The tone of the briefing document posted by the FDA for Wednesday’s Endocrinologic and Metabolic Drugs Advisory Committee (EMDAC) meeting suggested sponsor Amylin Pharmaceutics LLC, a wholly owned subsidiary of Bristol-Myers Squibb Co. (BMS), may have a skeptical panel on its hands reviewing the biologics license application (BLA) for metreleptin (recombinant methionyl human leptin) in metabolic disorders associated with lipodystrophy.