Intrigued by results from a 13-patient, phase II pilot study with peroxisome proliferator-activated receptor (PPAR) delta agonist MBX-8025 for homozygous familial hypercholesterolemia (HoFH), Cymabay Therapeutics Inc. has begun exploring the prospect of combining it with a proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor to make the drug work even better.