February 7 (EP), February 1 (WO)

Affymetrix WO 01/07464

Preserving gene ratios

Santa Clara, Calif.

Even length proportional amplification of nucleic acids that preserves the relative proportions of gene sequences.

Ajinomoto EP 1 074 564

von Willebrand factor binding assay

Tokyo

Immobilized von Willebrand factor; for detecting modulation of its binding to glycoprotein Ib.

Albert Einstein Coll. Med. WO 01/07627

Recombination-associated protein

Bronx, N.Y.

Drosophila recombination-associated protein, encoding gene sequences; for making knockouts and gene therapy vectors.

Amgen WO 01/07074 & 07477

VGF peptides

Thousand Oaks, Calif.

VGF peptides and selective binding agents, recombinant production methods; for diagnostics and therapeutics.

Arrow Therapeutics WO 01/07651

Determining essential genes

Carshalton, UK

Transposon-mediated differential hybridization for determining essential genes.

Artus Molec. Biol. Diagnostics Inst. WO 01/07648

Detection of sepsis inducers

Hamburg, Germany

Species-specific detection of prokaryotes and eukaryotes; for finding sepsis inducers.

Aventis Pharma WO 01/07602

Human eg5 antisense

Frankfurt, Germany

Oligonucleotides to a defined part of human eg5 gene or a mutated form; for expression inhibition.

Becton Dickinson WO 01/07642

Culture media formulation

Franklin Lakes, N.J.

Software and devices for computer-assisted formulation of optimized culture media.

British Secretary of State WO 01/07640 & 07650

SNP analysis methods

Birmingham, UK

Enhanced sensitivity and specificity in methods for analyzing single nucleotide polymorphisms.

California, Univ. of WO 01/07084

Drug delivery fusions

Oakland, Calif.

Anti-growth factor receptor avidin fusion proteins; for drug delivery via antibody receptor-mediated endocytosis.

California, Univ. of WO 01/07572

Stable gene integration

Oakland, Calif.

Specific and stable integration of genes into eukaryotic cells using a bacteriophage recombination system.

California, Univ. of WO 01/07583-07585

Cell membrane analysis

Oakland, Calif.

Cell membrane and tissue analysis via controlled electroporation.

California, Univ. of WO 01/07653

Biomolecule biosensor

Oakland, Calif.

Flow-through microchannel biosensor for the detection of multiple, different nucleic acids or protein targets.

California, Univ. of WO 01/07660

Ataxia telangiectasia SNPs

Oakland, Calif.

Automated methods for detection of ataxia telangiectasia mutations and single nucleotide polymorphisms.

Ctr. Genetic Engineer. & Biotech EP 1 074 561

Treating endotoxin disorders

Havana, Cuba

Analogs of lipopolysaccharide-binding protein; for treating endotoxin-associated disorders.

Children's Hosp. WO 01/07598

Tagged cDNA library for cloning

Boston

Expression cloning using cDNA constructs expressing a tagged polypeptide having a biological activity of interest.

Chiron WO 01/07614

Adenocarcinoma-related genes

Emeryville, Calif.

Genes differentially expressed in adenocarcinomas, encoded proteins, antibodies; for diagnostics and therapeutics.

Chugai EP 1 074 268

Intestinal disease antibodies

Tokyo

Therapeutics for inflammatory intestinal diseases that include interleukin-6 receptor antibodies.

Cincinnati, Univ. of WO 01/06910

_2-adrenergic receptor gene polymorphisms

Cincinnati, Ohio

Assay for polymorphisms in the _2-adrenergic receptor gene; for measuring drug response variation.

Clinical Micro Sensors WO 01/07665

Sequence determination methods

Pasadena, Calif.

Sequence determination of nucleic acids using self-assembled monolayers and electronic detection methods.

Connaught Labs WO 01/07619

Moraxella outer membrane protein

Toronto

Recombinant high molecular weight major outer membrane protein of Moraxella, encoding gene; for vaccines.

CuraGen WO 01/07595

FGF-CX

New Haven, Conn.

Fibroblast growth factor-CX, encoding gene, variants, mutants, fragments, antibodies; for therapeutics.

Dade Behring EP 1 074

Monkey lentivirus

Marburg, Germany

Monkey lentivirus, encoded proteins, fragments; for diagnostics and therapeutics [in German].

Daiichi EP 1 074 562

Blood clotting therapeutic

Tokyo

Thrombin-antithrombin III complex monoclonal antibodies; for diagnosing and treating blood clotting disorders.

DCV WO 01/07472

Cytokine activating factor

Wilmington, Del.

Highly purified cytokine activating factor, encoding gene sequences; for immune system and cancer therapeutics.

Diacrin WO 01/07568

Muscle cell transplants

Charlestown, Mass.

Transplantable skeletal muscle cells; for cardiac repair in congestive heart failure.

Diagnostic Products WO 01/07616

Endometriosis autoantigens

Los Angeles

Gene sequences encoding autoantigens associated with endometriosis, encoded proteins; for diagnostics.

Doheny Eye Inst. EP 1 074 618

Cadherins

Los Angeles

Cadherins 4 to 12, encoding genes, antibodies, recombinant production methods; for developing therapeutics.

Electrochemical Industry Consortium WO 01/07620

Protein production system

Munich, Germany

Mushroom pyrF gene, encoded protein; for use as a marker in expressing heterologous genes in fungi.

Epigenomics WO 01/07647

Gene methylation assay

Berlin

Methods for relative quantitation of the methylation of cytosine-type bases in DNA samples.

Estivill Palleja, X. WO 01/06848

Psychiatric disorder transgenics

Barcelona, Spain

Transgenic mice that overexpress the NTRK3 gene located on chromosome 15; for studying psychiatric disorders.

Fbit WO 01/07483

Cancer antibodies

Ramat Gan, Israel

Antibodies that bind to phosphorylated Met protein; for cancer diagnostics and therapeutics.

Gen-Probe WO 01/07661

Template-specific amplification

San Diego

Enzyme-based polynucleotide template-specific amplification methods; for improved reaction yields.

Genaissance Pharma WO 01/07662

Drug target isogenes

New Haven, Conn.

Polymorphisms in the prostaglandin-endoperoxide synthase 2 gene; for identifying drug target isogenes.

Genentech WO 01/07599

Plasmid DNA purification

S. San Francisco

Methods for RNase- and organic solvent-free purification of plasmid DNA using tangential flow filtration.

Genentech WO 01/07611

Proteins

S. San Francisco

Proteins, encoding gene sequences, chimeras, antibodies; for diagnostics and therapeutics.

Glaxo WO 01/07082

Cell growth arrest

Greenford, UK

Anti-Ep-cellular adhesion molecule antibodies combined with a chemotherapeutic agent; for stopping cell growth.

Heinkelein, M., et al. WO 01/07646

Finding antivirals

Wurzburg, Germany

Transfecting cells with viral vectors and treating them with putative antivirals; for finding therapeutics.

Helix Res. Inst. WO 01/07607

Progenitor cell genes

Chiba, Japan

Full length cDNA clones isolated from progenitor cells, encoded proteins; for diagnostics and therapeutics.

Heme-Biotech WO 01/07065

Treating porphyric disease

Hillerod, Denmark

Production of rhPBGD for treating a deficiency in the heme biosynthetic pathway for porphyric disease therapy.

Henkel WO 01/07631

Glycosyltransferase

Dusseldorf, Germany

Glycosyltransferase, encoding gene sequences, derivatives, fragments, production methods; for making glycosides.

Human Genome Sciences WO 01/07459

29 secreted proteins

Rockville, Md.

29 human secreted proteins, encoding genes, antibodies, production methods; for diagnostics and therapeutics.

Human Genome Sciences WO 01/07476

Human prostate proteins

Rockville, Md.

25 human prostate and prostate cancer associated proteins, encoding genes, antibodies; for diagnostics/therapeutics.

Human Genome Sciences WO 01/07608

Keratinocyte-derived interferon

Rockville, Md.

Keratinocyte-derived interferon, encoding gene sequences; for finding modulators and developing therapeutics.

Human Genome Sciences WO 01/07658

ABC transporter

Rockville, Md.

Human ABC transporter, encoding gene sequences, antibodies, recombinant production methods; for therapeutics.

HyGene EP 1 074 620

TGF-_ superfamily protein

Neuhausen am Rheinfall, Switzerland

Monomeric protein of the TGF-_ superfamily, encoding gene sequences; for diagnostics and therapeutics.

Imperial Coll. Innovations WO 01/07479

Prion disease therapeutics

London

Peptides, binding agents, and antibodies useful in diagnosing and treating prion diseases.

Incyte Genomics WO 01/07470

Nervous system-associated proteins

Palo Alto, Calif.

Human nervous system-associated proteins, encoding genes, antibodies, modulators; for diagnostics and therapeutics.

Incyte Genomics WO 01/07471

Cell cycle proteins

Palo Alto, Calif.

Cell cycle and proliferation proteins, encoding genes, antibodies, modulators; for diagnostics and therapeutics.

Incyte Genomics WO 01/07612

Receptors and associated proteins

Palo Alto, Calif.

Human receptors and associated proteins, encoding gene sequences, antibodies, modulators; for therapeutics.

Incyte Genomics WO 01/07628

Human synthetases

Palo Alto, Calif.

Human synthetases, encoding gene sequences, antibodies, modulators; for diagnostics and therapeutics.

Inst. Genomic Res. WO 01/07587-07589, 07591, 07621, 07622, 07624 & 07629

Pseudomonas genes

Rockville, Md.

Gene sequences from several Pseudomonas species, encoded proteins; for designing diagnostics and therapeutics.

INSERM (Natl. Inst. Hlth. & Med. Res.) EP 1 074 842

Modulating Factor VIII degradation

Paris

Catalytic anti-Factor VIII allo-antibodies; for degradation of Factor VIII and modulation of this process.

Introgene WO 01/07571

Adenoviral vector complementation

Leiden, Netherlands

Cells having a gene encoding adenovirus E2A; for complementing adenovirus vectors in gene therapy.

Iowa State Univ. WO 01/07664

Mapping genetic traits

Ames, Iowa

Identifying and mapping genomic markers that contribute to specific genetic traits; for assigning gene function.

Isis Pharma WO 01/07456, 07457, 07461, 07594, 07655 & 07656

Antisense modulation

Carlsbad, Calif.

Jun N-terminal kinase-1, PTEN, MEKK1, MEKK5, SHP-1, and SHP-2 antisense; for modulating gene expression.

Johns Hopkins Univ. WO 01/07610

Polyamide-modulated factor 1

Baltimore

Polyamide-modulated factor 1, encoding gene sequences, antibodies; for gene expression modulation.

Knoll WO 01/07617

Obesity therapeutics

Ludwigshafen, Germany

Human homolog of bovine neuroendocrine secretory protein, encoding gene sequences; for obesity therapeutics.

Large Scale Biology WO 01/07613

Enhancing protein production

Vacaville, Calif.

Methods for enhancing protein production using non-native 5' untranslated sequences in recombinant viral nucleic acids.

Lexigen Pharma WO 01/07081

Enhancing immunogenicity

Lexington, Mass.

Fusing selected antigens to immunoglobulin heavy chain constant regions; for enhancing immunogenicity.

Lion Bioscience EP 1 074 633

Sequencing GC-rich templates

Heidelberg, Germany

Modified deoxy guanosine triphosphates; for cycle sequencing of GC-rich templates.

L'Oreal WO 01/07604

Skin calcium-binding protein

Paris

Calcium-fixing protein family member from the horny layer of skin, encoding gene; for treating skin disease.

Massachusetts, Univ. of WO 01/07466

Kinase-blocking peptides

Boston

Eg2 kinase-blocking polypeptides, encoding gene sequences, antibodies; for diagnostics and therapeutics.

Massachusetts, Univ. of WO 01/07481

Hematopoietic tumor protein

Boston

Antibodies that bind to a 40 kD protein expressed in hematopoietic tumors; for diagnostics and therapeutics.

Mass. Gen. Hosp. WO 01/07654

Circadian rhythm modulators

Boston

Methods for identifying compounds that modulate circadian rhythm by affecting CRY and PER2 protein function.

MRC (Med. Res. Counc.) WO 01/07478

Artificial chromosome transgenics

London

Transgenics having artificial chromosome vectors expressing pituitary adenyl cyclase activating peptide receptor.

Mistle Biotech EP 1 074 560

Enhancing immune response

Kyonsangbuk-do, S. Korea

Crude and purified extracts from Korean mistletoe; for enhancement of immune responses.

Nova Molecular WO 01/07644

Paraoxonase 1 genotyping

Montreal

Genotyping of the paraoxonase 1 gene; for diagnosing disease risk and qualifying clinical trial participants.

Olympus Optical WO 01/07919

Hormone receptor ligand assay

Tokyo

Methods for examining substances interacting with hormone receptors using labelled receptors.

Ono Pharma EP 1 074 622

Smooth muscle growth protein

Osaka, Japan

Protein causing inhibition of vascular smooth muscle cell growth, encoding gene; for therapeutics.

Osaka Univ. Microbial Dis. Res. Fdn. EP 1 074 624

Chicken pox vaccines

Osaka, Japan

Attenuated chicken pox virus gene; for identifying strains appropriate for vaccines.

Otsuka Pharma EP 1 074 621

Lung cancer-related gene

Tokyo

Lung cancer-related gene, encoded protein; for cancer therapy and apoptosis modulation.

Pasteur Inst. EP 1 074 634

Alzheimer's disease diagnosis

Lille, France

Assay for ApoE gene alleles characteristic of Alzheimer's disease sufferers; for diagnostics and therapeutics.

Penula, P.A.J., et al. EP 1 074 619

Neuropeptide FF promoter

Jorvas, Finland

Neuropeptide FF promoter; for attachment to structural genes to make transgenics and perform gene therapy.

Phylos WO 01/07657

Ligating peptide acceptors to RNAs

Lexington, Mass.

Methods and reagents for the ligation of peptide acceptors to RNAs.

Princeton Univ. WO 01/07659

Signaling molecule inhibitors

Princeton, N.J.

Methods for identifying cellular responses attributable to signaling molecule inhibition and inhibitors.

Promega WO 01/07580

Nucleoside diphosphate kinase

Madison, Wis.

Thermostable nucleoside diphosphate kinase, purification methods; for nucleic acid detection.

Salk Inst. Biol. Studies WO 01/07579

Polyketide synthase modulator screen

La Jolla, Calif.

Crystallized polyketide synthases, encoding gene sequences; for identifying substrates and modulators.

Schering WO 01/06849

Kaposi's sarcoma transgenics

Kenilworth, N.J.

Transgenics having a constitutively active G-protein coupled receptor that produces Kaposi's sarcoma-like symptoms.

Sheffield, Univ. of WO 01/07605

Transfected CD154 ligand gene

Sheffield, UK

CD154 ligand gene transfected into non-CD154 expressing cells; for organ transplantation therapeutics.

Singapore Republic WO 01/07652

Detecting hepatitis B mutants

Singapore

Detection of human hepatitis B virus surface antigen mutants by specific amplification and the use of gene chips.

Smith, S. WO 01/07637

Attenuated HIV vaccines

Essex Falls, N.J.

HIV virus that can only replicate in the presence of tetracycline analogs; for attenuated HIV vaccines.

SmithKline Beecham EP 1 074 623

Antibacterial screen

Philadelphia

Bacterial ABC transporter, encoding gene, recombinant production methods; for antibacterial screens.

SmithKline Beecham WO 01/07458, 07460, 07463 & 07465

Antibacterial screens

Philadelphia

Bacterial lacR, fucR, treR, and galR proteins, encoding gene sequences, production methods; for antibacterial screens.

SmithKline Beecham WO 01/07482, 07606 & 07609

G-protein coupled receptors

Philadelphia

G-protein coupled receptors, encoding genes, recombinant production methods; for diagnostics and therapeutics.

Southern California, Univ. of WO 01/07059

Matrix-targeted fusions

Los Angeles

Matrix-targeted fusion polypeptides; for tissue regeneration and wound healing.

Sumitomo Pharma EP 1 074 267

Inducing T cells

Osaka, Japan

Induction of antigen-specific T cells using a combination of specific antigens and interferon.

Takara Shuzo WO 01/07593

DNA chip

Kyoto, Japan

DNA chip having aligned nucleic acid sequences immobilized under denaturing conditions.

U.S. Agriculture Dept. WO 01/07633

Sequential directional cloning

Washington, D.C.

Sequential directional cloning of multiple DNA sequences within a single vector using PCR-based techniques.

Utah, Univ. of WO 01/07638

Protease assay

Salt Lake City

Double-labelled protein biomolecular substrates for homogeneous fluorescence detection of proteases.

Vermicon WO 01/07649

Microorganism probes

Munich, Germany

Methods for detecting microorganisms using specific nucleic acid probes.

Virginia, Univ. of WO 01/07083

Sperm antibodies

Charlottesville, Va.

Recombinant antibody directed against a human sperm cell surface antigen; for contraception.

Wake Forest Univ. WO 01/07663

Periodontal disease gene mutations

Winston-Salem, N.C.

CTSC gene mutations associated with palmoplantar keratodermas and dysplasia and other periodontal diseases.

Yeda Res. & Develop. WO 01/07480

IL-18 inhibitors for metastases

Rehovot, Israel

Use of interleukin-18 inhibitors for the therapy of tumor metastases.

Zeneca WO 01/07639

Selectable marker gene

London

Transfection of cells with the glyoxalase I gene; for selection with toxins.

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