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BioWorld Science

Dec. 19, 2003

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Four related series of gamma-secretase inhibitors designed by Merck researchers

Kirin Brewery patent covers M-CSF inhibitors able to prevent bone metastasis and osteoporosis

New tyrosine kinase inhibitors, their preparation and use covered by Merck patent

Chugai researchers discover novel biguanide-based antidiabetic agents

Novel HDAC inhibitors idenified at AstraZeneca

Ximelagatran superior to warfarin in preventing VTE after total knee replacement

Clinical benefits of gene therapy with Ad-CD154 for CLL

Preliminary evaluation of NS-1209 in patients with status epilepticus

Potential use of bispecific antibody Bi20 in patients with B-cell lymphoma

Pixantrone shows antitumor efficacy in relapsed/refractory NHL

Active Biotech TTS development to focus on TTS CD3

AEterna focuses Neovastat program on NSCLC

APD-356 completes preclinical testing

Eligard approved in Australia

Clinical effect observed in phase I study of BCX-1777 in T-cell malignancies

Second phase I study of ETC-642 shows evidence of cholesterol mobilization

Enrollment completed in European rhATIII study

Interim analysis reported for Infergen/Actimmune in hepatitis C nonresponders

Enrollment under way in pivotal INSPIRE study of Actimmune for IPF

Riquent NDA submitted to FDA

New clinical study evaluates SEPA-enhanced testosterone

Phase II trials evaluate Vitaxin for prostate cancer and psoriasis

MBI-2401 is lead development candidate from Micrologix lipopeptide program

Vertex and OHSU enter drug discovery and development collaboration

Preclinical findings for SGN-40 summarized at ASH meeting

Oxycyte studied for cardiac surgery

Fuzeon 48-week data submitted to support full FDA approval

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