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Xiaolin Zhang, CEO, Dizal
ASCO 2025

Dizal's new chemical entities for lung, blood cancers

June 10, 2025
By Tamra Sami
No Comments
Dizal (Jiangsu) Pharmaceutical Co. Ltd.’s LYN/BTK dual inhibitor, DZD-8586, saw tumor shrinkage in 94.1% of patients with relapsed or refractory chronic lymphocytic leukemia/small lymphocytic lymphoma following Bruton's tyrosine kinase inhibitors, the company reported during an oral presentation at the American Society of Clinical Oncology (ASCO) 2025 conference.
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Xiaolin Zhang, CEO, Dizal

ASCO 2025: Dizal's new chemical entities for lung, blood cancers

June 4, 2025
By Tamra Sami
No Comments
Dizal (Jiangsu) Pharmaceutical Co. Ltd.’s LYN/BTK dual inhibitor, DZD-8586, saw tumor shrinkage in 94.1% of patients with relapsed or refractory chronic lymphocytic leukemia/small lymphocytic lymphoma following Bruton's tyrosine kinase inhibitors, the company reported during an oral presentation at the American Society of Clinical Oncology (ASCO) 2025 conference.
Read More
Cancer

BH-30643 targets full spectrum of EGFR-mutant lung cancer variants

June 4, 2025
No Comments
The use of tyrosine kinase inhibitors (TKIs) in the treatment of epidermal growth factor receptor (EGFR)-mutant non-small-cell lung cancer (NSCLC) has not produced the same durable clinical benefits observed with next-generation targeted therapies in ALK- and ROS1-rearranged NSCLC. Given the molecular heterogeneity of EGFR-mutant NSCLC, which includes over 100 distinct mutations, there is a continued need for more effective and mutation-specific therapeutic strategies.
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Illustration of cancer cell in crosshairs being destroyed
ASCO 2025

Protagonist-Takeda, Novartis post phase III wins

June 3, 2025
By Lee Landenberger
No Comments
More phase III data coursed through the annual American Society of Clinical Oncology (ASCO) conference on Sunday, as Protagonist Therapeutics Inc. and Takeda Pharmaceutical Co. Ltd. led the charge with positive results for its potential blockbuster rusfertide in treating a rare leukemia.
Read More
3D illustration of pancreatic cancer

ASCO 2025: Verastem has positive cancer data but stock sags

June 3, 2025
By Lee Landenberger
No Comments
New dose-escalation data from Verastem Oncology’s phase I/II cancer study in China prompted the company to say it was encouraged by the efficacy results. However, investors felt otherwise, as the stock lost about 20% of its value the day the initial results were released.
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Test tube, dropper, DNA illustration
Immuno-oncology

THNB-3 therapeutic shows promise in LIN28-positive tumors

June 3, 2025
No Comments
LIN28 is a family of RNA-binding proteins that regulate stem cell biology and pluripotency and are involved in oncogenesis through the interaction with tumor suppressor microRNA let-7. The expression of LIN28 leads to the loss of function of let-7, leading to tumorigenesis, and has been tied to tumor aggressiveness and poor survival in children with brain tumors.
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Cancer

Calidi’s novel systemic virotherapy approach demonstrates efficacy in preclinical models

June 3, 2025
No Comments
The systemic virotherapy strategy involves not only the direct delivery of therapeutic payloads encoded by viruses to tumors, but also the modification of the tumor microenvironment, aiming to target both primary and metastatic lesions. At the ongoing American Society of Clinical Oncology (ASCO) meeting, researchers from Calidi Biotherapeutics Inc. reported the development of a novel approach using a selected and engineered tumor-selective strain of vaccinia virus.
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Illustration of head with circuit board brain
ASCO 2025

It’s time for more trust in AI, panel says

June 2, 2025
By Lee Landenberger
No Comments
Despite the advancement of AI and machine learning technologies and their incorporation into cancer treatment and drug development, a lack of trust and understanding of these new approaches is impeding care and treatment.
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ASCO 2025: Regeneron, Merck-Gilead drugs drop disease, death rates

June 2, 2025
By Lee Landenberger
No Comments
New and positive phase III cancer data for two monoclonal antibodies from two pharma giants opened the second day of the American Society of Clinical Oncology (ASCO) conference this past weekend.
Read More
Illustration of cancer cell in crosshairs being destroyed

ASCO 2025: Protagonist-Takeda, Novartis post phase III wins

June 2, 2025
By Lee Landenberger
No Comments
More phase III data coursed through the annual American Society of Clinical Oncology (ASCO) conference on Sunday, as Protagonist Therapeutics Inc. and Takeda Pharmaceutical Co. Ltd. led the charge with positive results for its potential blockbuster rusfertide in treating a rare leukemia.
Read More
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