September 13 & 20 (EP), September 14 (WO); September 20 (GB)

Affymetrix EP 1 036 845

Genes downstream from WT1

Santa Clara, Calif.

Genes that are found downstream from the WT1 tumor suppressor gene; for diagnostics and therapeutics.

Ajinomoto WO 00/53740

Biomolecule activity regulators

Tokyo

Peptide libraries with members interacting with sites on biomolecules that modify activity; for finding regulators.

Akzo Nobel EP 1 035 203

Mutated IBD virus

Arnhem, Netherlands

Mutated infectious bursal disease (IBD) virus mutants that are able to grow in CEF cells.

Applied Gene Technol. WO 00/53809

Nucleic acid amplification

San Diego

Methods of amplifying nucleic acids that minimize the contamination with earlier amplification reactions.

Artemis Pharma EP 1 035 209

Flu vaccines

Cologne, Germany

Stable recombinant influenza viruses free of helper viruses; for high-yield expression of foreign genes in vaccines.

Artemis Pharma WO 00/53786

Foreign gene expression

Cologne, Germany

Stable recombinant influenza viruses free of helper viruses; for high-yield expression of incorporated foreign genes.

ASM Scientific WO 00/53805

Multiple sequence determination

Cambridge, Mass.

High-throughput method for determining multiple sequences in parallel without amplification or knowing prior sequences.

Atlantic Biopharma WO 00/53759

Expressing a-fetoprotein

Cambridge, Mass.

Nucleic acid, vector, cells, and processes for expressing recombinant human a-fetoprotein in mammalian cells.

Aventis Pasteur WO 00/53764

Chlamydia vaccines

Toronto

Chlamydia pneumoniae membrane protein, encoding gene sequences; for vaccines.

Aventis Pharma WO 00/53790

Targeted multivalent proteins

Frankfurt, Germany

Target cell-specific multivalent protein having targeting sequences linked to a binding structure.

Azur Environmental EP 1 035 216

Nucleic acid assay

Wokingham, UK

Semiconductor electrodes coated with rare earth metal oxides; for measuring nucleic acids in solution.

Bioalliance Pharma WO 00/53745

Antisense oligos

Paris

Antisense oligos stabilized by a secondary structure that breaks down upon binding; for gene expression inhibition.

BioChip Technol. EP 1 035 218

Polymer brushes

Freiburg, Germany

Immobilization of molecules on surfaces using polyfunctional polymer monolayers called polymer brushes.

Biosource Technol. WO 00/53780

Expressing foreign RNAs

Vacaville, Calif.

RNA vector system having RNA virus-derived RNA replicons and helper viruses; for expressing foreign RNAs.

Brown Univ. WO 00/53738

Memory modulation genes

Providence, R.I.

Methods for identifying genes involved in memory consolidation; for finding memory modulating agents.

California, Univ. of WO 00/53741

NPR1-interacting proteins

Oakland, Calif.

bZIP DNA binding proteins that interact with NPR1, encoding gene sequences; for finding additional modulators.

Ceptyr WO 00/53636

Cell growth inhibition

Bothell, Wash.

Dual-specificity phosphatase DSP-1, variants, encoding gene sequences; for finding antibodies to inhibit cell growth.

Chugai EP 1 035 132

Apoptosis-inducing antibodies

Tokyo

Monoclonal antibodies to human integrin-associated proteins; for inducing apoptosis in nucleated blood cells.

Chugai WO 00/53634

Leukemia therapeutics

Tokyo

Single chain Fv mouse antibody fragments that induce apoptosis of nucleated blood cells; for leukemia.

Chugai WO 00/53806

Gene expression patterns

Tokyo

Methods for making short DNA tags and their arrays; for identifying gene expression patterns.

Chugai Res. Inst. Molec. Med. EP 1 035 204

Hormone binding protein homologs

Ibaraki, Japan

Steroid hormone binding protein homologs, encoding gene sequences, expressed sequence tags.

Chugai Res. Inst. Molec. Med. EP 1 036 844

Peutz-Jeghers associated genes

Ibaraki, Japan

Peutz-Jeghers associated gene sequences, encoded proteins, antibodies; for diagnostics and therapeutics.

Cold Spr. Harbor Labs WO 00/5381

Memory formation genes

Cold Spr. Harbor, N.Y.

Use of gene chip technology to identify transcription-dependent memory formation-associated genes.

Columbia Univ. WO 00/53629

CD40 signal inhibition

New York

Tumor necrosis receptor-associated factor (TRAF)-3 deletion isoforms; for finding CD40-mediated cell signal inhibitors.

Columbia Univ. WO 00/53808

Cancer therapeutics

New York

Determination of the beclin allele status of patients; for viral-related cancer diagnostics and therapeutics.

Combimatrix WO 00/53625

Analyzing gene products

Burlingame, Calif.

Microarrays of peptide affinity probes formed on a porous membrane near an electrode; for analyzing gene products.

Connaught Labs WO 00/53767

RSV vaccines

Toronto

Non-replicating vectors encoding an F protein of respiratory syncytial virus (RSV); for nucleic acid vaccines.

CuraGen WO 00/53733

Autoimmunity therapeutics

New Haven, Conn.

Hermansky Pudlak Syndrome protein-interacting proteins, fragments, analogs; for treating autoimmunity.

CuraGen WO 00/53742

Membrane-associated proteins

New Haven, Conn.

Membrane-associated and secreted proteins, encoding gene sequences, fragments, antibodies; for therapeutics.

Diversa WO 00/53744

Directed evolution

San Diego

Non-stochastic polynucleotide site-saturation mutagenesis and reassembly; for directed evolution.

European Molec. Biol. Lab WO 00/53779

Translation regulation

Heidelberg, Germany

Regulating translation of RNAs of heterologous proteins using ribosome recruitment protein.

Fischer, M., et al. WO 00/53229

Vaccine protein conjugates

Munich, Germany

Protein conjugates having icosahedral lumazine synthases, encoding genes; for immunoassays and vaccines.

Genentech WO 00/53750, 53751, 53754 & 53755

Amplified cancer genes

S. San Francisco

Genes amplified in cancer, encoded proteins, antitumor proteins, chimeras, antibodies; for therapeutics.

Genentech WO 00/53752, 53753 & 53757

Angiogenesis modulators

S. San Francisco

Proteins modulating angiogenesis and cardiovascularization, encoding genes, chimeras, antibodies; for therapeutics.

Genentech WO 00/53756

Secreted proteins

S. San Francisco

Secreted and transmembrane proteins, encoding genes, antibodies, recombinant production methods.

Genentech WO 00/53758

Immune disease proteins

S. San Francisco

Proteins involved in immune-related diseases, encoding genes; for diagnostics and therapeutics.

Genentech WO 00/53760

Treating ocular disease

S. San Francisco

Proteins involved in preventing death of retinal neurons, encoding genes; for treating ocular disease.

German Res. Ctr. Hlth. & Welfare WO 00/53789

Gene therapy vectors

Neuherberg, Germany

Retroviral vectors with cell-specific modulatable promoters; for expressing therapeutics in gene therapy.

Ghent Univ. EP 1 035 219

Helicobacter typing

Ghent, Belgium

Gastric Helicobacter 16S rRNA and rDNA sequences; for detecting and typing ulcer-causing strains.

Glasgow, Univ. of WO 00/53218

Neurodegeneration therapy

Glasgow, UK

Subtype 1 of protein kinase C, encoding gene sequences; for treating neurodegeneration.

Glaxo WO 00/53785

Increased protein translation

Greenford, UK

Untranslated gene regions from heat shock proteins; for linkage to genes to increase protein translation.

Hager, J. WO 00/53802

Finding disease genes

Mennecy, France

Methods for identifying identical DNA fragments from two different sources; for finding disease genes.

Harvard Univ. WO 00/53812

Replica amplification of gene arrays

Cambridge, Mass.

Making immobilized nucleic acid arrays and producing amplified replicas of such arrays; for sequencing.

Hoffmann-La Roche GB 2 347 930

IGF-1 receptor interacting proteins

Basel, Switzerland

Insulin growth factor (IGF)-1 receptor interacting proteins, encoding gene sequences; for cancer therapeutics.

Japan Sci. & Technol. WO 00/53005

sno gene knockouts

Saitama, Japan

Heterogeneous and homogeneous mouse variants lacking the sno gene; for determining gene function.

JCR Pharma EP 1 035 202

DNA fragment cloning

Hyogo, Japan

Methods for cloning DNA fragments using arbitrarily primed PCR reactions.

Korea Res. Inst. Biotech. WO 00/53777

Glucagon fusions

Taejon, S. Korea

Preparation of recombinant proteins from microorganisms using human glucagon as a fusion partner.

Lexicon Genetics WO 00/53630

Blocking DNA repair

The Woodlands, Texas

Peptides that disrupt mammalian Rad51 activity; for blocking DNA repair pathways in cancer cells.

Louisiana State Univ. WO 00/53775

Toxin gene delivery

Baton Rouge, La.

Toxin genes linked to virus promoters for targeting virus-infected cells for death; for treating cancer.

Mass. Inst. Technol. WO 00/53813

Pangenomic libraries

Cambridge, Mass.

Pangenomic libraries representing all genes encoding functional proteins; for diagnostics and screens.

McGill Univ. WO 00/53735

Synaptic plasticity modulators

Montreal

Chimeric gene having a netrin promoter; for finding agents that modulate synaptic plasticity and cell motility.

MRC (Med. Res. Counc.) GB 2 347 931

Schwann cell mitogen

London

Mitogen that is upregulated during neuronal cell and tissue regeneration, encoding gene sequences.

Millennium Pharma WO 00/53769

Thioredoxin family proteins

Cambridge, Mass.

Thioredoxin family active site proteins, encoding genes, fusions, antibodies; for diagnostics and therapeutics.

Minnesota, Univ. of WO 00/53737

Mitomycin biosythesis modulation

Minneapolis, Minn.

Biosynthetic gene cluster for mitomycin; for modulating mitomycin biosynthesis.

Mitotix WO 00/53743

Growth inhibiting gene fragments

Cambridge, Mass.

Small gene fragments that interfere with the function of the genes from which they are derived; for growth inhibition.

Mitotix WO 00/53781

Cell growth gene identification

Cambridge, Mass.

Yeast strain mutants having condition-sensitive lethal mutations of cell growth genes; for identifying such genes.

Mitsubishi Rayon WO 00/53736 & 53739

Immobilizing fibers

Tokyo

Fibers for immobilizing biological substances, especially nucleic acids in gels, fiber bundles, bundle slices.

Mt. Sinai Hosp. WO 00/53747

Ig-like lectin gene

Toronto

Sialic acid-binding immunoglobulin (Ig)-like lectin and Ob-binding protein-like genes, encoded proteins.

Mt. Sinai Hosp. WO 00/53776

Kallikrein-like proteins

Toronto

Kallikrein-like proteins, encoding genes; for diagnostics and therapeutics.

MultiGene Biotech EP 1 035 207 & WO 00/53770

Fatty acid desaturase homologs

Wurzburg, Germany

Human fatty acid desaturase homologs, encoding gene sequences, antibodies, transgenics.

Nantes Univ. WO 00/53788

Gene therapy vectors

Nantes, France

Methods for high efficiency production of recombinant adeno-associated viruses; for gene therapy.

NIH (Natl. Inst. Hlth.) WO 00/53773

Mitochondrial gene therapy

Bethesda, Md.

Functional complementation of defective mitochondrial genes by targeting replacement genes to the nucleus.

Neurocrine Biosciences WO 00/53774

Metalloproteinases

San Diego

Metalloproteinases, variants, modulators; for diagnostics and therapeutics.

Nigu Chemie WO 00/53309

Purifying nucleotides

Waldkraiburg, Germany

Photolytic deprotection of nucleoside derivatives immobilized on a substrate; for purified nucleotides.

Nottingham, Univ. of WO 00/53804

Gene sequence copy screen

Nottingham, UK

Nucleic acid sequence copy screen using probes that have the same flanking sequences; for subsequent amplification.

Orion Genomics WO 00/53811

Transcription profiling

St. Louis, Mo.

Genomic DNA microarray chips having minimally overlapping sequences; for visual gene transcription profiling.

Ortho-Clinical Diagnostics EP 1 036 847

Hepatitis C diagnostics

Rochester, N.Y.

Oligonucleotide primers for efficient reverse transcription of hepatitis C virus RNA; for diagnostics.

Oxford BioMedica GB 2 347 932

Tumor-associated antigen

Oxford, UK

5T4 tumor-associated antigen, encoding gene sequences; for cancer immunotherapy and vaccines.

Paul Ehrlich Inst. EP 1 035 210

Lentiviral vectors

Langen, Germany

SIV-derived lentiviral vectors, preparation methods; for use in mammalian gene transfer [in German].

Pfizer EP 1 035 133

Pathogen vaccines

Groton, Conn.

Fusion protein having endogenous protein and pathogen antigen moieties; for pathogen vaccines.

Pittsburgh, Univ. of WO 00/53795

Adipose tissue engineering

Pittsburgh, Penn.

Adipose-derived stem cells and lattices for generating differentiated tissues and structures.

Protogene WO 00/53617

Long DNA sequences

Menlo Park, Calif.

Cost-effective methods for assembling long DNA sequences from short synthetic oligonucleotides.

RMF Dictagene WO 00/53749

Vascular adhesion proteins

Prilly, France

Confluency-regulated adhesion molecule-related vascular protein, antibodies; for treating inflammation and cancer.

Roche Diagnostics WO 00/53772

DNA polymerase

Mannheim, Germany

Pyrobaculum islandicum DNA polymerase; for use when 3'-5' exonuclease activity is required.

Saskatchewan, Univ. of WO 00/53765

Haemophilus vaccines

Saskatoon, Sask.

Haemophilus somnus transferrin-binding proteins, encoding genes; for diagnostics and vaccines.

Schering WO 00/53631

Mammalian cytokines

Kenilworth, N.J.

Mammalian cytokines, encoded proteins, antibodies; for diagnostics and therapeutics.

Schering WO 00/53734

Endothelial cell therapeutics

Berlin

Endothelial cell-specific expressed genes, mRNAs, encoded proteins; for therapeutics.

Shimadzu EP 1 036 846

Bacterial infection diagnostics

Kyoto, Japan

Oligonucleotide probes for detecting a variety of bacterial species using PCR; for infection diagnostics.

Showa Sangyo WO 00/53778

Increased a-amylase activity

Tokyo

Inserting restriction enzyme cleavage sites into the a-amylase gene 3' region; for increased promoter activity.

SmithKline Beecham WO 00/53748

Cancer-related proteins

Rixensart, Belgium

Cancer-related proteins, encoding genes, recombinant production techniques; for cancer vaccines.

Stanford Univ. WO 00/53019

Autoantigen injections

Palo Alto, Calif.

Injection of DNA encoding an autoantigen; for suppressing T cell responses in autoimmune disease.

Stichting Labs WO 00/53766

Pestivirus vaccines

Wageningen, Netherlands

Non-spreading pestivirus, pestivirus-like particles, vaccines; for preventing contagion.

Sumitomo Pharma EP 1 035 208

Gene integration

Osaka, Japan

Variant loxP sequences; for more efficient gene integration or replacement in eukaryotes.

Sumukin Bio-Science EP 1 035 217

PTH receptor gene polymorphisms

Kanagawa, Japan

Determining the parathyroid hormone (PTH) receptor gene polymorphisms; for predicting hyperthyroidism.

Tosoh EP 1 035 214

3'-modified DNA probes

Yamaguchi, Japan

Single-stranded nucleic acid probes modified at the 3' end; for hybridization and fluorescence detection.

Transgene WO 00/53803

Finding inserted vectors

Strasbourg, France

Single-stranded nucleotide fragment for detecting pBR322 replication origin sequences; for finding inserted vectors.

Vysis EP 1 035 215

Chromosomal cancer probes

Downers Grove, Ill.

Chromosomal probes for identifying aneusomic cells; for cancer detection.

Whatman WO 00/53807

Nucleic acid purification

Rockland, Mass.

Solid medium and processes for the storage and rapid purification of nucleic acids.

Whitehead Inst. Biomed. Res. EP 1 037 158

Clustering gene expression

Cambridge, Mass.

Methods and apparatus for clustering gene expression patterns from a plurality of genes.

ZymoGenetics WO 00/53761

Hematopoietic cell cytokine

Seattle

Cytokine involved in hematopoietic cell development, encoded protein, antibodies; for diagnostics and therapeutics.

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