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BioWorld - Saturday, July 19, 2025
Home » Topics » Conferences

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Scientific figure illustrating astrocytes and neuron synapse
Neurology/psychiatric

Glia 2025: Microglial crosstalk could be early Alzheimer’s targeting opportunity

July 14, 2025
By Anette Breindl
No Comments
“Loss of synapses and dysfunctional synapses in a region-specific way is important in Alzheimer’s. It’s actually the strongest correlate of cognitive decline, far more so than plaques and tangles, which are the pathological hallmarks,” Soyon Hong told the audience at the XVII Meeting on Glial Cells in Health and Disease, which was held in Marseille last week.
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Computer programming cards with numbers punched

At Glia 2025, searching for memories in the matrix

July 11, 2025
By Anette Breindl
No Comments
At first blush, the brain’s extracellular matrix (ECM) seems like the opposite of synaptic plasticity. Plasticity is the ability to change; the ECM is stable, to the point that it is often described as a scaffold – something to lend stability. “ECM proteins have some of the longest lifetimes of any protein in the brain,” Anna Molofsky told her audience at the XVII Meeting on Glial Cells in Health and Disease, which is being held in Marseille this week.
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Computer programming cards with numbers punched
Neurology/psychiatric

At Glia 2025, searching for memories in the matrix

July 10, 2025
By Anette Breindl
No Comments
At first blush, the brain’s extracellular matrix (ECM) seems like the opposite of synaptic plasticity. Plasticity is the ability to change; the ECM is stable, to the point that it is often described as a scaffold – something to lend stability. “ECM proteins have some of the longest lifetimes of any protein in the brain,” Anna Molofsky told her audience at the XVII Meeting on Glial Cells in Health and Disease, which is being held in Marseille this week.
Read More
Liver over digital lens background
Endocrine/metabolic

MWN-105 ameliorates MASH symptoms in the preclinical setting

July 9, 2025
No Comments
Metabolic dysfunction-associated steatohepatitis (MASH) is a progressive liver disease that has limited available therapies. Shanghai Minwei Biotechnology Co. Ltd. has developed and presented data for MWN-105, a GLP-1/GIP/FGF21 triple agonist aimed at controlling metabolic dysfunction and fibrosis during MASH.
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Woman and 3D brain
Neurology/psychiatric

[68Ga]STZL-730 is promising approach for imaging of neuroinflammation

July 9, 2025
No Comments
Neuroinflammation is a common hallmark in several neurodegenerative disorders, including Alzheimer’s and Parkinson’s diseases, among others, where TREM2 (triggering receptor expressed on myeloid cells 2) is a crucial member involved in this biological process and is mainly expressed in microglial cells, being thus an attractive target for diagnostic imaging.
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Immune

IRF5 inhibitors show efficacy across autoimmune models

July 9, 2025
No Comments
Interferon regulatory factor 5 (IRF5) is a transcription factor activated downstream of Toll-like receptors (TLRs) 7, 8 and 9, and is predominantly expressed in dendritic cells, B cells, monocytes and macrophages. Once considered an undruggable target, IRF5 is now recognized as a key regulator of innate immunity, driving the production of type I interferons, pro-inflammatory cytokines and autoantibodies.
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Mantle cell lymphoma
Cancer

[161Tb]Tb-BL34L20S, new radiotracer targeting CXCR4 for cancer

July 8, 2025
No Comments
A team of researchers at the University of British Columbia investigated the potential of radiopharmaceutical therapy based on Terbium-161 (161Tb) both in vitro and in vivo using a novel tracer, [161Tb]Tb-BL34L20S, which uses the C-X-C chemokine receptor type 4 (CXCR4)-targeting peptide BL34L20S labeled to 161Tb.
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Illustration of heart analysis for DNA and drug impacts
Cardiovascular

From maps to gene therapies, who’s who in cardiovascular disease

July 8, 2025
By Mar de Miguel
No Comments
Cellular atlases and omics studies, such as genomics, transcriptomics and proteomics, have become key tools for identifying the diversity of all the elements that make up the cardiovascular system. These approaches help scientists understand how cells, genes and molecules function and interact in both healthy and diseased conditions, revealing critical points where targeted interventions could not only relieve symptoms but potentially reverse the underlying pathology at its origin.
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Illustration of triple-negative breast cancer cells
Diagnostics

New radiotracer shows encouraging results in TNBC

July 7, 2025
No Comments
One of the functions of tumor-associated macrophages (TAMS) is to protect the tumor against the immune system, inhibiting T-cell engagement and reducing the efficacy of checkpoint inhibitors. Polyamidoamine hydroxyl dendrimers (HDs) target TAM without the need of a targeting ligand and are retained by TAMs for up to 1 month allowing radiation to deposit in the tumor.
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3D rendering conceptualizing theranostics
Cancer

Theranostic agent for CA9-expressing tumors presented

July 7, 2025
No Comments
Carbonic anhydrase IX (CAIX, CA9) is a membrane-associated isoform of the α-carbonic anhydrase enzyme family, involved in pH regulation and the acidification of the tumor microenvironment (TME) in solid tumors. It is widely recognized as a marker of tumor hypoxia and serves as a prognostic indicator in multiple human cancers.
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