December 6 & 13 (EP & GB), November 30 & December 7 (WO)

Agrochemical Res. Ctr. EP 1 057 892

Pathogenic E. coli assay

Brussells, Belgium

Attenuated mammalian enterpathogenic E. coli strains having deleted intimin genes; for diagnostics and therapeutics.

Alabama, Univ. of WO 00/72803

Streptococcus vaccines

Birmingham, Ala.

Mutant Streptococcus pneumoniae strains having reduced levels of capsular polysaccharides; for attenuated vaccines.

American Red Cross WO 00/71714

Factor VIII variants

Falls Church, Va.

Increasing Factor VIII half-life by substituting amino acid residues in the A2 or C2 domains; for enhanced therapeutics.

Aventis Pharma WO 00/71710

Cholesterol metabolism modulation

Antony, France

Chromosome 9 genes associated with cholesterol metabolism, encoded proteins, antibodies; for disease treatment.

Aventis Pharma WO 00/71747 & 71749

Finding binding partners

Frankfurt, Germany

Detection system using nucleic acids bound to solid supports; for identifying binding partners.

Aventis Pharma WO 00/71756

Mathematical expression analysis

Bridgewater, N.J.

Bayesian-based mathematical analysis for the estimation of changes in the levels of gene expression.

Avi Biopharma WO 00/71706

c-myc antisense

Corvallis, Ore.

Antisense oligonucleotides to c-myc; for treating polycystic kidney disease.

Bayer WO 00/71744

Staphylococcus antimicrobial assays

Leverkusen, Germany

Staphylococcus aureus fmhB protein, encoding gene sequences; for finding homologs and developing antimicrobials.

Benju Pharma EP 1 059 353

Retinal calpain

Osaka, Japan

Calpain specifically expressed in the retina of the eye, encoding gene sequences, production methods.

Bieger, W., et al. EP 1 058 116

Lymphocyte reactive antigens

Munich, Germany

Antigens that react with lymphocytes; for finding allergens and cell proliferation factors [in German].

Bio Merieux WO 00/71750

Polymorphism assay

Marcy l'Etoile, France

Analyzing genetic predisposition to disease by low resolution, followed by high resolution, SNP hybridization.

Biomethodes WO 00/71730

Vector gene insertion

Evry, France

Methods for inserting nucleic acid fragments into vectors using matrices, hybridization, and PCR.

Boehringer Ingelheim WO 00/72666

Inhibiting myeloid cell growth

Ingelheim, Germany

Transgenic mice lacking JunB expression in myeloid cell lineages; for finding inhibitors of myeloid cell growth.

Cambridge Antibody Technol. GB 2 350 612

TGF-_ antibody fragments

Royston, U.K.

Antibody variable domains as binding partners of transforming growth factor-_; for immune therapeutics.

Canji WO 00/71718

Pulmonary disease treatment

San Diego

Use of recombinant vectors expressing viral interleukin-10 to treat pulmonary inflammatory diseases.

Cell Genesys WO 00/72686

Systemic immune response regulation

Foster City, Calif.

Regulating of systemic immune responses to tumors utilizing cytokines and antigens.

Cell Genesys WO 00/73316

Modified viral capsids

Foster City, Calif.

Modified viral capsid polypeptides that bind to antibodies or block virus binding; for enhanced transduction.

CNRS (Natl. Ctr. Sci. Res.) WO 00/71578

Fusion defective virus rescue


Surface subunit polypeptides from viral envelope glycoproteins; for rescuing fusion defective viruses.

CNRS (Natl. Ctr. Sci. Res.) WO 00/71734

Starch granules for therapeutics


Starch granules containing a starch synthase-recombinant protein fusion; for making pharmaceutical compositions.

Chugai Res. Inst. Molec. Med. WO 00/72670

Cancer knockouts

Ibaraki, Japan

Knockouts that have period- and tissue-specific disruption of LKB1 expression; for Peutz-Jeghers and cancer therapy.

Chiron WO 00/71725

Neisseria vaccines

Siena, Italy

Fusion proteins from Neisseria meningitidis and Neisseria gonorrhoeae, encoding gene sequences; for vaccines.

Connex WO 00/71698

Neutralizing enzyme inhibitors

Martinsried, Germany

Mixtures of albumin, spermidine, and antibodies for neutralizing enzyme inhibitors in reaction vessels.

Curie, Univ. Pierre & Marie EP 1 059 357

Gene delivery vehicle


Replicating and semi-replicating retroviral constructs, preparation methods; for gene delivery.

Dana-Farber Cancer Inst. WO 00/72886

Episomal lentiviral vectors


Episomally replicating lentiviral vectors with targeting sequences and without gag/pol and env in the same vector.

Eisai WO 00/71743

Mammalian two-hybrid system


Two-hybrid assay methods in mammalian cells using reporter genes and transcriptional activators.

Hickman, J.J. WO 00/71742

Neural modulator assay

Falls Church, Va.

High-throughput functional genomics assay using electrically active cells as reporters; for finding neural modulators.

Human Genome Sciences WO 00/71152


Rockville, Md.

Fibroblast growth factor-10, encoding gene, antibodies, recombinant production methods; for therapeutics.

Human Genome Sciences WO 00/71577

Anti-angiogenic proteins

Rockville, Md.

Thrombospondin-related anti-angiogenic proteins, encoding genes, production methods; for diagnostics and therapeutics.

Human Genome Sciences WO 00/71582


Rockville, Md.

Fibroblast growth factor-14, encoding gene, antibodies, recombinant production methods; for therapeutics.

Human Genome Sciences WO 00/71584

Seven transmembrane receptors

Rockville, Md.

Seven transmembrane receptors, encoding genes, antibodies, production methods; for diagnostics and therapeutics.

Human Genome Sciences WO 00/71715


Rockville, Md.

Fibroblast growth factor-11, encoding gene, antibodies, recombinant production methods; for therapeutics.

Human Genome Sciences WO 00/73321

TNF receptor TR10

Rockville, Md.

Human tumor necrosis factor receptor TR10, encoding gene, antibodies, production methods; for therapeutics.

Hyseq WO 00/71719

Fetal chemokine

Sunnyvale, Calif.

Chemokine obtained from a cDNA library of fetal liver-spleen, encoding gene sequences.

Hyseq WO 00/73320

IL-1 receptor antagonist

Sunnyvale, Calif.

Interleukin-1 receptor antagonist, IL-1 Hy2, encoding gene sequences; for developing therapeutics.

Immunex WO 00/71720

IL-1 eta


Interleukin-1 eta, encoding gene sequences, fragments, antibodies, production methods; for therapeutics.

Incyte Genomics WO 00/71679

Human oxidoreductases

Palo Alto, Calif.

Human oxidoreductase proteins, encoding gene sequences, antibodies, modulators; for developing therapeutics.

INSERM (Natl. Inst. Hlth. & Med. Res.) WO 00/71708

Smooth muscle disease agents


Antisense and antibodies that inhibit the activity or expression of EF-Ts; for treating smooth muscle diseases.

INSERM (Natl. Inst. Hlth. & Med. Res.) WO 00/71709

GABA polypeptide carriers


Polypeptide carriers for GABA, encoding gene sequences, screens for modulators of amino acid transport.

Interleukin Genetics WO 00/71753

Restenosis predisposition

San Antonio

Methods for determining the predisposition to restenosis using gene mutation analysis.

Japanese Agency Ind. Sci. & Technol. WO 00/71700

Analyzing viral genes


Methods for separating, fractionating, and analyzing genes from viruses in water.

Jomaa, H. WO 00/72022

Antifungal assays

Giessen, Germany

Using genes of the deoxy-D-xylulose biosynthetic pathway to alter isoprenoid concentrations; for finding antifungals.

Karolinska Innovations WO 00/70945

Fatty acid elongation genes

Stockholm, Sweden

Fatty acid elongation genes, encoded proteins; for developing skin and eye disorder therapeutics.

Kyowa Hakko Kogyo WO 00/71712

Transcriptional elongation promotion


Promoting transcriptional elongation by transfecting a vector containing the DSIF gene into cells.

Life Technol. WO 00/71757

Nucleic acid labelling

Rockville, Md.

Fluorescent labelling of nucleic acid molecules using reverse transcriptases; for diagnostics.

Lohmann Animal Hlth. EP 1 057 895

Shiga toxin fusions

Cuxhaven, Germany

Fusion proteins using Shiga toxin fragment B that also have terminal tags; for diagnostics and therapeutics [in German].

Lu, Z. WO 00/71746

Microchip production

Jiangsu, China

Methods for making microchips using micro reaction chamber fixed point synthesis, produced microchips.

Ludwig Inst. Cancer Res. WO 00/72021

Cancer-associated antigens

New York

Identification of cancer-associated antigens by autologous antibody screening of breast cancer nucleic acid libraries.

Max Planck Inst. WO 00/71682

Crystallized gingipain R

Munich, Germany

Crystal structure of the cysteine protease gingipain R; for the design of inhibitors.

Mayo Fdn. WO 00/71576

Brain natriuretic peptide delivery

Rochester, Minn.

Adenoviral vectors encoding brain natriuretic peptide; for treating heart failure.

Mayo Fdn. WO 00/71726

Xenotransplant virus transmission

Rochester, Minn.

Methods and compositions for inhibiting infectious agent transmission during xenotransplantation.

Medarex WO 00/71585

Staphylococcus antibodies

Annandale, N.J.

Human antibodies to methicillin-resistant Staphylococcus aureus produced in non-human animals; for therapeutics.

MRC (Med. Res. Counc.) GB 2 350 613

Gene insertion vectors


Yeast artificial chromosome vectors with replication origins that are flanked by LoxP elements; for gene insertion.

MRC (Med. Res. Counc.) WO 00/71692

Refolding thrombin


Methods for correctly refolding thrombin and its precursors by using molecular chaperones and a foldase.

Methylgene WO 00/71703

Preventing cell growth induction

St. Laurent, Que.

Antisense oligonucleotides that inhibit histone deacetylase; for preventing induction of cell proliferation.

Mt. Sinai Sch. Med. WO 00/72887

Adenovirus packaging vectors

New York

Packaging cell line for the rescue, production, and titration of high-capacity adenovirus amplicon vectors.

Myriad Genetics WO 00/71751

Diabetes polymorphisms

Salt Lake City, Utah

Assay for polymorphisms in the angiotensinogen gene; for diagnosing insulin-dependent diabetes.

Nebraska, Univ. of WO 00/70944

Estrogen-induced cancer models

Lincoln, Neb.

Transgenic animals having modified genetic loci associated with estrogen-induced cancers; for making model systems.

New England Biolabs WO 00/71701

Generating split genes

Beverly, Mass.

Methods for generating split genes that can express active protein products but are not transferable to other cells.

New Jersey, Univ. of Med. & Dent. of WO 00/71678

Lentiviral vector packaging cells

New Brunswick, N.J.

Ecdysone-inducible packaging cell lines for lentiviral vectors; for gene therapy and in vitro screening assays.

New Jersey, Univ. of Med. & Dent. of WO 00/71754

Schizophrenia susceptibility

New Brunswick, N.J.

Methods for identifying individuals genetically susceptible to schizophrenia; for diagnosis and therapy.

New York Univ. WO 00/71671

Mutant amyloid protein precursors

New York

Mutant amyloid protein precursors and their genes that are associated with Familial British and Danish Dementias.

Oncodia EP 1 059 352

Human carcinoma culture

Zurich, Switzerland

Methods for longterm culture of human squamous carcinoma from the head and neck.

Ortho-McNeil Pharma WO 00/71741

Serotonin receptor modulators

Raritan, N.J.

Gene sequences encoding the B subunit of the human 5-HT serotonin receptor, encoded subunit; for finding modulators.

Oxford BioMedica WO 00/71693

Selecting retroviral vectors

Oxford, U.K.

Methods for selecting retroviral vectors having improved packaging efficiency by mutation introduction.

Oxford BioMedica WO 00/71737

Retroviral vector production

Oxford, U.K.

Inhibiting the production of envelope protein receptor in retroviral producer cells; for retroviral vector production.

Panorama Res. WO 00/71702

Interaction-activated proteins

Mountain View, Calif.

Fragment pairs of Class A _-lactamase that depend upon heterologous proteins for their functional reassembly.

Phage Biotech WO 00/71731

Targeted protein synthesis

Irvine, Calif.

Infecting recombinant bacteria with phages having genes that target proteins; for increased targeted protein synthesis.

Photogen WO 00/73319

Protein yield increase

Knoxville, Tenn.

Methods and cell lines for enhanced protein stabilization and production; for increasing protein yields.

Phylos WO 00/72869

Nucleic acid-protein conjugates

Lexington, Mass.

Methods for generating 5'-nucleic acid-protein conjugates; for therapeutics.

Portsmouth, Univ. of WO 00/71681

Polynucleotide motor

Portsmouth, U.K.

Polynucleotide motor associated with a substance that can be bound to it; for ligand assays.

Praelux WO 00/71755

Amptamer-based sequencing

Lawrenceville, N.J.

Sequencing and characterizing nucleic acids using aptamers, methods of producing aptamers.

Prendergast, P.T. WO 00/72868

Immune system disease therapy

Straffan, Ireland

Peptides effective in diseases associated with elevated TNF, IL-1/2, and IFN levels; for immune system therapeutics.

Roche Diagnostics WO 00/71723

Regulating protein conformation

Mannheim, Germany

Methods for regulating protein conformation and avoiding misfolding and aggregation using molecular chaperones.

Rosetta Inpharmatics WO 00/71161

Antifungal drug assays

Kirkland, Wash.

Essential Saccharomyces yeast genes, encoded proteins; for developing antifungal drugs.

Saatchioglu, F. WO 00/71711

Prostate cancer genes

Blindern, Norway

Genes that are differentially expressed in prostate cancer that are identified using subtractive hybridization.

Saksela, K. WO 00/72742

Src homology region binding

Helsinki, Finland

Controlled modification of Src homology region 3 domains to alter binding properties; for diagnostics and therapeutics.

Sankyo WO 00/71697

NF-kappaB stimulation inhibition


Methods for screening for inhibitors of IL-1_ and TNF-a cell stimulation mediated by the NF-kappaB transcription factor.

Schering EP 1 058 117

Finding steroid receptor ligands


Finding ligands that modify SLIM3 binding to androgen or estrogen receptors; for modifying transcription [in German].

Scios WO 00/71713 & 71716

VEGF variants

Sunnyvale, Calif.

Vascular endothelial growth factor variants that have enhanced biological activity, dimers; for therapeutics.

Scripps Res. Inst. WO 00/71694

Combinatorial phage libraries

La Jolla, Calif.

Display of heterodimeric proteins on filamentous phages using pVII/pIX proteins; for making combinatorial libraries.

Singapore Natl. Cancer Ctr. WO 00/71707

Nasopharyngeal cancer therapy


Methods and compositions useful for differential diagnosis and therapy of nasopharyngeal cancer.

SmithKline Beecham WO 00/71568

Staphylococcal antibacterial screens


Staphylococcal ICA operon, encoded proteins, recombinant production methods; for antibacterial screens.

SmithKline Beecham WO 00/71583

IL-1 homolog


Mouse interleukin-1 homolog, encoding gene, recombinant production methods; for diagnostics and therapeutics.

SmithKline Beecham WO 00/71724

BASB polypeptides

Rixensart, Belgium

BASB polypeptides, encoding gene sequences, recombinant production methods; for diagnostics and therapeutics.

SmithKline Beecham WO 00/72863

Epilepsy treatment

Brentford, U.K.

Use of human TREK1 proteins and encoding gene sequences to treat epilepsy and sleep disorders.

Sumitomo Pharma WO 00/71580

Secreted protein libraries

Osaka, Japan

Inducing secretion from cultured cells followed by antibody-based purification; for making secreted protein libraries.

Takeda Chemical EP 1 057 890

Endocrine disrupter antibodies

Osaka, Japan

Monoclonal antibodies to endocrine dirupters or their degradation products; for immunologically-based assays.

Takeda Chemical WO 00/71581

Secretory protein

Osaka, Japan

Secretory protein; for modulator assays to develop immune system therapeutics.

Tanabe EP 1 057 896

PPAR modulators

Osaka, Japan

Identifying modulators of peroxisome proliferator activated receptor (PPAR) using cells having reporter constructs.

Texas, Univ. of WO 00/71752

Tumor tubulin mutations

Austin, Texas

Detection of tubulin mutations in tumor cells that confer paclitaxel resistance; for optimizing chemotherapy.

Vanderbilt Univ. WO 00/73322

Veno-occlusive disease therapy

Nashville, Tenn.

Human carbamyl phosphate synthetase 1 polymorphism; for diagnosing and treating hepatic veno-occlusive disease.

Virginia, Univ. of WO 00/72679

Calcifying cancer cells

Charlottesville, Va.

Osteonectin gene control regions; for making vectors to transfect cancer cells and cause calcification.

ZymoGenetics WO 00/71717

Secreted a-helical protein


Secreted a-helical protein, encoding gene sequences, antibodies; for regulating the immune system.