Total: $710.16M

Company
(Symbol)#

Type Of Financing

Number Of Shares, Units Or Warrants (M)

Amount Raised (M)

Investors; Placement Agents; Details (Date)@


Aerogen Inc. (AEGN)

Private sale of convertible preferred stock and warrants

5S and 5W

$15

Aerogen sold Series A-1 preferred stock initially convertible into 5M shares, and warrants to purchase up to 5M shares at $3.25 per share; Xmark Funds was lead investor; others were HealthCap, OrbiMed Advisors, Perceptive Life Sciences Fund Ltd. and SF Capital Partners; CIBC World Markets Corp. was placement agent in the financing, which was the first closing of a $32.7M round (3/24)

Amylin Pharmaceuticals Inc. (AMLN)

Private placement of convertible notes

N/A

$175

Amylin sold $175M of 2.5% convertible senior notes due 2011; the initial conversion price per share is $34.35, a 45% premium; purchasers have an option to buy another $25M of the notes (3/31)

Australian Cancer Technology Ltd. (Australia; ASX:ACU)

Private placement of stock

9.52S

A$3 (US$2.3)

ACT sold the shares at A31.5 cents each, a 17% discount to the year-to-date average; Jaguar Advisory Services Pty. Ltd. underwrote the financing (3/16)

Bioenvision Inc. (AMEX:BIV)

Private placement of stock and warrants

2S and 0.4W

$12.8

The shares were priced at a 10% discount to the five-day average price, and the warrants are exercisable at $7.50 per share; existing Series A preferred shareholders have a 30 day right to buy shares under the same terms; SCO Securities LLC was placement agent (3/23)

Corautus Genetics Inc. (AMEX:CAQ)

Private placement of stock and warrants

0.376S and 0.19W

$2.25

The shares were priced at 88% of their value the previous day, and the two institutional investors got warrants exercisable at $8.375 per share; no placement fees were paid (3/19)

CuraGen Corp. (CRGN)

Sale of convertible subordinated notes

N/A

$10

Purchasers of $100M in notes in February exercised their option on another $10M in the 4% notes due 2011; they can be converted into common stock at $9.69 per share (3/16)

Cytomedix Inc. (OTC BB: CYME)

Private placement of preferred stock and warrants

0.0028S and 2.8W

$2.8

Cytomedix issued 280 Series C convertible preferred shares at $10,000 per share; each share is convertible into 10,000 common shares; the five-year warrants are exercisable at $1.50 each (3/29)

Cytos Biotechnology AG (Switzerland; SWX:CYTN)

Private placement of stock

0.75S

CHF30 (US$23.1)

Cytos placed the shares with new and existing investors at a discount of about 20% to the prior day's close; global coordinator Deutsche Bank Group has an option on 100,000 additional shares (3/25)

Discovery Laboratories Inc. (DSCO)

Underwritten offering

2.2S

$24.2M

Discovery Labs sold the shares from a shelf registration statement at $11 per share; Bear, Stearns & Co. Inc. was lead manager (3/30)

DOR BioPharma Inc. (AMEX:DOR)

Private placement of stock and warrants

4.11S and 1.65W

$3.25

DOR sold the shares to instutional investors, which also got five-year warrants exercisable at 87 cents per share (3/4)

DOV Pharmaceutical Inc. (DOVP)

Private placement of stock

0.667S

$10

DOV sold the shares at $15 each to undisclosed institutional investors (3/29)

Draxis Health Inc. (Canada; DRAX)

Bought-deal sale of units

3.053U

C$20 (US$15.3)

The units, priced at C$6.55 each, consist of one common share and one-half of one share warrant; each two-year whole warrant entitles the holder to acquire one share at C$8.50; underwriters have an option to purchase another 458,016 units (3/31)

Genesis Bioventures Inc. (AMEX:GBI)

Private placement of securities

ND

$2

Genesis raised the money in conjunction with its proposed acquisition of Corgenix Medical Corp., which will be advanced $0.5M from the proceeds; terms of the financing were not disclosed; Sterling Financial Investment Group was placement agent (3/16)

GenoMed Inc. (OTC BB:GMED)

Private equity deal

N/A

$0.5

Pierpoint Investissements SA agreed to invest at least $500,000 and up to $2M in GenoMed for the next 10 years in return for restricted shares priced at a modest discount; Pierpoint will keep active warrants for another 35M shares that could be converted only if the share price reaches $1 (3/3)

GTC Biotherapeutics Inc. (GTCB)

Private placement of stock

6.4S

$15

GTC placed the stock covered under a shelf registration statement with institutional investors at $2.35 per share; lead SG Cowen Securities Corp. and Rodman & Renshaw LLC were placement agents (3/16)

Helix BioMedix Inc. (OTC BB:HXBM)

Private placement of stock and warrants

0.55S and 0.193W

$1.1

Helix said the money raised represented what was expected to be the first closing in the financing; terms on the warrants were not disclosed (3/22)

Incyte Corp. (INCY)

Private placement of convertible notes

N/A

$50

Purchasers of $200M of notes in February bought another $50M of the 3.5% notes due 2011; the notes have an initial conversion price of about $11.22 per share (3/8)

InSite Vision Inc. (AMEX:ISV)

Private placement of units

0.194U

$2

Each unit consists of 20,000 shares of common stock at $0.50 per share and 5,000 Class A and 5,000 Class B warrants, with each warrant enabling the holder to purchase common shares at $0.75 each; the deal is expected to be the initial closing in a $16.5M financing; Paramount BioCapital Inc. was placement agent (3/29)

Integrated Pharmaceuticals Inc. (OTC BB:INTP)

Privateplacement of stock and warrants

4.2S and 2.1W

$4.2

The shares were priced at $1 each and the warrants are exercisable through 2006 at $2.50 per share; one investor also received a 90-day option to buy up to $1.2M in common stock (3/11)

La Jolla Pharmaceutical Co. (LJPC)

Underwritten stock sale

1.3S

$4.1

Pacific Growth Equities LLC exercised its option to purchase 1.3M additional shares from a financing that priced in February; gross proceeds of the sale totaled about $31.5M (3/5)

Large Scale Biology Corp. (LSBC)

Private placement of stock and warrants

5.2S and 1.3W

$8.2

Large Scale sold the shares at about $1.58 each; the five-year warrants were priced at a premium of 20%; The Shemano Group Inc. was placement agent (3/10)

Lynx Therapeutics Inc. (LYNX)

Private placement of stock and warrants

0.788S and 0.181W

$4

Lynx sold the shares to institutional investors at $5.10 per share; the warrants are exercisable at $6.25 per share (3/10)

MacroChem Corp. (MCHM)

Private placement of stock and warrants

5.4S and 1.08W

$7.29

MacroChem sold about 5.4M shares at $1.35 per share to institutional investors, which also got five- year warrants to purchase 1.08M shares at $2.09 per share; JMP Securities LLC was placement agent (3/10)

Matritech Inc. (AMEX:MZT)

Private placement of stock and warrants

4.86S and 1.65W

$6.56

Matritech sold the shares at $1.35 each; the war- rants are exercisable at $2 per share; Rodman & Renshaw LLC was placement agent and got 434,475 of the warrants that were issued (3/19)

MediGene AG (Germany; FSE:MDG)

Private placement of stock

1.1S

€7.5 (US$9.2)

MediGene sold the shares at €6.80 each to insti- tutional investors in the first of three steps to raise €16M; Techno Management Ventures participated in the deal (3/11)

MGI Pharma Inc. (MOGN)

Private placement of convertible notes

N/A

$35

Placement agents in a February sale of 2.25% notes exercised their option on another $35M in notes, which have an initial conversion price of $62.92 per share; the financing now totals $260M (3/2)

Microbix Biosystems Inc. (Canada; TSE:MBX)

Convertible debenture sale

N/A

C$0.5 (US$0.38)

Microbix entered a deal to sell an 8% convertible debenture to an existing shareholder; the note is convertible into common stock at C$0.90 per share for eight years (3/22)

MicroIslet Inc. (OTC BB:MIIS)

Private placement of stock and warrants

9.8S and 4.9W

$12.8

The shares were sold at about $1.31 each; warrant terms were not disclosed; Burnham Hill Partners and Duncan Capital were placement agents (3/10)

Miraculins Inc. (Canada; VSE:MOM)

Private placements of units

4U

C$2 (US$1.53)

The units, priced at C$0.50 each, consist of one common share and one-half of a warrant; each whole warrant is exercisable at C$0.75 for six months; Bieber Securities Inc. was agent for the financing (3/26)

Nanogen Inc. (NGEN)

Private placement of stock

4.25S

$33.75

Nanogen sold the shares from a shelf registration statement to institutional investors at $7.94 each; Seven Hills Partners LLC was placement agent (3/5)

NaPro Biotherapeutics Inc. (NPRO)

Private placement of stock

2S

$5.2

NaPro sold the shares from a shelf registration statement to two institutional investors (3/26)

Neurobiological Technologies Inc. (NTII)

Private placement of stock and warrants

3.88S and 0.582W

$19.4

NTI sold the shares at $5 each, and the warrants are exercisable at $6.73 per share; Merriman Curhan Ford & Co. was placement agent (3/2)

Neurogen Corp. (NRGN)

Private placement of stock

14.29S

$100

Neurogen sold the shares at $7 each; Warburg Pincus LLC and Baker Brothers Investments were lead investors (3/19)

Oncolytics Biotech Inc. (Canada; ONCY)

Private placement of stock and warrants

1.077S and 0.539W

C$6.73 (US$5.1)

A European institutional investor purchased the shares and warrants, which are exercisable at C$7.75 per share (3/24)

Pheromone Sciences Corp. (Canada; TSE:PHS)

Private placement of convertible debentures

N/A

C$0.33 (US$0.25)

Each C$1 principal amount is convertible into 10 shares and 10 warrants; each warrant allows the holder to purchase one share at C$0.10 by Feb. 4, 2005 (3/4)

Point Therapeutics Inc. (OTC BB:POTP)

Private placement of stock and warrants

3S and 0.9W

$13.5

PTI sold the shares at $4.50 each and the five-year warrants are exercisable at $6.25 per share; RBC Capital Markets and Paramount BioCapital Inc. were placement agents (3/25)

SuperGen Inc. (SUPG)

Private placement of stock and warrants

4.86S and 0.729W

$34

SuperGen sold the shares at $7 each to institutional investors; the warrants are exercisable at $10 per share; Rodman & Renshaw was placement agent (3/5)

Tissera Inc. (Israel; OTC BB:TSSR)

Private equity placement

ND

$5.5

Details of the financing with individual and institutional investors were not disclosed (3/22)

Titan Pharmaceuticals Inc. (AMEX:TTN)

Private placement of stock

3S

$15

Titan sold the shares from a shelf registration at $5 each to institutional and an individual investor; Rodman & Renshaw LLC was placement agent (3/26)

Vical Inc. (VICL)

Registered direct offering

3.4S

$18.6

Vical is selling the shares from a shelf registration at $5.50 each to institutional investors; SG Cowen Securities Corp. was placement agent (3/23)


Notes:

This chart does not include real estate or manufacturing plant financings.

# Unless otherwise indicated, shares are traded on the Nasdaq exchange.

@ Dates refer to the date of the press release.

Currency conversions reflect rates at the time of the deal.

N/A = Not available, applicable or reported.

AMEX = American Stock Exchange; ASX = Australian Stock Exchange; FSE = Frankfurt Stock Exchange; OTC BB = Over-the-Counter Bulletin Board; SWX = Swiss Stock Exchange; TSE = Toronto Stock Exchange; VSE = Vancouver Stock Exchange.