December 6 & 13 (EP & GB), November 30 & December 7 (WO)
Agrochemical Res. Ctr. EP 1 057 892
Pathogenic E. coli assay
Attenuated mammalian enterpathogenic E. coli strains having deleted intimin genes; for diagnostics and therapeutics.
Alabama, Univ. of WO 00/72803
Mutant Streptococcus pneumoniae strains having reduced levels of capsular polysaccharides; for attenuated vaccines.
American Red Cross WO 00/71714
Factor VIII variants
Falls Church, Va.
Increasing Factor VIII half-life by substituting amino acid residues in the A2 or C2 domains; for enhanced therapeutics.
Aventis Pharma WO 00/71710
Cholesterol metabolism modulation
Chromosome 9 genes associated with cholesterol metabolism, encoded proteins, antibodies; for disease treatment.
Aventis Pharma WO 00/71747 & 71749
Finding binding partners
Detection system using nucleic acids bound to solid supports; for identifying binding partners.
Aventis Pharma WO 00/71756
Mathematical expression analysis
Bayesian-based mathematical analysis for the estimation of changes in the levels of gene expression.
Avi Biopharma WO 00/71706
Antisense oligonucleotides to c-myc; for treating polycystic kidney disease.
Bayer WO 00/71744
Staphylococcus antimicrobial assays
Staphylococcus aureus fmhB protein, encoding gene sequences; for finding homologs and developing antimicrobials.
Benju Pharma EP 1 059 353
Calpain specifically expressed in the retina of the eye, encoding gene sequences, production methods.
Bieger, W., et al. EP 1 058 116
Lymphocyte reactive antigens
Antigens that react with lymphocytes; for finding allergens and cell proliferation factors [in German].
Bio Merieux WO 00/71750
Marcy l'Etoile, France
Analyzing genetic predisposition to disease by low resolution, followed by high resolution, SNP hybridization.
Biomethodes WO 00/71730
Vector gene insertion
Methods for inserting nucleic acid fragments into vectors using matrices, hybridization, and PCR.
Boehringer Ingelheim WO 00/72666
Inhibiting myeloid cell growth
Transgenic mice lacking JunB expression in myeloid cell lineages; for finding inhibitors of myeloid cell growth.
Cambridge Antibody Technol. GB 2 350 612
TGF-_ antibody fragments
Antibody variable domains as binding partners of transforming growth factor-_; for immune therapeutics.
Canji WO 00/71718
Pulmonary disease treatment
Use of recombinant vectors expressing viral interleukin-10 to treat pulmonary inflammatory diseases.
Cell Genesys WO 00/72686
Systemic immune response regulation
Foster City, Calif.
Regulating of systemic immune responses to tumors utilizing cytokines and antigens.
Cell Genesys WO 00/73316
Modified viral capsids
Foster City, Calif.
Modified viral capsid polypeptides that bind to antibodies or block virus binding; for enhanced transduction.
CNRS (Natl. Ctr. Sci. Res.) WO 00/71578
Fusion defective virus rescue
Surface subunit polypeptides from viral envelope glycoproteins; for rescuing fusion defective viruses.
CNRS (Natl. Ctr. Sci. Res.) WO 00/71734
Starch granules for therapeutics
Starch granules containing a starch synthase-recombinant protein fusion; for making pharmaceutical compositions.
Chugai Res. Inst. Molec. Med. WO 00/72670
Knockouts that have period- and tissue-specific disruption of LKB1 expression; for Peutz-Jeghers and cancer therapy.
Chiron WO 00/71725
Fusion proteins from Neisseria meningitidis and Neisseria gonorrhoeae, encoding gene sequences; for vaccines.
Connex WO 00/71698
Neutralizing enzyme inhibitors
Mixtures of albumin, spermidine, and antibodies for neutralizing enzyme inhibitors in reaction vessels.
Curie, Univ. Pierre & Marie EP 1 059 357
Gene delivery vehicle
Replicating and semi-replicating retroviral constructs, preparation methods; for gene delivery.
Dana-Farber Cancer Inst. WO 00/72886
Episomal lentiviral vectors
Episomally replicating lentiviral vectors with targeting sequences and without gag/pol and env in the same vector.
Eisai WO 00/71743
Mammalian two-hybrid system
Two-hybrid assay methods in mammalian cells using reporter genes and transcriptional activators.
Hickman, J.J. WO 00/71742
Neural modulator assay
Falls Church, Va.
High-throughput functional genomics assay using electrically active cells as reporters; for finding neural modulators.
Human Genome Sciences WO 00/71152
Fibroblast growth factor-10, encoding gene, antibodies, recombinant production methods; for therapeutics.
Human Genome Sciences WO 00/71577
Thrombospondin-related anti-angiogenic proteins, encoding genes, production methods; for diagnostics and therapeutics.
Human Genome Sciences WO 00/71582
Fibroblast growth factor-14, encoding gene, antibodies, recombinant production methods; for therapeutics.
Human Genome Sciences WO 00/71584
Seven transmembrane receptors
Seven transmembrane receptors, encoding genes, antibodies, production methods; for diagnostics and therapeutics.
Human Genome Sciences WO 00/71715
Fibroblast growth factor-11, encoding gene, antibodies, recombinant production methods; for therapeutics.
Human Genome Sciences WO 00/73321
TNF receptor TR10
Human tumor necrosis factor receptor TR10, encoding gene, antibodies, production methods; for therapeutics.
Hyseq WO 00/71719
Chemokine obtained from a cDNA library of fetal liver-spleen, encoding gene sequences.
Hyseq WO 00/73320
IL-1 receptor antagonist
Interleukin-1 receptor antagonist, IL-1 Hy2, encoding gene sequences; for developing therapeutics.
Immunex WO 00/71720
Interleukin-1 eta, encoding gene sequences, fragments, antibodies, production methods; for therapeutics.
Incyte Genomics WO 00/71679
Palo Alto, Calif.
Human oxidoreductase proteins, encoding gene sequences, antibodies, modulators; for developing therapeutics.
INSERM (Natl. Inst. Hlth. & Med. Res.) WO 00/71708
Smooth muscle disease agents
Antisense and antibodies that inhibit the activity or expression of EF-Ts; for treating smooth muscle diseases.
INSERM (Natl. Inst. Hlth. & Med. Res.) WO 00/71709
GABA polypeptide carriers
Polypeptide carriers for GABA, encoding gene sequences, screens for modulators of amino acid transport.
Interleukin Genetics WO 00/71753
Methods for determining the predisposition to restenosis using gene mutation analysis.
Japanese Agency Ind. Sci. & Technol. WO 00/71700
Analyzing viral genes
Methods for separating, fractionating, and analyzing genes from viruses in water.
Jomaa, H. WO 00/72022
Using genes of the deoxy-D-xylulose biosynthetic pathway to alter isoprenoid concentrations; for finding antifungals.
Karolinska Innovations WO 00/70945
Fatty acid elongation genes
Fatty acid elongation genes, encoded proteins; for developing skin and eye disorder therapeutics.
Kyowa Hakko Kogyo WO 00/71712
Transcriptional elongation promotion
Promoting transcriptional elongation by transfecting a vector containing the DSIF gene into cells.
Life Technol. WO 00/71757
Nucleic acid labelling
Fluorescent labelling of nucleic acid molecules using reverse transcriptases; for diagnostics.
Lohmann Animal Hlth. EP 1 057 895
Shiga toxin fusions
Fusion proteins using Shiga toxin fragment B that also have terminal tags; for diagnostics and therapeutics [in German].
Lu, Z. WO 00/71746
Methods for making microchips using micro reaction chamber fixed point synthesis, produced microchips.
Ludwig Inst. Cancer Res. WO 00/72021
Identification of cancer-associated antigens by autologous antibody screening of breast cancer nucleic acid libraries.
Max Planck Inst. WO 00/71682
Crystallized gingipain R
Crystal structure of the cysteine protease gingipain R; for the design of inhibitors.
Mayo Fdn. WO 00/71576
Brain natriuretic peptide delivery
Adenoviral vectors encoding brain natriuretic peptide; for treating heart failure.
Mayo Fdn. WO 00/71726
Xenotransplant virus transmission
Methods and compositions for inhibiting infectious agent transmission during xenotransplantation.
Medarex WO 00/71585
Human antibodies to methicillin-resistant Staphylococcus aureus produced in non-human animals; for therapeutics.
MRC (Med. Res. Counc.) GB 2 350 613
Gene insertion vectors
Yeast artificial chromosome vectors with replication origins that are flanked by LoxP elements; for gene insertion.
MRC (Med. Res. Counc.) WO 00/71692
Methods for correctly refolding thrombin and its precursors by using molecular chaperones and a foldase.
Methylgene WO 00/71703
Preventing cell growth induction
St. Laurent, Que.
Antisense oligonucleotides that inhibit histone deacetylase; for preventing induction of cell proliferation.
Mt. Sinai Sch. Med. WO 00/72887
Adenovirus packaging vectors
Packaging cell line for the rescue, production, and titration of high-capacity adenovirus amplicon vectors.
Myriad Genetics WO 00/71751
Salt Lake City, Utah
Assay for polymorphisms in the angiotensinogen gene; for diagnosing insulin-dependent diabetes.
Nebraska, Univ. of WO 00/70944
Estrogen-induced cancer models
Transgenic animals having modified genetic loci associated with estrogen-induced cancers; for making model systems.
New England Biolabs WO 00/71701
Generating split genes
Methods for generating split genes that can express active protein products but are not transferable to other cells.
New Jersey, Univ. of Med. & Dent. of WO 00/71678
Lentiviral vector packaging cells
New Brunswick, N.J.
Ecdysone-inducible packaging cell lines for lentiviral vectors; for gene therapy and in vitro screening assays.
New Jersey, Univ. of Med. & Dent. of WO 00/71754
New Brunswick, N.J.
Methods for identifying individuals genetically susceptible to schizophrenia; for diagnosis and therapy.
New York Univ. WO 00/71671
Mutant amyloid protein precursors
Mutant amyloid protein precursors and their genes that are associated with Familial British and Danish Dementias.
Oncodia EP 1 059 352
Human carcinoma culture
Methods for longterm culture of human squamous carcinoma from the head and neck.
Ortho-McNeil Pharma WO 00/71741
Serotonin receptor modulators
Gene sequences encoding the B subunit of the human 5-HT serotonin receptor, encoded subunit; for finding modulators.
Oxford BioMedica WO 00/71693
Selecting retroviral vectors
Methods for selecting retroviral vectors having improved packaging efficiency by mutation introduction.
Oxford BioMedica WO 00/71737
Retroviral vector production
Inhibiting the production of envelope protein receptor in retroviral producer cells; for retroviral vector production.
Panorama Res. WO 00/71702
Mountain View, Calif.
Fragment pairs of Class A _-lactamase that depend upon heterologous proteins for their functional reassembly.
Phage Biotech WO 00/71731
Targeted protein synthesis
Infecting recombinant bacteria with phages having genes that target proteins; for increased targeted protein synthesis.
Photogen WO 00/73319
Protein yield increase
Methods and cell lines for enhanced protein stabilization and production; for increasing protein yields.
Phylos WO 00/72869
Nucleic acid-protein conjugates
Methods for generating 5'-nucleic acid-protein conjugates; for therapeutics.
Portsmouth, Univ. of WO 00/71681
Polynucleotide motor associated with a substance that can be bound to it; for ligand assays.
Praelux WO 00/71755
Sequencing and characterizing nucleic acids using aptamers, methods of producing aptamers.
Prendergast, P.T. WO 00/72868
Immune system disease therapy
Peptides effective in diseases associated with elevated TNF, IL-1/2, and IFN levels; for immune system therapeutics.
Roche Diagnostics WO 00/71723
Regulating protein conformation
Methods for regulating protein conformation and avoiding misfolding and aggregation using molecular chaperones.
Rosetta Inpharmatics WO 00/71161
Antifungal drug assays
Essential Saccharomyces yeast genes, encoded proteins; for developing antifungal drugs.
Saatchioglu, F. WO 00/71711
Prostate cancer genes
Genes that are differentially expressed in prostate cancer that are identified using subtractive hybridization.
Saksela, K. WO 00/72742
Src homology region binding
Controlled modification of Src homology region 3 domains to alter binding properties; for diagnostics and therapeutics.
Sankyo WO 00/71697
NF-kappaB stimulation inhibition
Methods for screening for inhibitors of IL-1_ and TNF-a cell stimulation mediated by the NF-kappaB transcription factor.
Schering EP 1 058 117
Finding steroid receptor ligands
Finding ligands that modify SLIM3 binding to androgen or estrogen receptors; for modifying transcription [in German].
Scios WO 00/71713 & 71716
Vascular endothelial growth factor variants that have enhanced biological activity, dimers; for therapeutics.
Scripps Res. Inst. WO 00/71694
Combinatorial phage libraries
La Jolla, Calif.
Display of heterodimeric proteins on filamentous phages using pVII/pIX proteins; for making combinatorial libraries.
Singapore Natl. Cancer Ctr. WO 00/71707
Nasopharyngeal cancer therapy
Methods and compositions useful for differential diagnosis and therapy of nasopharyngeal cancer.
SmithKline Beecham WO 00/71568
Staphylococcal antibacterial screens
Staphylococcal ICA operon, encoded proteins, recombinant production methods; for antibacterial screens.
SmithKline Beecham WO 00/71583
Mouse interleukin-1 homolog, encoding gene, recombinant production methods; for diagnostics and therapeutics.
SmithKline Beecham WO 00/71724
BASB polypeptides, encoding gene sequences, recombinant production methods; for diagnostics and therapeutics.
SmithKline Beecham WO 00/72863
Use of human TREK1 proteins and encoding gene sequences to treat epilepsy and sleep disorders.
Sumitomo Pharma WO 00/71580
Secreted protein libraries
Inducing secretion from cultured cells followed by antibody-based purification; for making secreted protein libraries.
Takeda Chemical EP 1 057 890
Endocrine disrupter antibodies
Monoclonal antibodies to endocrine dirupters or their degradation products; for immunologically-based assays.
Takeda Chemical WO 00/71581
Secretory protein; for modulator assays to develop immune system therapeutics.
Tanabe EP 1 057 896
Identifying modulators of peroxisome proliferator activated receptor (PPAR) using cells having reporter constructs.
Texas, Univ. of WO 00/71752
Tumor tubulin mutations
Detection of tubulin mutations in tumor cells that confer paclitaxel resistance; for optimizing chemotherapy.
Vanderbilt Univ. WO 00/73322
Veno-occlusive disease therapy
Human carbamyl phosphate synthetase 1 polymorphism; for diagnosing and treating hepatic veno-occlusive disease.
Virginia, Univ. of WO 00/72679
Calcifying cancer cells
Osteonectin gene control regions; for making vectors to transfect cancer cells and cause calcification.
ZymoGenetics WO 00/71717
Secreted a-helical protein
Secreted a-helical protein, encoding gene sequences, antibodies; for regulating the immune system.