Biotech Co.* (Country; Symbol) Pharma Co. (Country) Type/Product Area Terms/Details (Date)

Ablynx NV* (Belgium) Boehringer Ingelheim GmbH (Germany) Agreement to develop Nanobodies against 10 targets The €1.3B ($1.8B) deal includes €45M in committed funds, €30M over the research portion of the deal, and 125M in development milestone payments for each of the targets (9/7)
Acura Pharmaceuticals Inc. (OTC BB:ACUR) King Pharmaceuticals Inc. Agreement to develop and commercialize opioid analgesics using Acura's Aversion abuse-deterrent technology platform King licensed Acura's Phase III pain drug Acurox and will pay $30M up front to Acura, research and development funding and up to $28M in milestone payments plus royalties for each of four products initially targeted in the deal (10/31)
Akebia Therapeutics Inc.* Procter & Gamble Pharmaceuticals Inc. Licensing agreement for oral hypoxia-inducible factor prolyl hydroxylase inhibitor designed to increase natural production of erythropoietin in anemic patients, and a first-in-class program targeting HPTP-beta phosphatase to stimulate angiogenesis in the treatment of peripheral artery disease Akebia holds worldwide rights to both programs (9/14)
Amgen Inc. (AMGN) Dompe Biotec SpA (Italy) Amgen and Dompe combined commercial operations in Italy to form Amgen-Dompe, which will operate as an affiliate of Amgen The newly formed business will be comprised of Amgen and Dompe staff plus current Amgen R&D staff in Italy (10/4)
Anacor Pharmaceuticals Inc.* GlaxoSmithKline plc (UK) Agreement for the discovery, development and commercialization of small-molecule, boron-based antivirals and antibacterials Anacor will manage discovery and development through proof of concept; GSK will have an option to license eight candidates against four targets; it will pay Anacor $12M up front and make a $10M equity investment; Anacor also could receive milestones, ranging from $252M to $331M for each product, as well as tiered, double-digit royalties (10/8)
Antares Pharma Inc. (AMEX:AIS) Undisclosed pharmaceutical company Worldwide development and license agreement focused on a product in the field of opioid analgesia that will be delivered transmucosally using Antares' Easy-Tec oral disintegrating tablet delivery platform Antares will receive an up-front payment, clinical and regulatory milestone payments and continued funding for development and technology transfer activities; Antares also will receive royalties (10/11)
Asuragen Pharmacogenomic Services (a unit of Asuragen Inc.*) Merck & Co. Inc. Research collaboration to develop a biomarker and pharmacogenomic test for cancer clinical trials Asuragen will receive an undisclosed payment for the development of the test (10/23)
Asuragen Inc.* Roche Molecular Systems Inc. (a unit of F. Hoffmann-La Roche Ltd.; Switzerland) Licensing agreement for real-time quantitative PCR technology Asuragen will use the technology for clinical gene expression profiling and DNA analysis in its clinical service programs (10/8)
BioLineRx Ltd.* (Israel) (TA: BLRX)(Israel) Yeda Research and Development Company Ltd. Worldwide exclusive license agreement to develop and commercialize BL-4050, a peptide for treating cancer Financial terms were not disclosed (10/1)
BioMarin Pharmaceutical Inc. (BMRN) Asubio Pharma Co. Ltd. (subsidiary of Daiichi Sankyo Co. Ltd.) Licensing agreement for exclusive rights to data and intellectual property contained in the Kuvan new drug application Asubio will use the data to supplement its current filing for approval in Japan of its BH4 product for the treatment of phenyl-ketonuria (9/17)
Bionas GmbH* (Germany) Solvay Pharmaceuticals GmbH (Germany) Service contract covering the metabolic profiling of several drug candidates identified in the context of Solvay's obesity research program Financial details were not disclosed (10/1)
BioWa Inc.* GlaxoSmithKline Agreement for access to BioWa's Potelligent Technology platform for the development of antibody-dependent cellular cytotoxicity-enhanced antibodies The agreement grants GSK nonexclusive rights to research and develop antibodies based on Potelligent Technology for an undisclosed number of targets; BioWa will receive an up-front payment and license fees (10/19)
BrainCells Inc.* Taisho Pharmaceutical Co. Ltd. (Japan) Licensing agreement to develop compounds for central nervous system indications, including mood disorders Taisho retained rights to the program in Japan and China; BCI has rights in the rest of the world (9/27)
Celera Group (NYSE:CRA) Merck & Co. Inc. Research collaboration to develop biomarker and pharmacogenomic tests for cancer patients Celera will evaluate the use of certain gene expression profiles identified by Merck, with the goal of developing diagnostic predictors for use in Merck's clinical trials; Celera will receive an undisclosed payment (9/17)
Cephalon Inc. (CEPH) ECR Pharmaceuticals Agreement to acquire North American rights to Amrix (cyclobenzaprine hydrochloride extended-release capsules), a muscle relaxant approved by the FDA Cephalon is paying ECR $100M in cash for the rights; it will launch the product early in the fourth quarter (8/23)
Compugen Ltd. (CGEN) Teva Pharmaceutical Industries Ltd. (Israel) Agreement covering CGEN-54, a Compugen-discovered splice variant of MCP1 (monocyte chemoattractant protein 1) The companies will collaborate on initial research, with Teva retaining an option for a worldwide exclusive development and commercialization license in exchange for milestones and royalties (8/28)
Convivia Inc.* Raptor Pharmaceuticals Corp. Agreement to acquire from Convivia various assets, including a product candidate targeting aldehyde dehydrog-enase deficiency Further details were not disclosed (10/22)
Critical Outcome Technologies Inc. (UK; CDNX: COT) Merck Serono (division of Merck KGaA; Germany) Pilot project agreement to identify drug development candidates for an undisclosed oncology cellular target Financial terms call for Merck to make a project commencement payment to COTI, and additional preclinical milestone payments (10/18)
Crucell NV (the Netherlands; CRXL) Merck & Co. Inc. Agreement under which Merck exercised an option for the exclusive use of Crucell's PER.C6 technology and an option for access to Crucell's AdVac vaccine technology in two infectious disease areas Crucell acquires rights to certain cell-line technology developed by Merck for the manufacturing of recombinant proteins (9/10)
DARA BioSciences Inc.* Bayer Pharmaceuticals Corp. License agreement granting DARA exclusive worldwide rights to a series of patents and compounds for treating metabolic diseases, in particular Type II diabetes and dyslipidemia DARA will develop and commercialize products while Bayer will receive an up-front payment, milestone payments and royalties during the development and commercialization; Bayer has certain rights to commercialize products (10/17)
Debiopharm Group SA* (Switzerland) NanoCarrier Co. Ltd. (Japan) Licensing agreement for ex-Japan development and commercialization rights to cancer drug DACH-Platin Polymeric Micelle Debiopharm will provide DACH-platin starting material and pay NanoCarrier an up-front fee, milestone payments, manufacturing costs and royalties (10/31)
Draxis Health Inc. (Canada; DRAX) Med Discovery SA (Switzerland) Research agreement to use DraxImage's radio-pharmaceutical expertise to radiolabel Med Discovery's targeted protein therapeutics for cancer Terms were not disclosed (8/22)
Dyax Corp. (DYAX) Bayer Schering Pharma AG (Germany) Agreement for the discovery of therapeutic antibodies Dyax will identify therapeutic antibodies for two targets provided by Bayer, and Dyax will be allowed to work on additional targets and/or allow Bayer to exercise an option for an antibody library license (9/5)
Dynavax Technologies Corp. (DVAX) Merck & Co. Inc. Agreement to develop the Phase III hepatitis B virus vaccine Heplisav The deal provides $31.5M up front, with $105M in potential milestone payments plus royalties (11/1)
Flamel Technologies SA (France; FLML) Wyeth Pharmaceuticals Agreement for development and licensing of a marketed protein to be delivered using Flamel's Medusa technology Flamel will receive an up-front payment and potential development fees, milestones and royalty payments (9/12)
Galapagos NV (Belgium; BR:GLPG) Janssen Pharmaceutica NV (unit of Johnson & Johnson) Rheumatoid arthritis deal, involving up to 12 possible RA targets; the development component could involve up to seven targets It could bring Galapagos $1.43B in up-front payments, license fees and milestones, and could involve as many as 15 to 19 targets (10/24)
GeneGo Inc.* Bristol-Myers Squibb Co. Licensing agreement for access to all major GeneGo products BMS got access to various systems biology technology (9/25)
Gene Logic Inc. (GLGC) Merck Serono (Switzerland) Agreement for drug repositioning and development for several Merck Serono drug candidates that were discontinued for reasons other than safety Gene Logic is entitled to success-based milestone payments, as well as royalties (8/28)
Gene Logic Inc. (GLGC) Solvay Pharmaceuticals Inc. (Brussels) Agreement for drug repositioning and development for multiple Solvay drug candidates that were discontinued or de-prioritized for reasons other than safety Gene Logic is entitled to undisclosed mile-stone and royalty payments in the deal (8/27)
Genomatrix Software GmbH* (Germany) Sanofi-Aventis (France) Renewed license agreement for multisite access to Genomatrix microarray products Terms of the deal were not disclosed (9/27)
Glenmark Pharmaceuticals Ltd.* (India) Eli Lilly & Co. Agreement for rights to Glenmark's TRPV1 antagonist molecules, including GRC 6211 The deal is worth at least $350M, including a $45M up-front payment and $215M in development and sales milestones for the initial indication of pain; it also includes royalties, and up to $90M in additional milestones for other indications (10/30)
Halozyme Therapeutics Inc. (HALO) Baxter International Inc. Agreement to develop a subcutaneous version of Gammagard, an intravenous immune globulin product for primary immunodeficiency disorders Halozyme will receive $10M up front, and potentially up to $111M in regulatory and sales milestones for each of the first three targets (9/10)
IDEA AG* (Germany) Alpharma Inc. Licensing agreement for exclusive U.S. rights to ketoprofen in Transfersome gel from IDEA Terms include a $60M payment to IDEA at closing, along with $77M in potential clinical and regulatory milestone payments, and $45M or $65M on FDA approval (9/6)
ImClone Systems Inc. (IMCL) and Bristol-Myers Squibb Co. Merck KGaA (Germany) Collaboration to develop Erbitux in Japan Once approved, Merck Serono Japan would distribute the product and record sales; Bristol-Myers and Merck would use their Japanese sales forces and would share profits and losses; Merck would receive 50% and ImClone and Bristol-Myers each would get 25%; ImClone also would receive a royalty equal to 4.75% of total net sales in Japan (10/17)
Immunicon Corp. (IMMC) Merck Serono (Switzerland) Laboratory service and assay development agreements They cover laboratory service testing and development of specialized biomarker assays based on circulating tumor cells within the scope of an early clinical drug study (8/29)
Innovive Pharmaceuticals Inc. (OTC BB:IVPH) TMRC Co. Ltd. Agreement for Innovive to acquire exclusive European rights to develop and commercialize tamibarotene, a synthetic retinoid drug candidate Innovive gained European rights to tamibarotene for acute promyelocytic leukemia, with an option to include other oncology disease areas; TMRC received an up-front fee and will be eligible for milestones and royalties (9/10)
Isis Pharmaceuticals Inc. (ISIS) Ortho-McNeil Inc. (subsidiary of Johnson & Johnson) Licensing agreement for two early stage, second-generation antisense drugs for diabetes In exchange for worldwide development and marketing rights to ISIS 325568 and ISIS 377131, Ortho-McNeil agreed to pay Isis $45M up front, $15M in research funding over two years, up to $230M in development and regulatory milestone payments, and undisclosed royalties; the companies will work to discover two more new drugs, which could bring Isis another $150M in milestone payments (9/13)
ISTA Pharmaceuticals Inc. (ISTA) Tanabe Seiyaku Co. Ltd. (Japan) Licensing agreement for exclusive North American rights to nasal-dosage forms of bepotastine for treating allergy symptoms ISTA will pay Tanabe $2M up front as well as potential milestone and royalty payments (9/27)
Keryx Bio-pharmaceuticals Inc. (KERX) of Japan Tobacco Inc.) Torii Pharmaceutical Co. Ltd. (subsidiary Agreement for Japanese rights to Keryx's Phase II phosphate binder, Zerenex The deal is potentially worth $100M, with $20M coming near term; Torii also will pay royalties on Zerenex (9/26)
KineMed Inc.* Merck Serono (Switzerland) Collaboration to discover new applications for drug candidates KineMed will identify new therapeutic uses in in vivo preclinical models by applying its translational medicine technologies; KineMed will receive an up-front payment, milestones and royalty payments in the deal (8/28)
Laboratorios Almirall SA*(Spain) Shire plc (UK) Definitive agreement to acquire a portfolio of eight marketed products along with their associated European sales teams Almirall will pay Shire $213M for the products, which include Solaraze, Vaniqa, Lodine, Colazide, Cebutid, Meptid, Robaxin and Mintec (10/8)
MacroGenics Inc.* Eli Lilly and Co. Agreement worth more than $1B to develop and commercialize teplizumab Lilly will acquire the exclusive rights to teplizumab, a drug being studied to treat Type I diabetes; MacroGenics will receive an up-front payment of $41M and $3M in other committed funds from Lilly; it also may receive up to $200M in development milestones for the Type I diabetes indication, and up to $250M in sales milestones, as well as double-digit royalties; milestones in additional indications could bring more than $600M to MacroGenics (10/18)
Medarex Inc. (MEDX) Johnson & Johnson Licensing arrangement under which Medarex will continue to allow Centocor to use its UltiMAb Human Antibody Development System Medarex will receive license fees, potential milestone payments and royalties (9/5)
MedImmune Inc. (LSE:MDI) GlaxoSmithKline plc (UK) Licensing agreement for reverse genetics intellectual property to support the development and construction of new vaccine strains to produce non-live human influenza vaccines MedImmune will receive an undisclosed up-front payment and has the potential to receive royalties on certain vaccine stockpiles or sales of other influenza products developed using the technology (9/24)
MedImmune Inc. (unit of AstraZeneca plc; UK; LSE:MDI) Novartis AG (Switzerland) Licensing agreement for reverse genetics technology to Novartis Novartis will use the technology to support development and construction of new vaccine strains to produce inactivated human seasonal, pre-pandemic and pandemic influenza vaccines (8/23)
Medivir AB (Sweden; SSE: MVIRB) Guangdong Lantai-Viewland Pharmaceutical Co. Ltd. (China) and Beijing Mefuvir Medicinal Technology Co. Ltd. (China) Agreement to transfer a license for the anti-HIV compound MIV-160 from Guangdong to Beijing Mefuvir The company will develop MIV-160 for HIV prophylactic and therapeutic use; royalty rates remain the same, but Medivir has returned the right to obtain 4% ownership in Guangdong and instead receives an equivalent right to obtain a 5% ownership in Beijing Mefuvir (8/21)
Medivir AB (Sweden; SSE: MVIRB) Hainan Noken Pharmaceutical Industry Ltd. (China) Licensing agreement for the antiviral compound MIV-210 Noken intends to develop MIV-210 as a pharmaceutical for the treatment of hepatitis B virus; Noken assumes responsibility for the clinical trials and has marketing rights in China, Hong Kong, Taiwan, Macao, Singapore, Japan, South Korea and Australia; Medivir retains marketing rights in other parts of the world; it may earn $7M in milestone payments and is entitled to a double-digit royalty on sales (9/4)
Microbia Inc.* Forest Laboratories Inc. Licensing agreement for the Phase IIb gastrointestinal drug linaclotide The companies will split U.S. development and marketing costs as well as any profits, and Microbia stands to get royalties from sales in Mexico and Canada: it is potentially worth $330M for Microbia, including $70M up front (9/17)
Neurocrine Biosciences Inc. (NBIX) Dainippon Sumitomo Pharma Co. Ltd. (Japan) Licensing agreement for Japanese development and marketing rights to the insomnia compound indiplon Neurocrine will receive an up-front payment of $20M and an additional $10M when Indiplon receives U.S. approval; it could earn up to another $100M if other milestones are met; the deal also includes double-digit royalties (11/1)
NitroMed Inc. (NTMD) N30 Pharma Licensing agreement covering the respiratory use of an s-nitrosothiol drug candidate Financial terms were not disclosed (10/29)
NPS Pharmaceuticals Inc. (NPSP) Nycomed (Switzerland) Agreement for the first right to look at Phase III results of Gattex and enter a potential $185M agreement The first right is in exchange for $10M to NPS; Nycomed will pay another $25M for the rights to the product in gastrointesintal indications outside North America; NPS also would be entitled to $150M in milestone payments, as well as double-digit royalties (9/26)
Pharmacopeia (PCOP) Bristol-Myers Squibb Co. Agreement for a selective androgen receptor modulator program, including PS178990 Pharmacopeia agreed to provide its medicinal chemistry resources to a separate BMS discovery program for up to three years; Pharmacopeia also will pay BMS milestones associated with submission and approval of any therapeutic product for marketing, plus a stepped royalty rate on any product sales (10/15)
Protherics plc (UK; PTIL; LSE:PTI) Myungmoon Pharma Co. Ltd.(Korea) Licensing agreement for rights to develop anti-inflammatory products using Protherics' sustained-release ReGel delivery system Protherics will receive a "small" up-front payment and royalties on any resulting sales in Korea (9/25)
Protherics plc (UK; PTIL; LSE:PTI) Nobilon International BV (unit of Akzo Nobel NV; the Netherlands) Licensing agreement for Protherics' CoVaccine HT adjuvant for use in pandemic influenza vaccines and seasonal influenza vaccines in the elderly Nobilon gains exclusive global rights, excluding the U.S., to develop, manufacture and commercialize two new influenza vaccines containing CoVaccine HT; Protherics will receive an up-front payment and is eligible for milestone payments and royalties (9/26)
Protiva Biotherapeutics Inc.* (Canada) Merck & Co. Inc. Nonexclusive license agreement to Protiva's SNALP technology for research and development of therapeutics in the RNAi field Protiva will receive a one-time payment from Merck with the potential for milestone and royalty payments (10/17)
Radius Health Inc.* Novartis AG (Switzerland) Option agreement for exclusive, worldwide rights to the Phase II osteoporosis drug BA058 outside Japan If Novartis decides to move forward, Radius would receive an option-exercise payment as well as potential development, regulatory and commercial milestone payments that could bring in $500M (9/17)
Salix Pharmaceuticals (SLXP) Wilmington Pharmaceuticals Agreement for exclusive worldwide rights to metoclopramide-Zydis Salix will make a small up-front payment, a regulatory milestone payment upon NDA approval and royalties on net sales (9/5)
Sapphire Therapeutics Inc.* Novo Nordisk A/S (Denmark) Licensing agreement for a discovery-stage ghrelin antagonist program Financial terms were not disclosed (10/30)
Scolr Pharma Inc. (AMEX:DDD) Dr. Reddy's Laboratories (India) Collaboration and license agreement to pursue development and commercialization of an undisclosed oral prescription drug with potential for the cardio-pulmonary market Dr. Reddy's will be responsbile for development, manufacturing and marketing, while Scolr will handle the formulation and assist with product scale-up activities (10/23)
SemBioSys Genetics Inc. (Canada; TSX:SBS) AVAC Ltd. (Canada) Agreement to develop Botaneco as an independent business AVAC paid $2.4M in nondilutive funding to develop Botaneco as an independent entity; the funding will be paid over 27 months; Botaneco will provide AVAC a modest royalty on all gross revenues until two times the gross amount invested has been paid (10/17)
Sepracor Inc. (SEPR) GlaxoSmithKline plc (UK) Agreement covering the insomnia product Lunesta in Europe and elsewhere Sepracor is entitled to a $20M up-front payment in the deal and up to $135M more in potential milestone payments, as well as escalating double-digit royalties on resulting sales; GSK has rights everywhere but the U.S., where Sepracor already sells the product (9/11)
Summit Corp. plc* (UK) Undisclosed pharmaceutical company Agreement for the use of Summit's zebrafish technology The deal is worth $450,000 and involves the assessment of compounds in a range of organs that are conserved between the zebrafish and the humans (10/30)
Synta Pharmaceuticals Corp. (SNTA) GlaxoSmithKline plc (UK) Partnership to develop and commercialize a product for metastatic melanoma The companies will share U.S. responsibility for STA-4783; GSK will hold rights everywhere else; total value could be more than $1 billion (10/10)
Theratechnol-ogies Inc. (Canada; TSX:TH) OctoPlus NV (the Netherlands) Exclusive worldwide rights to develop and commercialize its glucagon-like peptide-1 portfolio of analogues for the treatment of diabetes and other potential indications Theratechnologies received an undisclosed up-front payment in the deal, and is eligible to receive up to €36M ($51M) in milestone payments, as well as royalties (9/27)
Tolerx Inc.* GlaxoSmithKline plc (UK) Agreement to develop and commercialize otelixizumab Tolerx has the option to co-promote it in Type I diabetes in the U.S.; GSK has the exclusive rights to develop and commercialize the antibody in all other indications worldwide; Tolerx will receive an up-front payment, equity and advance R&D funding totaling $70M; it may receive up to $155M in future development costs, and another $350M in milestone payments; it also is entitled to $175M in sales milestone payments and tiered, double-digit royalties (10/23)
Verus Pharmaceuticals Inc.* AstraZeneca plc Agreement for AstraZeneca to acquire Verus' pediatric asthma development programs Verus is to receive an up-front payment of $30M, development expense reimbursements and a potential earn-out payment of $280M (9/24)
ViaCell Inc. (VIAC) EMD Serono Inc. (an affiliate of Merck KGaA; Germany) Agreement to support the clinical development of ViaCyte Financial terms were not disclosed (9/4)
Vitae Pharmaceuticals Inc.* Boehringer Ingelheim GmbH (Germany) Partnership to develop 11beta-HSD1 inhibitors for diabetes and other metabolic diseases Vitae will get $36.5M in up-front fees, equity investments and research funding, plus the chance to earn up to $300M in milestones; Vitae also will be eligible for royalties (10/15)
Vivalis (France; PARIS:VLS) Innate Pharma SAS (France; PARIS:IPH) Collaboration to evaluate Vivalis' EBx cell lines, derived from avian embryonic stem cells, for the production of monoclonal antibodies Innate will compare production of its monoclonal antibody in EBx and CHO cells, looking at the glycosylation profile and cytotoxic activity (9/12)
Vivalis (France; PARIS:VLS) Sanofi-Aventis SA (France) Agreement to evaluate Vivalis' EBx cell lines, cell substrates derived from avian embryonic stem cells, from the production of monoclonal antibodies Financial terms were not disclosed (10/17)
Xceleron Ltd.* (UK) Organon A/S cell expression technology (the Netherlands; unit of Akzo Nobel) Collaboration on a three-compound human microdose study focusing on candidate selection for further clinical development Xceleron will use its Accelerator MassSpectrometry technology to determine human plasma concentrations after microgram administration of the drug candidates (9/10)
XenoPort (XNPT) Xanodyne Pharmaceuticals Inc. Partnership for a preclinical candidate for menorrhagia Xanodyne picked up U.S. rights to develop and commercialize XP21510; XenoPort will receive an up-front cash payment of $12M and milestones of up to $130M; the firm also could receive $5M in milestones related to Xanodyne's XP12B and tiered, double-digit royalty payments on any future sales of XP21510, as well as escalating single-digit royalties on future sales of XP12B (10/15)
XOMA Ltd. (XOMA) Pfizer Inc. License agreement that provides Pfizer with non-exclusive, worldwide access to XOMA's patented bacterial cell expression technology XOMA gets a $30M up-front cash payment; the deal also calls for Pfizer to pay XOMA undisclosed fees and milestones, as well as potential royalties (8/28)

Notes:

# The information in the chart does not cover agricultural agreements or those between biotech companies.

* Private companies are indicated with an asterisk. ** Denotes the date the item ran in BioWorld International.

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