I. MODIFIED AGREEMENTS

Biotech Co.*
(Country;
Symbol)

Pharma Co.
(Country)

Change from original
agreement

Terms/Details (Date)


Gene Logic
Inc.
(GLGC)

Daiichi Pharmaceutical Co. Ltd. (Japan)

Daiichi continued its subscription to the BioExpress System

The focus of the multiyear subscription is primarily for discovery research; terms of the deal were not disclosed (6/7)

Gene Logic
Inc.
(GLGC)

Takeda Pharmaceutical Co. Ltd. (Japan)

Takeda extended its subscription to the BioExpress System

Takeda extended access through 2006 for use in drug discovery and development; terms of the deal were not disclosed (6/7)

GW
Pharmaceuticals
plc
(UK; LSE:GWP)

Bayer HealthCare AG (Germany)

They amended marketing deal on Sativex in the UK and Canada, after the product was approved in Canada first

Some details were changed, but milestone payments of £32.75M due to GW remain unchanged (5/11)

Indevus
Pharmaceuticals
Inc.
(IDEV)

Pliva d.d. (Croatia)

Saturn Pharmaceuticals Inc. acquired rights to market Sanctura from Odyssey Pharmaceuticals Inc.

Odyssey, a Pliva subsidiary, had acquired rights in April 2004; Indevus gets enhanced economic terms under the amended deal (5/16)

II. TERMINATED AGREEMENTS

Genta Inc. (GNTA)

Sanofi-Aventis Group (France)

They formally terminated their deal to develop Genta's cancer drug Genasense

Sanofi provided notice of the termination in November 2004; there are no further financial obligations between them (5/10)

NeoPharm Inc.
(NEOL)

Akorn Inc.

They ended a deal under which NeoPharm had access to manufacturing capacity at an Akorn facility

The deal granting capacity to NeoPharm was signed in 2002; NeoPharm already made arrangements for its manufacturing needs (5/16)


Notes:

# The information in the chart does not cover agreements between biotech companies or agricultural agreements.

* Private companies are indicated with an asterisk.

Unless otherwise noted, stock symbols listed are on the Nasdaq market.

LSE = London Stock Exchange.