September 6 (EP), August 31 (WO)

Acorda Therapeutics WO 00/50447

Cell adhesion modulators

Hawthorne, N.Y.

Carbohydrate epitope mimics that are proteins, analogs, variants, encoding genes; for modulating adhesion.

Amgen WO 00/50063

Liver cell transfection

Thousand Oaks, Calif.

Induction of semi-synchronous liver cell proliferation in vivo; for enhancing gene transfection.

Beckman Coulter WO 00/50457

Prostate cancer diagnostics

Fullerton, Calif.

Prostate-specific membrane antigens, modifications, antibodies; for diagnostic immunoassays.

Bernstein, E.F. WO 00/49876 & 50892

Oxidative damage assays

Wynnewood, Penn.

Transgenic fibroblasts with an elastin promoter generating reactive oxygen species; for oxidative damage assays.

British Columbia, Univ. of WO 00/49937

Prostate cancer therapy

Vancouver, B.C.

Reducing the expression of TRPM-2 using antisense; for treating prostate and renal cancer.

British Columbia, Univ. of WO 00/50570

Growth factor-dependent cells

Vancouver, B.C.

Modifying growth and differentiation of growth factor-dependent cells using growth factor fusions.

Canadian Natl. Res. Counc. WO 00/50619

Adenoviral gene therapy vector

Ottawa

Adenovirus mutants with a deleted protease gene that blocks replication; for use as a gene therapy vector.

Case Western Res. Univ. WO 00/50591

Chloride channel inhibitors

Cleveland

Identification of the regulatory domain of the CFTR chloride channel; for designing inhibitors.

Chiron WO 00/50075

Neisseria therapeutics

Siena, Italy

Enhancing bactericidal activity of Neisseria antigens using oligonucleotides having CG motifs.

Chugai EP 1 033 374

Sequence signal trap

Tokyo

Linking the secretory signal of the human mpl gene to a test DNA; for trapping signal sequences.

Chugai EP 1 033 403

Chondrocyte-derived gene

Tokyo

Human fetal chondrocyte-derived gene, encoded protein; for regulating cell cytoskeletal binding.

Cold Spr. Harbor Lab WO 00/50587

Complex genome sequencing

Cold Spr. Harbor, N.Y.

Genetically filtered shotgun sequencing of complex eukaryotic genomes that removes repetitive sequences.

Columbia Univ. WO 00/50566

Insect odorant receptors

New York

Genes encoding insect odorant receptors, encoded proteins; for controlling insect populations.

Connaught Labs WO 00/50604

HIV-1 gp140 glycoprotein

Toronto

Vector for expressing the gp140 glycoprotein of the primary isolate of HIV-1; for diagnostics and therapeutics.

Creative Biomolecules EP 1 033 574

Morphogenic protein screen

Hopkinton, Mass.

Epithelial cell assay system for screening morphogenic proteins.

CuraGen WO 00/50590

MDM2 interacting protein

New Haven, Conn.

Complexes of MDM2 protein and its interacting protein, gene encoding the interacting protein, fragments, analogs.

Cytotherapeutics WO 00/50572

Neural stem cell viability

Sunnyvale, Calif.

Use of collagenase to dissociate neural stem cells in culture; for increased viability and cell growth.

European Molec. Biol. Lab WO 00/50586

Cell free translation

Heidelberg, Germany

Cell free translation system that allows increased amounts of protein synthesis.

Genaissance Pharma WO 00/50436

TNF receptor gene SNPs

New Haven, Conn.

Tumor necrosis factor (TNF) receptor gene single nucleotide polymorphisms (SNPs), methods of identification.

Genetics Inst. WO 00/50592

Secreted proteins

Cambridge, Mass.

Secreted proteins, encoding gene sequences, recombinant production methods; for diagnostics and therapeutics.

Genset EP 1 033 401

Expressed sequence tags

Paris

Expressed sequence tags and upstream regulatory sequences from secreted proteins; for secretion vectors.

Georgetown Univ. WO 00/50008

Cancer-targeted liposomes

Washington, D.C.

Anti-transferrin antibody fragments inserted into p53 gene-containing immunoliposomes; for treating cancer.

Gout, I., et al. WO 00/50595

Melanoma-associated genes

London

Gene sequences associated with melanoma and thyroid tumors; for cancer diagnostics and therapeutics.

Haeggstrom, J. WO 00/50577

Anti-inflammatory drug design

Stockholm, Sweden

Leukotriene A4 hydrolase, complexes with inhibitors; for designing anti-inflammatory drugs.

Health Research WO 00/50561

Antifungal development

Rensselaer, N.Y.

Candida albicans yeast gene CaESS1, probes, encoded proteins; for antifungal drug development

Henry Ford Hlth. System WO 00/49871

Anti-angiogenic protein

Detroit, Mich.

Anti-angiogenic kringle protein derived from tissue plasminogen activator, mutants; for therapeutics.

Hoffmann-La Roche EP 1 033 404

Melanoma gene

Basel, Switzerland

Human melanoma cell gene that is down-regulated during tumor progression and/or metastasis, encoded protein.

Human Genome Sciences WO 00/50459

TNF receptor-like proteins

Rockville, Md.

Human tumor necrosis factor (TNF) receptor-like proteins, encoding genes, recombinant production methods.

Human Genome Sciences WO 00/50597

Neutrokine-a splice variant

Rockville, Md.

Neutrokine-a and a splice variant, encoding gene sequences, production methods; diagnostics and therapeutics.

Human Genome Sciences WO 00/50620

Human endokine-a

Rockville, Md.

Human endokine-a from the TNF cytokine family, encoding gene, production methods; for diagnostics and therapeutics.

Icagen WO 00/50444

Potassium channel modulator screen

Durham, N.C.

BK _ subunits of Slo family potassium channels, antibodies; for screening modulators.

Incyte Genomics WO 00/50588

Colon disease genes

Palo Alto, Calif.

Genes associated with diseases of the colon, encoded proteins, antibodies; for diagnostics and therapeutics.

Instrumentation Lab WO 00/50612

Protein C activator

Lexington, Mass.

Highly glycosylated snake protein C activator, encoding gene, variants; for blood coagulation diagnostics.

Iowa, Univ. of WO 00/50584

Gene delivery immunoresponse

Iowa City, Iowa

Gene delivery system using a biocompatible collagen-based carrier; for inducing immune responses.

Isis Pharma WO 00/50091

Akt-2 antisense

Carlsbad, Calif.

Antisense oligonucleotides to Akt-2; for modulating its expression in associated diseases.

Isis Pharma WO 00/50092, 50437, 50439 & 50440

Smad antisense

Carlsbad, Calif.

Antisense oligonucleotides to Smad1, 2, 4, & 5; for modulating its expression in associated diseases.

Isis Pharma WO 00/50438

Phospholipase A2 antisense

Carlsbad, Calif.

Antisense oligonucleotides to phospholipase A2 group IV; for modulating its expression in associated diseases.

Isis Pharma WO 00/50583

G-alpha-12 antisense

Carlsbad, Calif.

Antisense oligonucleotides to G-alpha-12; for modulating its expression in associated diseases.

Johns Hopkins Univ. WO 00/50453

Apoptosis regulator protein

Baltimore

Human apoptosis regulator protein, encoding gene sequences, antibodies, modulators.

Juridicial Fdn. WO 00/50618

Cancer therapy fusion protein

Tokyo

Viral vectors that encode a viral protein fused to a ligand that specifically binds MSH; for cancer therapy.

Kitasato Inst. EP 1 033 370

Treating worm infections

Tokyo

Isolation of small molecule organics from fungi that are useful for treating parasitic helminth worm infections.

Kitasato Inst. WO 00/50605

Antimicrobial polyketide synthesis

Tokyo

Avermectin aglycon synthase genes, variants, encoded enzymes; for antimicrobial polyketide biosynthesis.

Krebs Res. Ctr. WO 00/50451

CNS development gene

Heidelberg, Germany

Protein involved in the development of the central nervous system (CNS), encoding gene, ribozymes, transgenics.

Kyowa Hakko Kogyo WO 00/50608

Digestive cancer diagnostics

Tokyo

_1,3-galactose transferase-like protein, encoding gene sequences; for digestive cancer diagnosis.

Life Technologies WO 00/50625

Large scale nucleotide synthesis

Rockville, Md.

Efficient methods for synthesizing substantially pure nucleotides in large scale.

Ludwig Inst. Cancer Res. WO 00/50589

Stimulating CD4+ T cells

New York

Antigenic peptides from the tyrosine kinase receptor EphA3, encoding gene; for stimulating CD4+ T cells.

Merck WO 00/50563

Galanin-like receptors

Rahway, N.J.

G protein-coupled receptor resembling galanin receptors, encoding gene; for identifying modulators.

Merck WO 00/50627

Monkey GnRH receptor

Rahway, N.J.

Monkey gonadotropin releasing hormone (GnRH) receptor, encoding gene sequences; for diagnostics and therapeutics.

Microbiol. Res. Auth. WO 00/50074

Meningococcal disease vaccines

Salisbury, UK

Use of Neisseria extracts to induce immunoresponses; for meningococcal disease vaccines.

Microbiol. Res. Auth. WO 00/50600

Clostridium virulence induction

Salisbury, UK

Pheromones derived from Clostridium species; for enhancing the production of virulence factors.

Millennium Pharma WO 00/50442 & 50443

Secreted proteins

Cambridge, Mass.

Membrane-associated and secreted proteins, encoding gene sequences, transgenics, fusions, antibodies.

Millennium Pharma WO 00/50596

G-protein coupled receptor

Cambridge, Mass.

G-protein coupled receptor, encoding gene sequences; for cardiovascular disease therapeutics.

Mindset Biopharma WO 00/50089

Drug effect control

New York

Expression of a drug antibody in target cells transfected by gene therapy methods; for controlling administered drugs.

Mirus WO 00/50617

Intravascular gene therapy

Madison, Wis.

Delivery of non-viral gene therapy vectors intravascularly by increasing vessel permeability during transfection.

Montreal, Univ. of WO 00/50580

Phosphate regulating enzyme

Montreal

Soluble form of the type II integral membrane glycoprotein PHEX, a phosphate regulating enzyme.

Myriad Genetics WO 00/50564

DNA extraction method

Salt Lake City

Methods for extracting DNA from dried biological samples on solid substrates; for gene identification.

NIH (Natl. Inst. Hlth.) WO 00/50601

Yeast infection diagnostics

Bethesda, Md.

Hemoglobin-response genes in Candida albicans yeast, encoded proteins; for infection diagnostics.

Natl. Jewish Med. Ctr. WO 00/50081

Receptor desensitization

Denver

Regulatory compounds that uncouple B cell antigen receptors from associated transducers; for receptor desensitization.

Novo Nordisk WO 00/50567

DNA libraries in fungi

Bagsvaerd, Denmark

Fungal cells having an inactivated DNA mismatch repair system; for making DNA libraries.

Novo Nordisk WO 00/50576

Oxaloacetate hydrolase

Bagsvaerd, Denmark

Proteins with oxaloacetate hydrolase activity, encoding gene, recombinant production methods.

Novo Nordisk Biotech WO 00/50606

Galactose oxidase

Davis, Calif.

Proteins with galactose oxidase activity, encoding gene, recombinant production methods.

Nycomed Imaging WO 00/50449

Diphtheria toxin purification

Oslo, Norway

Process for purifying diphtheria toxin made by bacteria by using hydrophobic matrix ion exchange chromatography.

Ohio State Univ. WO 00/50061

Squamous cell carcinoma diagnostics

Columbus, Ohio

Diagnostic assay for the expression of the DESC1 gene; for detecting squamous cell carcinoma.

Oklahoma Med. Res. Fdn. WO 00/50445

Ubiquination protein

Oklahoma City, Okla.

Mammalian von Hippel-Lindau tumor suppressor complex component called Rbx1; for studying ubiquination.

Oncolytics WO 00/50051

Anti-cancer reoviruses

Calgary, Alberta

Administration of reoviruses to cells proliferating under the influence of ras; for treating various cancers.

Osaka Univ. WO 00/50603

Chicken pox vaccines

Osaka, Japan

Attenuated chicken pox virus Oka strain gene 62, variants; for identifying attenuated strains and making vaccines.

Otsuka Pharma EP 1 033 134

Smooth muscle inhibitors

Tokyo

Antibodies for inhibiting smooth muscle proliferation and diagnosing arteriosclerosis.

Papoutsakis, E.T. WO 00/50571

Enhanced T cell culture

Glenview, Ill.

Culture methods for enhancing stimulation and proliferation of T cells; for cellular immunotherapy.

Pittsburgh, Univ. of WO 00/50048

Liver repair

Pittsburgh, Penn.

Isolation of Thy-1 positive bone marrow cells; for transplants to regenerate and repair livers.

Purdue Univ. WO 00/50076

Viral latency proteins

West Lafayette, Ind.

Adenoviral vectors for expressing viral proteins involved in inducing latency, viral proteins, encoding gene sequences.

Reneuron WO 00/50568

Alzheimer's transplants

London

Intracerebral transplantation of hematopoietic stem cells; for treating Alzheimer's and Parkinson's disease.

Rome Univ. WO 00/50581

Silencing gene

Rome

Isolation and characterization of a Neurospora silencing gene; for transfection into heterologous cells.

Saus, J. WO 00/50607

Goodpasture antigen binding protein

Valencia, Spain

Goodpasture antigen binding protein, encoding gene, sequences, antibodies; for diagnostics.

SmithKline Beecham WO 00/50433

Antibacterial screens

Philadelphia

Bacterial Q13 polypeptides, encoding genes, recombinant production methods; for antibacterial screens.

SmithKline Beecham WO 00/50435

Antibacterial screens

Philadelphia

Bacterial tktA polypeptides, encoding genes, recombinant production methods; for antibacterial screens.

SmithKline Beecham WO 00/50458

Seven transmembrane receptor

Philadelphia

F2Y-like seven transmembrane receptor, encoding gene, production methods; for diagnostics and therapeutics.

SmithKline Beecham WO 00/50460 & 50461

IgE immunotherapy

Philadelphia

Epitopes/mimotopes from surface exposed regions of the IgE C-epsilon-2 and 4 domains, antagonists; for immunotherapy.

SmithKline Beecham WO 00/50599

Haemophilus antibacterials

Rixensart, Belgium

Haemophilus antigen, encoding gene sequences, recombinant production methods; for antibacterial screens.

SmithKline Beecham WO 00/50602

Antibacterial screens

Philadelphia

Bacterial tdk polypeptides, encoding genes, recombinant production methods; for antibacterial screens.

Statens Veterinary Med. WO 00/50450

Mite vaccines

Uppsala, Sweden

Major mite antigen, encoding gene sequences; for diagnostics and vaccines.

Sumitomo Electric EP 1 033 402

p16 binding proteins

Osaka, Japan

p16 tumor suppressor-binding proteins, encoding gene sequences, variants, antibodies.

Sumitomo Electric EP 1 033 406

Antigen-specific antibody inducer

Osaka, Japan

Inducer for making antigen-specific antibodies that is a chimera of an antigen and a B cell activator.

Sumitomo Electric WO 00/50611

Kinase-like protein

Osaka, Japan

Kinase-like protein called GANP, encoding gene sequences; for controlling abnormal B cell differentiation.

Synaptic Pharma WO 00/50562

Mammalian receptors

Paramus, N.J.

Mammalian receptors, encoding gene sequences, transgenics, antibodies; for identifying modulators.

Takara Shuzo EP 1 033 408

Cold-inducible vector

Kyoto, Japan

Expression vector having the 5' regulatory region of a cold-inducible gene; for regulated gene expression.

Tennessee, Univ. of WO 00/50593

Meniere's disease diagnostics

Memphis, Tenn.

_-tubulin autoantigen present in the membranous structures of the inner ear in Meniere's disease; for diagnostics.

Thomas Jefferson Univ. WO 00/50565

Tumor suppressor gene

Philadelphia

Human tumor suppressor gene FEZ1, encoded protein; for identifying modulators and affecting cell proliferation.

Tufts Univ. WO 00/50454

Cell proliferation suppressor

Medford, Mass.

Androgen-induced suppressor of cell proliferation, encoding gene, antibodies; for diagnostics and therapeutics.

Univ. College WO 00/50452

Cell adhesion destabilization

London

Mutants of the RAC cell adhesion protein that reduce or eliminate its cell adhesion destabilization function.

Univ. Technol. Intl. WO 00/50616

Proteins from insect cells

Calgary, Alberta

Gene sequences for improving the efficiency of the secretion of heterologous non-secreted proteins from insect cells.

Wistar Inst. WO 00/50569

T cell cytotoxicity modification

Philadelphia

Increasing cytotoxicity of T cell lines by culturing with IL-15 followed by gamma irradiation to halt cell growth.

Yoo, T.J. WO 00/50044

Dust mite vaccine

Memphis, Tenn.

Gene sequences encoding T-cell epitopes of the house dust mite; for DNA vaccines.

Yoo, T.J. WO 00/50455

Lupus diagnostics

Memphis, Tenn.

28 kD antigen from the intracellular signal transduction oncogene; for Systemic Lupus Erythematosis diagnostics.

ZymoGenetics WO 00/50594

Cell growth modulator protein

Seattle

Mammalian a-helical protein, encoding gene, antibodies; for cell growth modulation.

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