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Home » Topics » Conferences » AACR-NCI-EORTC Molecular Targets and Cancer Therapeutics

AACR-NCI-EORTC Molecular Targets and Cancer Therapeutics
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Cancer tumor in breast illustration
Cancer

CGT-6297 leads to tumor regression in breast cancer model

Nov. 25, 2024
Researchers from Cogent Biosciences Inc. have presented data on their PI3KA H1047R mutant inhibitor CGT-6297 PI3KA wild-type inhibitors can lead to toxicity issues such as hyperglycemia, gastrointestinal toxicity and skin reactions.
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Cancer

GSC-002639 shows antitumor efficacy against PIK3CA-mutant tumors

Nov. 22, 2024
Mutations in the PIK3CA gene are present in about 4% to 36% of cancers such as breast, ovarian, endometrial and colorectal cancer, among others.
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Cancer

GSC-000829, a selective FGFR2/FGFR3 inhibitor, for cancer therapy

Nov. 20, 2024
Changchun Genescience Pharmaceuticals Co. Ltd. has reported GSC-000829, a novel and selective FGFR2/FGFR3 inhibitor being developed for the potential treatment of cancer.
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Scientist looking in microscope, chemical structure concept image
Cancer

Synrx Therapeutics reports new PARG inhibitor

Nov. 19, 2024
Hangzhou Synrx Therapeutics Biomedical Technology Co. Ltd. recently presented the development and characterization of a novel PARG inhibitor, SYN-608, for the potential treatment of tumors with/without homologous recombination deficiency (HRD).
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Cancer

XPR1 unveiled as therapeutic target in lung cancer

Nov. 19, 2024
Tumor cell survival is dependent on phosphate homeostasis, which requires high amounts of energy. Researchers have demonstrated that the silencing of xenotropic and polytropic retrovirus receptor 1 (XPR1) led to reduced tumor growth in an ovarian cancer cell line xenograft, and similar vulnerability was found in lung cancer.
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Cancer

MBT-C101, a selective and potent HSP90 chaperone-mediated degrader of PI3Kα

Nov. 18, 2024
MBT-C101 is a selective, potentially first-in-class potent HSP90 chaperone-mediated degrader of PI3Kα, for the treatment of breast cancer. It was developed by Magicbullet Therapeutics Inc. using the company’s Chaperone-mediated Degrader (CM-Degrader) platform.
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Illustration of pill being analyzed
Cancer

Pan-TEAD and MEK inhibitor combination shows strong synergy in head and neck tumors

Nov. 15, 2024
Genetic alterations in FAT1, YAP1 or WWTR1 genes are commonly seen in head and neck squamous cell carcinoma (HNSCC) patients. Targeting Hippo and MAPK pathways in combination has proven effective in preclinical models of HNSCC.
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Cancer

NTS-071, small-molecule p53 Y220C reactivator with excellent antitumor efficacy in vivo

Nov. 15, 2024
NTS-071 is a novel orally bioavailable p53 Y220C reactivator recently discovered and characterized by Nutshell Therapeutics Inc.
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3D illustration and light micrograph of lung cancer.
Cancer

KO-2806 demonstrates potential as combination partner in models of treatment-resistant NSCLC and CRC

Nov. 14, 2024
The next-generation farnesyl transferase inhibitor KO-2806 is currently in phase I clinical development at Kura Oncology Inc. for the treatment of patients with solid tumors, including non-small-cell lung cancer (NSCLC) and colorectal cancer (CRC).
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Immuno-oncology

Duality Biologics reports preclinical findings with B7-H3/PD-L1-targeting ADC

Nov. 12, 2024
Duality Biologics Ltd. presented preclinical data on DB-1419, a potentially first-in-class bispecific antibody-drug conjugate (ADC) consisting of a humanized antibody targeting B7-H3 and PD-L1 conjugated to a DNA topoisomerase I inhibitor under development for the treatment of cancer.
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