September 21 (WO)

Alphagene WO 00/55375

Secreted proteins

Woburn, Mass.

Secreted proteins, encoding gene sequences; for diagnostics and therapeutics.

Amersham Pharmacia Biotech WO 00/55363

Gene expression patterns

Amersham, UK

Rapid and efficient analysis of differential gene expression patterns in biological systems.

Amersham Pharmacia Biotech WO 00/55364

Genetic analysis

Little Chalfont, UK

Whole genome analysis using terminal restriction site profiling arrays.

Aventis Pasteur WO 00/55326

Chlamydia vaccines

Toronto, Ont.

Chlamydia membrane protein antigens, encoding gene sequences; for vaccines.

Biosyn WO 00/55192

Cancer diagnostics

Felbach, Germany

Nucleic acid sequences encoding hemocyanin, fragments, and domains, encoded proteins, fusions; for cancer diagnostics.

Brigham & Women's Hosp. WO 00/54580

Leukotriene receptor transgenics


Transgenics having the human leukotriene B4 receptor gene inserted into their leukocytes; for overexpression.

Bristol, Univ. of WO 00/55330

Fatty acid saturation

Bristol, UK

Polyunsaturated fatty acid elongase from C. elegans, encoding gene; for modulating fatty acid saturation levels.

British Columbia, Univ. of WO 00/55318

Cholesterol level modulation

Vancouver, B.C.

ABC1 nucleic acids, encoded proteins; for diagnosing and controlling abnormal cholesterol regulation.

California, Univ. of WO 00/55367

Melanoma detection

Oakland, Calif.

Nucleic acid probes to a chromosomal region that is amplified in melanomas; for diagnosis.

Cambia Biosystems WO 00/55333

_-glucuronidase genes

Bellevue, Wash.

Microbial _-glucuronidase genes, encoded proteins; for polysaccharide modification.

Chicago, Univ. of WO 00/54574

Recombination stimulation


Chemical and physical treatments that stimulate recombination; for modifying phenotypes.

Children's Hosp. WO 00/54796

Antiangiogenic peptides


Antiangiogenic peptides that inhibit endothelial cell proliferation.

Chiron WO 00/54813

Eye disease gene therapy

Emeryville, Calif.

Recombinant adeno-associated virus vectors for treating or preventing diseases of the eye.

Chiron WO 00/55343

Retroviral vector production

Emeryville, Calif.

Retroviral vector producing cells having multiple stably integrated copies and secreting multiple infectious viruses.

Columbia Univ. WO 00/55310

Tetracycline-controlled transactivator

New York

Protein Translation Peptide Elongation Factor-1 a promoter; for making a reverse tetracycline controlled transactivator.

Connaught Labs WO 00/55191

Hemophilus adhesin proteins

Toronto, Ont.

Recombinant Hemophilus influenzae adhesin proteins, encoding gene sequences; for diagnostics.

Corixa WO 00/55194

Tuberculosis antigens


Mycobacterium tuberculosis antigens, fragments, encoding genes; for tuberculosis diagnostics and therapeutics.

Dana-Farber Cancer Inst. WO 00/55335 & 55378

Pseudotyped lentiviral vectors


Pseudotyped lentiviral vectors; for high quantity screening of specific targets from desired cells.

Devgen WO 00/54815

C. elegans disease models

Zwijnaarde, Belgium

Expression of genes in C. elegans excretory cells using the UL6 gene promoter; for disease modeling.

Du Pont WO 00/55311

Gene modification

Wilmington, Del.

Homologous recombination methods using selectable markers; for gene modification.

Eos Biotech WO 00/55373

Destructive macrophage development

S. San Francisco

Identifying nucleic acids and expression profiles characteristic of destructive macrophage development.

Exelixis WO 00/55178

Tumor suppressor modulators

S. San Francisco

Insect p53 tumor suppressor genes, encoded proteins; for identifying modulators to control cancer.

Exelixis WO 00/55376

Biogenic amine receptors

S. San Francisco

Invertebrate biogenic amine receptors, encoding gene sequences; for identifying therapeutic modulators.

Genentech WO 00/55319

Antitumor proteins

S. San Francisco

Identification of antitumor proteins, encoding gene sequences, antibodies; for inhibiting cancers.

Geron WO 00/55374

Pathogenic fungi therapy

Menlo Park, Calif.

Methods for inhibiting self-splicing of Group I introns; for inhibiting pathogenic fungi growth.

Guy, J., et al. WO 00/54595

Demyelination modulation

Gainesville, Fla.

Adeno-associated virus transfer of catalase or superoxide dismutase to optic nerves; for modulating demyelination.

Harvard Univ. WO 00/54730

Papillomavirus vaccines

Cambridge, Mass.

Production of soluble multimers of human papillomavirus L1 proteins in bacteria; for vaccines.

Hope Heart Inst. WO 00/55206

Stimulating endothelium


Endothelial cell stimulation by a complex of fibronectin and vascular endothelial growth factor; for wound healing.

Human Genome Sciences WO 00/54651

TNF receptor-like genes

Rockville, Md.

Human tumor necrosis factor (TNF) receptor-like genes, encoded receptors, recombinant production methods.

Human Genome Sciences WO 00/55171, 55175-55177, 55198-55201, 55352, & 55371

471 secreted proteins

Rockville, Md.

471 human secreted proteins, encoding genes, antibodies, production methods; for diagnostics and therapeutics.

Human Genome Sciences WO 00/55173

Breast cancer genes

Rockville, Md.

Human breast and ovarian cancer-associated genes, encoded proteins, antibodies; for diagnostics and therapeutics.

Human Genome Sciences WO 00/55174

Prostate cancer genes

Rockville, Md.

Human prostate cancer-associated genes, encoded proteins, antibodies; for diagnostics and therapeutics.

Human Genome Sciences WO 00/55180

Lung cancer genes

Rockville, Md.

Human lung cancer-associated genes, encoded proteins, antibodies; for diagnostics and therapeutics.

Human Genome Sciences WO 00/55204

Interleukin-17 receptor-like protein

Rockville, Md.

Interleukin-17 receptor-like protein, encoding gene sequences; for identifying modulators.

Human Genome Sciences WO 00/55320

Pancreatic cancer genes

Rockville, Md.

Human pancreatic cancer-associated genes, encoded proteins, antibodies; for diagnostics and therapeutics.

Human Genome Sciences WO 00/55350

Human cancer genes

Rockville, Md.

Human cancer-associated genes, encoded proteins, antibodies; for diagnostics and therapeutics.

Human Genome Sciences WO 00/55351

Colon cancer genes

Rockville, Md.

Human colon cancer-associated genes, encoded proteins, antibodies; for diagnostics and therapeutics.

Hybritech WO 00/55308

Prostate diagnostics

San Diego

Detection of human kallikrein 2/protease inhibitor-6 complexes in prostate tumor tissue; for diagnosis.

Incyte Genomics WO 00/55332

Intracellular phosphorylation regulators

Palo Alto, Calif.

Regulators of intracellular phosphorylation, encoding genes, antibodies, modulators; for diagnostics and therapeutics.

Introgen Therapeutics WO 00/54839

Antitumor immune responses

Austin, Texas

Dendritic cells transformed with a self gene upregulated in tumor cells; for immune response induction.

Krebs Res. Ctr. WO 00/55316

Cell proliferation modification

Heidelberg, Germany

RNA polymerase 1 transcription factor, encoding gene sequences; for modifying cell proliferation rates.

LJL Biosystems WO 00/55372

Polymorphism detection

Sunnyvale, Calif.

Methods and devices for detecting nucleic acid polymorphisms using a luminescence-based assay.

Mass. Gen. Hosp. WO 00/54731 & 55181



Syndesmos, a syndecan-binding protein, encoding gene; for modulating extracellular matrix adhesion and interactions.

McGill Univ. WO 00/55307

Full-length cDNA clones

Montreal, Que.

Increasing the processivity of DNA- and RNA-dependent polymerases; for generating full-length cDNA clones.

MRC (Med. Res. Counc.) WO 00/55183

Protein refolding


Refolding proteins having immunoglobulin G domains using chaperones and foldases.

Merck WO 00/55205

Psychiatric disorder therapy

Rahway, N.J.

Mouse serotonin 5-HT2c receptor isoforms; for identifying modulators to treat psychiatric disorders.

Michigan, Univ. of WO 00/55196

Protamine fragments

Ann Arbor, Mich.

Bioactive, low-toxicity protamine fragments; for neutralizing heparin and reducing bleeding.

Millipore WO 00/55185

Chromatographic separation

Bedford, Mass.

Metal-loaded ligand bound membranes; for metal ion affinity chromatographic separation of proteins.

Mitokor WO 00/55323

Organellar gene expression

San Diego

Differential expression of organellar gene products; for diagnosing and treating organellar-associated diseases.

NIH (Natl. Inst. Hlth.) WO 00/55207

Treating HIV infection

Bethesda, Md.

Bispecific fusion proteins having CD4 and Fv antibody domains; for treating HIV infection.

NIH (Natl. Inst. Hlth.) WO 00/55344

SV40 T antigen antisense

Bethesda, Md.

Adenoviral vector that expresses SV40 T antigen antisense RNA; for inducing apoptosis.

New York Blood Ctr. WO 00/55377

HIV therapeutics

New York

Screening of antiviral antibodies targeted to the HIV-1 gp41 core structure; for therapeutics.

North Carolina, Univ. of WO 00/55366

Electrochemical DNA detection

Chapel Hill, N.C.

Electropolymerizable film adhered to an electrode; for electrochemical detection of single-stranded DNA probes.

Novo Nordisk WO 00/55203

GLP-1 purification

Bagsvaerd, Denmark

Ion exchange chromatographic methods of separating glucagon-like peptide (GLP)-1 and related peptides.

Ortho-McNeil Pharma WO 00/55305

CD8+ cell isolation

Raritan, N.J.

Isolation of CD8+ cells using antibodies that do not activate these cells, antibodies.

Oxford Biomedica WO 00/55341

Viral vector production

Oxford, UK

Viral vector production system for use in making viral particles for treating and preventing viral infection.

Paradigm Genetics WO 00/55346

Gene knock-out libraries

Res. Triangle Park, N.C.

Facilitated site-directed homologous recombination for rapid and high volume production of gene knock-out libraries.

Pasteur Inst. WO 00/55362

Tuberculosis vaccination detection


Probes and antibodies for differentiating between vaccination and infection by Mycobacteria tuberculosis.

Pennsylvania, Univ. of WO 00/55342

AAV gene therapy vectors


Methods of producing helper-free recombinant adeno-associated viruses (AAV); for gene therapy.

Perkin-Elmer WO 00/55368

Multiplex sequence detection

Foster City, Calif.

Nucleic acid probes having tags and mobility modifiers; for multiplex nucleic acid detection.

Photocure WO 00/54802

Antigen internalization

Oslo, Norway

Photochemical internalization of antigens in antigen-presenting cells; for surface presentation and vaccines.

Phylogeny WO 00/54814

Oncogenic transformation control

Columbus, Ohio

Identification of Hsp72 gene expression modulators; for affecting oncogenic transformation.

Pierre Fabre Medicament WO 00/55317

Brain cell protein

Boulogne-Billancourt, France

Brian cell surface expressed protein, encoding gene; for finding modulators and treating CNS diseases.

Pro-Virus WO 00/55306

CNS stem cell implants

Gaithersburg, Md.

Stem cells isolated from the central nervous system (CNS) and then immortalized; for implants.

Proteotech WO 00/55187

Alzheimer's therapeutics

Kirkland, Wash.

P400, a _-amyloid binding protein from serum; for Alzheimer's diagnostics and therapeutics.

Regeneron Pharma WO 00/55193

Cerberus-related proteins

Tarrytown, N.Y.

Cerberus-related protein, encoded proteins, probes; for identifying modulators.

Romagnolo Oncology Inst. WO 00/55360

DNA sequence alterations

Forli, Italy

Detecting DNA sequence alterations using endonuclease cleavase 1 and internal labelling of DNA fragments.

Sankyo WO 00/55334

Virus activating protease


Virus activating protease, encoding gene sequences, variants; for infectious disease therapeutics.

Schackert, H.K., et al. WO 00/55361

Identifying organisms

Dresden, Germany

Primers and hybridization probes for PCR identification of organisms using comparative genetic analysis.

SmithKline Beecham WO 00/55202

Frazzled proteins


Frazzled proteins, encoding gene sequences; for finding modulators and treating immune system diseases.

SmithKline Beecham WO 00/55327

Identified proteins

Rixensart, Belgium

Identified proteins, encoding gene sequences, recombinant production methods; for diagnostics and therapeutics.

Stanford Univ. WO 00/55369

Mismatch repair detection

Palo Alto, Calif.

Screening for DNA sequence variations by placing them in the bacterial MRD gene and measuring colony growth.

Stanford Univ. WO 00/55620

Neurodegeneration therapeutics

Palo Alto, Calif.

Trangenics having adult onset neurodegenerative phenotype; for identifying therapeutics.

Takeda Chemical WO 00/55197

Cancer diagnostics

Osaka, Japan

Secretory proteins, encoding gene sequences, fragments, antibodies; for cancer diagnostics and therapeutics.

Tennessee, Univ. of WO 00/55312

Gene expression patterns

Knoxville, Tenn.

Temporally ordered panels of cDNA libraries from human microclones; for determining gene expression patterns.

Tepnel Medical WO 00/55365

Target detection

Manchester, UK

Target molecule detection using enzymatically catalyzed signal amplification of target-associated structures.

Texas, Univ. of WO 00/55345

Cytokine tumor therapy

Austin, Texas

Insect cells containing baculoviruses expressing cytokines; for direct injection into tumors.

Thomas Jefferson Univ. WO 00/55169

T-cell malignancy gene


TCL-1b gene located at the chromosome 14q32.1 locus; for detecting and treating T-cell malignancies.

United Therapeutics WO 00/55314

Inhibiting endothelin-1 synthesis


Human preproendothelin-1 mRNA sequences; for making antisense that inhibits endothelin-1 synthesis.

Virginia Commonwealth Univ. WO 00/55304

CHC biosynthetic gene cluster

Richmond, Va.

CHC biosynthetic gene cluster; for transfection and metabolism modulation.

Vistagen WO 00/55370

Gene expression patterns

Mountain View, Calif.

Identifying nucleic acid sequence using a limited number of probes; for measuring gene expression patterns.

Wakamoto Pharma WO 00/55186

Flavobacterium antibiotic


Gram-positive antibiotic isolated from Flavobacteria strains, production methods.

Washington Univ. WO 00/55321

Axon growth guidance

St. Louis, Mo.

Vertebrate slit protein, encoding gene sequences, production methods; for repulsive guidance of axon growth.

Wisconsin, Univ. of WO 00/55208

Chimeric neurotoxin

Madison, Wis.

Chimeric toxin having botulinim neurotoxin heavy chain and non-clostridial toxin moieties; for neurological disorders.

Xenogen WO 00/54581

Sepsis animal model

Alameda, Calif.

Labeling sepsis-causing microorganisms with a reporter gene; for monitoring sepsis progression in animal models.

Xoma Technol. WO 00/55322

Recombinant protein production

Berkeley, Calif.

Methods for more efficient production of recombinant proteins from bacterial cells.

ZymoGenetics WO 00/55321

Mouse interferon-a


Mouse interferon-a, encoding gene sequences; for immune system diagnostics and therapeutics.

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