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BioWorld - Thursday, June 19, 2025
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BIO2025: John Crowley and Martin Makary

BIO 2025: Makary lays out FDA’s path, launches pilot review program

June 18, 2025
By Karen Carey
No Comments
On the same day that FDA Commissioner Martin Makary spoke in a fireside chat during the 2025 Biotechnology Innovation Organization’s International Convention, the agency unveiled a pilot commissioner’s national priority voucher program that will enable companies to receive a shortened FDA review time of one to two months.
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Ernst Haeckel's 1874 drawings of embryonic development.
Cardiovascular

A human heart developed in a pig embryo over 21 days

June 18, 2025
By Mar de Miguel
No Comments
Chinese researchers are preparing the details for the publication of another scientific milestone, the creation of a chimera with a human heart and a kidney developed from human stem cells in pig embryos.
Read More
Microscopic image of acute myeloid leukemia (AML) cells.
Cancer

HPK1 inhibitor BGB-15025 exerts antileukemic activity in mice

June 18, 2025
No Comments
Despite an initial complete remission of 60%-80% in patients receiving anthracycline/cytarabine induction, acute myeloid leukemia (AML) shows a suboptimal long-term outcome rate. Serine/threonine kinase HPK1 has emerged as a promising therapeutic target, demonstrating pan-cancer prognostic significance.
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Test tubes, dropper and capsules
Musculoskeletal

SAN-523 demonstrates anti-inflammatory efficacy in preclinical models of microcrystalline arthropathies

June 18, 2025
No Comments
University of Lausanne has reported promising preclinical data on SAN-523, a first-in-class positive allosteric modulator of cystathionine gamma-lyase (CSE), developed as a potential therapeutic for microcrystalline arthropathies, including gout and calcium pyrophosphate deposition (CPPD) disease.
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Cancer tumor in breast illustration
Biomarkers

miR-7974 is a predictor of poor survival in ER+ breast cancer

June 18, 2025
No Comments
Estrogen receptor-positive (ER+) breast cancer remains a major challenge even with well-defined treatment options. The identification of reliable markers for early detection of the disease is crucial for improving patient outcomes.
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3D representation of tumor microenvironment
Cancer

EACR 2025: Immune rewiring in cancer orchestrates tumor microenvironment

June 18, 2025
By Coia Dulsat
No Comments
Among the presentations included in the Top Abstracts category at the recently inaugurated Annual Congress of the European Association for Cancer Research (EACR) in Lisbon, it is worth highlighting two that respectively addressed the role of cytokines and lipid-sensing receptors as key modulators of the tumor microenvironment, a central theme in current cancer research.
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BIO 2025: Bridging the gap with a ‘molecule-to-medicine expressway’

June 17, 2025
By Karen Carey
No Comments
For years, the biopharma industry has spent increasing amounts of money on R&D without improving success rates, leaving many executives searching for new, more predictable drug development paths.
Read More
Ernst Haeckel's 1874 drawings of embryonic development.
Cardiovascular

A human heart developed in a pig embryo over 21 days

June 17, 2025
By Mar de Miguel
No Comments
Chinese researchers are preparing the details for the publication of another scientific milestone, the creation of a chimera with a human heart and a kidney developed from human stem cells in pig embryos. These studies aim to address the shortage of immunocompatible organ donors while shedding light on some of the most fundamental questions in developmental biology.
Read More
Fibroblast illustration
Immune

AM-1476 inhibits 5-HT2B receptor with preclinical antifibrotic effects

June 17, 2025
No Comments
Systemic sclerosis (SSc) is a particularly severe form of fibrotic disease that affects multiple organs. SSc is the most deadly autoimmune rheumatic disease.
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Musculoskeletal

New tracer has diagnostic utility for rheumatoid arthritis

June 17, 2025
No Comments
Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by inflammation and damage of the joints. PET/CT imaging is a useful tool for early disease assessment and monitoring treatment efficacy.
Read More
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