October 19 (WO)

Antibioticos WO 00/61767

Cephalosporin synthesis

Leon, Spain

Acremonium chrysogenum protease with CPC-acetyl hydrolase activity; for synthesizing deacetylated cephalosporin.

Arbor Vita WO 00/61747

Screening immunomodulators

Sunnyvale, Calif.

Cell surface cadherin-like asymmetry protein-2, encoding gene, fusions, antibodies; for immunomodulator screens.

Arcturus Engineering WO 00/61806

Customized arrays

Mountain View, Calif.

Customized arrays of nucleic acids and proteins; for concurrent quantification of multiple macromolecules.

Aventis Pharma WO 00/61727

Procarboxy-peptidase B production

Frankfurt, Germany

Production of pancreatic procarboxy-peptidase B, isoforms, and muteins in microorganisms, encoding genes.

Bayer WO 00/61792

Antibacterial screens

Leverkusen, Germany

Genes essential to the survival of E. coli strains, encoded proteins; for antibacterial screens.

Biomira WO 00/61766

Telomerase antigens

Edmonton, Alberta

Telomerase-specific T-cell antigens; for generating immune responses against telomeres and making cancer vaccines.

California, Univ. of WO 00/61634 & 61782

Serine protease modulators

Oakland, Calif.

Engineering ecotin variants and derivatives for modulating serine protease activity.

California, Univ. of WO 00/61814

Melanoma chromosome probes

Oakland, Calif.

Use of probes to detect chromosome copy number changes that can distinguish melanocytic nevi from malignant melanoma.

Calif. Inst. Technol. WO 00/61819

Detecting age-related mutations

Pasadena, Calif.

Polynucleotide sequences useful in detecting age-related mutations, especially in mitochondrial sequences.

CNRS (Natl. Ctr. Sci. Res.) WO 00/61798

Mapping DNA


Ad infinitum nucleic acid amplification steps; for mapping DNA molecules.

Chicago, Univ. of WO 00/61749

Regulating herpesviruses


Herpesvirus regulatory protein ligand p60; for determining the binding site and modulating herpesvirus effects.

Chicago, Univ. of WO 00/61794

Herpesvirus infection inhibition


Posttranslational modification of herpesvirus protein US1.5; for affecting the progression of viral infection.

Chiron WO 00/61755

Secreted human proteins

Emeryville, Calif.

15 secreted human proteins, encoding genes; for targeting cell membranes and stimulating blood cell generation.

Chiron WO 00/61770

Inducing interferon production

Emeryville, Calif.

Expression cassettes that cause formation of double-stranded RNA that induces interferon production.

Chiron WO 00/61772

Immunoresponse generation

Emeryville, Calif.

Methods for generating an immune response by using alphavirus-based vector systems.

Chugai Res. Inst. Molec. Med. WO 00/61744

Human fetal genes

Ibaraki, Japan

Human fetal liver genes that are expressed in various cancer cells; for cancer drug development.

Columbia Univ. WO 00/61638

hCG isoforms

New York

Detection of cancer and abnormal pregnancy using monoclonal antibodies to human chorionic gonadotropin isoforms.

Corixa WO 00/61612

Lung cancer


Lung tumor protein, encoding gene sequences; for lung cancer immunotherapy and vaccines.

Corixa WO 00/61753 & 61756

Breast cancer genes


Genes preferentially expressed in breast tumors, encoded proteins; for diagnostics and therapeutics.

CuraGen WO 00/61754

Membrane-associated proteins

New Haven, Conn.

Membrane-associated and secreted proteins, encoding gene sequences; for diagnostics and therapeutics.

Digital Gene Technol. WO 00/61738

Cancer gene expression

La Jolla, Calif.

Encoded proteins and gene sequences related to regulated genes characteristic of oncogenic transformation.

Exact Labs WO 00/61808

Cancer diagnostics

Maynard, Mass.

Methods for screening tissues and body fluids for nucleic acids that indicate the presence of cancers or precancers.

Genentech WO 00/61741

Gene identification

S. San Francisco

PCR amplification-based methods for cloning genes; for identifying genes.

Genentech WO 00/61757

TNF homologs

S. San Francisco

Tumor necrosis factor homologs, encoding gene sequences, antibodies, recombinant production methods.

Genome Pharma WO 00/61793

Antibacterial screens

Martinsried, Germany

Methods for identifying inhibitors of the expression of genes encoding proteins essential for bacterial growth.

Genzyme Transgenics WO 00/61725

Transgenic therapeutic purification

Framingham, Mass.

Methods for separating and purifying heterologous proteins expressed in transgenics.

Geron WO 00/61813

Telomerase modulators

Menlo Park, Calif.

Human tankyrase II, encoding gene sequences; for telomerase activity modulator screens.

Hanmi Pharma WO 00/62062

TGF-_1 assay

Kyungki-do, S. Korea

Binding of transforming growth factor-_1 in samples to added receptor; for measuring levels and detecting cancer.

Harvard Univ. WO 00/61630

Kidney tubule formation

Cambridge, Mass.

Administration of Wnt polypeptides and agonists for stimulating kidney tubule formation.

Hitachi Chemical WO 00/62066

Type II diabetes diagnosis


Detection of anti-Reg autoantibodies; for diagnosis of non-insulin dependent diabetes.

Human Genome Sciences WO 61596, 61620, 61623-61628, 61748 & 61779

501 secreted proteins

Rockville, Md.

Human secreted proteins, encoding genes, recombinant production methods; for diagnostics and therapeutics.

Human Genome Sciences WO 00/61614

Uncoupling proteins

Rockville, Md.

Uncoupling proteins, encoding gene sequences, production methods; for diagnostics and therapeutics.

Human Genome Sciences WO 00/61774

Bone morphogenic proteins

Rockville, Md.

Bone morphogenic proteins, encoding genes, antibodies, production methods; for diagnostics and therapeutics.

Iconix Pharma WO 00/61809

Biological response modifiers

Mountain View, Calif.

Vector combinations for development of rapid and parallel measurement of biological response modifier activities.

Illinois, Univ. of WO 00/61751

Cell growth genes

Urbana, Ill.

Identification of genes regulated by p21; for modulating cell cycle progression, cell growth, and apoptosis.

Imperial College Innovations WO 00/62068

Prion typing


Methods for typing prions; for prion disease diagnostics and therapeutics.

Imperial College of Science WO 00/62069

Detecting pathogenic E. coli


Methods for detecting intimin-expressing pathogenic E. coli using antisera against conserved protein antigenic regions.

Incyte Pharma WO 00/61622

Kidney disease-associated genes

Palo Alto, Calif.

Kidney disease-associated genes, encoded proteins, antibodies; for diagnostics and therapeutics.

Innogenetics WO 00/61795

Amplifying HLA Class I alleles

Ghent, Belgium

Defined primers for locus-specific amplification of various exons of HLA Class I alleles.

Isis Pharma WO 00/61599

Microtubule-associated protein antisense

Carlsbad, Calif.

Antisense modulation of microtuble-associated protein 4 expression; for disease treatment.

Isis Pharma WO 00/61600

Smad3 antisense

Carlsbad, Calif.

Antisense modulation of Smad3 expression; for Smad3-associated disease treatment.

Isis Pharma WO 00/61601

G-alpha-11 antisense

Carlsbad, Calif.

Antisense modulation of G-alpha-11 expression; for disease treatment.

Isis Pharma WO 00/61602

STAT3 antisense

Carlsbad, Calif.

Antisense modulation of STAT3 expression; for disease treatment.

Isis Pharma WO 00/61786

PDK-1 antisense

Carlsbad, Calif.

Antisense modulation of PDK-1 expression; for disease treatment.

Japan Tobacco WO 00/61745

G protein-coupled receptor ligands


Screening G protein-coupled receptor ligands using cloned and expressed receptors.

Johns Hopkins Univ. WO 00/61613

Antiviral agents

Baltimore, Md.

Glycosylphosphatidylinositol-anchored protein binding channel forming toxins; for antiviral agents.

Johns Hopkins Univ. WO 00/61815

Ribosome evolution


Methods for selecting rRNA variants that catalyze formation of non-standard polymers; for in vitro ribosome evolution.

Katus, H.A., et al. WO 00/61742

Treating cardiac disease

Ratzeburg, Germany

Treating cardiac power failure by administering S100 proteins, mutants, fragments or their gene sequences.

Keygene WO 61800 & 61801

SNP detection

Wageningen, Netherlands

Detection of single nucleotide polymorphisms in amplified restriction fragments using primer extension techniques.

Khanna, P. WO 00/61619

Diabetes therapeutic

New Delhi, India

Effective hypoglycemic polypeptide K from Momordica charantia; for treating diabetes.

Kyowa Hakko Kogyo WO 00/61739

Immunological control


Methods for controlling the activity of immunologically functional molecules.

Lexicon Genetics WO 00/61765

Mammalian lipoxygenases

The Woodlands, Texas

Mammalian lipoxygenases, encoding gene sequences obtained from human gene trap libraries.

Maxygen WO 00/61740

Modified lipid production

Redwood City, Calif.

Gene clusters involved in lipid biosynthesis; for modifying lipid synthetic and metabolic activity.

Merck WO 00/61606

Voltage-gated potassium channel

Rahway, N.J.

Human voltage-gated potassium channel, encoding gene sequences; for diagnosing macular dystrophy.

Merck WO 00/61781

Antiprotozoal agents

Rahway, N.J.

Protozoan cyclic GMP-dependent protein kinases, encoding genes; for antiprotozoal agents.

Merlin WO 00/61796

Bacterial genotyping

Bornheim-Hersel, Germany

Genotyping of bacterial strains using probes to specific groups of genes.

Minton, Treharne & Davies WO 00/61799

Nucleic acid tagging

Cardiff, UK

Marking materials with nucleic acid tags; for detecting the presence and amount of a specific material in a sample.

Modex Therapeutics WO 00/61617

Transiently immortalized cells

Lausanne, Switzerland

Cells transiently immortalized using a herpes virus VP22-HIV TAT protein chimeras; for use in cell and gene therapy.

Nanogen WO 00/61803

Magnetic bead arrays

San Diego

Bead array counter system having strand displacement amplification and magnetoresistive micro sensor chips.

Nanogen-Becton Dickinson WO 00/60919, 61720, 61805, 61816-61818 & 62036

Electronic microchips

San Diego

Anchored strand displacement amplification on electronically addressable microchips; for finding SNPs in alleles.

NIH (Natl. Inst. Hlth.) WO 00/61611

Attenuated RSV vaccines

Bethesda, Md.

Chimeric respiratory syncytial virus genomes having various mutations; for attenuated vaccines.

NIH (Natl. Inst. Hlth.) WO 00/61737

Attenuated RNA vaccines

Bethesda, Md.

Recombinant negative strand RNA viruses having mutations that cause attenuation; for vaccines.

NIH (Natl. Inst. Hlth.) WO 00/61790

High-sensitivity phage display

Bethesda, Md.

Bound recombinant phages that can still infect bacteria; for high-sensitivity phage display of heterologous proteins.

NIH (Natl. Inst. Hlth.) WO 00/61811

HIV diagnostics

Bethesda, Md.

Detection of interleukin-10 gene polymorphisms; for predicting susceptibility to HIV infection progression.

NIH (Natl. Inst. Hlth.) WO 00/62065

Factor H assays

Bethesda, Md.

Binding of small integrin-binding ligand, n-linked glycoproteins to complement Factor H; for assays.

New Jersey, Univ. of Med. & Dent. WO 00/61780

Life span kinase

New Brunswick, N.J.

Specific inhibition of EF-2 kinase for increased protein turnover and life span.

North Western Hlth. Care Network WO 00/61758

Hepatitis B variants

Parkville, Australia

Hepatitis B variants with reduced susceptibility to nucleoside analogs; for monitoring infections.

Northwest Biotherapeutics WO 00/62063

Prostate cancer diagnostics


Detection of expression of flt-4, the VEGF receptor; for metastatic prostate cancer diagnostics and therapeutics.

November Inst. Molec. Med. WO 00/61616

Viral delivery vehicles

Erlangen, Germany

Fragments of polyoma virus proteins 1 through 3; for transporting therapeutic materials.

Oasis Biosciences WO 00/61807

Sequencing primer pairs

San Diego

Amplification primer pairs with an oligonucleotide anchor and primer having sections that hybridize to form a stem.

Oasis Biosciences WO 00/61810

RNA cleavage antisense

San Diego

Antisense oligonucleotides having universal or degenerate bases and modified backbone linkages; for cleaving RNA.

Pharmacia & Upjohn WO 00/61724

Bacterial vaccines

Kalamazoo, Mich.

Identification of Gram negative bacterial virulence genes; for finding bacterial mutants useful in vaccines.

Queen Mary & Westfield College WO 00/61728

Skin disease treatment


Mutant human elastase I, encoding gene sequences; for treating skin diseases.

Res. Corp. Technol. WO 00/61636

Cancer diagnostics

Tucson, Ariz.

Correlation of aberrantly glycosylated antibodies with the development of cancer; for diagnosing and treating cancer.

Ribozyme Pharma WO 00/61729

Regulating repressor genes

Boulder, Colo.

Nucleic acid molecules that inhibit the expression of repressor genes.

Schering-Plough WO 00/61773

Adenoviral gene therapy

Lucerne, Switzerland

Adenoviruses having insertions and deletions in the early gene region; for gene therapy.

Sergeev, P. WO 00/61775

Intracellular therapeutic synthesis

Zurich, Switzerland

Intracellular hybridization of inserted oligomers attached to precursor molecules; for synthesizing therapeutics.

Shionogi WO 00/61743

Apoptosis modulator screen

Osaka, Japan

Protein that induces chromatin agglutination, encoding gene sequences; for screening apoptosis modulators.

Sloan-Kettering Inst. WO 00/61605

Prostate-specific gene

New York

Prostate-specific membrane antigen-like gene, encoded protein; for diagnostics and therapeutics.

SmithKline Beecham WO 00/61637

Erythropoiesis inducers


Erythropoietin receptor agonist and antagonist antibodies; for enhancing erythropoiesis.

SmithKline Beecham WO 00/61778

Staphyloccus antibacterials


Staphylococcus aureus mvaA gene, encoded protein, recombinant production methods; for antibacterial screens.

SmithKline Beecham WO 00/61785

Cathepsin K modulator screen


Monkey cathepsin K gene, encoded protein, recombinant production methods; for finding therapeutic modulators.

SmithKline Beecham WO 00/61787

Antibacterial screens


Bacterial gyrA gene, encoded protein, recombinant production methods; for antibacterial screens.

South Carolina, Med. Univ. of WO 00/61804

Antibacterial toxins

Charleston, S.C.

Tissue- and pathogen-specific toxic agents and ribozymes; for eradicating bacterial infections.

Stanford Univ. WO 00/61632


Palo Alto, Calif.

Interaction of MHC Class II proteins with PCNA protein family members; for finding immune system modulators.

Sugen WO 00/61750

Tyrosine kinase substrate proteins

S. San Francisco

Tyrosine kinase substrate proteins, encoding gene sequences; for diagnostics and therapeutics.

Techlab WO 61761 & 61762

Clostridium vaccines

Blacksburg, Va.

Recombinant Clostridium difficile toxins; for polysaccharide conjugate vaccines.

Toronto, Univ. of WO 00/61618

HIV neutralizing antibodies


Fab epitope complex from the HIV-1 cross-neutralizing monoclonal antibody 2F5; for increased immunogenicity.

Urogenesys WO 61610 & 61746

Prostate cancer genes

Santa Monica, Calif.

Prostate gland-expressed genes associated with cancer, encoded proteins; for diagnostics and therapeutics.

Washington Univ. WO 00/61752

Complement receptor 1 variants

St. Louis

Complement receptor 1 variants; for modulating complement system function.

Washington Univ. WO 00/62067

Transduction fusions

St. Louis

Fusion molecules that can be introduced into cells and tissues for transduction.

Yeda Res. & Develop. WO 00/61768

Biologically active proteins

Rehovot, Israel

Preparing active proteins from inactive precursors by mutating the cleavage site to make it protease sensitive.