Published August 25 (EPO); August 19 (WO)

Alabama, Univ. of WO 99/41359

Modified adenovirus fibers

Birmingham, Ala.

Adenovirus having a modified fiber protein used for inserting other peptide moieties; for cell targeting.

Aventis Res. & Technol. WO 99/41390

DEAD protein production

Frankfurt, Germany

Insect cell expression vectors; for the production of DEAD family proteins.

Beth Israel Deaconess Hosp. WO 99/41412

Prostate tumor gene


NPG-1 gene differentially expressed in prostate tumors, encoded protein, antibodies, transgenics.

Cadus Pharma WO 99/41385

Apoptosis regulation

Tarrytown, N.Y.

MEKK1 proteins, fragments, encoding gene sequences; for finding modulators and regulating apoptosis.

California, Univ. of WO 99/41363

Inflammatory sialomucins

Oakland, Calif.

Podocalyxin-like sialomucins having selectin ligand activity, encoding gene sequences; for inflammation.

California, Univ. of WO 99/41403

Targeting DNA to cells

Oakland, Calif.

Liposomes with ligand polymeric scaffolds; for targeting exogenous nucleic acids to cells.

Champagne Moet & Chandon WO 99/41391 & 41392

Stress-induced promoter

Epernay, France

Stress- and pathogen-induced plant promoter, stilbene synthase gene, transgenics; for improved resistance.

Curagen WO 99/41376

Retinoblastoma protein complexes

New Haven, Conn.

Complexes of retinoblastoma protein and its interacting proteins, fragments, encoding genes; for therapeutics.

Dow Agro Sciences WO 99/41395

Antibiotic resistance alternatives


Bacteria having feedback-insensitive threonine dehydratase deaminase; for antibiotic resistance alternatives.

DSM WO 99/41386

Pectin degradation

Hoorlen, Netherlands

Endo-xylogalacturonase, encoding gene sequences; for degrading pectin.

Genetics Inst. WO 99/41284

Secreted proteins

Cambridge, Mass.

Secreted proteins, encoding gene sequences; for diagnostics and therapeutics.

GenVec WO 99/41398

Vector toxin expression

Rockville, Md.

Expressing viral vector genes encoding toxins or apoptosis-inducers in eukaryotic cells using blocking genes.

Genzyme WO 99/41399

AAV vector production

Framingham, Mass.

High level production of adeno-associated viral (AAV) vectors; for high yields of helper virus-free vector stocks.

Genzyme WO 99/41400

Pseudoadenovirus production

Framingham, Mass.

Pseudoadenoviral vector production in cells using helper adenoviruses that do not also get packaged.

Hepatix WO 99/40793

C3A clonal cell line

La Jolla, Calif.

C3A clonal cell line, serum-free cell culture; for producing proteins, screening compounds, and making artificial livers.

Hyseq WO 99/41382

IL-3 variant

Sunnyvale, Calif.

Interleukin (IL)-3 variant isolated from fetal liver-spleen tissue, encoding gene sequence; for therapeutics.

Immune Complex WO 99/40934

Hepatitis B vaccine

San Diego

Hepatitis B core protein modified to have a reactive amino acid residue for linkage to a hapten and T cell epitope.

Immunex WO 99/41388

Metalloprotease disintegrins


Metalloprotease disintegrins SVP3-13 and 17, encoding gene sequences, fragments, antibodies; for therapeutics.

Incyte Pharma WO 99/41373

Transport-associated proteins

Palo Alto, Calif.

Human transport-associated proteins, encoding genes, antibodies, modulators; for diagnostics and therapeutics.

Incyte Pharma WO 99/41374

Short-chain TNF protein

Palo Alto, Calif.

Human short-chain tumor necrosis factor (TNF) receptor family protein, encoding gene, antibodies, modulators.

Incyte Pharma WO 99/41375

Human receptor proteins

Palo Alto, Calif.

Human receptor proteins, encoding genes, antibodies, modulators; for diagnostics and therapeutics.

Incyte Pharma WO 99/41387

Prostate-associated serine protease

Palo Alto, Calif.

Prostate-associated serine protease, encoding gene sequence, antibodies, modulators; for diagnostics and therapeutics.

INSERM (Natl. Inst. Hlth. Med. Res.) WO 99/41378 & 41379

D52 gene homolog


Mouse homolog of the D52 gene, novel isoform, fragments, probes; for in situ gene expression mapping.

Kyowa EPO 937 775

_ 1,3-N-acetylglucosaminyltransferase


_ 1,3-N-acetylglucosaminyltransferase, encoding gene sequences, antibodies; for therapeutics.

Max Planck Inst. WO 99/41404

Activating nucleotides


Nucleotide kinases, methods of identification; for activation of nucleotide drugs.

Maxygen WO 99/41368

Gene vaccine immunoresponse

Santa Clara, Calif.

Optimization of the immunomodulatory properties of genetic vaccines, identification of immunomodulators.

Maxygen WO 99/41369

Gene vaccine engineering

Santa Clara, Calif.

Genetic vaccine vector engineering; for increased uptake, antigenicity, and intracellular stability.

Maxygen WO 99/41383

Antigen library construction

Santa Clara, Calif.

Constructing antigen libraries with antigens having improved immunogenicity.

Maxygen WO 99/41402

Targeting gene vaccines

Santa Clara, Calif.

Reagents for increasing the specificity of genetic vaccines for target cells or tissue types.

McGill Univ. WO 99/41370

Cancer cell differentiation


Carcinoembryonic antigen (CEA) antibodies; for inducing tumor cells to differentiate.

Merck WO 99/41367

DNA chromatography

Darmstadt, Germany

Chromatography media having heteroaromatic oligamides linked to an affinity ligand; for isolating nucleic acids.

Minnesota, Univ. of WO 99/40789

Apo gene alterations

Minneapolis, Minn.

Apolipoprotein (Apo) gene alterations having protective effects against developing atherosclerosis.

New York, State Univ. of WO 99/41355

HIV chemokine

Buffalo, N.Y.

Gene from the long terminal repeat region of HIV encoding a chemokine that acts as a co-factor for HIV entry into cells.

Novo Nordisk WO 99/41358

Homologous cross-out

Bagsvaerd, Denmark

Prokaryotic cells with two gene copies transcribed in opposite directions; for avoiding homologous cross-out.

Ohio State Univ. WO 99/41414

Identifying mutations

Columbus, Ohio

Methods for identifying nucleic acid mutations using mismatch modification.

Ortho-McNeil Pharma WO 99/41365

H2-O gene knockouts

Raritan, N.J.

Transgenics with altered H2-O genes; for disease modeling and therapeutic development.

Oxford Biomedica WO 99/41397

Producing viral vectors

Oxford, UK

Viral vector production system for producing virus particles without degradation; for infection prevention.

Pfizer WO 99/41389


Groton, Conn.

Streptomyces avermitilis gene directing avermectin B1-B2 ratios, mutations; for controlling avermectin production.

Pioneer Hi-Bred Intl. WO 99/41394

Maize gene

Des Moines, Iowa

Maize RAD51 gene, encoded protein, fusion proteins, plasmids; for making transgenic plants.

Pioneer Hi-Bred Intl. WO 99/41415

Identifying tagged genes

Des Moines, Iowa

Identification and amplification of transposable element-tagged genes; for gene identification.

Rhone-Poulenc Rorer WO 99/41396

Negative regulatory gene sequences

Antony, France

Negative regulatory gene sequences; for targeted expression of transgenes in nerve cells.

SmithKline Beecham EPO 937 777

GABA receptors

Brentford, UK

GABA receptors, encoding gene sequences, production methods; for diagnostics and therapeutics.

SmithKline Beecham WO 99/41384

p101 splice variants

Brentford, UK

Splice variants of p101 protein, encoding gene sequences, production methods; for diagnostics and therapeutics.

Sonderegger, P. WO 99/41381

Neuroserpin therapeutics

Zurich, Switzerland

Nervous system diagnostic and therapeutic applications using neuroserpin.

Stanford Univ. WO 99/41366

Gene skin vaccination

Palo Alto, Calif.

Introduction of genes via skin cells using naked or liposome-encapsulated DNA; for genetic immunization.

Strata Biosciences WO 99/41371

Combinatorial ribozyme libraries

Alameda, Calif.

Combinatorial ribozyme libraries; for targeting genes to identify their function.

Toyo Kohan WO 99/41362

Gene sequence comparison


Immobilization and amplification of DNA libraries; for comparing gene sequences.

Vercelli, D., et al. WO 99/41380

Anti-allergen screen

Milan, Italy

Regulatory sequence of the gamma-4 germline transcript; for screening anti-allergenic substances.

Wales, Univ. of WO 99/41401

Intracellular substance transfer

Cardiff, UK

Using lipid-coated tips to transfer substances into cell membranes and cytoplasm.

Wistar Inst. WO 99/41364

Enhancing wound healing


Mice strains having enhanced wound healing abilities; for identifying involved genes and encoded proteins.

Yeda Res. & Develop. WO 99/41410

Increasing polymerase stability

Rehovot, Israel

Using osmoprotectants to increase DNA polymerase thermal stability; for amplification and sequencing.

Zeneca WO 99/41372

Potassium channel


Potassium channel from the human brain, encoding gene sequences; for identifying modulators.

Zeneca WO 99/41393

Insecticidal plants


Insecticidal proteins, homologs, variants, derivatives, fragments; encoding gene sequences; for transgenic plants.

Zymogenetics WO 99/41377

Cystine knot protein


Cystine knot family protein, encoding gene sequences, antagonists; for diagnostics and therapeutics.

- Compiled by Chester A. Bisbee