September 6 (EP), August 31 (WO)
Acorda Therapeutics WO 00/50447
Cell adhesion modulators
Carbohydrate epitope mimics that are proteins, analogs, variants, encoding genes; for modulating adhesion.
Amgen WO 00/50063
Liver cell transfection
Thousand Oaks, Calif.
Induction of semi-synchronous liver cell proliferation in vivo; for enhancing gene transfection.
Beckman Coulter WO 00/50457
Prostate cancer diagnostics
Prostate-specific membrane antigens, modifications, antibodies; for diagnostic immunoassays.
Bernstein, E.F. WO 00/49876 & 50892
Oxidative damage assays
Transgenic fibroblasts with an elastin promoter generating reactive oxygen species; for oxidative damage assays.
British Columbia, Univ. of WO 00/49937
Prostate cancer therapy
Reducing the expression of TRPM-2 using antisense; for treating prostate and renal cancer.
British Columbia, Univ. of WO 00/50570
Growth factor-dependent cells
Modifying growth and differentiation of growth factor-dependent cells using growth factor fusions.
Canadian Natl. Res. Counc. WO 00/50619
Adenoviral gene therapy vector
Adenovirus mutants with a deleted protease gene that blocks replication; for use as a gene therapy vector.
Case Western Res. Univ. WO 00/50591
Chloride channel inhibitors
Identification of the regulatory domain of the CFTR chloride channel; for designing inhibitors.
Chiron WO 00/50075
Enhancing bactericidal activity of Neisseria antigens using oligonucleotides having CG motifs.
Chugai EP 1 033 374
Sequence signal trap
Linking the secretory signal of the human mpl gene to a test DNA; for trapping signal sequences.
Chugai EP 1 033 403
Human fetal chondrocyte-derived gene, encoded protein; for regulating cell cytoskeletal binding.
Cold Spr. Harbor Lab WO 00/50587
Complex genome sequencing
Cold Spr. Harbor, N.Y.
Genetically filtered shotgun sequencing of complex eukaryotic genomes that removes repetitive sequences.
Columbia Univ. WO 00/50566
Insect odorant receptors
Genes encoding insect odorant receptors, encoded proteins; for controlling insect populations.
Connaught Labs WO 00/50604
HIV-1 gp140 glycoprotein
Vector for expressing the gp140 glycoprotein of the primary isolate of HIV-1; for diagnostics and therapeutics.
Creative Biomolecules EP 1 033 574
Morphogenic protein screen
Epithelial cell assay system for screening morphogenic proteins.
CuraGen WO 00/50590
MDM2 interacting protein
New Haven, Conn.
Complexes of MDM2 protein and its interacting protein, gene encoding the interacting protein, fragments, analogs.
Cytotherapeutics WO 00/50572
Neural stem cell viability
Use of collagenase to dissociate neural stem cells in culture; for increased viability and cell growth.
European Molec. Biol. Lab WO 00/50586
Cell free translation
Cell free translation system that allows increased amounts of protein synthesis.
Genaissance Pharma WO 00/50436
TNF receptor gene SNPs
New Haven, Conn.
Tumor necrosis factor (TNF) receptor gene single nucleotide polymorphisms (SNPs), methods of identification.
Genetics Inst. WO 00/50592
Secreted proteins, encoding gene sequences, recombinant production methods; for diagnostics and therapeutics.
Genset EP 1 033 401
Expressed sequence tags
Expressed sequence tags and upstream regulatory sequences from secreted proteins; for secretion vectors.
Georgetown Univ. WO 00/50008
Anti-transferrin antibody fragments inserted into p53 gene-containing immunoliposomes; for treating cancer.
Gout, I., et al. WO 00/50595
Gene sequences associated with melanoma and thyroid tumors; for cancer diagnostics and therapeutics.
Haeggstrom, J. WO 00/50577
Anti-inflammatory drug design
Leukotriene A4 hydrolase, complexes with inhibitors; for designing anti-inflammatory drugs.
Health Research WO 00/50561
Candida albicans yeast gene CaESS1, probes, encoded proteins; for antifungal drug development
Henry Ford Hlth. System WO 00/49871
Anti-angiogenic kringle protein derived from tissue plasminogen activator, mutants; for therapeutics.
Hoffmann-La Roche EP 1 033 404
Human melanoma cell gene that is down-regulated during tumor progression and/or metastasis, encoded protein.
Human Genome Sciences WO 00/50459
TNF receptor-like proteins
Human tumor necrosis factor (TNF) receptor-like proteins, encoding genes, recombinant production methods.
Human Genome Sciences WO 00/50597
Neutrokine-a splice variant
Neutrokine-a and a splice variant, encoding gene sequences, production methods; diagnostics and therapeutics.
Human Genome Sciences WO 00/50620
Human endokine-a from the TNF cytokine family, encoding gene, production methods; for diagnostics and therapeutics.
Icagen WO 00/50444
Potassium channel modulator screen
BK _ subunits of Slo family potassium channels, antibodies; for screening modulators.
Incyte Genomics WO 00/50588
Colon disease genes
Palo Alto, Calif.
Genes associated with diseases of the colon, encoded proteins, antibodies; for diagnostics and therapeutics.
Instrumentation Lab WO 00/50612
Protein C activator
Highly glycosylated snake protein C activator, encoding gene, variants; for blood coagulation diagnostics.
Iowa, Univ. of WO 00/50584
Gene delivery immunoresponse
Iowa City, Iowa
Gene delivery system using a biocompatible collagen-based carrier; for inducing immune responses.
Isis Pharma WO 00/50091
Antisense oligonucleotides to Akt-2; for modulating its expression in associated diseases.
Isis Pharma WO 00/50092, 50437, 50439 & 50440
Antisense oligonucleotides to Smad1, 2, 4, & 5; for modulating its expression in associated diseases.
Isis Pharma WO 00/50438
Phospholipase A2 antisense
Antisense oligonucleotides to phospholipase A2 group IV; for modulating its expression in associated diseases.
Isis Pharma WO 00/50583
Antisense oligonucleotides to G-alpha-12; for modulating its expression in associated diseases.
Johns Hopkins Univ. WO 00/50453
Apoptosis regulator protein
Human apoptosis regulator protein, encoding gene sequences, antibodies, modulators.
Juridicial Fdn. WO 00/50618
Cancer therapy fusion protein
Viral vectors that encode a viral protein fused to a ligand that specifically binds MSH; for cancer therapy.
Kitasato Inst. EP 1 033 370
Treating worm infections
Isolation of small molecule organics from fungi that are useful for treating parasitic helminth worm infections.
Kitasato Inst. WO 00/50605
Antimicrobial polyketide synthesis
Avermectin aglycon synthase genes, variants, encoded enzymes; for antimicrobial polyketide biosynthesis.
Krebs Res. Ctr. WO 00/50451
CNS development gene
Protein involved in the development of the central nervous system (CNS), encoding gene, ribozymes, transgenics.
Kyowa Hakko Kogyo WO 00/50608
Digestive cancer diagnostics
_1,3-galactose transferase-like protein, encoding gene sequences; for digestive cancer diagnosis.
Life Technologies WO 00/50625
Large scale nucleotide synthesis
Efficient methods for synthesizing substantially pure nucleotides in large scale.
Ludwig Inst. Cancer Res. WO 00/50589
Stimulating CD4+ T cells
Antigenic peptides from the tyrosine kinase receptor EphA3, encoding gene; for stimulating CD4+ T cells.
Merck WO 00/50563
G protein-coupled receptor resembling galanin receptors, encoding gene; for identifying modulators.
Merck WO 00/50627
Monkey GnRH receptor
Monkey gonadotropin releasing hormone (GnRH) receptor, encoding gene sequences; for diagnostics and therapeutics.
Microbiol. Res. Auth. WO 00/50074
Meningococcal disease vaccines
Use of Neisseria extracts to induce immunoresponses; for meningococcal disease vaccines.
Microbiol. Res. Auth. WO 00/50600
Clostridium virulence induction
Pheromones derived from Clostridium species; for enhancing the production of virulence factors.
Millennium Pharma WO 00/50442 & 50443
Membrane-associated and secreted proteins, encoding gene sequences, transgenics, fusions, antibodies.
Millennium Pharma WO 00/50596
G-protein coupled receptor
G-protein coupled receptor, encoding gene sequences; for cardiovascular disease therapeutics.
Mindset Biopharma WO 00/50089
Drug effect control
Expression of a drug antibody in target cells transfected by gene therapy methods; for controlling administered drugs.
Mirus WO 00/50617
Intravascular gene therapy
Delivery of non-viral gene therapy vectors intravascularly by increasing vessel permeability during transfection.
Montreal, Univ. of WO 00/50580
Phosphate regulating enzyme
Soluble form of the type II integral membrane glycoprotein PHEX, a phosphate regulating enzyme.
Myriad Genetics WO 00/50564
DNA extraction method
Salt Lake City
Methods for extracting DNA from dried biological samples on solid substrates; for gene identification.
NIH (Natl. Inst. Hlth.) WO 00/50601
Yeast infection diagnostics
Hemoglobin-response genes in Candida albicans yeast, encoded proteins; for infection diagnostics.
Natl. Jewish Med. Ctr. WO 00/50081
Regulatory compounds that uncouple B cell antigen receptors from associated transducers; for receptor desensitization.
Novo Nordisk WO 00/50567
DNA libraries in fungi
Fungal cells having an inactivated DNA mismatch repair system; for making DNA libraries.
Novo Nordisk WO 00/50576
Proteins with oxaloacetate hydrolase activity, encoding gene, recombinant production methods.
Novo Nordisk Biotech WO 00/50606
Proteins with galactose oxidase activity, encoding gene, recombinant production methods.
Nycomed Imaging WO 00/50449
Diphtheria toxin purification
Process for purifying diphtheria toxin made by bacteria by using hydrophobic matrix ion exchange chromatography.
Ohio State Univ. WO 00/50061
Squamous cell carcinoma diagnostics
Diagnostic assay for the expression of the DESC1 gene; for detecting squamous cell carcinoma.
Oklahoma Med. Res. Fdn. WO 00/50445
Oklahoma City, Okla.
Mammalian von Hippel-Lindau tumor suppressor complex component called Rbx1; for studying ubiquination.
Oncolytics WO 00/50051
Administration of reoviruses to cells proliferating under the influence of ras; for treating various cancers.
Osaka Univ. WO 00/50603
Chicken pox vaccines
Attenuated chicken pox virus Oka strain gene 62, variants; for identifying attenuated strains and making vaccines.
Otsuka Pharma EP 1 033 134
Smooth muscle inhibitors
Antibodies for inhibiting smooth muscle proliferation and diagnosing arteriosclerosis.
Papoutsakis, E.T. WO 00/50571
Enhanced T cell culture
Culture methods for enhancing stimulation and proliferation of T cells; for cellular immunotherapy.
Pittsburgh, Univ. of WO 00/50048
Isolation of Thy-1 positive bone marrow cells; for transplants to regenerate and repair livers.
Purdue Univ. WO 00/50076
Viral latency proteins
West Lafayette, Ind.
Adenoviral vectors for expressing viral proteins involved in inducing latency, viral proteins, encoding gene sequences.
Reneuron WO 00/50568
Intracerebral transplantation of hematopoietic stem cells; for treating Alzheimer's and Parkinson's disease.
Rome Univ. WO 00/50581
Isolation and characterization of a Neurospora silencing gene; for transfection into heterologous cells.
Saus, J. WO 00/50607
Goodpasture antigen binding protein
Goodpasture antigen binding protein, encoding gene, sequences, antibodies; for diagnostics.
SmithKline Beecham WO 00/50433
Bacterial Q13 polypeptides, encoding genes, recombinant production methods; for antibacterial screens.
SmithKline Beecham WO 00/50435
Bacterial tktA polypeptides, encoding genes, recombinant production methods; for antibacterial screens.
SmithKline Beecham WO 00/50458
Seven transmembrane receptor
F2Y-like seven transmembrane receptor, encoding gene, production methods; for diagnostics and therapeutics.
SmithKline Beecham WO 00/50460 & 50461
Epitopes/mimotopes from surface exposed regions of the IgE C-epsilon-2 and 4 domains, antagonists; for immunotherapy.
SmithKline Beecham WO 00/50599
Haemophilus antigen, encoding gene sequences, recombinant production methods; for antibacterial screens.
SmithKline Beecham WO 00/50602
Bacterial tdk polypeptides, encoding genes, recombinant production methods; for antibacterial screens.
Statens Veterinary Med. WO 00/50450
Major mite antigen, encoding gene sequences; for diagnostics and vaccines.
Sumitomo Electric EP 1 033 402
p16 binding proteins
p16 tumor suppressor-binding proteins, encoding gene sequences, variants, antibodies.
Sumitomo Electric EP 1 033 406
Antigen-specific antibody inducer
Inducer for making antigen-specific antibodies that is a chimera of an antigen and a B cell activator.
Sumitomo Electric WO 00/50611
Kinase-like protein called GANP, encoding gene sequences; for controlling abnormal B cell differentiation.
Synaptic Pharma WO 00/50562
Mammalian receptors, encoding gene sequences, transgenics, antibodies; for identifying modulators.
Takara Shuzo EP 1 033 408
Expression vector having the 5' regulatory region of a cold-inducible gene; for regulated gene expression.
Tennessee, Univ. of WO 00/50593
Meniere's disease diagnostics
_-tubulin autoantigen present in the membranous structures of the inner ear in Meniere's disease; for diagnostics.
Thomas Jefferson Univ. WO 00/50565
Tumor suppressor gene
Human tumor suppressor gene FEZ1, encoded protein; for identifying modulators and affecting cell proliferation.
Tufts Univ. WO 00/50454
Cell proliferation suppressor
Androgen-induced suppressor of cell proliferation, encoding gene, antibodies; for diagnostics and therapeutics.
Univ. College WO 00/50452
Cell adhesion destabilization
Mutants of the RAC cell adhesion protein that reduce or eliminate its cell adhesion destabilization function.
Univ. Technol. Intl. WO 00/50616
Proteins from insect cells
Gene sequences for improving the efficiency of the secretion of heterologous non-secreted proteins from insect cells.
Wistar Inst. WO 00/50569
T cell cytotoxicity modification
Increasing cytotoxicity of T cell lines by culturing with IL-15 followed by gamma irradiation to halt cell growth.
Yoo, T.J. WO 00/50044
Dust mite vaccine
Gene sequences encoding T-cell epitopes of the house dust mite; for DNA vaccines.
Yoo, T.J. WO 00/50455
28 kD antigen from the intracellular signal transduction oncogene; for Systemic Lupus Erythematosis diagnostics.
ZymoGenetics WO 00/50594
Cell growth modulator protein
Mammalian a-helical protein, encoding gene, antibodies; for cell growth modulation.