February 7 (EP), February 1 (WO)
Affymetrix WO 01/07464
Preserving gene ratios
Santa Clara, Calif.
Even length proportional amplification of nucleic acids that preserves the relative proportions of gene sequences.
Ajinomoto EP 1 074 564
von Willebrand factor binding assay
Immobilized von Willebrand factor; for detecting modulation of its binding to glycoprotein Ib.
Albert Einstein Coll. Med. WO 01/07627
Drosophila recombination-associated protein, encoding gene sequences; for making knockouts and gene therapy vectors.
Amgen WO 01/07074 & 07477
Thousand Oaks, Calif.
VGF peptides and selective binding agents, recombinant production methods; for diagnostics and therapeutics.
Arrow Therapeutics WO 01/07651
Determining essential genes
Transposon-mediated differential hybridization for determining essential genes.
Artus Molec. Biol. Diagnostics Inst. WO 01/07648
Detection of sepsis inducers
Species-specific detection of prokaryotes and eukaryotes; for finding sepsis inducers.
Aventis Pharma WO 01/07602
Human eg5 antisense
Oligonucleotides to a defined part of human eg5 gene or a mutated form; for expression inhibition.
Becton Dickinson WO 01/07642
Culture media formulation
Franklin Lakes, N.J.
Software and devices for computer-assisted formulation of optimized culture media.
British Secretary of State WO 01/07640 & 07650
SNP analysis methods
Enhanced sensitivity and specificity in methods for analyzing single nucleotide polymorphisms.
California, Univ. of WO 01/07084
Drug delivery fusions
Anti-growth factor receptor avidin fusion proteins; for drug delivery via antibody receptor-mediated endocytosis.
California, Univ. of WO 01/07572
Stable gene integration
Specific and stable integration of genes into eukaryotic cells using a bacteriophage recombination system.
California, Univ. of WO 01/07583-07585
Cell membrane analysis
Cell membrane and tissue analysis via controlled electroporation.
California, Univ. of WO 01/07653
Flow-through microchannel biosensor for the detection of multiple, different nucleic acids or protein targets.
California, Univ. of WO 01/07660
Ataxia telangiectasia SNPs
Automated methods for detection of ataxia telangiectasia mutations and single nucleotide polymorphisms.
Ctr. Genetic Engineer. & Biotech EP 1 074 561
Treating endotoxin disorders
Analogs of lipopolysaccharide-binding protein; for treating endotoxin-associated disorders.
Children's Hosp. WO 01/07598
Tagged cDNA library for cloning
Expression cloning using cDNA constructs expressing a tagged polypeptide having a biological activity of interest.
Chiron WO 01/07614
Genes differentially expressed in adenocarcinomas, encoded proteins, antibodies; for diagnostics and therapeutics.
Chugai EP 1 074 268
Intestinal disease antibodies
Therapeutics for inflammatory intestinal diseases that include interleukin-6 receptor antibodies.
Cincinnati, Univ. of WO 01/06910
_2-adrenergic receptor gene polymorphisms
Assay for polymorphisms in the _2-adrenergic receptor gene; for measuring drug response variation.
Clinical Micro Sensors WO 01/07665
Sequence determination methods
Sequence determination of nucleic acids using self-assembled monolayers and electronic detection methods.
Connaught Labs WO 01/07619
Moraxella outer membrane protein
Recombinant high molecular weight major outer membrane protein of Moraxella, encoding gene; for vaccines.
CuraGen WO 01/07595
New Haven, Conn.
Fibroblast growth factor-CX, encoding gene, variants, mutants, fragments, antibodies; for therapeutics.
Dade Behring EP 1 074
Monkey lentivirus, encoded proteins, fragments; for diagnostics and therapeutics [in German].
Daiichi EP 1 074 562
Blood clotting therapeutic
Thrombin-antithrombin III complex monoclonal antibodies; for diagnosing and treating blood clotting disorders.
DCV WO 01/07472
Cytokine activating factor
Highly purified cytokine activating factor, encoding gene sequences; for immune system and cancer therapeutics.
Diacrin WO 01/07568
Muscle cell transplants
Transplantable skeletal muscle cells; for cardiac repair in congestive heart failure.
Diagnostic Products WO 01/07616
Gene sequences encoding autoantigens associated with endometriosis, encoded proteins; for diagnostics.
Doheny Eye Inst. EP 1 074 618
Cadherins 4 to 12, encoding genes, antibodies, recombinant production methods; for developing therapeutics.
Electrochemical Industry Consortium WO 01/07620
Protein production system
Mushroom pyrF gene, encoded protein; for use as a marker in expressing heterologous genes in fungi.
Epigenomics WO 01/07647
Gene methylation assay
Methods for relative quantitation of the methylation of cytosine-type bases in DNA samples.
Estivill Palleja, X. WO 01/06848
Psychiatric disorder transgenics
Transgenic mice that overexpress the NTRK3 gene located on chromosome 15; for studying psychiatric disorders.
Fbit WO 01/07483
Ramat Gan, Israel
Antibodies that bind to phosphorylated Met protein; for cancer diagnostics and therapeutics.
Gen-Probe WO 01/07661
Enzyme-based polynucleotide template-specific amplification methods; for improved reaction yields.
Genaissance Pharma WO 01/07662
Drug target isogenes
New Haven, Conn.
Polymorphisms in the prostaglandin-endoperoxide synthase 2 gene; for identifying drug target isogenes.
Genentech WO 01/07599
Plasmid DNA purification
S. San Francisco
Methods for RNase- and organic solvent-free purification of plasmid DNA using tangential flow filtration.
Genentech WO 01/07611
S. San Francisco
Proteins, encoding gene sequences, chimeras, antibodies; for diagnostics and therapeutics.
Glaxo WO 01/07082
Cell growth arrest
Anti-Ep-cellular adhesion molecule antibodies combined with a chemotherapeutic agent; for stopping cell growth.
Heinkelein, M., et al. WO 01/07646
Transfecting cells with viral vectors and treating them with putative antivirals; for finding therapeutics.
Helix Res. Inst. WO 01/07607
Progenitor cell genes
Full length cDNA clones isolated from progenitor cells, encoded proteins; for diagnostics and therapeutics.
Heme-Biotech WO 01/07065
Treating porphyric disease
Production of rhPBGD for treating a deficiency in the heme biosynthetic pathway for porphyric disease therapy.
Henkel WO 01/07631
Glycosyltransferase, encoding gene sequences, derivatives, fragments, production methods; for making glycosides.
Human Genome Sciences WO 01/07459
29 secreted proteins
29 human secreted proteins, encoding genes, antibodies, production methods; for diagnostics and therapeutics.
Human Genome Sciences WO 01/07476
Human prostate proteins
25 human prostate and prostate cancer associated proteins, encoding genes, antibodies; for diagnostics/therapeutics.
Human Genome Sciences WO 01/07608
Keratinocyte-derived interferon, encoding gene sequences; for finding modulators and developing therapeutics.
Human Genome Sciences WO 01/07658
Human ABC transporter, encoding gene sequences, antibodies, recombinant production methods; for therapeutics.
HyGene EP 1 074 620
TGF-_ superfamily protein
Neuhausen am Rheinfall, Switzerland
Monomeric protein of the TGF-_ superfamily, encoding gene sequences; for diagnostics and therapeutics.
Imperial Coll. Innovations WO 01/07479
Prion disease therapeutics
Peptides, binding agents, and antibodies useful in diagnosing and treating prion diseases.
Incyte Genomics WO 01/07470
Nervous system-associated proteins
Palo Alto, Calif.
Human nervous system-associated proteins, encoding genes, antibodies, modulators; for diagnostics and therapeutics.
Incyte Genomics WO 01/07471
Cell cycle proteins
Palo Alto, Calif.
Cell cycle and proliferation proteins, encoding genes, antibodies, modulators; for diagnostics and therapeutics.
Incyte Genomics WO 01/07612
Receptors and associated proteins
Palo Alto, Calif.
Human receptors and associated proteins, encoding gene sequences, antibodies, modulators; for therapeutics.
Incyte Genomics WO 01/07628
Palo Alto, Calif.
Human synthetases, encoding gene sequences, antibodies, modulators; for diagnostics and therapeutics.
Inst. Genomic Res. WO 01/07587-07589, 07591, 07621, 07622, 07624 & 07629
Gene sequences from several Pseudomonas species, encoded proteins; for designing diagnostics and therapeutics.
INSERM (Natl. Inst. Hlth. & Med. Res.) EP 1 074 842
Modulating Factor VIII degradation
Catalytic anti-Factor VIII allo-antibodies; for degradation of Factor VIII and modulation of this process.
Introgene WO 01/07571
Adenoviral vector complementation
Cells having a gene encoding adenovirus E2A; for complementing adenovirus vectors in gene therapy.
Iowa State Univ. WO 01/07664
Mapping genetic traits
Identifying and mapping genomic markers that contribute to specific genetic traits; for assigning gene function.
Isis Pharma WO 01/07456, 07457, 07461, 07594, 07655 & 07656
Jun N-terminal kinase-1, PTEN, MEKK1, MEKK5, SHP-1, and SHP-2 antisense; for modulating gene expression.
Johns Hopkins Univ. WO 01/07610
Polyamide-modulated factor 1
Polyamide-modulated factor 1, encoding gene sequences, antibodies; for gene expression modulation.
Knoll WO 01/07617
Human homolog of bovine neuroendocrine secretory protein, encoding gene sequences; for obesity therapeutics.
Large Scale Biology WO 01/07613
Enhancing protein production
Methods for enhancing protein production using non-native 5' untranslated sequences in recombinant viral nucleic acids.
Lexigen Pharma WO 01/07081
Fusing selected antigens to immunoglobulin heavy chain constant regions; for enhancing immunogenicity.
Lion Bioscience EP 1 074 633
Sequencing GC-rich templates
Modified deoxy guanosine triphosphates; for cycle sequencing of GC-rich templates.
L'Oreal WO 01/07604
Skin calcium-binding protein
Calcium-fixing protein family member from the horny layer of skin, encoding gene; for treating skin disease.
Massachusetts, Univ. of WO 01/07466
Eg2 kinase-blocking polypeptides, encoding gene sequences, antibodies; for diagnostics and therapeutics.
Massachusetts, Univ. of WO 01/07481
Hematopoietic tumor protein
Antibodies that bind to a 40 kD protein expressed in hematopoietic tumors; for diagnostics and therapeutics.
Mass. Gen. Hosp. WO 01/07654
Circadian rhythm modulators
Methods for identifying compounds that modulate circadian rhythm by affecting CRY and PER2 protein function.
MRC (Med. Res. Counc.) WO 01/07478
Artificial chromosome transgenics
Transgenics having artificial chromosome vectors expressing pituitary adenyl cyclase activating peptide receptor.
Mistle Biotech EP 1 074 560
Enhancing immune response
Kyonsangbuk-do, S. Korea
Crude and purified extracts from Korean mistletoe; for enhancement of immune responses.
Nova Molecular WO 01/07644
Paraoxonase 1 genotyping
Genotyping of the paraoxonase 1 gene; for diagnosing disease risk and qualifying clinical trial participants.
Olympus Optical WO 01/07919
Hormone receptor ligand assay
Methods for examining substances interacting with hormone receptors using labelled receptors.
Ono Pharma EP 1 074 622
Smooth muscle growth protein
Protein causing inhibition of vascular smooth muscle cell growth, encoding gene; for therapeutics.
Osaka Univ. Microbial Dis. Res. Fdn. EP 1 074 624
Chicken pox vaccines
Attenuated chicken pox virus gene; for identifying strains appropriate for vaccines.
Otsuka Pharma EP 1 074 621
Lung cancer-related gene
Lung cancer-related gene, encoded protein; for cancer therapy and apoptosis modulation.
Pasteur Inst. EP 1 074 634
Alzheimer's disease diagnosis
Assay for ApoE gene alleles characteristic of Alzheimer's disease sufferers; for diagnostics and therapeutics.
Penula, P.A.J., et al. EP 1 074 619
Neuropeptide FF promoter
Neuropeptide FF promoter; for attachment to structural genes to make transgenics and perform gene therapy.
Phylos WO 01/07657
Ligating peptide acceptors to RNAs
Methods and reagents for the ligation of peptide acceptors to RNAs.
Princeton Univ. WO 01/07659
Signaling molecule inhibitors
Methods for identifying cellular responses attributable to signaling molecule inhibition and inhibitors.
Promega WO 01/07580
Nucleoside diphosphate kinase
Thermostable nucleoside diphosphate kinase, purification methods; for nucleic acid detection.
Salk Inst. Biol. Studies WO 01/07579
Polyketide synthase modulator screen
La Jolla, Calif.
Crystallized polyketide synthases, encoding gene sequences; for identifying substrates and modulators.
Schering WO 01/06849
Kaposi's sarcoma transgenics
Transgenics having a constitutively active G-protein coupled receptor that produces Kaposi's sarcoma-like symptoms.
Sheffield, Univ. of WO 01/07605
Transfected CD154 ligand gene
CD154 ligand gene transfected into non-CD154 expressing cells; for organ transplantation therapeutics.
Singapore Republic WO 01/07652
Detecting hepatitis B mutants
Detection of human hepatitis B virus surface antigen mutants by specific amplification and the use of gene chips.
Smith, S. WO 01/07637
Attenuated HIV vaccines
Essex Falls, N.J.
HIV virus that can only replicate in the presence of tetracycline analogs; for attenuated HIV vaccines.
SmithKline Beecham EP 1 074 623
Bacterial ABC transporter, encoding gene, recombinant production methods; for antibacterial screens.
SmithKline Beecham WO 01/07458, 07460, 07463 & 07465
Bacterial lacR, fucR, treR, and galR proteins, encoding gene sequences, production methods; for antibacterial screens.
SmithKline Beecham WO 01/07482, 07606 & 07609
G-protein coupled receptors
G-protein coupled receptors, encoding genes, recombinant production methods; for diagnostics and therapeutics.
Southern California, Univ. of WO 01/07059
Matrix-targeted fusion polypeptides; for tissue regeneration and wound healing.
Sumitomo Pharma EP 1 074 267
Inducing T cells
Induction of antigen-specific T cells using a combination of specific antigens and interferon.
Takara Shuzo WO 01/07593
DNA chip having aligned nucleic acid sequences immobilized under denaturing conditions.
U.S. Agriculture Dept. WO 01/07633
Sequential directional cloning
Sequential directional cloning of multiple DNA sequences within a single vector using PCR-based techniques.
Utah, Univ. of WO 01/07638
Salt Lake City
Double-labelled protein biomolecular substrates for homogeneous fluorescence detection of proteases.
Vermicon WO 01/07649
Methods for detecting microorganisms using specific nucleic acid probes.
Virginia, Univ. of WO 01/07083
Recombinant antibody directed against a human sperm cell surface antigen; for contraception.
Wake Forest Univ. WO 01/07663
Periodontal disease gene mutations
CTSC gene mutations associated with palmoplantar keratodermas and dysplasia and other periodontal diseases.
Yeda Res. & Develop. WO 01/07480
IL-18 inhibitors for metastases
Use of interleukin-18 inhibitors for the therapy of tumor metastases.
Zeneca WO 01/07639
Selectable marker gene
Transfection of cells with the glyoxalase I gene; for selection with toxins.