Published August 19 (EPO); August 13 (WO); August 19 (GB)

AmradWO 98/34951

Cytokine family

Richmond, Australia

Newly identified family of mammalian cytokines; for diagnostics and therapeutics.

Baxter Intl.WO 98/35028

Interdependent adenoviral vectors

Deerfield, Ill.

Adenoviral vectors that induce anticancer immune responses and cell death while being interdependent for replication.

British Secretary of DefenseGB 2 322 130

Herpes vaccine

Farnborough, U.K.

Recombinant viral-based vectors encoding simian herpes B virus glycoprotein D; for vaccines.

California, Univ. ofWO 98/35032

Vpr-induced cell stasis

Oakland, Calif.

Induction of cell stasis and death using the HIV Vpr protein and its analogs.

Ctr. for Disease ControlWO 98/35024

Human spumavirus

Atlanta, Ga.

Spumavirus isolated from humans exposed to infected non-human primates, antibodies; for gene therapy and vaccines.

CNRS (Natl. Ctr. Sci. Res.)WO 98/35034

Neuronal amiloride channel

Paris

Mammalian neuronal amiloride-sensing cationic channel, encoding gene sequences; for screening modulators.

CorixaWO 98/35045

Leishmaniasis vaccine

Seattle

Leishmania antigens, fragments, encoding gene sequences; for vaccination for leishmaniasis.

Cornell Univ.WO 98/34948

G protein-coupled receptor modulators

Ithaca, N.Y.

Tethering of peptides from combinatorial libraries to G protein-coupled receptors; for identifying modulators.

Epoch PharmaWO 98/34945

Targeted CCR-5 gene modification

Bothell, Wash.

Modified oligos that form triple-stranded complexes and cross-link with the CCR-5 gene encoding the HIV co-receptor.

GeneMedicineWO 98/34952

IL-2 gene delivery

The Woodlands, Tex.

Plasmid expression systems encoding interleukin (IL)-2, lipid/DNA delivery systems, preparation methods.

GenentechWO 98/35036

Heregulin variants

S. San Francisco

Heregulin variants that bind ErbB-4 receptors, encoding gene sequences; for therapeutics.

GenentechWO 98/35037

Actin polymerization

S. San Francisco

Tyrosine phosphorylated cleavage furrow-associated proteins, encoding gene sequences, homologs; for actin polymerization.

Genetics Inst.WO 98/35043

Chondrocyte growth protein

Cambridge, Mass.

Human SDF-5 proteins, encoding gene sequences; for affecting chondrocyte and cartilage growth and differentiation.

Harvard Univ.WO 98/35040

Muscle cell genes

Cambridge, Mass.

Genes preferentially expressed in the aorta or striated muscle, encoded proteins; for vascular injury.

HoechstEPO 859 008

Cell cycle-regulated expression

Frankfurt, Germany

Vector with a chimeric promoter that is cell cycle sensi-tive; for gene regulation.

HoechstEPO 859 058

Protease activation vector

Frankfurt, Germany

Nucleic acid construct for the expression of protease-acti-vatable substances [in German].

Hoechst Marion RousselWO 98/35027

NGF exon promoters

Cincinnati, Ohio

Promoters from exons 1 and 3 from human nerve growth factor (NGF), fragments; for making vectors and transgenics.

Human Genome SciencesWO 98/35039

Dendritic cell-derived growth factor

Rockville, Md.

Dendritic cell-derived growth factor, encoding gene sequences, production method, modulator screen; for immunotherapy.

Incyte PharmaWO 98/35038

Dosage compensation-associated protein

Palo Alto, Calif.

Human dosage compensation-associated protein, encoding gene sequences, vectors, antisense, antibodies, modu-lators.

Incyte PharmaWO 98/35041

Human LEA-Motif protein

Palo Alto, Calif.

Human LEA-Motif protein, encoding gene sequences, vectors, antisense, antibodies, modu-lators.

Japanese Natl. Inst. Animal IndustryEPO 859 059

Egg-inserted genes

Ibaragi, Japan

Introducing exogenous genes with associated sequences insulating them from adjacent gene effects into chromosomes.

Johns Hopkins Univ.WO 98/35019

Growth differentiation factor-11

Baltimore

Transgenic animals with disrupted growth differentiation factor-11 gene, antibodies and antisense for therapy.

Kirin BreweryEPO 859 010

Thrombopoietin antibodies

Tokyo

Monoclonal antibodies to human thrombopoietin (TPO); for purifica-tion and immunochemical quantification of TPO.

Life TechnologiesWO 98/35018

Lyophilizing competent cells

Rockville, Md.

Lyophilized cells that are competent for transformation and can be stably stored for extended time periods.

Lingappa, J.R., et al.WO 98/35062

HIV capsid assembly

San Francisco, Calif.

Multistep, ATP-dependent cell-free system for assembling HIV capsids; for identifying modulators.

Mass. Inst. Technol.WO 98/34946

Fas-binding protein Daxx

Cambridge, Mass.

Gene sequences and fragments encoding a Fas-binding protein called Daxx, encoded protein, antibodies.

MerckWO 98/34640

HIV immunity

Rahway, N.J.

Synthetic genes encoding HIV gag protein that use preferred codons for host cells; for immune protec-tion from infection.

MerckWO 98/35015

Cyclin-dependent kinase variant

Rahway, N.J.

Gene sequences for a variant cyclin-dependent kinase, encoded protein, biologically active mutants.

MerckWO 98/35016

Protein kinase 2

Rahway, N.J.

Gene sequences for protein kinase 2, encoded protein, pro-duction methods; for identifying modulators.

Nakamura, T.EPO 859 009

Hepatocyte growth factor

Fukuoka, Japan

Recombinant vector expressing leukocyte-derived hepato-cyte growth factor; for liver diagnostics and therapeutics.

NIH (Natl. Inst. Hlth.)WO 98/35042

Neurotrophic factor

Bethesda, Md.

Activity dependent neurotrophic factor III, encoding gene sequences, antibodies; for treating CNS disease.

OntarioWO 98/35033

Gila monster venom protein

Toronto

Gene sequences encoding proexendin isolated from Gila monster venom, encoded protein, antibodies.

Oriental YeastWO 98/35049

Protein disulfide isomerase

Tokyo

Recombinant modified yeast protein disulfide isomerase, encoding gene; for secretion and purification.

Princeton Univ.WO 98/35048

Engineered protein kinases

Princeton, N.J.

Engineered protein kinases using modified nucleotide tri-phosphates, encoding gene sequences, production methods.

Rochester, Univ. ofWO 98/35031

PSA gene regulatory sequences

Rochester, N.Y.

Non-coding, regulatory sequences of the prostate-specific anti-gen (PSA) gene, PSA expressing transgenics.

ShionogiWO 98/35035

HIV inhibitor screen

Osaka, Japan

Gene sequences for CXC chemokine receptor, encoded protein, cells expressing the protein; for HIV inhibitor screen.

SmithKline BeechamEPO 859 052

Human GPR14 receptor

Philadelphia

Human GPR14 receptor, encoding gene sequences, production methods; for therapeutics.

SmithKline BeechamEPO 859 053

Human G-protein coupled receptor

Philadelphia

Human G-protein coupled receptor, encoding gene se-quences, production methods; for therapeutics.

SmithKline BeechamEPO 859 054

Drug binding protein

Philadelphia

Drug binding protein, encoding gene sequences, production methods; for therapeutics.

SmithKline BeechamEPO 859 055

G-protein 7 transmembrane receptor

Philadelphia

G-protein 7 transmembrane receptor, encoding gene sequences, production methods; for therapeutics.

Sumitomo ChemicalWO 98/35050

Bacterial transformation vectors

Osaka, Japan

Plasmids and transformation vectors for affecting gene expression in ammonia oxidizing bacteria.

SyntexEPO 859 056

NGF from insect cells

Palo Alto, Calif.

Vector for producing human nerve growth factor (NGF) in insect cells using a baculovirus expression system.

Takara ShuzoEPO 859 057

Protein expression plasmid

Kyoto, Japan

Plasmid vector having a promoter that can be recognized by a foreign RNA polymerase; for protein expression.

Tennessee, Univ. ofWO 98/34950

Yeast antifungals

Knoxville, Tenn.

Candida albicans oligopeptide transport gene; for develop-ing yeast antifungals.

Vanderbilt Univ.WO 98/35029

Mycobacterial antigen genes

Nashville, Tenn.

Synthetic genes encoding mycobacterial antigens and having codons optimized for host cell expression; for therapy.

Viromedica PacificGB 2 322 131

High titer retroviral vectors

Seoul, S. Korea

Retroviral vectors having high titer and directing increased expression levels; for gene therapy.

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