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BioWorld - Saturday, June 10, 2023

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Home » Topics » Conferences
  • June 9, 2023

    Nonmucosal intradermal dmLT-M. tuberculosis Ag85 complex combination vaccine confers enhanced mucosal immunity

    Tuberculosis (TB) is the 13th leading cause of death in the world, and it is rising together with the increased prevalence of drug-resistant TB in many countries. The Bacille Calmette-Guerin (BCG) vaccine is the only available TB vaccine, and it has been given to more people than any other vaccine. While the BCG vaccine has saved tens of millions of lives, it confers suboptimal protection against pulmonary TB as it is limited to providing protection only until early childhood. Significantly, the BCG vaccine is administered intradermally to confer exceptional mucosal immunity as compared to most other vaccines, which are more commonly administered intramuscularly. Novel strategies to improve the duration of TB mucosal immunity are urgently needed.
  • June 9, 2023

    UR-238 demonstrates efficacy in preclinical models of endometrial cancer

    At the recent ASCO meeting, researchers from the University of Rochester reported preclinical data for on a new small-molecule inhibitor of WAP four-disulfide core domain protein 2 (HE4) – UR-238 – that is being investigated for the treatment of cancer.
  • June 9, 2023

    Autotaxin inhibitor from Mitsubishi Tanabe Pharma demonstrates antifibrotic effects in systemic sclerosis models

    Autotaxin (ATX) is an enzyme responsible for the production of lysophosphatidic acid (LPA), which plays a role in the pathogenesis of systemic sclerosis (SSc). Researchers from Mitsubishi Tanabe Pharma Corp. and colleagues have reported on the preclinical evaluation of MT-5562, a novel oral ATX inhibitor, as a therapeutic option for SSc.
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