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Home » Newsletters » BioWorld Science

BioWorld Science

Sep. 27, 2024

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Handshake with tech background

Generate:Biomedicines signs up Novartis to $1B+ multitarget deal

Novartis AG is enlisting the help of Generate:Biomedicines Inc. and its artificial intelligence platform to generate drugs for multiple undisclosed targets. The number of targets and therapeutic areas also weren’t disclosed. Novartis will pick the targets, although the targets Generate has been working on are off limits. Generate will be responsible for creating the lead candidate, at which point Novartis will take over development. Read More

Anti-IL-6 receptor inhibition attenuates myelitis severity

Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune demyelinating disorder of the optic nerves and the spinal cord that is linked to the presence of anti-aquaporin (AQP4) autoantibodies. Satralizumab, a humanized anti-IL-6 receptor (IL-6R) antibody, has been approved for the treatment of NMOSD but the effects of IL-6R inhibition in myelitis severity have not been fully explored. Read More
migraine-headache-brain-tbi-neuro.png

Lundbeck and Iambic collaborate on drug discovery to treat migraine

H. Lundbeck A/S and Iambic Therapeutics Inc. have entered into a strategic research collaboration focused on the discovery of a small-molecule therapeutic for the treatment of migraine. The collaboration will leverage Iambic’s artificial intelligence (AI)-powered drug discovery platform. Read More
Endometrial/uterine cancer illustration

MYO3B promotes endometrial cancer progression and its targeting may be an approach

Endometrial cancer (EC) accounts for 20% to 30% of most malignant tumors of the female reproductive system, making it one of the most common. Furthermore, the 5-year survival rate of patients with early-stage EC is 90%, but this number decreases to 20% in late-stage disease. Read More

Preclinical characterization of orally available BRD4 inhibitor

Researchers from Maruho Co. Ltd. published data regarding the development and preclinical evaluation of a novel orally available bromodomain-containing protein 4 (BRD4) inhibitor for the treatment of melanoma. Read More
Cholesterol plaque in artery

Repair Biotechnologies and Genevant Sciences collaborate on mRNA-LNP therapy for atherosclerosis

Repair Biotechnologies Inc. and Genevant Sciences Corp. have entered into a collaboration and nonexclusive license agreement to combine Repair’s Cholesterol Degrading Platform (CDP) mRNA technology with Genevant’s proprietary lipid nanoparticle (LNP) technology in the development of a potential novel treatment for atherosclerosis. Read More

Insilico Medicine discovers CDK8/19 dual inhibitors

Insilico Medicine Inc. has synthesized cyclin-dependent kinase 8/19 (CDK8/19) dual inhibitors reported to be useful for the treatment of autoimmune disease and cancer. Read More
Drug vials

Evaxion and MSD sign option agreement for preclinical vaccine candidates

Evaxion Biotech A/S has entered into an option and license agreement with MSD (Merck & Co. Inc.) for two preclinical vaccine candidates. Read More

Breakpoint Therapeutics presents new POLθ inhibitors

Breakpoint Therapeutics GmbH has identified DNA polymerase θ (POLθ) inhibitors reported to be useful for the treatment of cancer. Read More

STAT3 inhibitors named in Vividion Therapeutics patent

Vividion Therapeutics Inc. has patented 2-azaspiro[3.3]heptane derivatives acting as signal transducer and activator of transcription 3 (STAT3) inhibitors potentially useful for the treatment of cancer. Read More
Conceptual image for brain cancer treatment

RBD-8088, a BBB-penetrating oligonucleotide with efficacy in glioblastoma models

Suzhou Ribo Life Science Co. Ltd. recently reported on the development and preclinical characterization of a novel blood-brain barrier (BBB)-penetrating oligonucleotide drug, RBD-8088, for the treatment of glioblastoma. Read More

Axcynsis Therapeutics patents new ADCs for treatment of cancer

Work at Axcynsis Therapeutics Pte. Ltd. has led to the creation of antibody-drug conjugates (ADCs) comprising antibodies covalently linked to ecteinascidin and lurbinectedin derivatives through a linker; they are reported to be useful for the treatment of cancer. Read More

Cancer Research Technology, My-T Bio identify new PKMYT1 inhibitors

Cancer Research Technology Ltd. and My-T Bio Ltd. have jointly developed biarylamide derivatives acting as membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (PKMYT1) inhibitors with potential for the treatment of cancer. Read More
3D illustration of cancer in crosshairs

Discovery of PD-L1-degrading PROTACs with promising antitumor efficacy

A new series of proteolytic targeting chimeras (PROTACs) was designed by Zhejiang University of Technology scientists based on a previously described PD-L1 inhibitor, and systematic screening of ligands and linkers, combined with structure-activity relationship analysis of the degraders, led to the identification of compounds [I] and [II] as the most active candidates. Read More

Other news to note for Sept. 27, 2024

Additional early-stage research and drug discovery news in brief, from: Abivax, Ovid Therapeutics. Read More

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