I. U.S. Initial Public Offerings

Company

Offering Month

Offering Price

2000 Close

% Change

Praecis Pharmaceuticals Inc.

April

$10

$29.25

193%

InterMune Pharmaceuticals Inc.

March

$20

$44.63

123%

Inspire Pharmaceuticals Inc.

August

$12

$26.06

117%

Specialty Laboratories Inc.

December

$16

$33.13

107%

Eden BioScience Corp.

September

$15

$29.94

100%

LION Bioscience AG

August

$39.68

$75.38

90%

Orchid BioSciences Inc.

May

$8

$14

75%

Charles River Laboratories Corp.

June

$16

$27.38

71%

Luminex Corp.

March

$17

$26.06

53%

Dendreon Corp.

June

$10

$15

50%

Adolor Corp.

November

$15

$22

47%

Paradigm Genetics Inc.

May

$7

$10

43%

Rigel Pharmaceuticals Inc.

November

$7

$10

43%

Cepheid

June

$6

$8.44

41%

Dyax Corp.

August

$15

$21.20

41%

Genaissance Pharmaceuticals Inc.

August

$13

$18

38%

Tanox Inc.

April

$28.50

$39.19

38%

Sangamo BioSciences Inc.

April

$15

$19.50

30%

ViroLogic Inc.

May

$7

$9.13

30%

Packard Bioscience Co.

April

$9

$11.63

29%

The Medicines Co.

August

$16

$20.50

28%

Pain Therapeutics Inc.

July

$12

$14.88

24%

Harvard Bioscience Inc.

December

$8

$9.88

23%

Pozen Inc.

October

$15

$18.25

22%

Esperion Therapeutics Inc.

August

$9

$10.88

21%

Array Biopharma Inc.

November

$7.50

$8.94

19%

Rosetta Inpharmatics Inc.

August

$14

$16

14%

Exelixis Pharmaceuticals Inc.

April

$13

$14.63

13%

Ista Pharmaceuticals Inc.

August

$10.50

$11.25

7%

Regeneration Technologies Inc.

August

$14

$14.25

2%

Keryx Biopharmaceuticals Inc.

July

$10

$10.13

1%

Illumina Inc.

July

$16

$16.06

0.40%

Durect Corp.

September

$12

$12

0%

Genencor International Inc.

July

$18

$18

0%

GenVec Inc.

December

$9.50

$9.50

0%

Genomic Solutions Inc.

May

$8

$7.63

-5%

Telik Inc.

August

$7

$6.63

-5%

Applied Molecular Evolution Inc.

July

$19

$17.06

-10%

AeroGen Inc.

November

$12

$10.63

-11%

Introgen Therapeutics Inc.

October

$8

$7

-13%

Arena Pharmaceuticals Inc.

July

$18

$15.50

-14%

Variagenics Inc.

July

$14

$11.86

-15%

Ciphergen Biosystems

September

$16

$13.25

-17%

Versicor Inc.

August

$11

$8.63

-22%

Lexicon Genetics Inc.

April

$22

$16.63

-24%

Diversa Corp.

February

$24

$17.94

-25%

Kosan Biosciences Inc.

October

$14

$10.50

-25%

OraPharma Inc.

March

$18

$13.25

-26%

Deltagen Inc.

August

$15

$10.44

-30%

Transgenomic Inc.

July

$15

$10.50

-30%

Discovery Partners International Inc.

July

$18

$12.13

-33%

MediChem Life Sciences Inc.

October

$7

$4.63

-34%

InforMax Inc.

October

$16

$10.38

-35%

IntraBiotics Pharmaceuticals Inc.

March

$15

$9.63

-36%

AtheroGenics Inc.

August

$8

$5

-38%

Compugen Ltd. Inc.

August

$10

$6.25

-38%

Antigenics LLC

February

$18

$11.06

-39%

deCODE genetics Inc.

July

$18

$10.50

-42%

Argonaut Technologies Inc.

July

$15

$8.50

-43%

Large Scale Biology Corp.

August

$17

$9.50

-44%

Sequenom Inc.

February

$26

$14

-46%

Aclara Biosciences Inc.

March

$21

$10.88

-48%

Pharsight Corp.

August

$10

$4.75

-53%

Allos Therapeutics Inc.

March

$18

$8.06

-55%

Crucell N.V.

October

$14.89

$6.31

-58%

Gemini Genomics plc

July

$14

$5.63

-60%

Genomica Corp.

September

$19

$5.28

-72%

Average Change: +7.3%