies, fusions, transgenics; for therapeutics.
Netherlands Koninkiljke Acad. EPO 968 724
Vectors for injured nerves
Adenoviral and adeno-associated viral vectors; for treating injured nervous tissue.
Neuronova WO 99/67363
CNS stem cells
Ependymal central nervous system (CNS) stem cells, isolation methods; for use in therapeutic preparations.
Olympus Optical EPO 969 083
Nucleic acid detection
Cylindrical glass capillaries having multiple independent probe regions; for nucleic acid detection.
Pasteur Inst. WO 99/67376
Interacting viral peptides
Analysis of viral protein-protein interactions using a yeast two-hybrid system; for defining minimal peptides.
Paysan, J., et al. EPO 969 284
Cell molecule interactions
Investigation of the interaction between cellular molecules using fluorescent localization in cells [in German].
Pennsylvania, Univ. of WO 99/66946
Apoptosis induction in cancer
Compositions and methods for inducing apoptosis in cells expressing the E6 oncogene; for cancer treatment.
Pharmacia Biotech EPO 969 103
Nucleic acid sequencing
Consecutive oligonucleotide primers for parallel primer extension nucleic acid sequence analysis.
Promega WO 99/67371
Stabilization of polymerases and other enzymes in aqueous solutions using cationic surfactants.
Qiagen EPO 969 090
Rapid and simple process for isolating circular nucleic acids using alkaline conditions and silica matrices.
Sagami Chem. Res. Ctr. WO 99/67399
Human glycoprotease-like proteins, encoding gene sequences; recombinant production methods; for sugar protein studies.
Selective Genetics WO 99/66959
Neuronal gene therapy
Devices for delivering DNA encoding neurotrophic agents; for promoting neuronal survival and regeneration.
SmithKline Beecham EPO 969 091
Leptin receptor gene-related protein
Leptin receptor gene-related protein, encoding gene sequences; for diagnostics and therapeutics.
SmithKline Beecham EPO 969 093
Drug binding proteins
Cytokine suppressive anti-inflammatory drug binding proteins, encoding gene sequences; for drug screens.
SmithKline Beecham WO 99/67391
Origin of replication (oriC) polypeptides, encoding genes, recombinant production methods; for antibacterial screens.
SmithKline Beecham WO 99/67422
RNA transcript mapping
Fine array RNA transcript mapping; for differential expression and identifying gene functions.
South Carolina, Med. Univ. of WO 99/67400
Tissue-specific and target RNA-specific ribozymes; for the treatment of cancer and infectious diseases.
Stanford Univ. WO 99/66947
Palo Alto, Calif.
Adjuvant for redirecting a Th2-type cytokine response into a Th1-type response for a selected antigen; for asthma
Sumitomo Chemical EPO 969 094
Thermostable esterase, encoding gene sequences; for manufacturing therapeutics.
Temple Univ. WO 99/67380
Vector causing overexpression of the c-Cbl proto-oncogene; for suppressing or reversing neoplastic transformation.
Texas, Univ. of WO 99/67426
Absorptive hypercalciuria gene
Absorptive hypercalciuria-associated gene locus on human chromosome 1; for diagnostics and therapeutics.
Thomas Jefferson Univ. WO 99/67269
Gene sequence encoding an ankyrin repeat TVL-1 protein, encoded protein, antibodies; for apoptosis regulation.
Tosoh EPO 969 101
Single-stranded RNA assay
Assay methods for specific sequence single-stranded RNA at constant temperature.
Toyoda, T., et al. WO 99/67396
Hepatitis C polymerase
Hepatitis C virus-derived RNA polymerase gene; for detecting viral growth inhibitors.
United Biomedical WO 99/66950
Synthetic somatostatin linked to a helper T cell epitope; for making high titer somatostatin antibodies.
United Biomedical WO 99/66952
Luteinizing hormone releasing hormone (LHRH)linked to a helper T cell epitope; for making LHRH antibodies.
United Biomedical WO 99/66954
VP1 capsid protein of Foot-and-Mouth Disease virus (FMDV) linked to a helper T cell epitope; for making vaccines.
United Biomedical WO 99/66957
Artificial helper T cell epitopes; for use as stimulators for synthetic peptide immunogens.
United Biomedical WO 99/67293
Third constant domain of the epsilon heavy chain of IgE linked to a helper T cell epitope; for treating allergies.
United Biomedical WO 99/67294
CDR-2 like domain of CD4 linked to a helper T cell epitope; for treating HIV infection and immune disorders.
Vermont, Univ. of WO 99/67381
Genes encoding anti-staphylococcal proteins; for delivery to cells and transgenics in gene therapy.
Virologic WO 99/67427
Monitoring retroviral therapy
S. San Francisco
Phenotypic susceptibility and genotypic assays to monitor reverse transcriptase inhibitor antiretroviral therapy.
Zurich Univ. WO 99/67375
Transfection of DNA libraries into host cells; for screening modulator peptides by their interaction profiles.
Compiled by Chester A. Bisbee