The number of biopharma deals with nonprofits or government entities has dropped over last year, partly due to fewer COVID-19-related alliances, but the activity in 2022 is still strong in comparison to pre-pandemic years.

An increasing number and rising value of high-money biopharma deals has placed early 2022 above all recent years, even though there are fewer partnerships overall.

Stocks that make up BioWorld’s Drug Developers Index have tumbled by more than 17% since the start of the year, with only five of the 30 component companies showing a rise in share price. The Nasdaq Biotechnology Index and the Dow Jones Industrial Average also are down by 12.2% and 2.41%, respectively, indicating the biotech industry, which has experienced huge stock surges during the past two years, is now struggling, dropping more sharply than the broader markets.

The amount of money raised in January by biopharma companies has fallen 55% from the same month in 2021 and 31% from January of 2020, indicating less enthusiasm from investors and a potential slowdown in financings for 2022. In total, January of 2022 has recorded significantly less fundraising than each of the past two years, with $4.8 billion (79 transactions), well below 2021’s $10.79 billion (159 transactions) and down from 2020’s $6.95 billion (131 transactions).