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BioWorld Science

May 7, 2019

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Novel selective PI3Kgamma inhibitors induce specific conformational changes

Myelin from hair stem cells

Small-molecule HDAC6 inhibitor improves memory and learning in fragile X syndrome in vivo

Orally active small molecule against influenza A hemagglutinin mimicking a broadly neutralizing Ab

AlzeCure redirects development of ACD-855 from cognition to eye indication

By itself, GITR stimulation can't "GIT'R done"

Targeting metabolism prevents epilepsy after TBI

KalVista presents data on PKa inhibitors for retinal edema

Antitumor activity of IC9-Luc90-CD828Z demonstrated in vitro

Huntington's hopefuls present at AAN 2019

FDA clears OnKure's IND to initiate phase I studies of OKI-179

Daewoong Pharmaceutical patents BTK and ITK dual inhibitors

Adaptimmune announces clinical progress with ADP-A2M4 in synovial sarcoma and other solid tumors

FDA approves Vyndaqel and Vyndamax for the treatment of cardiomyopathy caused by ATTR-CM

Gilead Sciences divulges new HIV protease inhibitors

Esteve Pharmaceuticals presents new analgesics

Shanghai Longwood Biopharmaceuticals identifies PD-1/PD-L1 inhibitors

Skyhawk and Takeda collaborate to develop small-molecule treatments for neurodegenerative diseases

European Commission approves Palynziq to treat PKU

Sunshine Lake Pharma divulges compounds for HBV infections

Onxeo treats first patient in phase Ib study of AsiDNA for solid tumors

Verona initiates phase IIb study of nebulized ensifentrine in moderate to severe COPD

DSMB recommends continuation of phase I/II PIONEER study of GS-030 in retinitis pigmentosa

Axsome announces expedited development and pivotal status for AXS-05 for the treatment of MDD

First patient dosed in phase I DUET-3 study of XmAb-23104

Phase III trial of Epidiolex in TSC meets primary endpoint

CytoDyn reports data from leronlimab monotherapy study

Simple, reversible mouse model mimics secondary glaucoma

FDA approves Ruzurgi for pediatric patients with Lambert-Eaton myasthenic syndrome