Published Feb. 24 (EPO); Feb. 18 (WO)

Ajinomoto WO 99/07853
Glutamic acid production
Corynebacterium strain having enhanced production of glutamic acid; for production.

Alexion Pharma WO 99/07829
Large animal transgenics
New Haven, Conn.
Introduction of genomic DNA into early stage embryos about to express paternal genomes; for large animal transgenics.

Allied Colloids WO 99/07838
Bradford, U.K.
Acrylamidase enzymes from Rhodococcus strains; for reducing free acrylamides in polyacrylamide gels.

Altwell Biotech WO 99/07859
Recombinant oral polio vaccine
Taejon, S. Korea
Replication-competent recombinant Sabin type 1 strain of poliovirus; for making oral mucosal vaccines.

American Home Products WO 99/07847
Estrogen receptor-_
Madison, N.J.
Human estrogen receptor-_, antibodies, methods for identifying modulators.

Anticancer WO 99/07858
High methioninase expression
San Diego
High expression modules having tandem copies of methioninase genes; for high level expression and cancer therapy.

Bio Merieux WO 99/07408
Neurodegenerative factors
Marcy l'Etoile, France
Protein factors associated with neurodegenerative and autoimmune diseases; for therapeutics.

Bioinvent Intl. WO 99/07842
Phage ligand binders
Lund, Sweden
Selection for phages that display ligand binders and use of differential bacterial infectivity for their production.

Bioniche WO 99/07383
Apoptosis regulator
London, Ontario
Mycobacterial DNA used as an agent to regulate cell growth and cell death.

Bristol-Myers Squibb WO 99/07832
Potassium channels
Princeton, N.J.
Potassium channels, encoding gene sequences; for finding modulators and treating neuronal diseases.

California, Univ. of WO 99/07892
DNA alteration detection
Oakland, Calif.
DNA sequences from regions of copy number change on chromosome 20; for array-based alteration detection.

Cantab Pharma WO 99/07834
Improved herpes yields
Cambridge, U.K.
Harvesting herpes virus from cell cultures using hypertonic aqueous solutions; for improved yields.

Cell Genesys WO 99/07833
AAV vector production
Foster City, Calif.
Increased efficiency of adeno-associated viral (AAV) vector production by controlling REP and CAP protein expression.

Chiron EPO 897 987
Signal sequence secretion
Emeryville, Calif.
Expression vector having a gamma-interferon signal sequence; for increased secretion from transfected mammalian cells.

Chiron WO 99/07862
Yeast production system
Emeryville, Calif.
Yeast gene regulatory sequences; for expression and secretion of recombinant proteins.

Chiron WO 99/07870
Genetically modified T cells
Emeryville, Calif.
Activation of T cells with a CD3 binding agent followed by transfection with a gene transfer vehicle.

Chugai WO 99/07846
PDZ domain protein
Ibaraki, Japan
TNF-a induced protein from human umbilical vascular endothelial cells that has a PDZ domain.

CSIRO (Comm. Sci. Indus. Res. Org.) WO 99/07852
Fowlpox virus
Campbell, Australia
Recombinant fowlpox virus whose nucleic acid does not encode an active reticuloendothelial virus.

Creative Peptides Sweden WO 99/07735
Multimeric insulin C peptide
Djursholm, Sweden
Expression of multimeric insulin C peptide, encoding gene sequences; for therapeutics.

Diversa WO 99/07837
Thermostable DNA polymerases
San Diego
Isolation and identification of thermostable DNA polymerases from thermophilic prokaryotes.

Dompe WO 99/07831
Hematopoietic stem cell growth
L'Aquila, Italy
Methods for ex vivo expansion of hematopoietic stem cells, culture medium for stem cell growth.

Florida, Univ. of WO 99/07869
Vaccinia virus vaccine
Gainesville, Fla.
Live, replication-deficient, orally-delivered vaccinia virus vaccine; for inducing immunity.

Fred Hutchinson Cancer Inst. WO 99/07725
Neuroectodermal tumors
Measurement of neurogenic bHLH gene expression; for detecting neuroectodermal-derived tumors.

French Atomic Energy Comm. WO 99/07836
Cyclin protein kinases
Kinase-activating dependent cyclin protein kinases; for use as fungicides.

Genetics Inst. WO 99/07840
Secreted protein genes
Cambridge, Mass.
Genes encoding secreted proteins, encoded proteins, vectors; for identifying secreted protein genes.

Genset WO 99/07737
Lipolysis-stimulated receptor
Lipolysis-stimulated receptor, encoding gene sequences; for identifying modulators of obesity and diabetes.

Georgetown Univ. WO 99/07394
HSV-based tumor therapeutics
Herpes simplex virus (HSV) vectors that preferentially infect tumor cells; for anticancer therapeutics.

Glaxo WO 99/07856
Greenford, U.K.
Newly identified metalloproteases, encoding gene sequences; for contraceptive vaccines.

Harvard Univ. WO 99/07888
Surface-bound DNA arrays
Cambridge, Mass.
Surface-bound DNA with one strand linked to solid supports and the second strand bound to the first; for making arrays.

Hoffmann-La Roche EPO 897 984
D-sorbitol dehydrogenase
Basel, Switzerland
D-sorbitol dehydrogenase, encoding gene sequences, vectors, production methods.

Hoffmann-La Roche WO 99/07843
GDNF expression modifiers
Basel, Switzerland
Glial cell line-derived neurotrophic factor (GDNF) promoters; for finding compounds affecting GDNF expression.

Human Genome Sciences WO 99/07891
90 secreted proteins
Rockville, Md.
90 human secreted proteins, encoding gene sequences, production methods; for diagnosis and therapy.

Immunex EPO 897 983
CD40 ligand antibodies
Antibodies reactive against CD40 ligand or CD40 ligand immunogens.

Incyte Pharma WO 99/07849
Reticulocalbin isoforms
Palo Alto, Calif.
Human reticulocalbin isoforms, encoding gene sequences, encoding gene sequences, modulators; for therapeutics.

Joslin Diabetes Ctr. WO 99/07868
Immunologically privileged cells
Immunologically privileged cells from the intermediate lobe of the pituitary; for delivering insulin.

Lab Medicine Products & Pharmaceut. WO/07861
Mycobacterial vaccines
Amadora, Portugal
Site-specific integration of DNA into mycobacterial strains; for making highly stable recombinant mycobacterial vaccines.

Lexicon Genetics WO 99/07389
Targeted gene discovery
The Woodlands, Texas
Retroviral integrase fusions with DNA binding proteins; for generating libraries and rapid functional analysis.

Massachusetts, Univ. of WO 99/07890
Nucleic acid quantitation
Hybridization-based and ligation-dependent methods of nucleic acid quantitation; for studying ligand interactions.

Mass. Inst. Technol. WO 99/07727
Properly folded proteins
Cambridge, Mass.
Eukaryotic disulfide bond-forming proteins; for increased yields of properly folded recombinant proteins.

Memorec Stoffel WO 99/07855
Neutral sphingomyelinase
Cologne, Germany
Eukaryotic neutral sphingomyelinase, encoding gene sequences.

Merck WO 99/07828
Chloride channel modulators
Rahway, N.J.
Glutamate-gated chloride channels from cat fleas, encoding gene sequences; for screening channel modulators.

Millennium Biotherapeutics WO 99/07850
Tango family proteins
Cambridge, Mass.
Tango-related family proteins, encoding gene sequences; for diagnostics and therapeutics.

Mycogen WO 99/07864
Toxins against insects
San Diego
Bacillus thuringinesis strains, isolates, toxins, and encoding genes; for controlling insect pests.

NIH (Natl. Inst. Hlth.) WO 99/07844
Restenosis oligos
Bethesda, Md.
Osteopontin antisense oligos; for treating restenosis following vascular surgery.

Netherlands Cancer Inst. WO 99/07871
Transposon-based gene transfer
Leiden, Netherlands
Transposon-based elements; for site-specific integration and excision of gene sequences.

Ontogeny WO 99/07854
Serine/threonine kinase receptors
Cambridge, Mass.
Serine/threonine kinase receptor family designated pan-s/tk, encoding gene sequences.

Pasteur Inst. WO 99/07414
Therapeutic delivery into cells
Vectors expressing repeat antibody-derived peptide units; for penetrating cells and delivering therapeutics.

Pasteur Inst. WO 99/07722
E. coli-specific oligos
Oligos that hybridize to E. coli ribosomal RNA; for detection and display of these bacteria.

Pasteur Merieux Serums & Vaccines WO 99/07741
Meningitis vaccine
Lyon, France
Human transferrin receptor subunit from Neisseria meningitis; for vaccines.

Regeneron Pharma WO 99/07738
Fetal heart receptor
Tarrytown, N.Y.
Orphan receptor expressed in pancreas and fetal heart; for developing assays that identify ligands.

Res. Counc. & Sci. App. Soc. WO 99/07384 & 07409
AIDS combination therapy
Double-stranded RNA combined with 6-benzyluracil; for combination antiviral therapy for AIDS.

Rockefeller Univ. WO 99/07739
Synapsin III gene
New York
Human synapsin III gene located on chromosome 22 near the schizophrenia susceptibility region; for therapeutics.

Shriners Childrens Hosp. WO 99/07835
Vitamin D disorders
Tampa, Fla.
P450 moiety fragment of vitamin D 1-a-hydrolase, encoding gene sequences; for diagnosing vitamin D-related disorders.

SmithKline Beecham EPO 897 979
Human sdr2 peptides
Human sdr2 polypeptides, encoding gene sequences, production methods; for diagnostics and therapeutics.

SmithKline Beecham EPO 897 980
CXCR chemokine receptor variant
Splice variant of the human CXCR4 chemokine receptor, encoding gene sequences, production methods.

SmithKline Beecham EPO 897 981
Immunoglobulin-like peptides
Plgr-1 immunoglobulin-like polypeptides, encoding gene sequences, production methods; for autoimmune diseases.

SmithKline Beecham EPO 897 982
Sodium bicarbonate co-transporter
Nanterre, France
Sodium bicarbonate co-transporter polypeptides, encoding gene sequences, production methods; for heart disease.

SmithKline Beecham EPO 897 986
Aspartic proteinase
Aspartic proteinase 5 polypeptides, encoding gene sequences, production methods; for diagnostics and therapeutics.

SmithKline Beecham WO 99/07845
Adenosine nucleotide translocator
Nanterre, France
Adenosine nucleotide translocator polypeptides, encoding gene sequences; for diagnostics and therapeutics.

Stressgen Biotech WO 99/07860
HPV immunoresponse
Victoria, British Columbia
Vectors expressing human papillomavirus (HPV) antigens and a stress protein; for immunoresponses to HPV.

Sumitomo Pharma WO 99/07352
Enhanced LDL receptor expression
Osaka, Japan
Nitrogen-containing aromatic ring compounds that enhance LDL receptor gene expression; for treating hyperlipidemia.

Thomas Jefferson Univ. WO 99/07726
Colorectal cancer therapeutics
Colorectal cancer cell transcription product, variants; for diagnostics and therapeutics.

Toray WO 99/07851
Dog IL-18
Dog interleukin (IL)-18, IL-1_ convertase, encoding gene sequences; production process for insect cells.

Transgenomic WO 99/07899
Chromatographic mutation detection
San Jose, Calif.
Detection of DNA by mutations using denaturing matched ion chromatography.

Visible Genetics WO 99/07883
HLA Class I typing
Toronto, Ontario
HLA Class I typing methods that use intron-based primers in amplification protocols.

Vlaams Inst. Biotech WO 99/07839
Influenza vaccine
Zwijnaarde, Netherlands
Influenza antigen derived from a viral membrane protein; for making vaccines.

Washington, Univ. of WO 99/07893
Senescence control
Senescence-factor gene p23, encoded protein, antisense, antibodies, expression methods.

Wisconsin, Univ. of WO 99/07894
Low copy RNA detection
Madison, Wis.
Direct quantitation of low copy number RNA by capillary electrophoresis of RNA hybridized to DNA.

Zymogenetics WO 99/07848
Cytokine receptor-11 peptides