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ASCO 2025: Pancreatic cancer treatment progressing beyond chemotherapy

June 2, 2025
By Brian Orelli
No Comments
At the 61st American Society of Clinical Oncology (ASCO) Annual Meeting, multiple companies presented clinical trial data showing their drugs and devices helped patients with pancreatic cancer live longer or improve their ability to respond to treatment.
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AI generated illustration of lungs in the human body
Respiratory

MMP-7 inhibitor exhibits antifibrotic effects in preclinical IPF

June 2, 2025
No Comments
Preclinical findings have shown matrix metalloproteinase 7 (MMP-7) inhibition confers antifibrotic effects and thus, is a promising therapeutic strategy to treat idiopathic pulmonary fibrosis (IPF). Changchun Genescience Pharmaceutical Co. Ltd. has presented data on the siRNA technology-based MMP-7 inhibitor GenSciP117 for treating IPF.
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ASCO 2025: It’s time for more trust in AI, panel says

May 30, 2025
By Lee Landenberger
No Comments
Despite the advancement of AI and machine learning technologies and their incorporation into cancer treatment and drug development, a lack of trust and understanding of these new approaches is impeding care and treatment.
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Cancer

ZNF101 unveiled as a therapeutic target in TNBC

May 30, 2025
No Comments
Triple-negative breast cancer (TNBC) is the most aggressive breast cancer subtype with a lack of efficacious therapeutic approaches.
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Musculoskeletal

Novel BAG3-expressing gene therapy shows promise for IBM

May 29, 2025
No Comments
Inclusion body myositis (IBM) is the most common acquired myopathy in people over 50 years of age, characterized by chronic and progressive muscle weakness, where its pathogenesis involves inflammatory and degenerative pathways that are not well understood to date.
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Ocular

AAV8-RK-hBBS10 gene therapy restores vision in Bardet-Biedl syndrome type 10 model

May 29, 2025
No Comments
Bardet-Biedl syndrome (BBS) is a group of rare autosomal recessive ciliopathies characterized by dysfunction of primary cilia, which affects multiple organ systems and leads to early-onset obesity, progressive retinal degeneration resulting in vision loss or blindness, and renal abnormalities that may progress to renal failure. Mutations in the BBS10 gene are the second most prevalent cause of BBS, accounting for over 20% of cases.
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Liver and DNA
Immuno-oncology

Armored anti-GPC3 JW-004 shows increased potency against HCC

May 28, 2025
No Comments
Hepatocellular carcinoma (HCC) is a fatal cancer and the third cause of cancer-related deaths worldwide. Current therapies have focused on CAR T cells for treating HCC. Glypican-3 (GPC3) is a membrane protein that is overexpressed in HCC but not in healthy adult liver tissue, thus becoming a promising therapeutic target for HCC management.
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AI-generated art for viral infection of the lungs
Infection

Apollo Therapeutics’ APL-10456 exerts strong immune response against rhinovirus

May 28, 2025
No Comments
Rhinovirus (RV) infection is among the most common respiratory infections causing exacerbations of chronic obstructive pulmonary disease and asthma. The high antigenic diversity of RV is a barrier to the development of effective cross-protective vaccines for RV infection.
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Real fluorescence microscopic view of human neuroblastoma cells
Cancer

CID-078 exhibits robust antitumor efficacy in preclinical neuroblastoma models

May 28, 2025
No Comments
Neuroblastoma is a pediatric solid tumor characterized by dysregulation of the CDK-RB-E2F axis, leading to elevated E2F activity, uncontrolled progression through the G1/S transition and an aggressive tumor phenotype. Researchers from Circle Pharma Inc. and collaborators presented preclinical data on CID-078, a first-in-class oral macrocycle with dual cyclin A and B RxL inhibitory activity, in models of neuroblastoma.
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Cancer

SY-9453 shows efficacy at treating tumors with MTAP deficiency

May 27, 2025
No Comments
About 15% of all cancers have co-deletion of both the MTAP and CDKN2A genes, which results in sensitization to MAT2A inhibitors, thus opening a therapeutic window in these cancer types. MAT2A inhibitors have demonstrated efficacy in MTAD-deficient cancers. Shouyao Holdings (Beijing) Co. Ltd. has developed and released data for their MAT2A inhibitor SY-9453 for the treatment of MTAP-deficient cancers.
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