Company

Symbol

12/31/96

03/31/97

06/30/97

09/30/97

12/31/97

Change YTD

Aastrom Biosci

ASTM

7

5.75

7.125

7.687

4.375

-38

AccuMed Intl

ACMI

2.5

3.625

3.562

2.906

1.312

-48

Adv Magnetics

AVM

15.5

13.5

10.875

10.687

8.75

-44

Adv Poly Sys

APOS

7.625

7.75

8

7.75

6.625

-13

Adv Tissue Sci

ATIS

9.562

10.5

12.875

15.562

12.375

29

Affymetrix

AFFX

20.187

27

34.75

46

31.125

54

Agouron

AGPH

33.875

35.313

40.438

48.125

29.375

-13

Alexion Pharma

ALXN

8.687

10.375

8.875

14.75

12.5

44

Alkermes

ALKS

23.25

14

14.5

20.625

19.875

-15

Allelix

AXB*

16.8

11.55

10.8

14.25

11.5

-32

Alliance

ALLP

13.625

12.125

10.062

11.937

7.25

-47

Alpha Beta

ABTI

10.562

10.625

9.125

2.968

2.593

-75

AltaRex

AXO*

6.297

5.35

3.5

3.5

3

-52

Alteon

ALTN

5.25

3.312

4.218

5.312

7.312

39

Alza

AZA

25.875

27.5

29

29

31.812

23

Am Bio Sci

MABXA

4.062

3.562

3.187

3.687

1.906

-53

Amarillo Biosci

AMAR

4.75

3.75

3.625

3.75

5.5

16

AMBI Inc.

AMBI

2.875

2.875

2.375

2.5

1.937

-33

Amgen

AMGN

54.375

55.875

58.125

47.937

54.125

0

Amylin

AMLN

13

12.125

13.75

8.437

5.437

-58

Anergen

ANRG

3.75

3.625

3.062

3.25

2.125

-43

Anesta

NSTA

19.25

17.25

19

23.25

16.375

-15

AntiVirals

AVII

6.5

-------

7.125

7.187

6.812

5

Aphton

APHT

19.5

14

14.75

13.75

10.125

-48

Aquila Biopharma

AQLA

4.875

5

5.687

5.062

4.187

-14

Ariad Pharm

ARIA

5.062

6.062

6.437

5.875

4.25

-16

Aronex Pharma

ARNX

9.375

5.75

3.875

6.5

4.25

-55

ArQule

ARQL

15.75

15.5

17.375

21

22.937

46

Arris Pharm

ARRS

13.5

12.25

13.25

13

8.375

-38

Atlantic Pharma

ATLC

6.125

5.813

7

8

6.75

10

Atrix Labs

ATRX

10.75

10.875

12.25

19.5

14.75

37

Aurora Bioscience

ABSC

10

--------

10.375

14.312

13.125

31

AutoImmune

AIMM

15.375

11

1.843

2.812

3.312

-78

Avax Technologies

AVXT

3.83

--------

--------

4.25

3.687

-4

Avigen

AVGN

5

4.25

3.5

4

2.25

-55

Aviron

AVIR

7.5

9.5

12.25

25.125

27.125

262

Axogen

AXG/U

23.5

23

32

37.437

39.75

69

Bio-Tech Gen

BTGC

13.125

12.5

13.5

15

10.75

-18

Biochem Pharma

BCHE

25.125

21.5

22.25

31.5

20.875

-17

Biocircuits

BIOC

2.906

1.25

0.812

1

0.875

-70

BioCryst

BCRX

16.375

11.875

13.75

8

7

-57

Biogen

BGEN

38.75

37.375

33.875

32.437

36.375

-6

Bioject

BJCT

0.687

0.781

0.687

1

1.281

86

Biomatrix

BIOX

16

13.375

19

35.125

30

88

Biomira

BIOMF

4.75

5.125

5.062

5

2.125

-55

Biomune Sys

BIME

14.688

12.5

4.688

3.75

0.718

-95

Biora AB

BIORY

16.5

20

17.875

18.75

20.75

26

Bioreliance

BREL

15

--------

-------

26.25

23

53

Biotime

BTIM

9.333

10.422

11

17

19

104

BioTransplant

BTRN

6.5

6.875

6.75

5.625

5.75

-12

Boston Life

BLSI

6.875

0.656

7.25

7.187

2.281

-67

British Biotech

BBIOY

34.5

40.125

38.5

26.375

16.625

-52

Cadus Pharma

KDUS

8.75

12.125

14.25

11.375

6.375

-27

Calypte Biomed

CALY

8.25

6.875

4.5

7

3.875

-53

Cambridge Neuro

CNSI

11.875

10.625

4.125

2.25

1.968

-83

Cantab Pharm

CNTBY

9.5

16.75

14

13.5

9.625

1

Carrington

CARN

7.75

6

6.25

6.125

4.312

-44

Cel-Sci

HIV

4.25

4.312

3.75

7.25

6.625

56

Celgene

CELG

11.125

7.125

7.375

11.125

8.437

-24

Cell Genesys

CEGE

9.125

6.125

4.937

7.875

8.5

-7

Cell Therapeutics

CTIC

10

10

11.125

14.875

17

70

Cellegy Pharma

CLGY

4.5

4.375

2.75

6.313

8.375

86

CellPro

CPRO

12.5

6.437

6

4.687

2.312

-82

Celtrix

CTRX

2

2.437

2.312

2.625

1.812

-9

Centocor

CNTO

35.75

30.5

31.062

47.562

33.25

-7

Cephalon

CEPH

20.5

21

11.5

11.75

11.375

-45

ChemTrak

CMTR

1.343

1.718

1.187

0.687

0.75

-44

Chiron

CHIR

18.625

18.625

20.875

22.625

17

-9

Cholestech

CTEC

5.625

5.125

5.75

10.75

12.5

122

Chrysalis Intl

CRLS

4.375

5.125

4.25

4

2.156

-51

CIMA Labs

CIMA

6.125

6

4.125

6.75

4.25

-31

ClinTrials

CCRO

22.75

8.5

12

9.375

7.875

-65

CoCensys

COCN

5.75

5.375

3.125

5.875

3.437

-40

Collab. Clin. Res

CCLR

10.75

7.25

7

5.875

5.062

-53

CollaGenex

CGPI

8.125

14.25

12

10.125

12.5

54

Columbia Labs

COB

14.5

12.25

16.375

19

16.25

12

Connetics

CNCT

8.25

7.375

7

3.625

3.062

-63

Cor Thera

CORR

9.875

9.5

10.625

16.625

22.5

128

Corixa

CRXA

13

------

--------

---------

8.937

-31

Cortech

CRTQ

1.468

0.875

0.625

0.703

0.593

-60

Cortecs Intl

DLVRY

14.5

20.875

16.25

15.875

14.25

-2

Cortex

CORX

3.687

2.875

3.125

2.968

1.5

-59

Corvas

CVAS

5.625

5.5

6.5

5.125

3.875

-31

Coulter Pharma

CLTR

12

9.125

9.75

13.375

20.25

69

Creative Bio

CBMI

10.375

7.5

7.062

10.75

7.375

-29

Crescendo Pharma

CNDO

11.5

-------

------

--------

11.562

1

Cubist Pharma

CBST

6.125

10.5

6.5

5.875

5.812

-5

CV Therapeutics

CVTX

6.5

8.75

7.5

9.5

9.375

44

Cyanotech

CYAN

6.437

5.562

4.937

5.75

2.781

-57

Cygnus

CYGN

14.5

13.625

17.25

19.75

19.875

37

Cypress Bio

CYPB

1.937

1.687

2.125

1.968

1.437

-26

Cypros Pharma

CYPR

3.937

5.312

4.5

4.187

4.25

8

Cytel

CYTL

3.437

2.375

1.625

2.375

1.5

-56

Cytoclonal Pharma

CYPH

2.125

3.25

2.625

7.375

6.875

224

Cytogen

CYTO

5.5

5.812

4.875

3.937

1.625

-70

CytoTherapeut

CTII

9

8.125

5.375

5.5

4

-56

CytRx

CYTR

3.437

3.687

3.75

4.875

2.937

-15

Dekalb

DKB

25.5

26.625

39.875

44.375

39.25

54

DepoMed

DPMD

6.1

-------

-------

-------

4.25

-30

DepoTech

DEPO

16.375

15.25

13.625

13.5

3.562

-78

Diacrin

DCRN

10.25

13.25

11

11.25

10.125

-1

Diagnostic Prod

DP

25.875

29.875

31.562

30.187

27.75

7

Dianon Systems

DIAN

8.625

8.625

9.625

8.5

9.375

9

Diatide

DITI

7.125

6.25

5.25

12

9.125

28

Digene

DIGE

10.5

11.375

12.75

12.875

8.625

-18

Discovery Labs

DSCO

6

7.314

4.314

3.75

4

-33

DNAP Holding

DNAP

3.5

4.25

3.5

5

4.859

39

Draxis Health

DRAXF

2.187

2.406

2.375

2.812

3.062

40

Dura Pharm

DURA

47.75

35.75

39.875

43.625

45.875

-4

DynaGen

DYGN

1.312

1.437

1

0.562

0.14

-89

Ecogen

EECN

2.5

3.562

3.5

3.125

1.937

-23

Elan

ELN

33.25

34.125

45.25

50.062

51.187

54

Embrex

EMBX

6.5

6.875

7

6.562

5.312

-18

Emisphere

EMIS

18.625

16.25

22.25

22

18.625

0

Endorex

ENDR

14.063

7.969

2.625

2.625

5.5

-61

EntreMed

ENMD

16.25

12.75

12

9.937

11.312

-30

Envirogen

ENVG

3.375

2.562

2.937

3.25

1.5

-56

Enzo Biochem

ENZ

18.125

13.75

15.812

18

14.625

-19

Enzon

ENZN

2.937

2.562

2.25

4.875

5.5

87

Epitope

EPTO

11.5

10.5

7.875

8.25

5

-57

Epix Medical

EPIX

7

6.625

8

12

13

86

Ergo Science

ERGO

13.125

11.375

11

13.25

15.25

16

Ethical Hldgs

ETHCY

5.812

5

4.437

4.562

3.125

-46

Flamel Tech

FLMLY

7.5

6.625

4.562

4

1.812

-76

GalaGen

GGEN

4.375

2.562

2.75

2.25

1.875

-57

GelTex

GELX

24.25

21.25

20.125

26.75

26.5

9

Gene Logic

GLGC

8

-------

--------

--------

8

0

Genelabs

GNLB

6.125

4.375

2.812

4.25

2.812

-54

GeneMedicine

GMED

5.687

6.25

7.75

4.125

5.062

-11

Genentech

GNE

53.625

57.125

58.937

58.125

60.625

13

Genome Thera

GENE

10.75

6.875

8.625

8.75

6.312

-41

Genset

GENXY

16

15.875

19.375

21.125

19.75

23

Gensia Sicor

GNSA

4.625

3.937

4.437

6.937

5.812

26

Genta

GNTA

4.375

2.813

2.156

1.937

0.781

-82

Genz Tiss Repair

GENZL

7.125

9.875

10.125

9.75

6.875

-4

Genzyme

GENZ

21.75

22.5

27.75

29.75

27.75

28

Genzyme Trans

GZTC

6.125

8.125

8.5

11.5

9.625

57

Geron

GERN

13.25

9.75

7.5

10.875

8.25

-38

Gilead Sciences

GILD

25

22.875

27.625

44.375

38.25

53

Gliatech

GLIA

7.75

10.125

8.25

11.75

10.25

32

Guilford Pharm

GLFD

23.25

20.75

24.25

29.5

20.125

-13

Hemacare

HEMA

3.125

2.375

1.687

1

0.468

-85

Human Genome

HGSI

40.75

32.5

33.25

43.062

39.75

-2

Hycor Bio

HYBD

3

2.625

2.031

2.281

1.562

-48

Hyseq

HYSQ

14

-------

-------

19.875

9.625

-31

IBAH

IBAH

6.75

6.375

3.562

4.75

3.75

-44

ICN Pharma.

ICN

19.625

22.25

28.687

49.187

49

150

Icos

ICOS

7.625

7.312

8.25

12.625

18.312

140

ID Biomed

IDB*

5.75

4.9

5.2

4.15

3.4

-41

IDEC Pharm

IDPH

23.75

23.812

24.25

41.875

34.375

45

Idexx Labs

IDXX

36

14

12.437

16.75

15.937

-56

Igen

IGEN

5

5.25

7.5

13.5

13.25

165

ILEX Oncology

ILXO

12

12.125

15.875

12

7.375

-39

ImClone Sys

IMCL

9.75

5.75

6.125

8.125

8.125

-17

Immucell

ICCC

2.375

2.25

2.75

2.562

2.468

4

Immucor

BLUD

9.75

9.5

9.875

10.25

8.625

-12

ImmuLogic

IMUL

6.375

4.375

3.125

3.312

1.875

-71

Immune Resp

IMNR

8.25

8.375

7.625

12.625

11.125

35

Immunex

IMNX

19.5

26.5

36.25

67.25

54

177

ImmunoGen

IMGN

2.375

1.375

1.562

1.25

0.843

-65

Immunomed

IMMU

5.5

4.625

4.375

4.687

3.625

-34

Incyte Pharm

INCY

25.75

26

33.5

42

45

75

Inhale Ther Sys

INHL

15.125

19.125

24.75

31.375

26

72

InKine Pharma

INKP

0.75

2.656

2.063

1.844

1.375

83

Innovir

INVR

1.187

0.75

1.093

0.875

0.375

-68

InSite Vision

INSV

6

4.312

5.5

4.625

3.25

-46

Integra LifeScien

IART

4.625

3.812

3.125

4.187

4.437

-4

Intercardia

ITRC

21.5

22.25

23

22.5

17.875

-17

Interferon Sci

IFSC

6.625

6.25

9

8.625

8.687

31

Interneuron

IPIC

26

17.625

20.125

12

9.5

-63

Intl Murex

MURXF

7.312

6.937

8.562

9.5

10.062

38

Isis Pharm

ISIP

18

15

14.562

17.812

12.312

-32

La Jolla Pharm

LJPC

6

5

4.625

5

4.437

-26

LeukoSite

LKST

6

--------

-------

9.875

10.937

82

Lidak Pharm

LDAKA

1.75

2.375

2.187

2.468

2.375

36

Life Tech

LTEK

25

26.25

27.75

30.25

33.25

33

Lifecell

LIFC

3.125

6.5

5.875

7.875

4.625

48

Lifecore Bio

LCBM

18

14.875

13.75

18

21.875

22

Ligand

LGND

14.875

11.25

12.875

16.5

12.875

-13

Liposome

LIPO

19.125

20.375

8.937

6.937

4.625

-76

LXR Biotech

LXR

2.25

2.187

2.375

1.937

2.375

6

Lynx Therapeutics

LYNX

4

8.016

15

14.375

16.25

306

MacroChem

MCHM

6.5

4.937

6.812

8.75

9.125

40

Magainin

MAGN

9.625

8.5

7.25

11.437

8.062

-16

Martek Bio

MATK

20

17.5

11.75

15

8.25

-59

Matritech

NMPS

8.5

5.062

6.937

5.562

4.875

-43

Matrix

MATX

6.125

6.375

6.687

4.937

3.437

-44

Maxim Pharma

MMP

7

9

9.75

15.5

16.375

134

Medarex

MEDX

7

7.25

6.312

6.437

5.25

-25

MedImmune

MEDI

17

13.75

18.5

36.75

42.875

152

Megabios

MBIO

12

--------

--------

16.75

14.25

19

Meridian Diag

KITS

13

11

8.375

11.875

10.125

-22

Metra Biosys

MTRA

4.75

4.25

4.812

3.5

3.625

-24

Microcide Pharma

MCDE

10

12.5

11

12.5

8.875

-11

Micrologix Biotec

MBI*

3.6

4.25

4.27

5

3.6

0

Millennium

MLNM

17.375

13.625

16.125

19.5

19

9

Molec Dynam

MDYN

10.75

14.75

14

27

16.25

51

Molecular Bio

MB

6.5

9.125

9

11.625

8.5

31

Molecular Devices

MDCC

15.562

13.875

17.5

21.875

21.25

37

Mycogen

MYCO

21.5

23.25

19.625

23.5

18.75

-13

Myriad Genetics

MYGN

25.25

34.5

27

25.937

24.25

-4

NABI

NABI

8.75

6.812

6.625

7.312

3.406

-61

NaPro Biother

NPRO

11

13

7.25

8.625

2.5

-77

NeoPharm

NEO

8

7.625

4.875

5

5.25

-34

Neoprobe

NEOP

15.375

13.5

14

14

6

-61

NeoRx

NERX

4.125

4.937

4.437

7

5.625

36

Neose Technol

NTEC

18

13.75

12.75

18

15.25

-15

NeoTherapeutics

NEOT

4.125

5.437

15.875

14.125

10.5

155

Neurex

NXCO

17

11.875

14.125

14.75

13.875

-18

Neurobio Tech

NTII

3.75

1.75

2.25

3.25

0.875

-77

Neurocrine Biosci

NBIX

10

9

9

9.562

7.875

-21

Neurogen

NRGN

19.25

19

22.75

27

13.5

-30

NeXstar Pharm

NXTR

15

10

14.25

17.75

11.375

-24

North Am Vacc

NVX

24.375

20.125

19.312

25.25

24.937

2

Northfield Labs

NFLD

10.75

11.125

10.375

11.5

9.125

-15

Novavax

NOX

3.437

3.375

4.125

5.437

5

45

Noven

NOVN

14

9

7.125

7

7

-50

NPS Pharm

NPSP

11

9.5

9.625

9.25

7.75

-30

Oncor

ONC

4

3.625

4

5.062

4.625

16

OncorMed

ONM

4.812

4.125

5.937

7.5

7

45

Onyx Pharma

ONXX

11.125

12

10.25

8.75

7.75

-30

OraVax

ORVX

5.25

2.75

2.75

2.75

1.75

-67

Organogenesis

ORG

14.563

11.359

15.797

23.906

26.25

80

Ortec Int'l

ORTC

10.375

8.625

9

13.75

13.062

26

OSI Pharma

OSIP

6.375

6.375

5.375

10.875

6.75

6

Osteotech

OSTE

7

7.875

10.5

20.125

27.25

289

Ostex Int'l

OSTX

5.5

3.75

2.375

3.625

2.625

-52

OXiGENE

OXGN

23.5

32

34.75

27.25

17.5

-26

Oxis Int'l

OXIS

1.25

0.968

0.687

0.625

0.421

-66

Pacific Pharma

PHA

1.25

1.187

1.437

1.875

0.937

-25

Paracelsian

PRLN

1.625

1.25

0.5

0.437

0.218

-87

Parexel Intl

PRXL

25.813

23

31.75

39.5

37

43

PathoGenesis

PGNS

21.75

25

29.125

35.5

37.125

71

Penederm

DERM

12.375

11

13.5

13.625

10

-19

PerSeptive Bio

PBIO

6.937

7.875

6.125

12

12.625

82

Pharma Prod Devlp

PPDI

25.25

20

22

20.375

15.375

-39

Pharmacopeia

PCOP

19.375

17.125

13.25

22.625

16

-17

Pharmacyclics

PCYC

16

15.875

15.5

24.75

25.625

60

Pharmos

PARS

1.468

1.375

1.843

2.781

2

36

Phoenix Intl

PHX*

12.25

9.7

10.85

11.35

10.25

-16

Procept

PRCT

7.438

6.125

3.281

2.188

1

-87

ProCyte

PRCY

2.25

1.75

1.125

1.156

0.937

-58

Progenics Pharma

PGNX

8

-------

--------

--------

14

75

Progenitor

PGEN

5.375

-------

-----

4.625

2.375

-56

Protein Design

PDLI

36.5

30

28.5

38.75

40

10

Protein Poly

PPTI

2.562

3.062

2.25

2.687

1.625

-37

Qiagen

QGENF

25.75

33.25

48.187

46.5

44.625

73

QLT PhotoTher

QLTIF

20.125

20.75

21

16.437

11.125

-45

Quidel

QDEL

4.5

3.875

3.25

4.937

3.625

-19

Quintiles

QTRN

33.125

26.938

34.813

42.625

38.25

15

Regeneron

REGN

16.125

8

10.125

11.187

8.562

-47

Repligen

RGEN

1.187

1.468

1.187

1.156

0.781

-34

Ribi Immuno

RIBI

3.875

4.437

4.625

4.25

3.687

-5

Ribozyme Pharma

RZYM

11

10.875

8.75

11.5

8

-27

SangStat Med

SANG

26.5

27.125

23.125

30.625

40.5

53

SciClone

SCLN

8

6.562

5.125

5.625

3.437

-57

Scios

SCIO

6.14

6.812

6.375

9.75

10

63

Sepracor

SEPR

16.625

23.062

25.812

32.875

40.062

141

Sequana Therap

SQNA

16.75

12.75

10.875

13.75

11

-34

Sequus Pharm

SEQU

16

7.625

6.375

8.625

7.437

-54

Shaman

SHMN

5.875

5.125

5.937

6.75

4.937

-16

Sheffield

SHM

3.75

2.75

2.937

2.437

1.375

-63

SIBIA Neurosci

SIBI

7.5

8.25

6.5

8.375

6.5

-13

Siga Pharma

SGPH

5

-------

-------

5.375

4.625

-8

Somatogen

SMTG

11

6.125

4.625

6.937

4.437

-60

Sonus Pharma

SNUS

29.75

26.375

28.125

42

33.125

11

Sparta Pharm

SPTA

1.468

0.718

0.625

0.75

0.375

-74

Sugen

SUGN

12.875

10.5

12.875

20.125

13.125

2

SunPharm

SUNP

5

3.75

3.687

3.625

4.5

-10

SuperGen

SUPG

12.25

11.125

14.75

17.5

15

22

Synaptic Pharma

SNAP

12

14

13.125

13.5

10.875

-9

Synbiotics

SBIO

3.187

3.875

4.125

3.875

3.125

-2

Synsorb Biotech

SYB*

11.6

9

8.8

9.7

7.7

-34

T Cell Sci

TCEL

1.625

1.562

1.875

2.125

2.437

50

Targeted Genet

TGEN

4.5

3.5

2.75

5.437

2.625

-42

Techniclone Int'l

TCLN

4.5

4.937

4.375

3.031

2.187

-51

Teva Pharm

TEVIY

50.25

55.5

64.75

55.75

47.312

-6

Texas Biotech

TXB

4.375

4.5

4.875

5.75

6.187

41

Theratech

THRT

13.25

10.75

11.75

11.625

8

-40

Titan Pharma

TTNPU

12.875

4.125

3.562

5.5

6.562

-49

Transcend Ther

TSND

10

-------

-------

8.5

7.5

-25

Transkaryotic

TKTX

18.5

19.5

30.875

39.25

35.125

90

Trega Biosciences

TRGA

5.25

5.75

6.125

4.125

3.437

-35

Triangle Pharma

VIRS

22.875

15.75

24.875

19.25

14.625

-36

Trimeris

TRMS

12

--------

--------

--------

13

8

Trinity Bio

TRIBY

2.343

2.5

2.562

2.75

1.968

-16

Tripos

TRPS

11.75

15.25

15.625

19

14.625

24

Unigene

UGNE

2.031

3.375

4.75

3.812

2.625

29

UroCor

UCOR

9.562

9.25

9.375

8.75

6.187

-35

US Bioscience

UBS

12.625

11.625

9.625

11.375

9.062

-28

Vertex Pharm

VRTX

40.25

40.25

38.25

37.75

33

-18

Vical

VICL

16.5

14.5

12.75

14.125

12

-27

VimRx

VMRX

3.375

2.875

3.218

2.562

1.937

-43

Vion Pharma

VION

3.062

4.25

4.562

5.125

3.625

18

Viragen

VRGN

5.218

2.5

2.531

2.343

1.093

-79

ViroPharma

VPHM

8.75

13

17.875

22

17.625

101

Virus Research

VRII

5.75

8.25

6.75

6.5

4.5

-22

Visible Genetics

VGINF

8.75

3.75

6

10.25

8.562

-2

Vyrex

VYRX

12.75

6

6.078

7.375

6.125

-52

Xenova Group

XNVAY

3.25

5.687

5.25

4

2.25

-31

XOMA

XOMA

5.125

5.5

4.812

7.75

5.562

9

Zonagen

ZONA

9.375

16.125

21.875

36

18.187

94


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