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BioWorld Science

April 5, 2004

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Oral bisphosphonates prevent BMD loss in cystic fibrosis

Hormonal inhibitory effects of oral NOMA in male volunteers

Bristol-Myers Squibb presents CRF antagonists for treatment of anxiety

Oral recombinant human lactoferrin inhibits tumor growth

Monoclonal antibody effective against cancer progression in vivo

Dosing commences in phase IIa trial of BCX-1777

SnET2-PDT NDA submitted for AMD

Endo meets with FDA regarding oxymorphone approvable letter requirements

Japanese approval for Cypher sirolimus-eluting coronary stent

EMEA accepts Xyrem MAA for review

Enrollment completed in phase II trial of Liprostin for PVD

FDA accepts OrCel PMA

Completion of pilot study of Resurgex in immunocompromised patients

Feasibility study evaluates Tissue Repair Cells for nonunion large bone fractures

Gastrotech collaborates on IBS drug development

Interim results for BF-Derm1 shows reduction of urticaria symptoms

GlaxoSmithKline advances new Lp-PLA2 inhibitor into the clinic

Zyprexa Intramuscular approved for acute agitation

Antibacterial derivatives of lincomycin claimed in Vicuron patent

Potassium channel blockers emerge from ICAgen research

PDE4 inhibitors from Glenmark

Fujisawa discloses dual adenosine A1 and A2A receptor antagonists

Abbott patents azabicyclic compounds for treatment of pain

Monoamine reuptake inhibitors in early development at Pfizer

A VEGF-gelonin fusion protein inhibits metastasis to lung in a breast cancer model

PharmAthene files IND for clinical testing of ToxBlox

Preclinical data on the antitumor efficacy and hematological safety of C-1311

Synergistic effects of Targretin and cytotoxic agents in breast cancer and NSCLC

Systemic radioprotective effects found for CG-53135 in irradiated mice

Potent, selective VEGFR tyrosine kinase inhibitor presented by Pfizer at AACR meeting

Promising cytotoxic agent discovered at Taxolog

RWJ-540973, an ATP-competitive inhibitor of PDGFR kinase and autophosphorylation

Estrogen receptor beta agonist against rheumatoid arthritis

Further data on AP-23573 presented at AACR

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