Published August 25 (EPO); August 19 (WO)
Alabama, Univ. of WO 99/41359
Modified adenovirus fibers
Birmingham, Ala.
Adenovirus having a modified fiber protein used for inserting other peptide moieties; for cell targeting.
Aventis Res. & Technol. WO 99/41390
DEAD protein production
Frankfurt, Germany
Insect cell expression vectors; for the production of DEAD family proteins.
Beth Israel Deaconess Hosp. WO 99/41412
Prostate tumor gene
Boston
NPG-1 gene differentially expressed in prostate tumors, encoded protein, antibodies, transgenics.
Cadus Pharma WO 99/41385
Apoptosis regulation
Tarrytown, N.Y.
MEKK1 proteins, fragments, encoding gene sequences; for finding modulators and regulating apoptosis.
California, Univ. of WO 99/41363
Inflammatory sialomucins
Oakland, Calif.
Podocalyxin-like sialomucins having selectin ligand activity, encoding gene sequences; for inflammation.
California, Univ. of WO 99/41403
Targeting DNA to cells
Oakland, Calif.
Liposomes with ligand polymeric scaffolds; for targeting exogenous nucleic acids to cells.
Champagne Moet & Chandon WO 99/41391 & 41392
Stress-induced promoter
Epernay, France
Stress- and pathogen-induced plant promoter, stilbene synthase gene, transgenics; for improved resistance.
Curagen WO 99/41376
Retinoblastoma protein complexes
New Haven, Conn.
Complexes of retinoblastoma protein and its interacting proteins, fragments, encoding genes; for therapeutics.
Dow Agro Sciences WO 99/41395
Antibiotic resistance alternatives
Indianapolis
Bacteria having feedback-insensitive threonine dehydratase deaminase; for antibiotic resistance alternatives.
DSM WO 99/41386
Pectin degradation
Hoorlen, Netherlands
Endo-xylogalacturonase, encoding gene sequences; for degrading pectin.
Genetics Inst. WO 99/41284
Secreted proteins
Cambridge, Mass.
Secreted proteins, encoding gene sequences; for diagnostics and therapeutics.
GenVec WO 99/41398
Vector toxin expression
Rockville, Md.
Expressing viral vector genes encoding toxins or apoptosis-inducers in eukaryotic cells using blocking genes.
Genzyme WO 99/41399
AAV vector production
Framingham, Mass.
High level production of adeno-associated viral (AAV) vectors; for high yields of helper virus-free vector stocks.
Genzyme WO 99/41400
Pseudoadenovirus production
Framingham, Mass.
Pseudoadenoviral vector production in cells using helper adenoviruses that do not also get packaged.
Hepatix WO 99/40793
C3A clonal cell line
La Jolla, Calif.
C3A clonal cell line, serum-free cell culture; for producing proteins, screening compounds, and making artificial livers.
Hyseq WO 99/41382
IL-3 variant
Sunnyvale, Calif.
Interleukin (IL)-3 variant isolated from fetal liver-spleen tissue, encoding gene sequence; for therapeutics.
Immune Complex WO 99/40934
Hepatitis B vaccine
San Diego
Hepatitis B core protein modified to have a reactive amino acid residue for linkage to a hapten and T cell epitope.
Immunex WO 99/41388
Metalloprotease disintegrins
Seattle
Metalloprotease disintegrins SVP3-13 and 17, encoding gene sequences, fragments, antibodies; for therapeutics.
Incyte Pharma WO 99/41373
Transport-associated proteins
Palo Alto, Calif.
Human transport-associated proteins, encoding genes, antibodies, modulators; for diagnostics and therapeutics.
Incyte Pharma WO 99/41374
Short-chain TNF protein
Palo Alto, Calif.
Human short-chain tumor necrosis factor (TNF) receptor family protein, encoding gene, antibodies, modulators.
Incyte Pharma WO 99/41375
Human receptor proteins
Palo Alto, Calif.
Human receptor proteins, encoding genes, antibodies, modulators; for diagnostics and therapeutics.
Incyte Pharma WO 99/41387
Prostate-associated serine protease
Palo Alto, Calif.
Prostate-associated serine protease, encoding gene sequence, antibodies, modulators; for diagnostics and therapeutics.
INSERM (Natl. Inst. Hlth. Med. Res.) WO 99/41378 & 41379
D52 gene homolog
Paris
Mouse homolog of the D52 gene, novel isoform, fragments, probes; for in situ gene expression mapping.
Kyowa EPO 937 775
_ 1,3-N-acetylglucosaminyltransferase
Tokyo
_ 1,3-N-acetylglucosaminyltransferase, encoding gene sequences, antibodies; for therapeutics.
Max Planck Inst. WO 99/41404
Activating nucleotides
Berlin
Nucleotide kinases, methods of identification; for activation of nucleotide drugs.
Maxygen WO 99/41368
Gene vaccine immunoresponse
Santa Clara, Calif.
Optimization of the immunomodulatory properties of genetic vaccines, identification of immunomodulators.
Maxygen WO 99/41369
Gene vaccine engineering
Santa Clara, Calif.
Genetic vaccine vector engineering; for increased uptake, antigenicity, and intracellular stability.
Maxygen WO 99/41383
Antigen library construction
Santa Clara, Calif.
Constructing antigen libraries with antigens having improved immunogenicity.
Maxygen WO 99/41402
Targeting gene vaccines
Santa Clara, Calif.
Reagents for increasing the specificity of genetic vaccines for target cells or tissue types.
McGill Univ. WO 99/41370
Cancer cell differentiation
Montreal
Carcinoembryonic antigen (CEA) antibodies; for inducing tumor cells to differentiate.
Merck WO 99/41367
DNA chromatography
Darmstadt, Germany
Chromatography media having heteroaromatic oligamides linked to an affinity ligand; for isolating nucleic acids.
Minnesota, Univ. of WO 99/40789
Apo gene alterations
Minneapolis, Minn.
Apolipoprotein (Apo) gene alterations having protective effects against developing atherosclerosis.
New York, State Univ. of WO 99/41355
HIV chemokine
Buffalo, N.Y.
Gene from the long terminal repeat region of HIV encoding a chemokine that acts as a co-factor for HIV entry into cells.
Novo Nordisk WO 99/41358
Homologous cross-out
Bagsvaerd, Denmark
Prokaryotic cells with two gene copies transcribed in opposite directions; for avoiding homologous cross-out.
Ohio State Univ. WO 99/41414
Identifying mutations
Columbus, Ohio
Methods for identifying nucleic acid mutations using mismatch modification.
Ortho-McNeil Pharma WO 99/41365
H2-O gene knockouts
Raritan, N.J.
Transgenics with altered H2-O genes; for disease modeling and therapeutic development.
Oxford Biomedica WO 99/41397
Producing viral vectors
Oxford, UK
Viral vector production system for producing virus particles without degradation; for infection prevention.
Pfizer WO 99/41389
Avermectins
Groton, Conn.
Streptomyces avermitilis gene directing avermectin B1-B2 ratios, mutations; for controlling avermectin production.
Pioneer Hi-Bred Intl. WO 99/41394
Maize gene
Des Moines, Iowa
Maize RAD51 gene, encoded protein, fusion proteins, plasmids; for making transgenic plants.
Pioneer Hi-Bred Intl. WO 99/41415
Identifying tagged genes
Des Moines, Iowa
Identification and amplification of transposable element-tagged genes; for gene identification.
Rhone-Poulenc Rorer WO 99/41396
Negative regulatory gene sequences
Antony, France
Negative regulatory gene sequences; for targeted expression of transgenes in nerve cells.
SmithKline Beecham EPO 937 777
GABA receptors
Brentford, UK
GABA receptors, encoding gene sequences, production methods; for diagnostics and therapeutics.
SmithKline Beecham WO 99/41384
p101 splice variants
Brentford, UK
Splice variants of p101 protein, encoding gene sequences, production methods; for diagnostics and therapeutics.
Sonderegger, P. WO 99/41381
Neuroserpin therapeutics
Zurich, Switzerland
Nervous system diagnostic and therapeutic applications using neuroserpin.
Stanford Univ. WO 99/41366
Gene skin vaccination
Palo Alto, Calif.
Introduction of genes via skin cells using naked or liposome-encapsulated DNA; for genetic immunization.
Strata Biosciences WO 99/41371
Combinatorial ribozyme libraries
Alameda, Calif.
Combinatorial ribozyme libraries; for targeting genes to identify their function.
Toyo Kohan WO 99/41362
Gene sequence comparison
Tokyo
Immobilization and amplification of DNA libraries; for comparing gene sequences.
Vercelli, D., et al. WO 99/41380
Anti-allergen screen
Milan, Italy
Regulatory sequence of the gamma-4 germline transcript; for screening anti-allergenic substances.
Wales, Univ. of WO 99/41401
Intracellular substance transfer
Cardiff, UK
Using lipid-coated tips to transfer substances into cell membranes and cytoplasm.
Wistar Inst. WO 99/41364
Enhancing wound healing
Philadelphia
Mice strains having enhanced wound healing abilities; for identifying involved genes and encoded proteins.
Yeda Res. & Develop. WO 99/41410
Increasing polymerase stability
Rehovot, Israel
Using osmoprotectants to increase DNA polymerase thermal stability; for amplification and sequencing.
Zeneca WO 99/41372
Potassium channel
London
Potassium channel from the human brain, encoding gene sequences; for identifying modulators.
Zeneca WO 99/41393
Insecticidal plants
London
Insecticidal proteins, homologs, variants, derivatives, fragments; encoding gene sequences; for transgenic plants.
Zymogenetics WO 99/41377
Cystine knot protein
Seattle
Cystine knot family protein, encoding gene sequences, antagonists; for diagnostics and therapeutics.
- Compiled by Chester A. Bisbee