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BioWorld - Wednesday, June 7, 2023

Neurology/Psychiatric

Home » Topics » Disease categories and therapies » Neurology/Psychiatric
  • June 7, 2023

    RIPK1 inhibitors described in Sanofi patent

    Sanofi SA has prepared and tested isoxazolidines acting as receptor-interacting serine/threonine-protein kinase 1 (RIPK1; RIP-1) inhibitors. As such, they are reported to be useful for the treatment of Alzheimer’s disease, multiple sclerosis, amyotrophic lateral sclerosis and incontinentia pigmenti.
  • June 7, 2023

    Vigil Neuroscience patents describe TREM2 agonists

    Two Vigil Neuroscience Inc. patents describe triggering receptor expressed on myeloid cells 2 (TREM2) agonists reported to be useful for the treatment of frontotemporal dementia, multiple sclerosis, rheumatoid arthritis, stroke, prion infections, Parkinson’s, Alzheimer’s and Nasu-Hakola diseases.
  • Max planck institute amyloid and myelin hero
    June 7, 2023
    By Anette Breindl

    Myelin damage distracts microglia from amyloid plaques

    “One of the many reasons we don’t have effective therapies for AD at the moment ... is that we don’t understand the beginnings of the disease,” Constanze Depp told BioWorld. Understanding those beginnings is likely to be a necessary prerequisite for truly turning the tide on Alzheimer’s disease (AD). “The brain is so bad at repairing itself, and once a neuron is lost, it will most likely not regenerate,” she elaborated. Now, Depp and her colleagues have reported on a contributor to those beginnings.
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