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Home » Newsletters » BioWorld

BioWorld

Jan. 29, 2025

View Archived Issues
RFK Senate hearing 1-29-25

Confirmation hearings begin for RFK as US HHS secretary

In a U.S. Senate Finance Committee confirmation hearing marked by shouted protests, outbursts of applause and tense exchanges on several issues, including ones beyond the reach of the Department of Health and Human Services (HHS), Robert F. Kennedy Jr. (RFK) tried to present himself as someone who follows the science, not a conspiracy theorist or anti-vaxxer. Read More
Child vaccine

The science on vaccines and autism: no there there

At his confirmation hearing, Robert F. Kennedy Jr., the nominee for secretary of the U.S. Department of Health and Human Services, claimed that he is not anti-vaccine. But his record does not bear that out. Kennedy is a longstanding vaccine denier, and in 2021 was identified as one of the “Disinformation Dozen” – the 12 accounts responsible for the majority of disinformation about COVID-19 vaccines on social media platforms – by the British-American nonprofit Center for Countering Digital Hate. Read More
Heart patch produced from induced pluripotent stem cells derived heart muscle cells in a collagen hydrogel

For the 99%, allografts can patch up failing heart

Implanted patches of iPS-derived heart muscle integrated with heart tissue in a primate model of heart failure, and in patients being treated in a clinical trial, marks progress toward a potential option for patients with advanced heart failure. Read More

FDA diversity-in-trials rules evaporate after ‘strident’ Trump EO

President Donald Trump’s recently issued executive order (EO) putting a stop to diversity, equity, and inclusion programs in the U.S. government is sending ripples far and wide, into areas that some might not have anticipated. The FDA has taken down from its website the guidelines regarding action plans related to achieving diversity in clinical trials. Read More
Illustration of polycystic kidney

Regulus heads to phase III after more positive kidney disease data

In an indication that has proved difficult for biopharma to conquer, Regulus Therapeutics Inc. disclosed further positive data from its ongoing phase Ib study testing RGLS-8429 in autosomal dominant polycystic kidney disease and laid out its plans to move straight into a phase III trial later this year, with the potential for an accelerated U.S. approval. Read More

Zentalis creates a path for its cancer study with layoffs

It’s one step backward in order to take two steps forward at Zentalis Pharmaceuticals Inc. In a restructuring to help fund the second part of its potentially registration-enabling Denali study, Zentalis has laid off 40% of its workforce. The clinical trial of azenosertib, Zentalis’ lead candidate and a WEE1 kinase inhibitor, is for treating advanced solid tumors and hematologic malignancies. The therapy is designed to make cancer cells self-destruct. Read More
Dollar symbol with arrow graph

Biopharma financings hit $102B in 2024, third highest year on record

Biopharma financings saw their third highest year, with companies collectively raising $102.15 billion in 2024, behind only 2020 and 2021. The amount marked a 44% jump from $70.97 billion in financings in 2023 and a 68% increase from $60.81 billion in 2022. The fourth quarter (Q4) contributed $15.45 billion, the lowest quarter of the year, following $16.38 billion in Q3, $23.07 billion in Q2, and a strong $47.25 billion in Q1. Read More

VC financings lead rising UK investment in 2024, analysis shows

The final tally shows U.K. biotechs raised £3.5 billion (US$4.35 billion) in 2024, a stonking 93% more than in 2023, and surpassing the total in 2020, before the life sciences investment boom sparked by the pandemic. Of this, £2.1 billion was in venture capital, a 64.8% increase on 2023, while U.K biotechs attracted £1.5 billion in follow-on offerings, most of it raised by companies listed on Nasdaq. Read More

FCA cases reach new high in 2024, but value of recoveries no outlier

False Claims Act litigation in the U.S. spiked significantly according to a new report by Gibson, Dunn & Crutcher, LLP, at least in terms of the number of cases brought to the courts. However, the report added that the total dollar value of these cases is in line with historical norms, suggesting that the average recovery amount has tapered off significantly. Read More

Appointments and advancements for Jan. 29, 2025

New hires and promotions in the biopharma industry, including: Allogene, Alumis, Beximco, Clarametyx, Commit, Concerto, OS Therapies, Precision, Roche, Scholar Rock. Read More

Financings for Jan. 29, 2025

Biopharmas raising money in public or private financings, including: Atalanta, Beyondspring, Calidi, Clarametyx, Commit Biologics, Lineage Cell Therapeutics, Lutris, Medexus, Metsera, Nrx, Oncomatryx, Oncozenge, Orgenesis, Processa, Virpax. Read More

In the clinic for Jan. 29, 2025

Clinical updates, including trial initiations, enrollment status and data readouts and publications: Atai, Genentech, Inbrain, Intensity, ITM, Leap, Kashiv, Roche, Sab. Read More

Other news to note for Jan. 29, 2025

Biopharma happenings, including deals and partnerships, grants, preclinical data and other news in brief: Bioage, Humacyte, Invisishield, Neurocrine, Pluristyx, RLS, Takeda, Telix. Read More

Regulatory actions for Jan. 29, 2025

Regulatory snapshots, including global drug submissions and approvals, clinical trial approvals and other regulatory decisions and designations: Apellis, Astrazeneca, Beacon, CSL, Daiichi, GSK, March Biosciences, Saol, Seed. Read More

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