Transplanted human cortical organoids integrate anatomically and functionally into the rodent brain
Nov. 3, 2022
Self-organizing organoids resembling specific regions of the nervous system, including human cortical organoids (hCO), can be generated and used as disease models. However, the application of hCOs is precluded by several limitations, including the lack of integration into in vivo circuits that generate behavioral outputs. To overcome these issues, transplantation of hCOs into intact living brains has been proposed.