The most comprehensive study to date of how lung cancer evolves in response to selection pressures indicates the genetic profile at diagnosis can be used to predict how a tumor is likely to progress, opening up new prospects for personalized medicine and potential therapeutic targets. The data were generated in Tracerx (Tracking cancer evolution through therapy), a £14 million (US$17.4 million) study funded by the charity Cancer Research UK (CRUK) with the aim of defining how clonal heterogeneity of tumor cells affects the risk of recurrence and survival. Read More
The analysis of thousands of proteins in the brain has revealed the association of astrocytes with obsessive-compulsive disorder (OCD). A proteomic study by researchers from the University of California Los Angeles (UCLA) has identified them in different cellular compartments of astrocytes and neurons. One such protein, the postsynaptic protein SAPAP3, appeared to regulate the organization of the actin cytoskeleton. Its deficit in astrocytes could cause OCD. Read More
Researchers from Georgia State University presented the discovery and preclinical evaluation of novel antiviral candidates against the SARS... Read More
Fusion Pharmaceuticals Inc. has announced the clearance of IND applications for [225Ac]-FPI-2068 (FPI-2068) and corresponding imaging analogue... Read More
Pancreatic cancer is the third leading cause of cancer-related deaths with a 5-year survival rate of 11.5%. The toxicity and chemoresistance to... Read More
Acid sphingomyelinase (ASM) is a sphingolipid metabolizing enzyme that catalyzes the hydrolysis of sphingomyelin to ceramide. Previous studies revealed high activity of ASM in the blood and brain of old vs. young individuals or mice, and they implicated this enzyme in neurodegenerative disease pathology. Read More
Recent Vanderbilt University patents describe metabotropic glutamate mGlu5 receptor negative allosteric modulators reported to be useful for the treatment of amyotrophic lateral sclerosis, Angelman syndrome, anxiety disorder, autism spectrum disorders, substance abuse and dependence, Alzheimer’s disease, diabetes and obesity, among others. Read More
Tumor cells are known to produce high amounts of intracellular lipids, leading to increased levels of fatty acids, cholesterol and membrane phospholipids. Death domain-associated protein (DAXX) is a small ubiquitin-related modifier (SUMO)-binding protein that plays a role in transcription regulation by interacting with transcription factors such as p53 and NF-κB. Read More
Long Island University and Mount Sinai School of Medicine have jointly developed intermediate conductance KCa3.1 (IKCa1) channel blockers reported to be useful for the treatment of renal disorders. Read More
Clevudine derivatives and its phosphoramidates have been detailed in an Emory University patent as potentially useful for the treatment of hepatitis B virus (HBV) infection. Read More
Studies in animal models and humans have identified an important role for peripheral chemoreceptors in the pathogenesis of heart failure. Thus, inhibiting their hyperactivity has been proposed as a potential therapeutic strategy for this major public health problem. Read More
Lomond Therapeutics Inc. has prepared and tested compounds having N-arylpyrimidin-2-amine derivatives and acting as protein kinase inhibitors, particularly mitogen-activated protein kinase kinase kinase kinase 1 (MAP4K1; HPK1; MEKKK1). As such, they are reported to be useful for the treatment of autoimmune diseases, sepsis, neurodegeneration, male infertility, vascular and inflammatory disorders, cancer and viral infections. Read More
