Published April 24 & May 1 (EPO & GB); April 18 & 25 (WO)

Amgen Multi-G oligos WO 96/11266

Thousand Oaks, Calif.

Multi-G oligonucleotides; for inhibiting smooth muscle cell growth inarteries ex vivo in restenosis.

Amgen Keratinocyte WO 96/11949, 11950,

Thousand Oaks, Calif. growth factor 11951, & 11952

Keratinocyte growth factor, analogues, purification methods; fortreating diabetes.

Apollon Hepatitis B/C WO 96/10997

Malvern, Pa. fusion vaccine

Hepatitis B and C genomic fusions linked to regulatory elementsoperable in humans; for vaccination.

Applied Res. Systems Cytoplasmic IL-1 WO 96/12022

Curacao, receptor antagonist

Netherlands Antilles

Gene for cytoplasmic isoform of the interleukin-1 (IL-1) receptorantagonist, production methods; for therapy.

Asahi Tyrosine WO 96/11212

Osaka, Japan kinase ligand

Gene for a receptor-type tyrosine kinase ligand expressed inundifferentiated blood cells, encoded protein.

Assoc. Molec. Brain endothelial WO 96/11278

Immunol. Develop. cells


Immortalized brain endothelial cells transfected with desired genes;for gene therapy.

BASF ICE disrupted WO 96/12025

Ludwigshaven, Germany transgenics

Transgenic animal with functionally disrupted interleukin-1aconverting enzyme (ICE) gene; for identifying inhibitors.

Bristol-Myers Squibb Receptor WO 96/12019

New York tyrosine kinase

Gene for a receptor tyrosine kinase related to epidermal growth factorreceptor, encoded protein; for therapy.

British Columbia, Univ. of Lipoprotein WO 96/11276

Vancouver, B.C. lipase mutation

Assay for lipoprotein lipase gene point mutation associated withincreased susceptibility to premature atherosclerosis.

California, Univ. of RNA translation WO 96/11211

Los Angeles inhibition

Selective inhibition of internally initiated RNA translation by anRNA oligonucleotide.

California, Univ. of Anti-HIV WO 96/11696

Los Angeles screen

Cells transfected with the HIV Vpr gene; for screening anti-HIVdrugs.

Cancer Inst. Transcriptional EPO 708 112

Tokyo control protein

Gene for a human protein that is homologous to a yeasttranscriptional control protein, encoded protein.

Cancer Res. Campaign Tech. Papilloma WO 96/11273

London virus vaccines

N-terminal region of papilloma virus structural proteins; for makingvaccines.

Cold Spring Harbor Labs Long-term WO 96/11270

Cold Spring Harbor, N.Y. memory genes

Cloning and characterization of genes associated with long-termmemory; for identifying antagonists.

Corvas Intl. Nematode WO 96/12021

San Diego anticoagulants

Serine protease inhibitors and anticoagulants isolated fromnematodes, genes encoding these proteins.

Devaron HIV antibody WO 96/12023

Dayton, N.J. detection

Antigenic protein, analogues, fragments, derivatives, and genesencoding them; for detecting HIV antibodies.

Dompe Bacterial WO 96/11277

L'Aquila, Italy delivery systems

Recombinant bacteria encoding a therapeutic protein; for delivery topatients.

E. Carolina Univ. Attenuated WO 96/11280

Greenville, N.C. methylated viruses

Attenuated viruses produced by adding DNA methylation sites; fordiagnosis and vaccine production.

Enzon Antigen-binding WO 96/11955

Piscataway, N.J. fusion proteins

Immunoeffector antigen-binding fusion proteins and fusions to otherproteins.

Goldberg, E.B. Bacteriophage WO 96/11947

Newton, Mass. nanostructures

Creation of nanostructures based on bacteriophage T4 tail fibers andvariants.

Harvard Univ. Dideoxynucleotide WO 96/12042

Cambridge, Mass. DNA polymerase

Modified gene encoding a DNA polymerase that preferentially usesdideoxynucleotides.

Health Res. p53as EPO 709 397

Buffalo, N.Y. antibodies

Polyclonal and monoclonal antibodies to p53as; for detection ofcancer cells.

Helsinki Univ. Cytoplasmic WO 96/11275

Helsinki, Finland tyrosine kinase

Genes for cytoplasmic tyrosine kinases, proteins encoded by thesegenes.

Hovius, E. Self-stabilizing WO 96/12015

Sassenheim, Netherlands DNA/RNA loop

Self-stabilizing DNA/RNA loop that is targeted to a specific positionin the genome.

Human Genome Sciences TGF-a1, activin WO 96/11259

Rockville, Md. receptors 1/3

Genes for TGF-a1, activin receptors 1 and 3, encoded proteins,antibodies; for cell growth inhibition.

Human Genome Sciences Endothelin- WO 96/11946

Rockville, Md. bombesin receptor

Gene for human endothelin-bombesin receptor, encoded protein; foridentifying antagonists.

IG Labs Polycystic kidney WO 96/12033

Framingham, Mass. disease

Genomic and cDNA sequences of the 5' end of the gene responsiblefor autosomal dominant polycystic kidney disease.

Immunex Cytokine WO 96/10911

Seattle LERK-6

Gene for the cytokine LERK-6, encoded protein, vectors andtransfected cells.

Immunomedics Humanized CEA WO 96/11013

Morris Plains, N.J. antibodies

Complementarity-determining region (CDR)-grafted type III anti-carcinoembryonic antigen (CEA) humanized antibodies.

Imutran Transgenic EPO 709 459

London transplants

Biological tissues in transgenics modified to express complementrestriction factors homologous to intended donors.

INSERM (Natl. Inst. Motor neuron EPO 708 178

Hlth. Med. Res.) survival


Gene for a protein that promotes motor neuron survival, encodedprotein; for treating motor neuron disease.

Karo Bio Multiple reporter WO 96/12011

Huddinge, Sweden cell lines

Cell lines with multiple reporter genes whose expression is controlledby endogenous factors, including glucocorticoids.

Krebs Res. Inst. Multi-zinc finger WO 96/11267

Heidelberg, Germany protein

Gene for a multi-zinc finger protein, encoded protein; for diagnosisand gene therapy of tumors.

Krebs Res. Inst. Adeno-associated WO 96/12010

Heidelberg, Germany virus mutants

Preparation of rep-negative adeno-associated virus mutants,expression vector, cells for production.

Eli Lilly Insulinotropic EPO 708 179

Indianapolis peptide

Glucagon-like insulinotropic peptide analogues and derivatives; forstimulating insulin secretion in beta cells.

Lynx Therapeutics Oligo tagging WO 96/12014

Hayward, Calif. system

Molecular tagging system using oligonucleotides; for isolation andsequencing of nucleic acids.

Marukin Shoyu Epimerase EPO 708 177

Kagawa, Japan

Gene for acylglucosamine 2-epimerase, encoded protein; forproducing glucosamines.

Massachusetts, Univ. a-actin mRNA WO 96/11265

Med. Ctr. localization

Worcester, Mass.

3'-noncoding sequences of the a-actin gene that cause localization ofa-actin mRNA to specific cytoplasmic regions.

Max Planck Inst. Phosphatidylinositol- WO 96/12024

Munich, Germany 3-kinase

Gene for phosphatidylinositol-3-kinase, encoded protein, antibodies;for diagnosis and therapy.

Medigene Papilloma WO 96/11272

Martinsreid, Germany virus-like particles

Recombinant papilloma virus-like particles made from partially-deleted viral structural proteins.

Merck Stabilized WO 96/12007

Rahway, N.J. cytomegalovirus protease

Human cytomegalovirus protease stabilized by introduced mutations;for screening antivirals.

Merck Methylase resistant WO 96/12008

Rahway, N.J. genes

Methylase resistant genes constructed by removing the methylaserecognition sites from these genes.

NIH (Natl. Inst. Hlth.) Chimeric WO 96/11274

Bethesda, Md. papilloma virus-like particles

Papilloma virus-like particles made from a fusion product of morethan one structural protein, chimeric genes.

NIH (Natl. Inst. Hlth.) Enhanced WO 96/11279

Bethesda, Md. immune response

Recombinant virus with genes for a disease-associated antigen and animmunostimulatory molecule.

Nisshin Flour Milling Glicentin EPO 709 455

Tokyo antibodies

Monoclonal antibodies to glicentin, hybridoma producing thisantibody; for assay kit.

Oregon Hlth. Sci. Univ. Bacterial WO 96/12020

Portland, Ore. hemoglobin receptors

Genes for bacterial hemoglobin receptors, encoded proteins; forvaccine production.

Otsuka Pharma Apoptosis gene WO 96/12017


Gene participating in apoptosis; for detection of proteinsparticipating in apoptosis.

Ottawa, Univ. of Neuronal apoptosis WO 96/12016

Ottawa, Ont. inhibitor protein

Gene for neuronal apoptosis inhibitor protein on chromosome 5,mutation associated with spinal muscular atrophy.

Ramot Univ. Radiation WO 96/11562

Ramot Aviv, Israel protecting gene

Gene encoding a protein involved in radiation protection, antisenseRNA; for cancer detection and treatment.

Regeneron Pharma TIE-2 ligand WO 96/11269

Tarrytown, N.Y.

TIE-2 ligand and its receptor, antibodies to them; for affecting bloodvessel growth.

Rhone Poulenc Rorer Adenovirus-based WO 96/12030

Antony, France vectors

Adenovirus-based vectors encoding a therapeutic and animmunoprotective gene; for immunomodulation.

Rockefeller Univ. Enzymatic WO 96/11263

New York microbial agent

An enzyme that cleaves a specific sequence in the surface proteins ofgram positive bacteria; for treatment.

Salk Inst. Immunophilin genes WO 96/12018

La Jolla, Calif.

Genes for immunophilin proteins expressed by T cells, encodedproteins; for screening immunomodulators.

Scottish Crop Res. Inst. Plant therapeutic WO 96/12027

Dundee, U.K. production

Plant virus-based vectors for producing chimeric proteins; fortherapeutic production.

Solvay Pseudomonas WO 96/12012

Brussels, Belgium strain lipase

Gene for a Pseudomonas strain lipase, encoded lipase that is activewithin a broad pH range.

Stanford Univ. Patched genes WO 96/11260

Palo Alto, Calif.

Invertebrate and vertebrate patched genes; for studying embryonicdevelopment and assaying antagonists.

Tykocinski, M.L. Engineered WO 96/12009

Shaker Heights, Ohio antigen-presenting cells

Methods for engineering antigen-presenting cells such that definedpeptides are presented on their cell membranes.

Warner-Lambert Lipoprotein WO 96/11268

Morris Plains, N.J. scavenging

Gene for a receptor that scavenges apo B containing lipoproteins; forgene therapy to treat atherosclerosis.

Warwick, Univ. of Phenylketinuric GB 2 294 464

Coventry, U.K. food

Gene for a modified edible protein having no phenylalanine residues,encoded protein; for phenylketinurics.

Zeneca Teleomere repeats GB 2 294 322


Method for detecting and amplifying teleomere repeat variants ingenomic DNA.

_ Compiled By Chester A . Bisbee


EPO = European Patent OfficeGB = Great BritainWO = World Intellectual Property

(c) 1997 American Health Consultants. All rights reserved.