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Home » Topics » Conferences » AACR-NCI-EORTC Molecular Targets and Cancer Therapeutics

AACR-NCI-EORTC Molecular Targets and Cancer Therapeutics
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Test tube, dropper
Cancer

Hutchmed’s HMPL-500 exerts superior efficacy in preclinical cancers

Nov. 12, 2024
Gain-of-function mutations and overexpression of the EZH2 gene lead to H3K27Me3 accumulation, which in turn initiates tumorigenesis and tumor progression, thus making it a promising target for therapy.
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Cancer

Discovery of new ALK5 inhibitor HM-279

Nov. 12, 2024
Activin receptor-like kinase 5 (ALK5) is a member of the transforming growth factor-β (TGF-β) family associated with tumor development and progression that impacts cancer immune response within the tumor microenvironment.
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Cancer

Selective PARP1 inhibitor yields durable antitumor response

Nov. 11, 2024
Nonselective poly(ADP-ribose) polymerase (PARP) inhibitors have shown antitumoral activity, but they are tied to hematotoxicity, most probably due to PARP2 inhibition. Instead, selective PARP inhibitors retain antitumoral activity without risking PARP2-related toxicity.
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Antibody-drug conjugate
Immuno-oncology

Preclinical characterization of ZW-220, a differentiated and Fc-silenced NaPi2b-targeted ADC

Nov. 11, 2024
Researchers from Zymeworks Inc. recently reported preclinical data for ZW-220, an antibody-drug conjugate (ADC) consisting of humanized IgG1 monoclonal antibody targeting sodium-dependent phosphate transport protein 2B (SLC34A2, NaPi2b) conjugated to a topoisomerase I inhibitor, being developed for the treatment of cancer.
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Illustration of tumor in breast
Cancer

OP-3136 enhances endocrine and CDK4/6 inhibitor therapy in breast cancer

Nov. 11, 2024
KAT6 is a histone lysine acetyl transferase involved in the epigenetic regulation of oncogenes and it is often dysregulated in cancer, including breast cancer. Inhibiting KAT6 blocks the transcription of genes such as ESR1 and CCND1 and the use of KAT6 inhibitors together with endocrine therapy and CDK4/6 inhibitor therapy may enhance the effectiveness in cancer.
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Cancer

Qilu Regor Therapeutics unveils new HPK1 inhibitor

Nov. 8, 2024
The inhibition of hematopoietic progenitor kinase 1 (HPK1), predominantly expressed in immune cells, has proven effective in reducing tumor growth across cancer immune response modulation.
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Illustration of cancer tumor
Cancer

CDK2-selective degrader inhibits tumor growth in preclinical models

Nov. 8, 2024
Data from preclinical studies conducted to evaluate the activity of NKT-3964, a first-in-class, orally bioavailable CDK2-selective PROTAC degrader being developed for the potential treatment of cancer, were reported by Nikang Therapeutics Inc.
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Cancer

SOS1 inhibitor HM-99462 demonstrates synergy with RTK-KRAS-MAPK signaling inhibitors

Nov. 8, 2024
SOS1 is a guanine nucleotide exchange factor (GEF) that activates KRAS, and recent preclinical studies have demonstrated that combining KRAS and EGFR inhibitors with SOS1 inhibitors can overcome resistance and achieve durable responses.
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Illustration of cancer cell in crosshairs being destroyed
Cancer

First-in-class dual-payload anti-HER2 agent presented

Nov. 8, 2024
Anti-HER2 antibody-drug conjugates (ADCs) have proven effective in multiple tumor types. However, between 64% and 85% of HER2+ breast and gastric cancer patients retain HER2 expression after treatment with trastuzumab deruxtecan (T-Dxd), which includes a topoisomerase I inhibitor payload.
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Cancer

Highly efficacious noncovalent WRN inhibitor for treating MSI-H tumors

Nov. 8, 2024
Nimbus Therapeutics LLC reported the identification of an allosteric, potent, selective, highly efficacious and noncovalent Werner syndrome helicase (WRN) inhibitor, NTX-452, for the potential treatment of microsatellite instability high (MSI-H) tumors.
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