August 31 & September 8 (WO)

Adv. Res. & Technol. Inst. WO 00/50868

Human Lhx3 genes


Human Lhx3 genes and isoforms on chromosome 9, encoded protein; for diagnostics and therapeutics.

Alabama, Univ. of WO 00/50646

RSV antivirals

Birmingham, Ala.

Screening for agents that treat respiratory syncytial virus (RSV) infections using loss of function of the M2-1 protein.

Allelix WO 00/52173

Sphingosine kinase homologs

Mississauga, Ont.

Cloned human sphingosine kinase homologs, encoded proteins; for diagnostics and therapeutics.

Amano Pharma WO 00/52177


Aichi, Japan

_-primeverosidase gene, encoded protein, modifications made by deletions, substitutions, insertions, or additions.

Ancobio WO 00/50629

Male infertility detection

Glasgow, UK

Mutations in the POLG gene encoding mitochondrial DNA polymerase; for detecting male infertility.

Arctic Partners WO 00/50899

Staging prostate cancer

Turku, Finland

Determining glandular kallikrein 2 and prostate-specific antigen levels; for staging prostate cancer.

Arkansas, Univ. of WO 00/52154

Altering IgE binding sites

Little Rock, Ark.

Alteration of immunoglobulin (Ig) E binding sites; for decreasing allergic reactions.

Auckland Uniservices WO 00/50638

Premature ovarian failure

Auckland, New Zealand

Inhibin gene mutations associated with premature ovarian failure; for diagnostics.

Aventis WO 00/52201

Splicing reaction detection

Frankfurt, Germany

Immobilized nucleic acids for detecting a splicing reaction without using gels.

Baylor Coll. Med. WO 00/50641

Autoimmune disease diagnostics


T cell receptor V_-D_-J_ gene sequences, methods of detection; for diagnosing autoimmune diseases.

Boehringer Ingelheim Intl. WO 00/52157

Tumor-associated antigen

Ingelheim, Germany

Tumor-associated antigen, immunogenic peptide fragments, encoding gene sequences; for cancer immunotherapy.

Caliper Technol. WO 00/50642

Sequencing methods

Mountain View, Calif.

Nucleotide analogs having 3'-blocking groups; for reversible chain termination in sequencing reactions.

Cell Genesys WO 00/52158

Angiogenesis inhibitors

Foster City, Calif.

Methods for inhibiting angiogenesis using cyclin-dependent kinase inhibitors and fusion proteins, delivery liposomes.

Cell Genesys WO 00/52159

Smooth muscle growth inhibition

Foster City, Calif.

Inhibiting smooth muscle cell proliferation using adenoviruses encoding cyclin-dependent kinase inhibitors.

Cell Genesys WO 00/52184

Cancer therapeutics

Foster City, Calif.

Chimeric gene encoding a regulatory sequence linked to a CDK1-adenovirus E4 protein fusion gene; for cancer therapy.

Cellomics WO 00/50872

Cell function modulator screen

Pittsburgh, Penn.

Rapid cell-based screening methods that measure fluorescent reporters; for finding agents that affect cell function.

Chicago, Univ. of WO 00/52208

Reusable oligo microchips


Customized, portable, and reusable oligo microchips that convert multiple genetic information to simpler patterns.

Chiron WO 00/52209

Gene pathway modification

Emeryville, Calif.

Microarrays with probes to genes encoding enzymes in specific biochemical pathways; for gene expression changes.

CSIRO (Comm. Sci. & Ind. Res. Org.) WO 00/52156

Prostate cancer therapy

Campbell, Australia

Regulatory constructs derived from the intron 3 of prostate specific membrane antigen gene; for treating cancer.

Corixa WO 00/50897

Chagas' disease diagnostics


Trypanosoma cruzi antigen epitopes, antibodies; for immunoassays to detect Chagas' disease.

Corixa WO 00/52165

Breast cancer diagnosis

Seattle, Wash.

Breast tumor antigens, fragments, encoding gene sequences; for diagnostics and therapeutics.

Exact Labs WO 00/50640

DNA extraction

Maynard, Mass.

Extracting DNA from biological samples in higher yield than conventional methods.

Fluorescience WO 00/50635

Protease activity assay

Leeds, UK

Protease enzyme activity assay using labelled protein multimers that are sensitive to proteolytic digestion.

Fluorescience WO 00/50896

Modifiable binding partners

Leeds, UK

Monitoring enzymatic activity as a function of the interaction of modifiable binding partners.

Gene Logic WO 00/52026

Renal hypertrophy gene

Gaithersburg, Md.

Identification of a cDNA whose expression is elevated in compensatory hypertrophy in renal tissue.

Genelabs Technol. WO 00/52179

Transcription regulation

Redwood City, Calif.

Gene sequences encoding a transcriptional regulatory proteins linked to a transgene; for screening regulators.

Genentech WO 00/52166

Human fused protein suppressor

S. San Francisco

Suppressor of the human fused protein homolog, encoding gene, fusions, chimeras, antibodies, production methods.

Georgia, Univ. of WO 00/52147

Bacterial growth inhibitors

Athens, Ga.

Prolyl peptidases, active analogs and fragments; for slowing bacterial growth by using enzyme inhibitors.

Gyllensten, U., et al. WO 00/50645

Cervical cancer diagnosis

Uppsala, Sweden

Detection of viral nucleic acid from cervical samples; for early cancer diagnosis.

Hartmann, M., et al. WO 00/52176


Munster, Germany

_-hexosaminidase from ciliates, encoding gene sequences; for modifying polysaccharides.

Hibergen WO 00/50637

Diabetic nephropathy genes

Cork, Ireland

Culturing mesangial cells with glucose; for differential expression assays to identify diabetic nephropathy genes.

Human Genome Sciences WO 00/52028

TNF receptors 6a/6_

Rockville, Md.

Tumor necrosis factor (TNF) receptors 6a and 6_, encoding genes, production methods; for finding immunomodulators.

Human Genome Sciences WO 00/52135

Making sialylated glycoproteins

Rockville, Md.

Manipulating multiple pathways involved in sialylation reactions; for engineering sialylated glycoproteins.

Human Genome Sciences WO 00/52136

Glycosylation enzymes

Rockville, Md.

Human glycosylation enzymes, encoding genes, antibodies, production methods; for diagnostics and therapeutics.

Human Genome Sciences WO 00/52160

Human serpin proteins

Rockville, Md.

Human serpin proteins, encoding gene sequences, antibodies, production methods; for diagnostics and therapeutics.

Imperial Cancer Res. Technol. WO 00/52046

T cell super-proliferation


Glycopeptide having the MUC1 tandem repeat; for causing super-proliferation of T cells.

Incyte Genomics WO 00/50869

SNP detection

Palo Alto, Calif.

Methods for detecting single nucleotide polymorphisms (SNPs), SNP probes, sandwich assay.

Incyte Genomics WO 00/52151

Secretory proteins

Palo Alto, Calif.

Human secretory proteins, encoding genes, antibodies, modulators; for diagnostics and therapeutics.

Incyte Genomics WO 00/52161

Leukocyte-associated proteins

Palo Alto, Calif.

Leukocyte- and blood-associated proteins, encoding genes, antibodies, modulators; for diagnostics and therapeutics.

Insight Strategy & Marketing WO 00/52178

Modifying heparanase activity

Rehovot, Israel

Polypeptide having heparanase activity, encoding gene sequences, antisense; for modulating heparanase.

Introgene WO 00/52186

Fibroblast cell transfection

Leiden, Netherlands

Adenovirus-based vector for fibroblast- or macrophage-like cell targeting of transgenes.

King's College WO 00/52203

Bacterial species identification


Identification of bacterial species by amplifying 23S rDNA using specific probes immobilized on solid carriers.

Kitasato Inst. WO 00/52043

Inhibiting HIV syncytia formation


Human peptide that inhibits the formation of syncytia by the HIV envelope glycoprotein; for treating AIDS.

Korea Inst. Inst. Biotech. WO 00/52133

Recombinant protein production

Seoul, S. Korea

Hanssenula polymorpha mutants that allow high yield production of recombinant proteins.

Levy, G. WO 00/51636

Modulating immune coagulation

Thornhill, Ont.

Nucleocapsid proteins from hepatitis virus induce flg2 prothrombinase; for modulating immune coagulation.

Lewandowski, G., et al. WO 00/52185

Herpes antiviral therapy

Tucson, Ariz.

Topical application of a herpes virus-based vector encoding interferon-gamma; for antiviral therapy.

Life Technologies WO 00/52027

Recombinational cloning

Rockville, Md.

Nucleic acid sequences encoding recombination sites; for recombinational cloning.

Life Technologies WO 00/52141

DNA gyrase modulators

Rockville, Md.

Host cells resistant to the killing effects of toxic genes; for identifying toxic genes that act upon DNA gyrase.

Life Technologies WO 00/52191

cDNA libraries

Rockville, Md.

Methods of making cDNA molecules and libraries, produced libraries.

Ludwig Inst. Cancer Res. WO 00/52163

Cancer diagnostics

New York

Cloning of cancer-associated antigens MAGE 5, 8, 9, and 11, encoding genes; for diagnostics and therapeutics.

Lynx Therapeutics WO 00/50632

Polymorphism identification

Hayward, Calif.

Generation of a reference library of restriction fragments for identifying polymorphisms.

Marahiel, M.A., et al. WO 00/52152

Peptide synthetases

Marburg, Germany

Non-ribosomal peptide synthetases, production methods; for producing native and artificial proteins.

Massachusetts, Univ. of WO 00/52145

Stem cell lines

Amherst, Mass.

Embryonic or stem-like cell lines produced by cross-species nuclear transplantation.

Mass. Gen. Hosp. WO 00/50633

Apoptosis modulator assay


Apoptosis modulator identification using cell assays and a transfected anti-cell death gene linked to a reporter.

Maxygen WO 00/52146

Encrypting traits

Redwood City, Calif.

Encrypting traits by having split genes in parental organisms or in an organism and a vector.

Maxygen WO 00/52153

Surrogate ligands

Redwood City, Calif.

Obtaining surrogate ligands for orphan receptors, methods for optimizing ligand biological activity.

Maxygen WO 00/52155

Recombination modulation

Redwood City, Calif.

Modulation of recombination of insertion modified nucleic acids; for use in nucleic acid shuffling procedures.

McGill Univ. WO 00/52205

Tetrahydrofolate reductase phenotypes

Montreal, Que.

Human methylene tetrahydrofolate reductase cDNA, probes, encoded protein; for detecting phenotype mutations.

Merck WO 00/52175

Histidine protein phosphatase

Darmstadt, Germany

Histidine protein phosphatase, encoding gene, homologs, variants, antibodies; for diagnostics and therapeutics.

Merck WO 00/52187

Adenoviral vector construction

Rahway, N.J.

High efficiency construction and production of adenoviral vectors using recombination methods.

Millennium Pharma WO 00/52022

Secreted proteins

Cambridge, Mass.

Secreted proteins, encoding genes, antisense, antibodies, transgenics; for diagnostics and therapeutics.

Millennium Pharma WO 00/52047

Dickkopf-related protein

Cambridge, Mass.

Human Dickkopf-related protein, encoding gene sequences, antibodies, transgenics, production methods.

Millennium Pharma WO 00/52164

Potassium channel proteins

Cambridge, Mass.

Potassium channel proteins, encoding genes, antisense, antibodies, transgenics; for diagnostics and therapeutics.

Mosaic Technol. WO 00/50644 & 50870

DNA purification


Electrophoretic methods and devices for DNA purification using a medium having immobilized capture probes.

NIH (Natl. Inst. Hlth.) WO 00/50643

Radiation exposure assay

Bethesda, Md.

Nucleic acid microarray hybridization for detecting biological effects of radiation exposure.

Nexstar Pharma WO 00/52207

Taq polymerase ligands

Boulder, Colo.

High-affinity ligands for thermostable Taq and other polymerases; for finding inhibitors.

Novartis WO 00/52202

Fungal pathogen detection

Basel, Switzerland

Detection of the fungal pathogen Monilinia fructicola using PCR-based assays.

Orchid Biosciences WO 00/50871

Biological assay microstructures

Princeton, N.J.

Microstructures made of siloxane polymers; for surface-based biological assays such as medical diagnostics.

Orntoft, T.F. WO 00/52204

Bladder cancer diagnosis

Aarhus, Denmark

Gene expression analysis of normal and cancerous bladder cells; for cancer diagnosis and therapy.

Oxford Biomedica WO 00/52188

Retroviral vector production

Oxford, UK

Packaging and producer cell lines for temperature regulatable production of retroviral vectors.

Pacific Northwest Res. Inst. WO 00/50900

Carcinoma diagnosis


Determination of soluble mesothelin related antigen; for carcinoma diagnosis.

PPL Therapeutics WO 00/51424

Genetically modified somatic cells

Roslin, UK

Somatic cells genetically engineered in vitro by gene targeting; for making genetically modified animals.

Regeneron WO 00/52167

Angiopoietin-related protein

Tarrytown, N.Y.

Angiopoietin-related protein, encoding gene, antibodies, production methods.

Sci. Applications & Res. Counc. Soc. WO 00/50636

Protein function assay


Screening databanks for nucleotide sequences that encode proteins believed to have a desired function.

Scripps Res. Inst. WO 00/52192

Catalytic DNA

La Jolla, Calif.

Catalytic and enzymatic DNA molecules that contain modified nucleotides that can cleave RNA in a site-specific manner.

Shanghai Biorigin Gene Develop. WO 00/52200

Large-scale cDNA cloning

Shanghai, China

Methods for large scale cDNA cloning and sequencing by circulating subtraction hybridization.

SmithKline Beecham WO 00/51430

Fatty acid synthase


Human fatty acid synthase, encoding gene sequences, production methods; for diagnostics and therapeutics.

SmithKline Beecham WO 00/52024

Organic anion transporter


Human organic anion transporter, encoding gene; for modulator screens and developing therapeutics.

SmithKline Beecham WO 00/52025

Antibacterial screens


Bacterial Q16 polypeptides, encoding gene sequences, production methods; for antibacterial screens.

SmithKline Beecham WO 00/52042

Moraxella infection diagnostics

Rixensart, Belgium

Moraxella catarrhalis polypeptides, encoding gene sequences, production methods; for diagnostics and therapeutics.

Stanford Univ. WO 00/52030

RANTES expression activation

Palo Alto, Calif.

Zinc finger transcription factor that activates RANTES cytokine gene expression; for modulating inflammation.

Suntory WO 00/52193

Modified OmpT protease

Osaka, Japan

Modified OmpT protease; for use in controlling the cleavage of polypeptides by this enzyme.

Sydney IVF WO 00/50895

Cytoplasm sampling

Sydney, Australia

Isolation of cellular cytoplasmic fractions without impairing the viability of oocytes and embryonic cells.

Tennessee, Univ. of WO 00/52162

Enkephalin antifungals

Knoxville, Tenn.

Yeast oligopeptide transporter of enkephalins, encoding gene sequences; for antifungal treatments.

Terragen Discovery WO 00/52180

Molecular diversity

San Diego, Calif.

Generation of molecular diversity by recombination of genomic DNA from a variety of organisms.

Texas, Univ. of WO 00/52144

Chemotherapeutic response

Austin, Texas

Manipulation of ABC transporters and ecto-phosphatases; for improving responses to chemotherapeutics.

Tufts Univ. WO 00/51635

Emulsan-based vaccines

Medford, Mass.

Bacterial emulsan or emulsan analog combined with an antigen; for making vaccines.

Van Haeringen Lab WO 00/52206

Detecting microorganisms

Wageningen, Netherlands

Detection and quantification of the presence of multiple microorganisms using PCR-based techniques.

Variagenics WO 00/50639

Genetic sequence variation

Cambridge, Mass.

Determination of genetic sequence variation for the prediction of patient response to therapeutic treatment.

Variagenics WO 00/52210

RNA function modulators

Cambridge, Mass.

Methods for identifying structural and sequence targets in RNA; for finding modulators.

Vialogy WO 00/51056

Mutation signatures

Altadena, Calif.

Identifying mutation signatures in a biochip using a dot spectrogram to extract tessellation parametrics.

Warner-Lambert WO 00/50889

Differential gene expression

Ann Arbor, Mich.

Data processing system for managing and presenting information derived from differential expression of genes.

Yissum Res. Develop. WO 00/52181

Foreign protein production

Jerusalem, Israel

GCN4 transcription factor promoter linked to a heterologous coding sequence; for production of foreign proteins.

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