October 12 (WO)

Adherex Technol. WO 00/59939

Inhibiting _-catenin degradation


Modulating agents for inhibiting degradation of cytoplasmic _-catenin; for stimulating cell differentiation.

Alton Ochsner Med. Fdn. WO 00/60127

Colitis-associated retrovirus

New Orleans

Identification of a retrovirus associated with Crohn's disease and ulcerative colitis.

AstraZeneca WO 00/60062

Serine/threonine protein kinase


Human signal transduction serine/threonine protein kinase, encoding gene sequences, antisense; for therapeutics.

Biocrystal WO 00/59540

Immune complex-mediated activation

Westerville, Ohio

Assays for biological responses inducible by activation of Fc-gamma-RI-expressing cells by shed antigen complexes.

Biomerieux WO 00/60049

Ultrasonic cell lysis

Marcy l'Etoile, France

Methods an devices for the ultrasonic lysis of biological cells; for preserving cellular DNA.

Bioniche Life Sciences WO 00/59518

Prostate cancer therapy

London, Ont.

Mycoplasm DNA complexed with cell wall material; for inducing apoptosis in prostate cancer cells.

Borstel Res. Ctr. WO 00/59943

Mcm3 antibodies

Borstel, Germany

Monoclonal antibodies to human Mcm3, hybridomas; for diagnostics and therapeutics.

Brigham & Women's Hosp. WO 00/60055

Stimulating immunoresponses


Dendritic cells modified to express a selectin polypeptide; for delivery to lymph nodes to stimulate immunoresponses.

California, Univ. of WO 00/59936

Diabetes treatment

Oakland, Calif.

Human neurogenin 3-encoding gene sequences, encoded protein, antibodies; for identifying _-cells and treating diabetes.

California, Univ. of WO 00/60109

Cancer diagnostic

Oakland, Calif.

Measuring the amplification state of the CYP24 gene; for cancer prognosis and diagnosis.

Canadian Ministry of Health WO 00/59944

Breast cancer antibodies


Monoclonal antibodies to estrogen-stimulated leucine aminopeptidase; for measuring levels in breast cancers.

Canbreal Therodiagnostics WO 00/60357

Breast cancer diagnostics


Monoclonal antibodies to several markers associated with breast cancer; for tandem diagnostic immunoassays.

Cantab Pharma Res. WO 00/59927

Purifying biological molecules

Cambridge, UK

Methods for reducing contaminant content in biological preparations of recombinant proteins from bacteria.

Ceptyr WO 00/60092 & 60098-60100

Dual-specificity phosphatases

Bothell, Wash.

Dual-specificity phosphatases, encoding gene sequences; for modulating cell proliferation and differentiation.

Children's Hosp. WO 00/59533

Autoimmune disease therapy

Los Angeles

Use of asparaginase and glutaminase to treat autoimmune and graft versus host disease.

Chiron WO 00/60079

TNF superfamily proteins

Emeryville, Calif.

Tumor necrosis factor (TNF) and TNF receptor superfamily proteins, encoding genes; for identifying modulators.

Chiron WO 00/60083

Stress-phosphorylated ER protein

Emeryville, Calif.

Endoplasmic reticulum (ER) protein whose phosphorylation is induced by stress, encoding gene sequences.

City of Hope WO 00/60115

Accessible RNA binding sites

Duarte, Calif.

Methods for identifying sites on target RNA that are accessible to pairing by antisense and ribozymes.

Cold Spr. Harbor Labs WO 00/60078

Human latheo

Cold Spr. Harbor, N.Y.

Human latheo, encoding gene, antibodies, antisense; for identifying cognitive dysfunction therapeutics.

Connolly, D.M. WO 00/60125

DNA detection methods

Rochester, N.Y.

High resolution DNA detection methods and devices using oligonucleotide probes integrated into electrical circuits.

Corixa WO 00/60076

Breast cancer proteins


Breast cancer proteins, immunogenic fragments, encoding gene sequences; for diagnostics and therapeutics.

Corixa WO 00/60077

Lung cancer proteins


Lung cancer proteins, immunogenic fragments, encoding gene sequences; for diagnostics and therapeutics.

Corixa WO 00/60084

Prostate cancer proteins


Prostate cancer proteins, encoding gene sequences, antibodies; for diagnostics and therapeutics.

Corixa WO 00/60090

Pathogen vaccines


Bacillus microti antigens, encoding gene sequences, antibodies; for infection treatment and vaccines.

CuraGen WO 00/60066

Protein binding disruption

New Haven, Conn.

Protein-protein complexes from yeast cells; for identifying compounds that disrupt the binding interaction.

Eli Lilly WO 00/59942

hOB-BP2h polypeptides


hOB-BP2h polypeptides, encoding gene sequences, chimerics, antibodies, transgenics, production methods.

European Molec. Biol. Lab WO 00/60071

Mitosis modulation

Heidelberg, Germany

Microtubule-associated protein TPX2; for modulation of mitosis.

Gene Logic WO 00/60122

Ischemic heart genes

Gaithersburg, Md.

Identification of a gene whose expression is increased in ischemic heart tissue.

Genentech WO 00/59525

Diabetes therapy

S. San Francisco

Use of ErbB receptor ligands, including antibodies, to treat diabetes or pancreatic cells for implant.

Genetics Inst. WO 00/59938

Angiopoietin-like proteins

Cambridge, Mass.

Angiopoietin-like proteins, Crisp proteins, encoding gene sequences; for diagnostics and therapeutics.

Genome Technologies WO 00/60121

Genome walking

Madison, Wis.

PCR-based amplification techniques for genome walking using synthetic primers.

Genome Technologies WO 00/60123

Primer selection

Madison, Wis.

Methods for selecting primers for PCR-based amplification of nucleic acids.

Harrington Arthritis Res. Ctr. WO 00/59297

Alzheimer's model


Transgenics with Alzheimer's-like activity in the posterior cingulate region of the brain; for identifying therapeutics.

Hisamitsu Pharma WO 00/60068

Therapeutics from squamous cells

Saga, Japan

Regulatory gene sequences that cause squamous cell-specific expression; for therapeutic production from these cells.

Icos WO 00/60355

LFA-1 ICAM binding site

Bothell, Wash.

LFA-1 regulatory binding site for intercellular adhesion molecule (ICAM); for modulating interactions.

Incyte Genomics WO 00/60080

Immune system proteins

Palo Alto, Calif.

Human immune system proteins, encoding genes, antibodies, modulators; for diagnostics and therapeutics.

Incyte Genomics WO 00/60082

Vesicle-associated proteins

Palo Alto, Calif.

Vesicle-associated proteins, encoding gene sequences, antibodies, modulators; for diagnostics and therapeutics.

Innogenetics WO 00/60070

Protein carrying scaffold

Ghent, Belgium

Polypeptide chain having a _ sandwich architecture; for use as a scaffold to carry antigen-binding fragments.

INRA (Natl. Agron. Res. Inst.) WO 00/60094

Oxidant stress protectant


Modified lactococci that express a heterologous catalase; for protecting cells from oxidant stress.

Isis Pharma WO 00/59474

Fusogenic lipids

Carlsbad, Calif.

Lipids that are fusogenic for cell membranes; for liposomal delivery of therapeutics.

Isis Pharma WO 00/59549

JNK antisense

Carlsbad, Calif.

Antisense oligonucleotides to Jun N-terminal kinase (JNK); for inducing apoptosis.

Isis Pharma WO 00/59919

p38 MAPK antisense

Carlsbad, Calif.

Antisense oligonucleotides to p38 mitogen-activated protein kinase (MAPK); for disease treatment.

Japan Sci. & Technol. WO 00/60074

Dendritic cell-expressed genes

Saitama, Japan

Genes that are highly expressed in human dendritic cells, encoded proteins; for diagnostics and therapeutics.

Japan Tobacco WO 00/60075

G-CSF antibody antigen


Gene encoding an antigen recognized by G-CSF inductive antibody, encoded protein.

Japanese Ind. Res. & Technol. Agency WO 00/60096

Thermostable aminotransferase


Aminotransferase that is stable at high temperatures and over a wide pH range.

Johns Hopkins Univ. WO 00/59538

Autoimmune disease therapy


Antigen-specific induction of immune tolerance using Fas ligand-myelin basic protein; for autoimmune disease therapy.

Kudos Pharma WO 00/60359

Ku polypeptide interactions

Cambridge, UK

Interactions of Ku polypeptides; for developing therapeutics to modulate various cellular processes.

Lions Eye Inst. WO 00/60067

Cathepsin D gene promoter

Nedlands, Australia

Cathepsin D gene promoter and regulatory element; for expression vector construction and gene expression control.

Mass. Gen. Hosp. WO 00/59941

Migratory cell movement


Modulating movement of human migratory cells in tumor and pathogenic infection sites.

Max Planck Inst. WO 00/60054

Collateral artery growth


Monocytes loaded with therapeutically active molecules; for inducing growth of collateral arteries.

Mayo Clinic WO 00/59935

Apoptosis inhibition

Rochester, Minn.

Anti-apoptotic fusion polypeptides; for inhibiting apoptosis.

McGill Univ. WO 00/60113

Polymorphism detection


Methods for using a transposon-based genetic marker to detect gene polymorphisms.

Medical Biosystems WO 00/60072

Polynucleotide synthesis

Totnes, UK

Polynucleotide synthesis using a processing enzyme whose conformation modulation allows nucleotide incorporation.

Medical Biosystems WO 00/60114

Polynucleotide sequencing

Totnes, UK

Polynucleotide sequencing using an immobilized helicase-primase enzyme.

Merck WO 00/60106

Adenoviral vector gene therapy

Rahway, N.J.

Methods for using helper-dependent recombinant adenoviral vectors of alternative serotypes; for repeated gene therapy.

Millennium Pharma WO 00/60085


Cambridge, Mass.

Fibroblast growth factor (FGF)-20, encoding gene sequences, antibodies, transgenics; for diagnostics and therapeutics.

Monsanto WO 00/60103

Protein production system

St. Louis

Linkage of heterologous structural genes to a cyanobacteria gene promoter; for expression of recombinant proteins.

Mortimer Davis Jewish Gen. Hosp. WO 00/60126

Gene expression patterns


Quantitative assay for gene expression patterns in deformable large-scale microarrays.

Mosaic Technologies WO 00/60120

Bacterial detection

Waltham, Mass.

Immobilized nucleic acid capture probes; for detecting bacteria in samples and finding gene mutations.

Neurotech WO 00/60051

Cell-based delivery

Evry, France

Non-tumorigenic, non-immunogenic human cell line ARPE-19; for use in encapsulated cell-based delivery systems.

New York, State Univ. of WO 00/59537

Recombinant protein secretion

Albany, N.Y.

Bacterial signal sequences, encoding gene sequences; for fusion to heterologous proteins for efficient secretion.

Novo Nordisk WO 00/60058-60060

Alkaline a-amylase activity

Bagsvaerd, Denmark

Proteins having alkaline a-amylase activity, variants, encoding gene sequences, production methods.

Novo Nordisk WO 00/60063

Lipase variant

Bagsvaerd, Denmark

Lipase variants, encoding gene sequences; for diagnostics and therapeutics.

Oklahoma Med. Res. Fdn. WO 00/60091

Cre recombinase variants

Oklahoma City

Methods of selecting Cre recombinase variants having a broadened specificity for the site of recombination.

Osiris Therapeutics WO 00/59933

Mesenchymal DNA fingerprinting


Human mesenchymal DNAs and expression products derived from open reading frames, antibodies; for DNA fingerprinting.

Proctor & Gamble WO 00/60064

Metalloprotease purification


Purification process for a calcium-binding metalloprotease using calcium-free buffer.

Ramot Univ. WO 00/60110

Bacterial infection detection

Ramat Aviv, Israel

Monitoring bacterial gene expression by electrochemical means; for detecting infection.

Rauche, H. WO 00/59917

Information-carrying polymers

Essen, Germany

Information-carrying and -processing polymers; for polymeric memories and DNA computers.

Schering WO 00/60107

Cholesterol lowering agents

Kenilworth, N.J.

Stereoselective reduction of a substituted azetidinone by bacteria; for producing serum cholesterol lowering agents.

SmithKline Beecham WO 00/59514

Antibacterial screens


Bacterial yeaZ proteins, encoding genes, recombinant production methods; for antibacterial screens.

SmithKline Beecham WO 00/59529

Mouse EDG1 gene


Mouse EDG1 gene, encoded protein, recombinant production methods; for diagnostics and therapeutics.

SmithKline Beecham WO 00/59923

Regulator proteins


Regulator proteins, encoding gene sequences, recombinant production methods; for diagnostics and therapeutics.

SmithKline Beecham WO 00/60056

Mouse EDG5 gene


Mouse EDG5 gene, encoded protein, recombinant production methods; for diagnostics and therapeutics.

SmithKline Beecham WO 00/60057

Rat GPR10 gene


Rat GPR10 gene, encoded protein, recombinant production methods; for diagnostics and therapeutics.

SmithKline Beecham WO 00/60104

Rat KIAA0001 gene


Rat KIAA0001 gene, encoded protein, recombinant production methods; for diagnostics and therapeutics.

SmithKline Beecham WO 00/60105

Antibacterial screens


Bacterial murA proteins, encoding genes, recombinant production methods; for antibacterial screens.

Sumitomo Pharma WO 00/60073

Cancer-associated gene

Osaka, Japan

Gene whose expression is induced by p53 inactivation, encoded protein; for cancer diagnostics and therapeutics.

Synaptic Pharma WO 00/60081

Orphan G protein-coupled receptor

Paramus, N.J.

DNA encoding an orphan G protein-coupled receptor, encoded protein; for diagnostics and therapeutics.

Thomas Jefferson Univ. WO 00/59526

Apoptosis modulation


Peptides conjugated to lipophilic moieties; for enhancing cellular uptake in order to modulate apoptosis.

Toronto, Univ. of WO 00/60069

Presenilin-associated protein


Presenilin-associated membrane protein, encoding gene sequences; for Alzheimer's diagnostics and therapeutics.

Tropix WO 00/60116

High-throughput assays

Bedford, Mass.

High-throughput, high-sensitivity assays requiring little purification that have amplification to maximize signals.

Utah, Univ. of WO 00/59918

Antibacterial drug development

Salt Lake City

Eubacterial tmDNA sequences and corresponding tmRNA sequences; for developing antibacterial drugs.

Victoria, Univ. of WO 00/60102

Presenting foreign peptides

Victoria, B.C.

Salmonella strains having heterologous fimbrin genes; for presentation of foreign peptide sequences.

Walters, R.E., et al. WO 00/60065

Cell electrofusion

Columbia, Md.

Tangential flow cell concentration and fusion apparatus; for cell electrofusion.

Wisconsin, Univ. of WO 00/60050

Flu vaccines

Madison, Wis.

Recombinant influenza viruses free of helper viruses; for preparing vaccines.

Yale Univ. WO 00/60124

DNA fingerprinting

New Haven, Conn.

Fixed address analysis of sequence tags by sorting tags by their sticky ends; for nucleic acid fingerprinting.

Zeneca Mogen WO 00/60086

Pathogen-inducible promoter

Leiden, Netherlands

Pathogen-inducible promoter; for making vectors in which a therapeutic structural gene is linked to this promoter.

ZymoGenetics WO 00/59934

Testis-specific protein


Testis-specific protein, encoding gene sequences; for diagnosing, staging, and treating cancer.