Oddsmakers wasted no time figuring the market chances after Merck & Co. Inc. rolled out data from the phase III Litespark-011 study testing its oral hypoxia-inducible factor-2 alpha (HIF-2α) inhibitor, Welireg (belzutifan), when used with tyrosine kinase inhibitor Lenvima (lenvatinib, Eisai Co.) in advanced renal cell carcinoma.

HIV-1 persistence in latent reservoirs of T lymphoid and myeloid origin is a major barrier for the cure of the disease, with complex and multifactorial mechanisms behind HIV-1 latency; thus, investigating these mechanisms is key for future targeted HIV therapies.

Gliadin is the major allergen of wheat-dependent exercise-induced anaphylaxis (WDEIA). YH-35324 (lesigercept, GI-301) is a long-acting IgEtrap-Fc fusion protein that targets FcεR1α that could serve as a therapeutic approach in WDEIA. It is under development by Yuhan Corp. in early clinical trials as an allergy treatment.