In a striking demonstration of how the success of mRNA vaccines against COVID-19 has opened up the potential of the technology in cancer, mice that cleared a tumor after a single administration of an mRNA vaccine, also cleared a second tumor without receiving further immunization. This display of potent immunogenicity formed part of a head-to-head study of three different mRNA technology platforms in human papillomavirus (HPV)-16 associated tumors. Read More
Bacteria inflaming the meninges have developed an immunosuppressive mechanism that contributes to their ability to attack the brain. Researchers found that, by activating pain receptors (nociceptors) to release chemical substances that block an immune cell receptor, Streptococcus pneumoniae and Streptococcus agalactiae deactivated the protective function of macrophages and weakened brain defenses. This, in turn, enabled them to invade the brain. Read More
Radiotherapy is commonly used to treat solid tumors; promoting DNA damage in tumoral cells is the main mechanism for its cytotoxic effect, and its potential to induce innate and adaptive immune responses is being explored. Read More
Amgen Inc. has synthesized heterocyclic compounds acting as GTPase KRAS (G12D mutant) inhibitors reported to be useful for the treatment of cancer. Read More
Bugworks Research India Pvt. Ltd. has identified oxazolidinone compounds acting as DNA gyrase and DNA topoisomerase IV (Escherichia coli) inhibitors reported to be useful for the treatment of bacterial infections, in particular gram-positive and gram-negative, as well as viral, fungal and protozoal infections. Read More
Lymphatic malformation (LM), a vascular anomaly originating from lymphatic endothelial cells, can progress to malignant lymphangiosarcoma (LAS) in a fraction of patients. Scientists from the University of Cincinnati College of Medicine recently conducted a study to unveil the mechanisms underlying LM malignant transformation to LAS and found that inhibiting autophagy can prevent this malignant transformation. Read More
Since episodes of idiopathic anaphylaxis (IA) are often accompanied by gastrointestinal (GI) manifestations, researchers from the National Institutes of Health aimed to investigate whether surrogate markers of GI permeability are aberrant in patients with IA. Read More
Medshine Discovery Inc. has divulged nuclear receptor ROR-γ (RORC) agonists or RORC inverse agonists reported to be useful for the treatment of cancer. Read More
The rare, deadly neurological disease called hereditary sensory and autonomic neuropathy 9 (HSAN9) is caused by mutations in the gene that encodes tectonin β-propeller repeat-containing protein 2 (TECPR2). Read More
Autifony Therapeutics Ltd. has described compounds acting as modulators of voltage-gated potassium channels from the Kv3 subfamily, such as Kv3.1, Kv3.2 and/or Kv3.3, reported to be useful for the treatment of myoclonic epilepsy, among others. Read More
