Published Nov. 19 & 26 (EPO); Nov. 13 & 20 (WO); Nov. 19 (GB)

Alabama, Univ. of WO 97/42217 Radiolabelled fusion toxins Birmingham, Ala. Radiolabelled fusion toxins in which the toxin and radiolabel are attached to growth factors.

Amgen WO 97/42323 Consensus interferon gene Thousand Oaks, Calif. Human consensus interferon gene, encoded protein, adenoviral expression vectors; for treating cancer.

Amgen WO 97/43412 Agouti-related gene Thousand Oaks, Calif. Agouti-related gene expressed in brain, adrenal, and lungs, encoded protein, preparation methods.

Appollon WO 97/41892 Chimeric HIV/kanamycin resistance genes Malvern, Pa. Chimeric kanamycin resistance gene vectors with herpes and HIV sequences; for bacterial production.

Appollon WO 97/42330 Chain reaction cloning Malvern, Germany One-step, site-specific ligation of DNA molecules by thermostable ligases; for PCR-based chain reaction cloning.

Astra GB 2 313 123 Positive selection vector Sodertalje, Sweden Bacterial expression vector system with an anti-sigma polypeptide gene; for positive selection of DNA clones.

BASF WO 97/43442 Human G-protein 33 subunit Ludwigshafen, Germany Gene for human G-protein 33 subunit, mutations, encoded proteins; for developing diagnostic assays.

Beth Israel Deaconess Hosp. WO 97/42309 B-adrenergic knockouts Boston Transgenic animals and somatic and germ cells with a B-adrenergic receptor gene knockout mutation.

Biogen EPO 807 683 ELAM genes Cambridge, Mass. Endothelial cell-leukocyte adhesion molecule (ELAM) genes, encoded proteins; for controlling leukocyte adhesion.

Biogen WO 97/43416 Cytokine receptor antibodies Cambridge, Mass. Antibodies that specifically bind the gamma chain of cytokine receptors; for treating immunological diseases.

Biotech. Res. Inst. WO 97/42335 DNA immunization against cancer Braunschweig, Germany Polycistronic expression vector encoding viral antigens; for DNA immunization of cancer patients.

Boehringer Ingelheim WO 97/42311 Cytomegalovirus protease inhibitors Ridgefield, Conn. Crystal structure of human cytomegalovirus protease; for designing inhibitors.

Boyce Thompson Inst. WO 97/43403 Baculovirus cloning system Ithaca, N.Y. Baculovirus cloning system that presents foreign proteins on the viral surface; for vaccines and antibody production.

Brigham & Women's Hosp. WO 97/42321 Osteoclast transport proteins Boston Osteoclast transport proteins, encoding genes, variants; for influencing osteoclast activity and bone remodeling.

Cedars-Sinai Med. Ctr. WO 97/42312 Leukemia inhibitory factor transgenics Los Angeles Transgenic animals expressing leukemia inhibitory factor in their pituitaries; for investigating pituitary disorders.

Cedars-Sinai Med. Ctr. WO 97/42314 Spinocerebellar ataxia gene Los Angeles Gene for spinocerebellar ataxia-associated protein, encoded protein, antisense; for diagnosis.

Centeon Pharma EPO 808 905 Adenoviral vectors Marburg, Germany Adenoviral vectors for transferring human genes into cells in vivo [in German].

Chiron WO 97/42211, 42213, 42218, & 42219 Mammalian sex comb gene Emeryville, Calif. Mammalian sex comb gene, encoded proteins; for identifying tumor suppressors and cell growth inhibitors.

Chiron WO 97/42338 Replication-deficient retroviruses Emeryville, Calif. Retroviral vectors with less than eight consecutive nucleotides in common; for making replication-deficient virus.

Clausen, H., et al. WO 97/43405 Galactosylaminotransferase Holte, Denmark Gene for a galactosylaminotransferase, encoded protein; for modifying the O-glycosylation pattern of cells.

Diapharm EPO 808 846 HIV-associated serum proteins St. Peter Port, U.K. HIV infection-associated serum proteins, antibodies to them; for diagnosis and vaccination.

Franz, W.-M. EPO 807 688 Smooth muscle expression vector Gross Gronau, Germany Nucleic acid vector construct for specific expression in smooth muscle cells [in German].

Glaxo WO 97/42337 Monocyte/Macrophage gene control Greenford, U.K. DNA sequence for a transcriptional regulatory sequence that controls gene expression in monocytes and macrophages.

Hoechst EPO 808 898 Mutant N-ras ribozyme Frankfurt, Germany Enzymatic RNA molecules designed to specifically cleave mutant N-ras mRNA; for treating abnormal cell growth.

Hoechst WO 97/43408 MP52 monoclonal antibodies Tokyo Mouse anti-human MP52 monoclonal antibodies; for assaying and purifying MP52.

Human Genome Sciences WO 97/42209 DNA repair genes Rockville, Md. Human RAD genes, encoded proteins; for diagnosis and therapy of DNA repair-related diseases.

Hybridon WO 97/43404 Ribozyme variants Cambridge, Mass. Ribozyme variants having improved catalytic activity in low magnesium conditions.

Iatron Labs WO 97/43315 D monomer fibrinogen antibodies Tokyo Monoclonal antibody that reacts with the D monomer of human fibrinogen; for analysis without fibrinogen interference.

Immuno EPO 808 901 Factor VIII/vWF protein Vienna, Austria Protein with Factor VIII procoagulant activity and von Willebrand Factor (vWF) binding activity [in German].

Immunodesigned Molecules EPO 808 897 Antigen-presenting macrophages Paris Antigen-presenting macrophage cells, process of preparation; for cellular vaccines.

Incyte Pharma WO 97/43413 Human kinesin homolog Palo Alto, Calif. Human homolog of a heavy chain member of the kinesin family, encoding genes; for X-linked congenital abnormalities.

Incyte Pharma WO 97/43426 Human protein disulfide isomerase Palo Alto, Calif. Gene for human protein disulfide isomerase, encoded protein, fragments, antibodies.

Kirin Beer WO 97/43411 T cell receptor peptide immunosuppression Tokyo T cell receptor-chain constant region peptides, encoding genes; for non-specific immunosuppression.

Mass. Gen. Hosp. WO 97/42212 SOK-1 gene Boston SOK-1 gene, encoded protein; for identifying modulators of SOK function.

MRC (Med. Res. Counc.) WO 97/43410 Retrovirus susceptibility genes London Retrovirus susceptibility genes, encoded proteins; for assaying for retroviral inhibitors.

MRC (Med. Res. Counc.) WO 97/43647 Nuclear localization signals London Nuclear localization signals derived from DP-3 and E2F-1 transcription factors; for designing reporter vectors.

Merck WO 97/42340 ob receptor isoforms Rahway, N.J. Genes for ob receptor splicing isoforms, encoded proteins, vectors, host cells.

Millennium Pharma WO 97/42210 Essential survival genes Cambridge, Mass. Strain with conditional lethal mutation essential for survival in restrictive growth conditions.

Mochida Pharma WO 97/42319 Fas antigen derivatives Tokyo Fas antigen with modifications in its extracellular region, encoding genes, production methods.

NIH (Natl. Inst. Hlth.) WO 97/42320 Jellyfish fluorescent proteins Bethesda, Md. Modified jellyfish fluorescent proteins with greater cellular fluorescence, encoding genes; for use as a reporter.

NIH (Natl. Inst. Hlth.) WO 97/42322 Glycoprotein hormone superagonists Bethesda, Md. Glycoprotein hormone subunits with residues modified to make them superagonists, encoding genes.

NIH (Natl. Inst. Hlth.) WO 97/43414 Basal cell carcinoma tumor suppressor Bethesda, Md. Tumor suppressor gene, inactivating mutations; for treating basal cell carcinoma.

Novo Nordisk WO 97/42310 Mutated phophatidylinositol 3-kinase Bagsvaerd, Denmark Gene for mutated regulatory p85 subunit of phosphatidylinositol 3-kinase; for use in diagnostics.

Novo Nordisk WO 97/43409 Testing genes Bagsvaerd, Denmark Assaying for biological activities of interest by inserting test DNA into sequences coding the activity.

Osaka Univ. WO 97/43420 Attenuated chickenpox virus Osaka, Japan Identification of attenuated chickenpox virus using restriction enzyme sites; for making vaccines.

Rhone-Poulenc Rorer WO 97/43421 Cobalamin biosynthesis Antony, France Biosynthetic preparation method for cobalamins and coenzyme B12 by recombinant DNA techniques.

Riken Inst. EPO 808 896 Mouse embryonic stem cells Saitama, Japan Embryonic stem cells derived from inbred mice strains; for making gene knock out transgenics.

St. Jude Chidren's Hosp. WO 97/43415 Cyclin D binding ligand Memphis, Tenn. Cyclin D binding ligand that is a myb-like transcription factor, encoding gene.

Schering WO 97/42324 IL-10 use in transplantation Kenilworth, N.J. Method for using interleukin (IL)-10 for inhibiting immune reactions to antigens in graft-versus-host disease.

Scripps Res. Inst. WO 97/43417 Cortistatin La Jolla, Calif. Gene for the neuropeptide cortistatin, encoded protein, antibodies; for sleep disorder therapy.

SmithKline Beecham EPO 807 686 & 808 904 ICE-like apoptotic proteases Philadelphia Interleukin-B- converting enzyme (ICE)-like apoptotic protease genes, encoded proteins; for cell injury diseases.

SmithKline Beecham EPO 807 687 Herpes protease structure Philadelphia Herpes virus proteases, active site determination; for identifying inhibitors.

SmithKline Beecham EPO 808 899 Marco scavenger receptor Philadelphia Gene for human marco scavenger receptor, encoded protein; for cardiovascular disease therapeutics.

SmithKline Beecham EPO 808 900 Benign prostate hypertrophy markers Philadelphia Genes and proteins specific for benign prostatic hypertrophy; for diagnosis and treatment.

SmithKline Beecham WO 97/43303 & 43304 Antibacterial compounds Philadelphia Genes encoding proteins useful for developing antibacterial compounds as therapeutics.

S. California Water District WO 97/42349 Encysted protozoan assay Los Angeles Nucleic acid probes for detecting encysted forms of protozoans; for assaying water supplies.

T Cell Sciences WO 97/42317 Complement binding DNA Needham, Mass. Nucleic acids that specifically bind complement protein C3b; for inhibiting C3b action and treating inflammation.

Takara Shuzo EPO 808 630 Cancer metastasis control Kyoto, Japan Control of E1AF gene expression; for detection, diagnosis, and control of cancer metastasis.

Takeda EPO 807 684 G-protein coupled receptors Osaka, Japan G-protein coupled receptors genes, encoded proteins, antagonists, agonists; for diagnostics and therapeutics.

Unisearch WO 97/42336 Hematopoietic cell vector Kensington, Australia Replication-defective retroviral vector without antibiotic resistance genes; for long-term expression in blood cells.

Visible Genetics WO 97/43441 BRCA1 gene mutation assay Toronto, Ont. PCR amplification and exon sequencing methods for the detection of BRCA1 gene mutations.

Yale Univ. WO 97/42325 Lyme disease treatment New Haven, Conn. Lyme disease bacterial proteins, antibodies, encoding genes, production system; for disease treatment.

Zeneca WO 97/42329 CEA monoclonal antibodies London Monoclonal antibodies to carcinoembryonic antigen (CEA), fragments, humanized antibodies, conjugates.

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