Published April 24 & May 1 (EPO & GB); April 18 & 25 (WO)
Amgen Multi-G oligos WO 96/11266
Thousand Oaks, Calif.
Multi-G oligonucleotides; for inhibiting smooth muscle cell growth inarteries ex vivo in restenosis.
Amgen Keratinocyte WO 96/11949, 11950,
Thousand Oaks, Calif. growth factor 11951, & 11952
Keratinocyte growth factor, analogues, purification methods; fortreating diabetes.
Apollon Hepatitis B/C WO 96/10997
Malvern, Pa. fusion vaccine
Hepatitis B and C genomic fusions linked to regulatory elementsoperable in humans; for vaccination.
Applied Res. Systems Cytoplasmic IL-1 WO 96/12022
Curacao, receptor antagonist
Netherlands Antilles
Gene for cytoplasmic isoform of the interleukin-1 (IL-1) receptorantagonist, production methods; for therapy.
Asahi Tyrosine WO 96/11212
Osaka, Japan kinase ligand
Gene for a receptor-type tyrosine kinase ligand expressed inundifferentiated blood cells, encoded protein.
Assoc. Molec. Brain endothelial WO 96/11278
Immunol. Develop. cells
Paris
Immortalized brain endothelial cells transfected with desired genes;for gene therapy.
BASF ICE disrupted WO 96/12025
Ludwigshaven, Germany transgenics
Transgenic animal with functionally disrupted interleukin-1aconverting enzyme (ICE) gene; for identifying inhibitors.
Bristol-Myers Squibb Receptor WO 96/12019
New York tyrosine kinase
Gene for a receptor tyrosine kinase related to epidermal growth factorreceptor, encoded protein; for therapy.
British Columbia, Univ. of Lipoprotein WO 96/11276
Vancouver, B.C. lipase mutation
Assay for lipoprotein lipase gene point mutation associated withincreased susceptibility to premature atherosclerosis.
California, Univ. of RNA translation WO 96/11211
Los Angeles inhibition
Selective inhibition of internally initiated RNA translation by anRNA oligonucleotide.
California, Univ. of Anti-HIV WO 96/11696
Los Angeles screen
Cells transfected with the HIV Vpr gene; for screening anti-HIVdrugs.
Cancer Inst. Transcriptional EPO 708 112
Tokyo control protein
Gene for a human protein that is homologous to a yeasttranscriptional control protein, encoded protein.
Cancer Res. Campaign Tech. Papilloma WO 96/11273
London virus vaccines
N-terminal region of papilloma virus structural proteins; for makingvaccines.
Cold Spring Harbor Labs Long-term WO 96/11270
Cold Spring Harbor, N.Y. memory genes
Cloning and characterization of genes associated with long-termmemory; for identifying antagonists.
Corvas Intl. Nematode WO 96/12021
San Diego anticoagulants
Serine protease inhibitors and anticoagulants isolated fromnematodes, genes encoding these proteins.
Devaron HIV antibody WO 96/12023
Dayton, N.J. detection
Antigenic protein, analogues, fragments, derivatives, and genesencoding them; for detecting HIV antibodies.
Dompe Bacterial WO 96/11277
L'Aquila, Italy delivery systems
Recombinant bacteria encoding a therapeutic protein; for delivery topatients.
E. Carolina Univ. Attenuated WO 96/11280
Greenville, N.C. methylated viruses
Attenuated viruses produced by adding DNA methylation sites; fordiagnosis and vaccine production.
Enzon Antigen-binding WO 96/11955
Piscataway, N.J. fusion proteins
Immunoeffector antigen-binding fusion proteins and fusions to otherproteins.
Goldberg, E.B. Bacteriophage WO 96/11947
Newton, Mass. nanostructures
Creation of nanostructures based on bacteriophage T4 tail fibers andvariants.
Harvard Univ. Dideoxynucleotide WO 96/12042
Cambridge, Mass. DNA polymerase
Modified gene encoding a DNA polymerase that preferentially usesdideoxynucleotides.
Health Res. p53as EPO 709 397
Buffalo, N.Y. antibodies
Polyclonal and monoclonal antibodies to p53as; for detection ofcancer cells.
Helsinki Univ. Cytoplasmic WO 96/11275
Helsinki, Finland tyrosine kinase
Genes for cytoplasmic tyrosine kinases, proteins encoded by thesegenes.
Hovius, E. Self-stabilizing WO 96/12015
Sassenheim, Netherlands DNA/RNA loop
Self-stabilizing DNA/RNA loop that is targeted to a specific positionin the genome.
Human Genome Sciences TGF-a1, activin WO 96/11259
Rockville, Md. receptors 1/3
Genes for TGF-a1, activin receptors 1 and 3, encoded proteins,antibodies; for cell growth inhibition.
Human Genome Sciences Endothelin- WO 96/11946
Rockville, Md. bombesin receptor
Gene for human endothelin-bombesin receptor, encoded protein; foridentifying antagonists.
IG Labs Polycystic kidney WO 96/12033
Framingham, Mass. disease
Genomic and cDNA sequences of the 5' end of the gene responsiblefor autosomal dominant polycystic kidney disease.
Immunex Cytokine WO 96/10911
Seattle LERK-6
Gene for the cytokine LERK-6, encoded protein, vectors andtransfected cells.
Immunomedics Humanized CEA WO 96/11013
Morris Plains, N.J. antibodies
Complementarity-determining region (CDR)-grafted type III anti-carcinoembryonic antigen (CEA) humanized antibodies.
Imutran Transgenic EPO 709 459
London transplants
Biological tissues in transgenics modified to express complementrestriction factors homologous to intended donors.
INSERM (Natl. Inst. Motor neuron EPO 708 178
Hlth. Med. Res.) survival
Paris
Gene for a protein that promotes motor neuron survival, encodedprotein; for treating motor neuron disease.
Karo Bio Multiple reporter WO 96/12011
Huddinge, Sweden cell lines
Cell lines with multiple reporter genes whose expression is controlledby endogenous factors, including glucocorticoids.
Krebs Res. Inst. Multi-zinc finger WO 96/11267
Heidelberg, Germany protein
Gene for a multi-zinc finger protein, encoded protein; for diagnosisand gene therapy of tumors.
Krebs Res. Inst. Adeno-associated WO 96/12010
Heidelberg, Germany virus mutants
Preparation of rep-negative adeno-associated virus mutants,expression vector, cells for production.
Eli Lilly Insulinotropic EPO 708 179
Indianapolis peptide
Glucagon-like insulinotropic peptide analogues and derivatives; forstimulating insulin secretion in beta cells.
Lynx Therapeutics Oligo tagging WO 96/12014
Hayward, Calif. system
Molecular tagging system using oligonucleotides; for isolation andsequencing of nucleic acids.
Marukin Shoyu Epimerase EPO 708 177
Kagawa, Japan
Gene for acylglucosamine 2-epimerase, encoded protein; forproducing glucosamines.
Massachusetts, Univ. a-actin mRNA WO 96/11265
Med. Ctr. localization
Worcester, Mass.
3'-noncoding sequences of the a-actin gene that cause localization ofa-actin mRNA to specific cytoplasmic regions.
Max Planck Inst. Phosphatidylinositol- WO 96/12024
Munich, Germany 3-kinase
Gene for phosphatidylinositol-3-kinase, encoded protein, antibodies;for diagnosis and therapy.
Medigene Papilloma WO 96/11272
Martinsreid, Germany virus-like particles
Recombinant papilloma virus-like particles made from partially-deleted viral structural proteins.
Merck Stabilized WO 96/12007
Rahway, N.J. cytomegalovirus protease
Human cytomegalovirus protease stabilized by introduced mutations;for screening antivirals.
Merck Methylase resistant WO 96/12008
Rahway, N.J. genes
Methylase resistant genes constructed by removing the methylaserecognition sites from these genes.
NIH (Natl. Inst. Hlth.) Chimeric WO 96/11274
Bethesda, Md. papilloma virus-like particles
Papilloma virus-like particles made from a fusion product of morethan one structural protein, chimeric genes.
NIH (Natl. Inst. Hlth.) Enhanced WO 96/11279
Bethesda, Md. immune response
Recombinant virus with genes for a disease-associated antigen and animmunostimulatory molecule.
Nisshin Flour Milling Glicentin EPO 709 455
Tokyo antibodies
Monoclonal antibodies to glicentin, hybridoma producing thisantibody; for assay kit.
Oregon Hlth. Sci. Univ. Bacterial WO 96/12020
Portland, Ore. hemoglobin receptors
Genes for bacterial hemoglobin receptors, encoded proteins; forvaccine production.
Otsuka Pharma Apoptosis gene WO 96/12017
Tokyo
Gene participating in apoptosis; for detection of proteinsparticipating in apoptosis.
Ottawa, Univ. of Neuronal apoptosis WO 96/12016
Ottawa, Ont. inhibitor protein
Gene for neuronal apoptosis inhibitor protein on chromosome 5,mutation associated with spinal muscular atrophy.
Ramot Univ. Radiation WO 96/11562
Ramot Aviv, Israel protecting gene
Gene encoding a protein involved in radiation protection, antisenseRNA; for cancer detection and treatment.
Regeneron Pharma TIE-2 ligand WO 96/11269
Tarrytown, N.Y.
TIE-2 ligand and its receptor, antibodies to them; for affecting bloodvessel growth.
Rhone Poulenc Rorer Adenovirus-based WO 96/12030
Antony, France vectors
Adenovirus-based vectors encoding a therapeutic and animmunoprotective gene; for immunomodulation.
Rockefeller Univ. Enzymatic WO 96/11263
New York microbial agent
An enzyme that cleaves a specific sequence in the surface proteins ofgram positive bacteria; for treatment.
Salk Inst. Immunophilin genes WO 96/12018
La Jolla, Calif.
Genes for immunophilin proteins expressed by T cells, encodedproteins; for screening immunomodulators.
Scottish Crop Res. Inst. Plant therapeutic WO 96/12027
Dundee, U.K. production
Plant virus-based vectors for producing chimeric proteins; fortherapeutic production.
Solvay Pseudomonas WO 96/12012
Brussels, Belgium strain lipase
Gene for a Pseudomonas strain lipase, encoded lipase that is activewithin a broad pH range.
Stanford Univ. Patched genes WO 96/11260
Palo Alto, Calif.
Invertebrate and vertebrate patched genes; for studying embryonicdevelopment and assaying antagonists.
Tykocinski, M.L. Engineered WO 96/12009
Shaker Heights, Ohio antigen-presenting cells
Methods for engineering antigen-presenting cells such that definedpeptides are presented on their cell membranes.
Warner-Lambert Lipoprotein WO 96/11268
Morris Plains, N.J. scavenging
Gene for a receptor that scavenges apo B containing lipoproteins; forgene therapy to treat atherosclerosis.
Warwick, Univ. of Phenylketinuric GB 2 294 464
Coventry, U.K. food
Gene for a modified edible protein having no phenylalanine residues,encoded protein; for phenylketinurics.
Zeneca Teleomere repeats GB 2 294 322
London
Method for detecting and amplifying teleomere repeat variants ingenomic DNA.
_ Compiled By Chester A . Bisbee
NOTES:
EPO = European Patent OfficeGB = Great BritainWO = World Intellectual Property
(c) 1997 American Health Consultants. All rights reserved.