September 13 & 20 (EP), September 14 (WO); September 20 (GB)
Affymetrix EP 1 036 845
Genes downstream from WT1
Santa Clara, Calif.
Genes that are found downstream from the WT1 tumor suppressor gene; for diagnostics and therapeutics.
Ajinomoto WO 00/53740
Biomolecule activity regulators
Peptide libraries with members interacting with sites on biomolecules that modify activity; for finding regulators.
Akzo Nobel EP 1 035 203
Mutated IBD virus
Mutated infectious bursal disease (IBD) virus mutants that are able to grow in CEF cells.
Applied Gene Technol. WO 00/53809
Nucleic acid amplification
Methods of amplifying nucleic acids that minimize the contamination with earlier amplification reactions.
Artemis Pharma EP 1 035 209
Stable recombinant influenza viruses free of helper viruses; for high-yield expression of foreign genes in vaccines.
Artemis Pharma WO 00/53786
Foreign gene expression
Stable recombinant influenza viruses free of helper viruses; for high-yield expression of incorporated foreign genes.
ASM Scientific WO 00/53805
Multiple sequence determination
High-throughput method for determining multiple sequences in parallel without amplification or knowing prior sequences.
Atlantic Biopharma WO 00/53759
Nucleic acid, vector, cells, and processes for expressing recombinant human a-fetoprotein in mammalian cells.
Aventis Pasteur WO 00/53764
Chlamydia pneumoniae membrane protein, encoding gene sequences; for vaccines.
Aventis Pharma WO 00/53790
Targeted multivalent proteins
Target cell-specific multivalent protein having targeting sequences linked to a binding structure.
Azur Environmental EP 1 035 216
Nucleic acid assay
Semiconductor electrodes coated with rare earth metal oxides; for measuring nucleic acids in solution.
Bioalliance Pharma WO 00/53745
Antisense oligos stabilized by a secondary structure that breaks down upon binding; for gene expression inhibition.
BioChip Technol. EP 1 035 218
Immobilization of molecules on surfaces using polyfunctional polymer monolayers called polymer brushes.
Biosource Technol. WO 00/53780
Expressing foreign RNAs
RNA vector system having RNA virus-derived RNA replicons and helper viruses; for expressing foreign RNAs.
Brown Univ. WO 00/53738
Memory modulation genes
Methods for identifying genes involved in memory consolidation; for finding memory modulating agents.
California, Univ. of WO 00/53741
bZIP DNA binding proteins that interact with NPR1, encoding gene sequences; for finding additional modulators.
Ceptyr WO 00/53636
Cell growth inhibition
Dual-specificity phosphatase DSP-1, variants, encoding gene sequences; for finding antibodies to inhibit cell growth.
Chugai EP 1 035 132
Monoclonal antibodies to human integrin-associated proteins; for inducing apoptosis in nucleated blood cells.
Chugai WO 00/53634
Single chain Fv mouse antibody fragments that induce apoptosis of nucleated blood cells; for leukemia.
Chugai WO 00/53806
Gene expression patterns
Methods for making short DNA tags and their arrays; for identifying gene expression patterns.
Chugai Res. Inst. Molec. Med. EP 1 035 204
Hormone binding protein homologs
Steroid hormone binding protein homologs, encoding gene sequences, expressed sequence tags.
Chugai Res. Inst. Molec. Med. EP 1 036 844
Peutz-Jeghers associated genes
Peutz-Jeghers associated gene sequences, encoded proteins, antibodies; for diagnostics and therapeutics.
Cold Spr. Harbor Labs WO 00/5381
Memory formation genes
Cold Spr. Harbor, N.Y.
Use of gene chip technology to identify transcription-dependent memory formation-associated genes.
Columbia Univ. WO 00/53629
CD40 signal inhibition
Tumor necrosis receptor-associated factor (TRAF)-3 deletion isoforms; for finding CD40-mediated cell signal inhibitors.
Columbia Univ. WO 00/53808
Determination of the beclin allele status of patients; for viral-related cancer diagnostics and therapeutics.
Combimatrix WO 00/53625
Analyzing gene products
Microarrays of peptide affinity probes formed on a porous membrane near an electrode; for analyzing gene products.
Connaught Labs WO 00/53767
Non-replicating vectors encoding an F protein of respiratory syncytial virus (RSV); for nucleic acid vaccines.
CuraGen WO 00/53733
New Haven, Conn.
Hermansky Pudlak Syndrome protein-interacting proteins, fragments, analogs; for treating autoimmunity.
CuraGen WO 00/53742
New Haven, Conn.
Membrane-associated and secreted proteins, encoding gene sequences, fragments, antibodies; for therapeutics.
Diversa WO 00/53744
Non-stochastic polynucleotide site-saturation mutagenesis and reassembly; for directed evolution.
European Molec. Biol. Lab WO 00/53779
Regulating translation of RNAs of heterologous proteins using ribosome recruitment protein.
Fischer, M., et al. WO 00/53229
Vaccine protein conjugates
Protein conjugates having icosahedral lumazine synthases, encoding genes; for immunoassays and vaccines.
Genentech WO 00/53750, 53751, 53754 & 53755
Amplified cancer genes
S. San Francisco
Genes amplified in cancer, encoded proteins, antitumor proteins, chimeras, antibodies; for therapeutics.
Genentech WO 00/53752, 53753 & 53757
S. San Francisco
Proteins modulating angiogenesis and cardiovascularization, encoding genes, chimeras, antibodies; for therapeutics.
Genentech WO 00/53756
S. San Francisco
Secreted and transmembrane proteins, encoding genes, antibodies, recombinant production methods.
Genentech WO 00/53758
Immune disease proteins
S. San Francisco
Proteins involved in immune-related diseases, encoding genes; for diagnostics and therapeutics.
Genentech WO 00/53760
Treating ocular disease
S. San Francisco
Proteins involved in preventing death of retinal neurons, encoding genes; for treating ocular disease.
German Res. Ctr. Hlth. & Welfare WO 00/53789
Gene therapy vectors
Retroviral vectors with cell-specific modulatable promoters; for expressing therapeutics in gene therapy.
Ghent Univ. EP 1 035 219
Gastric Helicobacter 16S rRNA and rDNA sequences; for detecting and typing ulcer-causing strains.
Glasgow, Univ. of WO 00/53218
Subtype 1 of protein kinase C, encoding gene sequences; for treating neurodegeneration.
Glaxo WO 00/53785
Increased protein translation
Untranslated gene regions from heat shock proteins; for linkage to genes to increase protein translation.
Hager, J. WO 00/53802
Finding disease genes
Methods for identifying identical DNA fragments from two different sources; for finding disease genes.
Harvard Univ. WO 00/53812
Replica amplification of gene arrays
Making immobilized nucleic acid arrays and producing amplified replicas of such arrays; for sequencing.
Hoffmann-La Roche GB 2 347 930
IGF-1 receptor interacting proteins
Insulin growth factor (IGF)-1 receptor interacting proteins, encoding gene sequences; for cancer therapeutics.
Japan Sci. & Technol. WO 00/53005
sno gene knockouts
Heterogeneous and homogeneous mouse variants lacking the sno gene; for determining gene function.
JCR Pharma EP 1 035 202
DNA fragment cloning
Methods for cloning DNA fragments using arbitrarily primed PCR reactions.
Korea Res. Inst. Biotech. WO 00/53777
Taejon, S. Korea
Preparation of recombinant proteins from microorganisms using human glucagon as a fusion partner.
Lexicon Genetics WO 00/53630
Blocking DNA repair
The Woodlands, Texas
Peptides that disrupt mammalian Rad51 activity; for blocking DNA repair pathways in cancer cells.
Louisiana State Univ. WO 00/53775
Toxin gene delivery
Baton Rouge, La.
Toxin genes linked to virus promoters for targeting virus-infected cells for death; for treating cancer.
Mass. Inst. Technol. WO 00/53813
Pangenomic libraries representing all genes encoding functional proteins; for diagnostics and screens.
McGill Univ. WO 00/53735
Synaptic plasticity modulators
Chimeric gene having a netrin promoter; for finding agents that modulate synaptic plasticity and cell motility.
MRC (Med. Res. Counc.) GB 2 347 931
Schwann cell mitogen
Mitogen that is upregulated during neuronal cell and tissue regeneration, encoding gene sequences.
Millennium Pharma WO 00/53769
Thioredoxin family proteins
Thioredoxin family active site proteins, encoding genes, fusions, antibodies; for diagnostics and therapeutics.
Minnesota, Univ. of WO 00/53737
Mitomycin biosythesis modulation
Biosynthetic gene cluster for mitomycin; for modulating mitomycin biosynthesis.
Mitotix WO 00/53743
Growth inhibiting gene fragments
Small gene fragments that interfere with the function of the genes from which they are derived; for growth inhibition.
Mitotix WO 00/53781
Cell growth gene identification
Yeast strain mutants having condition-sensitive lethal mutations of cell growth genes; for identifying such genes.
Mitsubishi Rayon WO 00/53736 & 53739
Fibers for immobilizing biological substances, especially nucleic acids in gels, fiber bundles, bundle slices.
Mt. Sinai Hosp. WO 00/53747
Ig-like lectin gene
Sialic acid-binding immunoglobulin (Ig)-like lectin and Ob-binding protein-like genes, encoded proteins.
Mt. Sinai Hosp. WO 00/53776
Kallikrein-like proteins, encoding genes; for diagnostics and therapeutics.
MultiGene Biotech EP 1 035 207 & WO 00/53770
Fatty acid desaturase homologs
Human fatty acid desaturase homologs, encoding gene sequences, antibodies, transgenics.
Nantes Univ. WO 00/53788
Gene therapy vectors
Methods for high efficiency production of recombinant adeno-associated viruses; for gene therapy.
NIH (Natl. Inst. Hlth.) WO 00/53773
Mitochondrial gene therapy
Functional complementation of defective mitochondrial genes by targeting replacement genes to the nucleus.
Neurocrine Biosciences WO 00/53774
Metalloproteinases, variants, modulators; for diagnostics and therapeutics.
Nigu Chemie WO 00/53309
Photolytic deprotection of nucleoside derivatives immobilized on a substrate; for purified nucleotides.
Nottingham, Univ. of WO 00/53804
Gene sequence copy screen
Nucleic acid sequence copy screen using probes that have the same flanking sequences; for subsequent amplification.
Orion Genomics WO 00/53811
St. Louis, Mo.
Genomic DNA microarray chips having minimally overlapping sequences; for visual gene transcription profiling.
Ortho-Clinical Diagnostics EP 1 036 847
Hepatitis C diagnostics
Oligonucleotide primers for efficient reverse transcription of hepatitis C virus RNA; for diagnostics.
Oxford BioMedica GB 2 347 932
5T4 tumor-associated antigen, encoding gene sequences; for cancer immunotherapy and vaccines.
Paul Ehrlich Inst. EP 1 035 210
SIV-derived lentiviral vectors, preparation methods; for use in mammalian gene transfer [in German].
Pfizer EP 1 035 133
Fusion protein having endogenous protein and pathogen antigen moieties; for pathogen vaccines.
Pittsburgh, Univ. of WO 00/53795
Adipose tissue engineering
Adipose-derived stem cells and lattices for generating differentiated tissues and structures.
Protogene WO 00/53617
Long DNA sequences
Menlo Park, Calif.
Cost-effective methods for assembling long DNA sequences from short synthetic oligonucleotides.
RMF Dictagene WO 00/53749
Vascular adhesion proteins
Confluency-regulated adhesion molecule-related vascular protein, antibodies; for treating inflammation and cancer.
Roche Diagnostics WO 00/53772
Pyrobaculum islandicum DNA polymerase; for use when 3'-5' exonuclease activity is required.
Saskatchewan, Univ. of WO 00/53765
Haemophilus somnus transferrin-binding proteins, encoding genes; for diagnostics and vaccines.
Schering WO 00/53631
Mammalian cytokines, encoded proteins, antibodies; for diagnostics and therapeutics.
Schering WO 00/53734
Endothelial cell therapeutics
Endothelial cell-specific expressed genes, mRNAs, encoded proteins; for therapeutics.
Shimadzu EP 1 036 846
Bacterial infection diagnostics
Oligonucleotide probes for detecting a variety of bacterial species using PCR; for infection diagnostics.
Showa Sangyo WO 00/53778
Increased a-amylase activity
Inserting restriction enzyme cleavage sites into the a-amylase gene 3' region; for increased promoter activity.
SmithKline Beecham WO 00/53748
Cancer-related proteins, encoding genes, recombinant production techniques; for cancer vaccines.
Stanford Univ. WO 00/53019
Palo Alto, Calif.
Injection of DNA encoding an autoantigen; for suppressing T cell responses in autoimmune disease.
Stichting Labs WO 00/53766
Non-spreading pestivirus, pestivirus-like particles, vaccines; for preventing contagion.
Sumitomo Pharma EP 1 035 208
Variant loxP sequences; for more efficient gene integration or replacement in eukaryotes.
Sumukin Bio-Science EP 1 035 217
PTH receptor gene polymorphisms
Determining the parathyroid hormone (PTH) receptor gene polymorphisms; for predicting hyperthyroidism.
Tosoh EP 1 035 214
3'-modified DNA probes
Single-stranded nucleic acid probes modified at the 3' end; for hybridization and fluorescence detection.
Transgene WO 00/53803
Finding inserted vectors
Single-stranded nucleotide fragment for detecting pBR322 replication origin sequences; for finding inserted vectors.
Vysis EP 1 035 215
Chromosomal cancer probes
Downers Grove, Ill.
Chromosomal probes for identifying aneusomic cells; for cancer detection.
Whatman WO 00/53807
Nucleic acid purification
Solid medium and processes for the storage and rapid purification of nucleic acids.
Whitehead Inst. Biomed. Res. EP 1 037 158
Clustering gene expression
Methods and apparatus for clustering gene expression patterns from a plurality of genes.
ZymoGenetics WO 00/53761
Hematopoietic cell cytokine
Cytokine involved in hematopoietic cell development, encoded protein, antibodies; for diagnostics and therapeutics.