Company*
(Country; Symbol)

Funding
Institution

Amount
(M)

Type#

Details (Date)


Advanced
Life Sciences
Holdings Inc.
(ADLS)

National Institute of Neurological Disorders and Stroke

ND

Phase I SBIR grant

Funds will support preclinical testing of the small molecule ALS-886 to reduce brain swelling leading to tissue damage following a stroke (2/7)

Advanced
Ocular Systems
Ltd.
(Australia;
ASX:AOS)

Australian government

A$1.4 ($1)

Commercial Ready grant

The funding will be provided over three years to match company funding and be used to support development (3/1)

Alba
Therapeutics
Corp.*

Maryland Industrial Partnerships

ND

Funding support

Funds will go toward completion of work on zonulin receptor cloning and characterization (2/21)

Alba
Therapeutics
Corp.*

National Institute of Diabetes, Digestive and Kidney Diseases

ND

SBIR grant

The grant will support development of Alba's lead molecule, AT-1001, for treating Type I diabetes (2/21)

Alnylam
Pharmaceuticals
Inc.
(ALNY)

U.S. Department of Defense

ND

Funding support

The funds will support development of RNAi therapeutics for pandemic influenza (12/14)

Arteriocyte Inc.*

National Institutes of Health

$1.4

STTR grant

Funds will support a Phase I trial evaluating the safety of adult- derived hemangioblasts to treat chronic ischemia (1/19)

Atom Sciences
Inc.*

National Institutes of Health

$0.6

Grant

Funds will support development of a technology for rapid identification of disease pathogens in case of a biowarfare attack or a major outbreak(2/10)

AVI BioPharma
Inc.
(AVII)

Department of Defense

$11

Defense appropriation

FY2006 appropriation bill includes $11M to fund ongoing programs studying Neugene technology for Ebola, Marburg and dengue viruses, and anthrax and ricin countermeasures (1/4)

BiondVax Pharmaceuticals* (Israel)

Israeli government

$1.1

Funding support

Funds will support development of its five-year, nasally administered, universal influenza vaccine (12/22)

Biopure Corp.
(BPUR)

U.S. Navy

$4

Defense
appropriation

FY2006 appropriations bill includes $4M in funding for the Navy to continue studying the use of Hemopure in trauma applications (1/3)

Biota Holdings
Ltd.
(Australia;
ASX:BTA)

National Health and Medical Research Council (Australia)

A$0.09 ($0.065)

Grant

Funds will support studies on a long-acting neuraminidase inhibitor against several avian flu strains (2/20)

Bioxel Pharma
Inc.
(Canada;
CDNX:BIP)

Natural Sciences and Engineering Research Council of Canada

C$0.273 ($0.234)

Funding support

The funding is to support formuation development of anticancer drugs; it will take the form of a grant, with installments paid upon completion of development milestones (12/16)

Blue Heron
Biotechnology
Inc.*

National Institute of General Medical Science and the National Human Genome Research Institute

$0.77

Phase II SBIR grant

The grant will fund research to develop methods for assembling very large recombinant DNA molecules (3/13)

Cepheid Inc.
(CPHD)

Canadian government

C$0.78 ($0.69)

Grant

Cepheid and the Public Health Agency of Canada's National Microbiology Laboratory will use the funds to develop assays for Ebola, Marburg and Lassa fever viruses (2/14)

Chaperone
Techologies
Inc.*

U.S. Army

$1

Defense appropriation

Chaperone, Lackawanna College and the University of Scranton will use the funds to develop methods for destroying drug-resistant bacteria (1/25)

Chiron Corp.
(CHIR)

UK government

ND

Contract

Contract calls for Chiron to supply the UK government pre-pandemic influenza vaccine for a stockpile based on the H5N1 avian influenza virus strain (2/24)

CombiMatrix
Group
(CBMX)

Department of Defense

$2.1

Contract

Conrtact focuses on integrating CombiMatrix's microarray technology with microelectronics and microfluidics to develop a system for detecting biothreats (2/13)

CombiMatrix
Group
(CBMX)

Department of Defense

$2.4

Defense appropriation

Funds will support further development of microarray technologies for detecting biological and chemical threat agents (1/17)

Compugen Ltd.
(Israel; CGEN)

European Commission

€3.1 ($3.7)

Funding support

Compugen is leading a consortium to develop a platform to simulate the cancer-related MAP kinase pathway; the consortium also includes Aureus Pharma and several institutions (3/7)

Copernicus
Therapeutics
Inc.*

Cystic Fibrosis Foundation Therapeutics Inc.

$1.5

Funding support

The $1.5M in 2006 funding will support development of a gene therapy for CF; another $4.6M could be paid in 2007 if progress continues (2/14)

GenVec Inc.
(GNVC)

National Institute of Allergy and Infectious Diseases

$0.3

Subcontract funding

Funds will support preliminary vector development in preparation for the manufacture of clinical-grade adenovector-based influenza vaccines (2/9)

Iceland Genomics
Corp.*
(Iceland)

European Union

ND

Sixth Framework Program award

A consortium including IGC, Bioinformatics ApS, University of Oxford and Radboud University will study the inherited risk of breast and prostate cancers (12/19)

Illumina Inc.
(ILMN)

National Cancer Institute

ND

Subcontract award

Illumina will perform whole- genome SNP scans on more than 2,500 prostate case and control samples, in support of the NCI's Cancer Genetic Markers of Susceptibility program(2/14)

Invitrogen
Corp.
(IVGN)

Department of Defense

$0.97

Contract award

Invitrogen Federal Systems will use the funding to produce and validate protein microarrays to biothreat agents (1/10)

Iomai Corp.
(IOMI)

National Institute of Allergy and Infectious Diseases

$1.4

Grant

Funds will support development of an immunostimulant needle-free patch to extend availability of stocks of influenza vaccine in the case of a pandemic (3/9)

Juvaris
BioTherapeutics
Inc.

National Institute of Allergy and Infectious Diseases

ND

SBIR-Advanced Technology grant

The 18-month grant will support testing of an HIV vaccine that uses Juvaris' JuvaVax vaccine platform (3/7)

Juvaris
BioTherapeutics
Inc.*

National Institute of Allergy and Infectious Diseases

ND

STTR grant

Juvaris and Stanford University will work on a next-generation influenza A vaccine, with an emphasis on avian influenza (1/9)

Lentigen Corp.

Maryland's Department of Business and Economic Development

ND

Challenge Investment Program funding

The funding will support development of the company's lenti-viral technology (12/13)

MaxThera Inc.

National Institute of Allergy and Infectious Diseases

$0.6

Phase I SBIR grant

Two-year grant will support effort to design and develop antibiotics for infections complicated by antibiotic resistance (2/1)

Medarex Inc.
(MEDX) and
PharmAthene Inc.*

Department of Defense

$2.05

Defense appropriation

The funding will support development of Valortim, a fully human antibody being developed to prevent and treat anthrax infection (1/10)

MNLpharma Ltd.*,
Cambridge
BioStability Ltd.*
and the University
of Cambridge (all UK)

Department of Trade and Industry (UK)

£1.5 ($2.6)

Grant

The three-year matching grant will support development of a room- temperature, stable, controlled-release vaccine technology (3/17)

Nanotrope
Inc.*

National Aeronautics and Space Administration

$0.6

Phase II SBIR grant

Funds will support development of nanoscale technology for new drug formulations and delivery protocols (2/3)

Northfield
Laboratories
Inc.
(NFLD)

Department of Defense

$3.5

Defense appropriation

FY2006 appropriations bill includes $3.5M for continued development of PolyHeme, the company's hemoglobin-based oxygen carrier (1/3)

Novavax Inc.
(NVAX)

National Institute of Allergy and Infectious Diseases

$1

Funding support

The additional money will fund the third year of a 4.5-year research program focused on an HIV/AIDS virus-like particle vaccine (3/16)

PolyMedix Inc.*

National Institute of Allergy and Infectious Diseases

$3

Phase II SBIR grant

Funds will be used to identify a lead compound and backups for an intravenous antibiotic to treat hospital-acquired infections (3/21)

Procyon
Biopharma Inc.
(Canada; TSE:PBP)

National Research Council Canada

$0.98

Industrial Research Assistance Program contribution

The repayable contribution will support development of the pro-tease inhibitor PPL-100 for treating drug-resistant HIV (1/13)

ProlX
Pharmaceuticals
Corp.*

National Cancer Institute

$5.6

National Cooperative Drug Discovery Group award

ProlX and four research institutions got the five-year award to discover therapies that target cells while minimizing damage to normal, healthy cells (12/7)

ProteoTech Inc.*

Michael J. Fox Foundation for Parkinson's Research

$3.1

Funding award

ProteoTech and collaborators will get up to $3.1M for work on a PD therapy that can disrupt or inhibit clumping of the protein alpha-synuclein (2/13)

QBI Life
Sciences
(division
of Quintessence
Biosciences Inc.)

National Institutes of Health

$0.75

Roadmap for Medical Research grant

QBI will develop a high-throughput molecular screening platform for membrane protein targets with the universities of Wisconsin and Helsinki (1/19)

RheoGene Inc.*

Michael J. Fox Foundation for Parkinson's Research

$4.2

Funding award

RheoGene will use the funds to develop its RheoSwitch Therapeutic System for gene therapy in Parkinson's disease (1/5)

Semafore
Pharmaceuticals
Inc.*

Indiana's 21st Century Research and Technology Fund

$2.27

Grant

The funds will help the company advance its lead targeted PI3 kinase inhibitor, SF1126, into Phase l trials in solid tumors later in 2006 (3/17)

Sinovac
Biotech Ltd.
(China; AMEX:SVA)

China Ministry of Science and Technology

RMB7 ($0.87)

Funding support

The funds will support preclinical trials of Sinovac's Panflu pandemic flu vaccine (12/9)

Solbec
Pharmaceuticals
Ltd.
(Australia;
ASX:SBP)

Australian Industry Department

A$2.26 ($1.66)

AusIndustry Commercial Ready grant

The funds are expected to cover half the cost of the upcoming Phase II trial of the cancer drug Coramsine (12/20)

Transgene SA
(France; Eurolist: FR0005175080)

Lyone Biopole Competitive Cluster (France)

€1.3 ($1.6)

Grant

The funds will support development over three years of the vaccine candidate TG4040 for treating hepatitis C (1/25)


Notes:

* Indicates a privately held company.

Currency conversions reflect values at the time of a deal's announcement.

SBIR = Small Business Innovation Research; STTR = Small Business Technology Transfer.

Unless otherwise indicated, symbols listed are on the Nasdaq market.

# Item occured before the time frame of this chart but was not included in previous chart.

AMEX = American Stock Exchange; ASX = Australian Stock Exchange; CDNX = Canadian Venture Exchange; TSE = Toronto Stock Exchange.