DynaGen Inc. announced Monday that it is accelerating clinicaldevelopment of NicErase-IA to treat nicotine addiction.
Based on a naturally occurring plant substance called lobelinethat appears to bind nicotine receptors, NicErase-IA is designedfor twice-daily injection to reduce nicotine withdrawalsymptoms, particularly in hospitalized patients who arerestricted from smoking.
The Cambridge, Mass., company (NASDAQ:DYGN) has submittedto the FDA an investigational new drug application forNicErase-IA for clearance to begin Phase III trials to examinethe impact of lobeline on short-term nicotine craving.
Lobeline is not expected to be addictive. It has been used in anoral form prior to the development of NicErase-IA andNicErase-CR by the company. NicErase-CR is based on thecompany's proprietary controlled-release technology, and isdesigned as a once-a-week injection for individuals who wantto quit smoking.
"Development of NicErase-IA increases the market potential forour smoking cessation programs," said Indu Muni, presidentand chief executive officer. "By the third quarter, we expect tohave two smoking cessation products in Phase III clinicaldevelopment."
(c) 1997 American Health Consultants. All rights reserved.