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Home » Newsletters » BioWorld

BioWorld

Oct. 2, 2024

View Archived Issues
Brain and DNA

Loqus23’s £35M series A targets Huntington’s disease

Loqus23 Therapeutics Ltd. has raised £35 million (US$46.6 million) in a series A to take forward small molecules it has discovered for the treatment of Huntington’s disease and other conditions that are driven by DNA mismatch repair (MMR). MMR fixes DNA insertions, deletions and misincorporation errors that occur during transcription and/or cellular replication. Smaller repairs are directed by MutSalpha, a protein that binds single base mismatches, while MutSbeta handles larger insertion/deletion loops. Huntington’s and other triplet repeat diseases are caused when trinucleotide repeats accumulate in somatic DNA to the extent that they interfere with protein expression. Read More

Sen. Cassidy: Time for US FDA to reclaim its Orange Book duties

It’s well past time for the U.S. FDA to end its silence on what device patents can be listed in the Orange Book as part of a drug-device combination product, Sen. Bill Cassidy (R-La.) said in an Oct. 1 letter that took FDA Commissioner Robert Califf to task for letting the FTC do the FDA’s job. Read More
Australian coins and bills

Cartherics' AU$15M series B advances CTH-401 for ovarian cancer

Immunotherapy company Cartherics Pty Ltd. raised AU$15 million (US$10.3 million) in an oversubscribed series B round that will support the first clinical trial for lead chimeric antigen receptor natural killer therapy CTH-401 for ovarian cancer, and to expand its pipeline to include other diseases. Read More

Neurobo stock falls on phase I obesity data for DA-1726

Neurobo Pharmaceuticals Inc., of Cambridge, Mass., reported top-line phase Ia study results of its obesity drug candidate, DA-1726, Sept. 30, causing the company’s shares to lose 11.7% of their value over two days. Read More
Adult fly brain 3D reconstruction

140,000 cells and 50M synapses make 1 adult fly brain

A collaboration led by the Flywire Consortium and comprising hundreds of scientists has completed a whole map of the adult fruit fly brain after several decades of collaborative work. By using electron microscopy and three-dimensional reconstruction supported by AI tools, the researchers have revealed the neural wiring of the Drosophila melanogaster brain, a connectome of 140,000 neurons with 50 million synaptic connections. In the future, researchers could possibly use this map as an artificial in silico model to study the brain as a simulator through its connections, though a lot of work remains to be done for this. Read More

BioWorld Insider podcast: Capricor’s CEO pursues a BLA and talks rare disease

Linda Marbán, CEO of Capricor Therapeutics Inc., discusses deramiocel (CAP-1002), the company’s allogeneic cardiac-derived cell therapy, for treating Duchenne muscular dystrophy. The company just wrapped up a visit with the U.S. FDA and is prepping to file a BLA for its treatment of the rare disease. Read More

Appointments and advancements for Oct. 2, 2024

New hires and promotions in the biopharma industry, including: Curve, Moderna, Norgine, Oculis, Odyssey, Pliant, Progentos, Tagworks. Read More

Financings for Oct. 2, 2024

Biopharmas raising money in public or private financings, including: Biohaven, Evoke, In8bio, Sanofi, Vicore, Wave Life. Read More

In the clinic for Oct. 2, 2024

Clinical updates, including trial initiations, enrollment status and data readouts and publications: Eirion, Gritstone, Hamlet, Incarda, Jaguar, Kiromic, Kura, Myrtelle, Plus, Remedy, Repare. Read More

Other news to note for Oct. 2, 2024

Biopharma happenings, including deals and partnerships, grants, preclinical data and other news in brief: Alphazyme, Amneal, Aytu, Biomarin, Bionomics, Briya, Camp4, Codexis, Combiphar, Curon, Curium, D-Wave, IGM, Japan Tobacco, Leadermed, Lupin, Maravai, Merck & Co., Metsera, Mochida, Moderna, Nestlé, Neuphoria, Nxera, Peptidream, Pdradiopharma, Shionogi, Seres, Spima. Read More

Regulatory actions for Oct. 2, 2024

Regulatory snapshots, including global drug submissions and approvals, clinical trial approvals and other regulatory decisions and designations: Astrazeneca, Bpgbio, Clinuvel, Daiichi, Formycon, Fresenius, Invivyd, Ionis, J&J, Oryzon, Papillon, PTC, Sagimet, Thryv. Read More

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