October 19 (WO)
Antibioticos WO 00/61767
Acremonium chrysogenum protease with CPC-acetyl hydrolase activity; for synthesizing deacetylated cephalosporin.
Arbor Vita WO 00/61747
Cell surface cadherin-like asymmetry protein-2, encoding gene, fusions, antibodies; for immunomodulator screens.
Arcturus Engineering WO 00/61806
Mountain View, Calif.
Customized arrays of nucleic acids and proteins; for concurrent quantification of multiple macromolecules.
Aventis Pharma WO 00/61727
Procarboxy-peptidase B production
Production of pancreatic procarboxy-peptidase B, isoforms, and muteins in microorganisms, encoding genes.
Bayer WO 00/61792
Genes essential to the survival of E. coli strains, encoded proteins; for antibacterial screens.
Biomira WO 00/61766
Telomerase-specific T-cell antigens; for generating immune responses against telomeres and making cancer vaccines.
California, Univ. of WO 00/61634 & 61782
Serine protease modulators
Engineering ecotin variants and derivatives for modulating serine protease activity.
California, Univ. of WO 00/61814
Melanoma chromosome probes
Use of probes to detect chromosome copy number changes that can distinguish melanocytic nevi from malignant melanoma.
Calif. Inst. Technol. WO 00/61819
Detecting age-related mutations
Polynucleotide sequences useful in detecting age-related mutations, especially in mitochondrial sequences.
CNRS (Natl. Ctr. Sci. Res.) WO 00/61798
Ad infinitum nucleic acid amplification steps; for mapping DNA molecules.
Chicago, Univ. of WO 00/61749
Herpesvirus regulatory protein ligand p60; for determining the binding site and modulating herpesvirus effects.
Chicago, Univ. of WO 00/61794
Herpesvirus infection inhibition
Posttranslational modification of herpesvirus protein US1.5; for affecting the progression of viral infection.
Chiron WO 00/61755
Secreted human proteins
15 secreted human proteins, encoding genes; for targeting cell membranes and stimulating blood cell generation.
Chiron WO 00/61770
Inducing interferon production
Expression cassettes that cause formation of double-stranded RNA that induces interferon production.
Chiron WO 00/61772
Methods for generating an immune response by using alphavirus-based vector systems.
Chugai Res. Inst. Molec. Med. WO 00/61744
Human fetal genes
Human fetal liver genes that are expressed in various cancer cells; for cancer drug development.
Columbia Univ. WO 00/61638
Detection of cancer and abnormal pregnancy using monoclonal antibodies to human chorionic gonadotropin isoforms.
Corixa WO 00/61612
Lung tumor protein, encoding gene sequences; for lung cancer immunotherapy and vaccines.
Corixa WO 00/61753 & 61756
Breast cancer genes
Genes preferentially expressed in breast tumors, encoded proteins; for diagnostics and therapeutics.
CuraGen WO 00/61754
New Haven, Conn.
Membrane-associated and secreted proteins, encoding gene sequences; for diagnostics and therapeutics.
Digital Gene Technol. WO 00/61738
Cancer gene expression
La Jolla, Calif.
Encoded proteins and gene sequences related to regulated genes characteristic of oncogenic transformation.
Exact Labs WO 00/61808
Methods for screening tissues and body fluids for nucleic acids that indicate the presence of cancers or precancers.
Genentech WO 00/61741
S. San Francisco
PCR amplification-based methods for cloning genes; for identifying genes.
Genentech WO 00/61757
S. San Francisco
Tumor necrosis factor homologs, encoding gene sequences, antibodies, recombinant production methods.
Genome Pharma WO 00/61793
Methods for identifying inhibitors of the expression of genes encoding proteins essential for bacterial growth.
Genzyme Transgenics WO 00/61725
Transgenic therapeutic purification
Methods for separating and purifying heterologous proteins expressed in transgenics.
Geron WO 00/61813
Menlo Park, Calif.
Human tankyrase II, encoding gene sequences; for telomerase activity modulator screens.
Hanmi Pharma WO 00/62062
Kyungki-do, S. Korea
Binding of transforming growth factor-_1 in samples to added receptor; for measuring levels and detecting cancer.
Harvard Univ. WO 00/61630
Kidney tubule formation
Administration of Wnt polypeptides and agonists for stimulating kidney tubule formation.
Hitachi Chemical WO 00/62066
Type II diabetes diagnosis
Detection of anti-Reg autoantibodies; for diagnosis of non-insulin dependent diabetes.
Human Genome Sciences WO 61596, 61620, 61623-61628, 61748 & 61779
501 secreted proteins
Human secreted proteins, encoding genes, recombinant production methods; for diagnostics and therapeutics.
Human Genome Sciences WO 00/61614
Uncoupling proteins, encoding gene sequences, production methods; for diagnostics and therapeutics.
Human Genome Sciences WO 00/61774
Bone morphogenic proteins
Bone morphogenic proteins, encoding genes, antibodies, production methods; for diagnostics and therapeutics.
Iconix Pharma WO 00/61809
Biological response modifiers
Mountain View, Calif.
Vector combinations for development of rapid and parallel measurement of biological response modifier activities.
Illinois, Univ. of WO 00/61751
Cell growth genes
Identification of genes regulated by p21; for modulating cell cycle progression, cell growth, and apoptosis.
Imperial College Innovations WO 00/62068
Methods for typing prions; for prion disease diagnostics and therapeutics.
Imperial College of Science WO 00/62069
Detecting pathogenic E. coli
Methods for detecting intimin-expressing pathogenic E. coli using antisera against conserved protein antigenic regions.
Incyte Pharma WO 00/61622
Kidney disease-associated genes
Palo Alto, Calif.
Kidney disease-associated genes, encoded proteins, antibodies; for diagnostics and therapeutics.
Innogenetics WO 00/61795
Amplifying HLA Class I alleles
Defined primers for locus-specific amplification of various exons of HLA Class I alleles.
Isis Pharma WO 00/61599
Microtubule-associated protein antisense
Antisense modulation of microtuble-associated protein 4 expression; for disease treatment.
Isis Pharma WO 00/61600
Antisense modulation of Smad3 expression; for Smad3-associated disease treatment.
Isis Pharma WO 00/61601
Antisense modulation of G-alpha-11 expression; for disease treatment.
Isis Pharma WO 00/61602
Antisense modulation of STAT3 expression; for disease treatment.
Isis Pharma WO 00/61786
Antisense modulation of PDK-1 expression; for disease treatment.
Japan Tobacco WO 00/61745
G protein-coupled receptor ligands
Screening G protein-coupled receptor ligands using cloned and expressed receptors.
Johns Hopkins Univ. WO 00/61613
Glycosylphosphatidylinositol-anchored protein binding channel forming toxins; for antiviral agents.
Johns Hopkins Univ. WO 00/61815
Methods for selecting rRNA variants that catalyze formation of non-standard polymers; for in vitro ribosome evolution.
Katus, H.A., et al. WO 00/61742
Treating cardiac disease
Treating cardiac power failure by administering S100 proteins, mutants, fragments or their gene sequences.
Keygene WO 61800 & 61801
Detection of single nucleotide polymorphisms in amplified restriction fragments using primer extension techniques.
Khanna, P. WO 00/61619
New Delhi, India
Effective hypoglycemic polypeptide K from Momordica charantia; for treating diabetes.
Kyowa Hakko Kogyo WO 00/61739
Methods for controlling the activity of immunologically functional molecules.
Lexicon Genetics WO 00/61765
The Woodlands, Texas
Mammalian lipoxygenases, encoding gene sequences obtained from human gene trap libraries.
Maxygen WO 00/61740
Modified lipid production
Redwood City, Calif.
Gene clusters involved in lipid biosynthesis; for modifying lipid synthetic and metabolic activity.
Merck WO 00/61606
Voltage-gated potassium channel
Human voltage-gated potassium channel, encoding gene sequences; for diagnosing macular dystrophy.
Merck WO 00/61781
Protozoan cyclic GMP-dependent protein kinases, encoding genes; for antiprotozoal agents.
Merlin WO 00/61796
Genotyping of bacterial strains using probes to specific groups of genes.
Minton, Treharne & Davies WO 00/61799
Nucleic acid tagging
Marking materials with nucleic acid tags; for detecting the presence and amount of a specific material in a sample.
Modex Therapeutics WO 00/61617
Transiently immortalized cells
Cells transiently immortalized using a herpes virus VP22-HIV TAT protein chimeras; for use in cell and gene therapy.
Nanogen WO 00/61803
Magnetic bead arrays
Bead array counter system having strand displacement amplification and magnetoresistive micro sensor chips.
Nanogen-Becton Dickinson WO 00/60919, 61720, 61805, 61816-61818 & 62036
Anchored strand displacement amplification on electronically addressable microchips; for finding SNPs in alleles.
NIH (Natl. Inst. Hlth.) WO 00/61611
Attenuated RSV vaccines
Chimeric respiratory syncytial virus genomes having various mutations; for attenuated vaccines.
NIH (Natl. Inst. Hlth.) WO 00/61737
Attenuated RNA vaccines
Recombinant negative strand RNA viruses having mutations that cause attenuation; for vaccines.
NIH (Natl. Inst. Hlth.) WO 00/61790
High-sensitivity phage display
Bound recombinant phages that can still infect bacteria; for high-sensitivity phage display of heterologous proteins.
NIH (Natl. Inst. Hlth.) WO 00/61811
Detection of interleukin-10 gene polymorphisms; for predicting susceptibility to HIV infection progression.
NIH (Natl. Inst. Hlth.) WO 00/62065
Factor H assays
Binding of small integrin-binding ligand, n-linked glycoproteins to complement Factor H; for assays.
New Jersey, Univ. of Med. & Dent. WO 00/61780
Life span kinase
New Brunswick, N.J.
Specific inhibition of EF-2 kinase for increased protein turnover and life span.
North Western Hlth. Care Network WO 00/61758
Hepatitis B variants
Hepatitis B variants with reduced susceptibility to nucleoside analogs; for monitoring infections.
Northwest Biotherapeutics WO 00/62063
Prostate cancer diagnostics
Detection of expression of flt-4, the VEGF receptor; for metastatic prostate cancer diagnostics and therapeutics.
November Inst. Molec. Med. WO 00/61616
Viral delivery vehicles
Fragments of polyoma virus proteins 1 through 3; for transporting therapeutic materials.
Oasis Biosciences WO 00/61807
Sequencing primer pairs
Amplification primer pairs with an oligonucleotide anchor and primer having sections that hybridize to form a stem.
Oasis Biosciences WO 00/61810
RNA cleavage antisense
Antisense oligonucleotides having universal or degenerate bases and modified backbone linkages; for cleaving RNA.
Pharmacia & Upjohn WO 00/61724
Identification of Gram negative bacterial virulence genes; for finding bacterial mutants useful in vaccines.
Queen Mary & Westfield College WO 00/61728
Skin disease treatment
Mutant human elastase I, encoding gene sequences; for treating skin diseases.
Res. Corp. Technol. WO 00/61636
Correlation of aberrantly glycosylated antibodies with the development of cancer; for diagnosing and treating cancer.
Ribozyme Pharma WO 00/61729
Regulating repressor genes
Nucleic acid molecules that inhibit the expression of repressor genes.
Schering-Plough WO 00/61773
Adenoviral gene therapy
Adenoviruses having insertions and deletions in the early gene region; for gene therapy.
Sergeev, P. WO 00/61775
Intracellular therapeutic synthesis
Intracellular hybridization of inserted oligomers attached to precursor molecules; for synthesizing therapeutics.
Shionogi WO 00/61743
Apoptosis modulator screen
Protein that induces chromatin agglutination, encoding gene sequences; for screening apoptosis modulators.
Sloan-Kettering Inst. WO 00/61605
Prostate-specific membrane antigen-like gene, encoded protein; for diagnostics and therapeutics.
SmithKline Beecham WO 00/61637
Erythropoietin receptor agonist and antagonist antibodies; for enhancing erythropoiesis.
SmithKline Beecham WO 00/61778
Staphylococcus aureus mvaA gene, encoded protein, recombinant production methods; for antibacterial screens.
SmithKline Beecham WO 00/61785
Cathepsin K modulator screen
Monkey cathepsin K gene, encoded protein, recombinant production methods; for finding therapeutic modulators.
SmithKline Beecham WO 00/61787
Bacterial gyrA gene, encoded protein, recombinant production methods; for antibacterial screens.
South Carolina, Med. Univ. of WO 00/61804
Tissue- and pathogen-specific toxic agents and ribozymes; for eradicating bacterial infections.
Stanford Univ. WO 00/61632
Palo Alto, Calif.
Interaction of MHC Class II proteins with PCNA protein family members; for finding immune system modulators.
Sugen WO 00/61750
Tyrosine kinase substrate proteins
S. San Francisco
Tyrosine kinase substrate proteins, encoding gene sequences; for diagnostics and therapeutics.
Techlab WO 61761 & 61762
Recombinant Clostridium difficile toxins; for polysaccharide conjugate vaccines.
Toronto, Univ. of WO 00/61618
HIV neutralizing antibodies
Fab epitope complex from the HIV-1 cross-neutralizing monoclonal antibody 2F5; for increased immunogenicity.
Urogenesys WO 61610 & 61746
Prostate cancer genes
Santa Monica, Calif.
Prostate gland-expressed genes associated with cancer, encoded proteins; for diagnostics and therapeutics.
Washington Univ. WO 00/61752
Complement receptor 1 variants
Complement receptor 1 variants; for modulating complement system function.
Washington Univ. WO 00/62067
Fusion molecules that can be introduced into cells and tissues for transduction.
Yeda Res. & Develop. WO 00/61768
Biologically active proteins
Preparing active proteins from inactive precursors by mutating the cleavage site to make it protease sensitive.