Published August 19 (EPO); August 13 (WO); August 19 (GB)
Newly identified family of mammalian cytokines; for diagnostics and therapeutics.
Baxter Intl.WO 98/35028
Interdependent adenoviral vectors
Adenoviral vectors that induce anticancer immune responses and cell death while being interdependent for replication.
British Secretary of DefenseGB 2 322 130
Recombinant viral-based vectors encoding simian herpes B virus glycoprotein D; for vaccines.
California, Univ. ofWO 98/35032
Vpr-induced cell stasis
Induction of cell stasis and death using the HIV Vpr protein and its analogs.
Ctr. for Disease ControlWO 98/35024
Spumavirus isolated from humans exposed to infected non-human primates, antibodies; for gene therapy and vaccines.
CNRS (Natl. Ctr. Sci. Res.)WO 98/35034
Neuronal amiloride channel
Mammalian neuronal amiloride-sensing cationic channel, encoding gene sequences; for screening modulators.
Leishmania antigens, fragments, encoding gene sequences; for vaccination for leishmaniasis.
Cornell Univ.WO 98/34948
G protein-coupled receptor modulators
Tethering of peptides from combinatorial libraries to G protein-coupled receptors; for identifying modulators.
Epoch PharmaWO 98/34945
Targeted CCR-5 gene modification
Modified oligos that form triple-stranded complexes and cross-link with the CCR-5 gene encoding the HIV co-receptor.
IL-2 gene delivery
The Woodlands, Tex.
Plasmid expression systems encoding interleukin (IL)-2, lipid/DNA delivery systems, preparation methods.
S. San Francisco
Heregulin variants that bind ErbB-4 receptors, encoding gene sequences; for therapeutics.
S. San Francisco
Tyrosine phosphorylated cleavage furrow-associated proteins, encoding gene sequences, homologs; for actin polymerization.
Genetics Inst.WO 98/35043
Chondrocyte growth protein
Human SDF-5 proteins, encoding gene sequences; for affecting chondrocyte and cartilage growth and differentiation.
Harvard Univ.WO 98/35040
Muscle cell genes
Genes preferentially expressed in the aorta or striated muscle, encoded proteins; for vascular injury.
HoechstEPO 859 008
Cell cycle-regulated expression
Vector with a chimeric promoter that is cell cycle sensi-tive; for gene regulation.
HoechstEPO 859 058
Protease activation vector
Nucleic acid construct for the expression of protease-acti-vatable substances [in German].
Hoechst Marion RousselWO 98/35027
NGF exon promoters
Promoters from exons 1 and 3 from human nerve growth factor (NGF), fragments; for making vectors and transgenics.
Human Genome SciencesWO 98/35039
Dendritic cell-derived growth factor
Dendritic cell-derived growth factor, encoding gene sequences, production method, modulator screen; for immunotherapy.
Incyte PharmaWO 98/35038
Dosage compensation-associated protein
Palo Alto, Calif.
Human dosage compensation-associated protein, encoding gene sequences, vectors, antisense, antibodies, modu-lators.
Incyte PharmaWO 98/35041
Human LEA-Motif protein
Palo Alto, Calif.
Human LEA-Motif protein, encoding gene sequences, vectors, antisense, antibodies, modu-lators.
Japanese Natl. Inst. Animal IndustryEPO 859 059
Introducing exogenous genes with associated sequences insulating them from adjacent gene effects into chromosomes.
Johns Hopkins Univ.WO 98/35019
Growth differentiation factor-11
Transgenic animals with disrupted growth differentiation factor-11 gene, antibodies and antisense for therapy.
Kirin BreweryEPO 859 010
Monoclonal antibodies to human thrombopoietin (TPO); for purifica-tion and immunochemical quantification of TPO.
Life TechnologiesWO 98/35018
Lyophilizing competent cells
Lyophilized cells that are competent for transformation and can be stably stored for extended time periods.
Lingappa, J.R., et al.WO 98/35062
HIV capsid assembly
San Francisco, Calif.
Multistep, ATP-dependent cell-free system for assembling HIV capsids; for identifying modulators.
Mass. Inst. Technol.WO 98/34946
Fas-binding protein Daxx
Gene sequences and fragments encoding a Fas-binding protein called Daxx, encoded protein, antibodies.
Synthetic genes encoding HIV gag protein that use preferred codons for host cells; for immune protec-tion from infection.
Cyclin-dependent kinase variant
Gene sequences for a variant cyclin-dependent kinase, encoded protein, biologically active mutants.
Protein kinase 2
Gene sequences for protein kinase 2, encoded protein, pro-duction methods; for identifying modulators.
Nakamura, T.EPO 859 009
Hepatocyte growth factor
Recombinant vector expressing leukocyte-derived hepato-cyte growth factor; for liver diagnostics and therapeutics.
NIH (Natl. Inst. Hlth.)WO 98/35042
Activity dependent neurotrophic factor III, encoding gene sequences, antibodies; for treating CNS disease.
Gila monster venom protein
Gene sequences encoding proexendin isolated from Gila monster venom, encoded protein, antibodies.
Oriental YeastWO 98/35049
Protein disulfide isomerase
Recombinant modified yeast protein disulfide isomerase, encoding gene; for secretion and purification.
Princeton Univ.WO 98/35048
Engineered protein kinases
Engineered protein kinases using modified nucleotide tri-phosphates, encoding gene sequences, production methods.
Rochester, Univ. ofWO 98/35031
PSA gene regulatory sequences
Non-coding, regulatory sequences of the prostate-specific anti-gen (PSA) gene, PSA expressing transgenics.
HIV inhibitor screen
Gene sequences for CXC chemokine receptor, encoded protein, cells expressing the protein; for HIV inhibitor screen.
SmithKline BeechamEPO 859 052
Human GPR14 receptor
Human GPR14 receptor, encoding gene sequences, production methods; for therapeutics.
SmithKline BeechamEPO 859 053
Human G-protein coupled receptor
Human G-protein coupled receptor, encoding gene se-quences, production methods; for therapeutics.
SmithKline BeechamEPO 859 054
Drug binding protein
Drug binding protein, encoding gene sequences, production methods; for therapeutics.
SmithKline BeechamEPO 859 055
G-protein 7 transmembrane receptor
G-protein 7 transmembrane receptor, encoding gene sequences, production methods; for therapeutics.
Sumitomo ChemicalWO 98/35050
Bacterial transformation vectors
Plasmids and transformation vectors for affecting gene expression in ammonia oxidizing bacteria.
SyntexEPO 859 056
NGF from insect cells
Palo Alto, Calif.
Vector for producing human nerve growth factor (NGF) in insect cells using a baculovirus expression system.
Takara ShuzoEPO 859 057
Protein expression plasmid
Plasmid vector having a promoter that can be recognized by a foreign RNA polymerase; for protein expression.
Tennessee, Univ. ofWO 98/34950
Candida albicans oligopeptide transport gene; for develop-ing yeast antifungals.
Vanderbilt Univ.WO 98/35029
Mycobacterial antigen genes
Synthetic genes encoding mycobacterial antigens and having codons optimized for host cell expression; for therapy.
Viromedica PacificGB 2 322 131
High titer retroviral vectors
Seoul, S. Korea
Retroviral vectors having high titer and directing increased expression levels; for gene therapy.