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Home » Newsletters » BioWorld Science

BioWorld Science

May 26, 2023

View Archived Issues
Endosome

Experimental painkiller blocks GPCR signaling inside the cell

Researchers have developed a new highly effective therapeutic for pain relief by altering the chemical properties of an antinausea drug, netupitant. The modified drug is able to enter the intracellular membrane-bound endosome and target the GPCRs therein, rather than at the cell surface, that leads to optimal pain relief. The study, published in the Proceedings of the National Academy of Sciences (PNAS) on May 22, 2023, was led by Nigel Bunnett, Professor and Chair of Molecular Pathobiology at NYU College of Dentistry, and illustrates how GPCR-mediated pain signaling occurs inside the endosomes rather than at the surface, highlighting the need for drugs that can reach receptors within the cells itself. Read More

Inhibition of YTHDF2 results in a more effective and safe radiotherapy

In a study published in Cancer Cell on May 25, 2023, researchers from the University of Chicago and colleagues reported that the inhibition of YTHDF2, an immune suppressor protein, can be a valuable strategy to improve radiotherapy outcomes by overcoming resistance while enabling extra help from the immune system. Read More
Cancer research illustration

PAK4 inhibitor from Hyperway Pharmaceutical has improved safety and PK profile

Work at Hyperway Pharmaceutical Co. Ltd. has led to the discovery of a novel PAK4 inhibitor... Read More
Brain and neural networks

Hanall and Daewoong partner with Nurron to advance compounds for neurodegenerative disorders

Hanall Biopharma Co. Ltd. and Daewoong Pharmaceutical Co. Ltd. have entered into... Read More

Bright Angel Therapeutics patent describes new Hsp90 inhibitors

Bright Angel Therapeutics Inc. has patented heat shock protein 90 inhibitors reported to be useful... Read More
Man sitting on bed holding head

Psilera nominates non-hallucinogenic psilocybin derivative as lead clinical candidate

Psilera Inc. has selected a novel, non-hallucinogenic psilocybin derivative, PSIL-006... Read More

MyoDys45-55 restores dystrophin and improves functional measures in murine model of DMD

Myogene Bio LLC has developed an approach through CRISPR7Cas9 technology... Read More

Teon Therapeutics identifies new cannabinoid CB2 receptor modulators for cancer

Teon Therapeutics Inc. has reported 4-hydroxy-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxamide... Read More
Art concept for inflamed human tissue

LTB4 antagonist shows efficacy in rat inflammation model

Cellular mediators like cytokines that are released as a reaction to cell injury or excessive stimulation can lead to the synthesis of chemotactic eicosanoid leukotriene B4 (LTB4) among others. This mediator acts as a potent chemokine promoting migration of macrophages and neutrophils into tissues during inflammation. Researchers from CNRS, Universitat de Barcelona and colleagues reported the synthesis and evaluation of new 1,4-benzodioxine derivatives with selective LTB4 antagonism activity that led to the identification of [I] as the lead compound, which had higher affinity for LTB4 receptor with an IC50 value of 288 nM. Read More

Humanwell Healthcare patents new 15-PGDH inhibitors

Research at Humanwell Healthcare (Group) Co. Ltd. has led to the development of heterocyclic 15-hydroxyprostaglandin dehydrogenase (15-PGDH) inhibitors reported to be useful for the treatment of acute lung injury, diabetes, fibrosis, graft-vs.-host disease, heart failure, inflammatory bowel disease, alopecia and osteoporosis, among others. Read More

Series D financing at Benchsci to expand Ascend AI drug discovery platform

Benchsci (Scinapsis Analytics Inc.), has announced a CAD$95 million (US$70 million) series D funding round. The funds will be used to expand the company’s artificial intelligence (AI) drug discovery platform, Ascend by Benchsci, which enables scientists to discover biological connections, reduce trial and error experimentation, and uncover risks early. Read More
DNA in test tubes

Evaxion develops genetic adjuvant technology to boost immune response to viral, bacterial and cancer vaccines

Evaxion Biotech A/S has unveiled the technology behind its proprietary genetic adjuvant developed to enhance the effectiveness of DNA and mRNA vaccines for infectious diseases and cancer. Read More

Fochon Biosciences describes new PI3Kα inhibitors for cancer

Phosphatidylinositol 3-kinase α (PI3Kα) inhibitors for the treatment of cancer have been revealed in a Fochon Biosciences Ltd. patent. Read More

AAV9-CLN5 improves symptoms in mice with Batten disease

Neuronal ceroid lipofuscinosis, commonly known as Batten disease, is an inherited pediatric neurodegenerative lysosomal storage disease caused by mutations in the CLN5 gene. The disease is incurable and there is an urgent medical need for novel therapies. A murine model of Batten disease was developed to study a novel AAV vector that expresses CLN5, AAV9-CLN5. In the study by University College London investigators, the gene therapy, driven by the synapsin promoter, was intracerebroventricularly administered into neonatal Cln5-knockout mice. Read More
Muscular dystrophy

Researchers create new mouse model of DMD using knock-in of human exon 50

Researchers from Huidagene Therapeutics Co. Ltd. have evaluated the effects of adenine base editing (ABE)-induced exon skipping of exon 50 in a humanized mouse model of Duchenne muscular dystrophy (DMD). Read More

Betta Pharmaceuticals prepares and tests new HIF-2α inhibitors

Betta Pharmaceuticals Co. Ltd. has described hypoxia-inducible factor-2α (HIF-2α; EPAS1) inhibitors reported to be useful for the treatment of Von Hippel-Lindau disease, cancer, autoimmune disease and inflammatory disorders. Read More

Other news to note for May 26, 2023

Additional early-stage research and drug discovery news in brief, from: Philogen, Reviva. Read More

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