August 31 & September 8 (WO)
Adv. Res. & Technol. Inst. WO 00/50868
Human Lhx3 genes
Indianapolis
Human Lhx3 genes and isoforms on chromosome 9, encoded protein; for diagnostics and therapeutics.
Alabama, Univ. of WO 00/50646
RSV antivirals
Birmingham, Ala.
Screening for agents that treat respiratory syncytial virus (RSV) infections using loss of function of the M2-1 protein.
Allelix WO 00/52173
Sphingosine kinase homologs
Mississauga, Ont.
Cloned human sphingosine kinase homologs, encoded proteins; for diagnostics and therapeutics.
Amano Pharma WO 00/52177
_-primeverosidase
Aichi, Japan
_-primeverosidase gene, encoded protein, modifications made by deletions, substitutions, insertions, or additions.
Ancobio WO 00/50629
Male infertility detection
Glasgow, UK
Mutations in the POLG gene encoding mitochondrial DNA polymerase; for detecting male infertility.
Arctic Partners WO 00/50899
Staging prostate cancer
Turku, Finland
Determining glandular kallikrein 2 and prostate-specific antigen levels; for staging prostate cancer.
Arkansas, Univ. of WO 00/52154
Altering IgE binding sites
Little Rock, Ark.
Alteration of immunoglobulin (Ig) E binding sites; for decreasing allergic reactions.
Auckland Uniservices WO 00/50638
Premature ovarian failure
Auckland, New Zealand
Inhibin gene mutations associated with premature ovarian failure; for diagnostics.
Aventis WO 00/52201
Splicing reaction detection
Frankfurt, Germany
Immobilized nucleic acids for detecting a splicing reaction without using gels.
Baylor Coll. Med. WO 00/50641
Autoimmune disease diagnostics
Houston
T cell receptor V_-D_-J_ gene sequences, methods of detection; for diagnosing autoimmune diseases.
Boehringer Ingelheim Intl. WO 00/52157
Tumor-associated antigen
Ingelheim, Germany
Tumor-associated antigen, immunogenic peptide fragments, encoding gene sequences; for cancer immunotherapy.
Caliper Technol. WO 00/50642
Sequencing methods
Mountain View, Calif.
Nucleotide analogs having 3'-blocking groups; for reversible chain termination in sequencing reactions.
Cell Genesys WO 00/52158
Angiogenesis inhibitors
Foster City, Calif.
Methods for inhibiting angiogenesis using cyclin-dependent kinase inhibitors and fusion proteins, delivery liposomes.
Cell Genesys WO 00/52159
Smooth muscle growth inhibition
Foster City, Calif.
Inhibiting smooth muscle cell proliferation using adenoviruses encoding cyclin-dependent kinase inhibitors.
Cell Genesys WO 00/52184
Cancer therapeutics
Foster City, Calif.
Chimeric gene encoding a regulatory sequence linked to a CDK1-adenovirus E4 protein fusion gene; for cancer therapy.
Cellomics WO 00/50872
Cell function modulator screen
Pittsburgh, Penn.
Rapid cell-based screening methods that measure fluorescent reporters; for finding agents that affect cell function.
Chicago, Univ. of WO 00/52208
Reusable oligo microchips
Chicago
Customized, portable, and reusable oligo microchips that convert multiple genetic information to simpler patterns.
Chiron WO 00/52209
Gene pathway modification
Emeryville, Calif.
Microarrays with probes to genes encoding enzymes in specific biochemical pathways; for gene expression changes.
CSIRO (Comm. Sci. & Ind. Res. Org.) WO 00/52156
Prostate cancer therapy
Campbell, Australia
Regulatory constructs derived from the intron 3 of prostate specific membrane antigen gene; for treating cancer.
Corixa WO 00/50897
Chagas' disease diagnostics
Seattle
Trypanosoma cruzi antigen epitopes, antibodies; for immunoassays to detect Chagas' disease.
Corixa WO 00/52165
Breast cancer diagnosis
Seattle, Wash.
Breast tumor antigens, fragments, encoding gene sequences; for diagnostics and therapeutics.
Exact Labs WO 00/50640
DNA extraction
Maynard, Mass.
Extracting DNA from biological samples in higher yield than conventional methods.
Fluorescience WO 00/50635
Protease activity assay
Leeds, UK
Protease enzyme activity assay using labelled protein multimers that are sensitive to proteolytic digestion.
Fluorescience WO 00/50896
Modifiable binding partners
Leeds, UK
Monitoring enzymatic activity as a function of the interaction of modifiable binding partners.
Gene Logic WO 00/52026
Renal hypertrophy gene
Gaithersburg, Md.
Identification of a cDNA whose expression is elevated in compensatory hypertrophy in renal tissue.
Genelabs Technol. WO 00/52179
Transcription regulation
Redwood City, Calif.
Gene sequences encoding a transcriptional regulatory proteins linked to a transgene; for screening regulators.
Genentech WO 00/52166
Human fused protein suppressor
S. San Francisco
Suppressor of the human fused protein homolog, encoding gene, fusions, chimeras, antibodies, production methods.
Georgia, Univ. of WO 00/52147
Bacterial growth inhibitors
Athens, Ga.
Prolyl peptidases, active analogs and fragments; for slowing bacterial growth by using enzyme inhibitors.
Gyllensten, U., et al. WO 00/50645
Cervical cancer diagnosis
Uppsala, Sweden
Detection of viral nucleic acid from cervical samples; for early cancer diagnosis.
Hartmann, M., et al. WO 00/52176
_-hexosaminidase
Munster, Germany
_-hexosaminidase from ciliates, encoding gene sequences; for modifying polysaccharides.
Hibergen WO 00/50637
Diabetic nephropathy genes
Cork, Ireland
Culturing mesangial cells with glucose; for differential expression assays to identify diabetic nephropathy genes.
Human Genome Sciences WO 00/52028
TNF receptors 6a/6_
Rockville, Md.
Tumor necrosis factor (TNF) receptors 6a and 6_, encoding genes, production methods; for finding immunomodulators.
Human Genome Sciences WO 00/52135
Making sialylated glycoproteins
Rockville, Md.
Manipulating multiple pathways involved in sialylation reactions; for engineering sialylated glycoproteins.
Human Genome Sciences WO 00/52136
Glycosylation enzymes
Rockville, Md.
Human glycosylation enzymes, encoding genes, antibodies, production methods; for diagnostics and therapeutics.
Human Genome Sciences WO 00/52160
Human serpin proteins
Rockville, Md.
Human serpin proteins, encoding gene sequences, antibodies, production methods; for diagnostics and therapeutics.
Imperial Cancer Res. Technol. WO 00/52046
T cell super-proliferation
London
Glycopeptide having the MUC1 tandem repeat; for causing super-proliferation of T cells.
Incyte Genomics WO 00/50869
SNP detection
Palo Alto, Calif.
Methods for detecting single nucleotide polymorphisms (SNPs), SNP probes, sandwich assay.
Incyte Genomics WO 00/52151
Secretory proteins
Palo Alto, Calif.
Human secretory proteins, encoding genes, antibodies, modulators; for diagnostics and therapeutics.
Incyte Genomics WO 00/52161
Leukocyte-associated proteins
Palo Alto, Calif.
Leukocyte- and blood-associated proteins, encoding genes, antibodies, modulators; for diagnostics and therapeutics.
Insight Strategy & Marketing WO 00/52178
Modifying heparanase activity
Rehovot, Israel
Polypeptide having heparanase activity, encoding gene sequences, antisense; for modulating heparanase.
Introgene WO 00/52186
Fibroblast cell transfection
Leiden, Netherlands
Adenovirus-based vector for fibroblast- or macrophage-like cell targeting of transgenes.
King's College WO 00/52203
Bacterial species identification
London
Identification of bacterial species by amplifying 23S rDNA using specific probes immobilized on solid carriers.
Kitasato Inst. WO 00/52043
Inhibiting HIV syncytia formation
Tokyo
Human peptide that inhibits the formation of syncytia by the HIV envelope glycoprotein; for treating AIDS.
Korea Inst. Inst. Biotech. WO 00/52133
Recombinant protein production
Seoul, S. Korea
Hanssenula polymorpha mutants that allow high yield production of recombinant proteins.
Levy, G. WO 00/51636
Modulating immune coagulation
Thornhill, Ont.
Nucleocapsid proteins from hepatitis virus induce flg2 prothrombinase; for modulating immune coagulation.
Lewandowski, G., et al. WO 00/52185
Herpes antiviral therapy
Tucson, Ariz.
Topical application of a herpes virus-based vector encoding interferon-gamma; for antiviral therapy.
Life Technologies WO 00/52027
Recombinational cloning
Rockville, Md.
Nucleic acid sequences encoding recombination sites; for recombinational cloning.
Life Technologies WO 00/52141
DNA gyrase modulators
Rockville, Md.
Host cells resistant to the killing effects of toxic genes; for identifying toxic genes that act upon DNA gyrase.
Life Technologies WO 00/52191
cDNA libraries
Rockville, Md.
Methods of making cDNA molecules and libraries, produced libraries.
Ludwig Inst. Cancer Res. WO 00/52163
Cancer diagnostics
New York
Cloning of cancer-associated antigens MAGE 5, 8, 9, and 11, encoding genes; for diagnostics and therapeutics.
Lynx Therapeutics WO 00/50632
Polymorphism identification
Hayward, Calif.
Generation of a reference library of restriction fragments for identifying polymorphisms.
Marahiel, M.A., et al. WO 00/52152
Peptide synthetases
Marburg, Germany
Non-ribosomal peptide synthetases, production methods; for producing native and artificial proteins.
Massachusetts, Univ. of WO 00/52145
Stem cell lines
Amherst, Mass.
Embryonic or stem-like cell lines produced by cross-species nuclear transplantation.
Mass. Gen. Hosp. WO 00/50633
Apoptosis modulator assay
Boston
Apoptosis modulator identification using cell assays and a transfected anti-cell death gene linked to a reporter.
Maxygen WO 00/52146
Encrypting traits
Redwood City, Calif.
Encrypting traits by having split genes in parental organisms or in an organism and a vector.
Maxygen WO 00/52153
Surrogate ligands
Redwood City, Calif.
Obtaining surrogate ligands for orphan receptors, methods for optimizing ligand biological activity.
Maxygen WO 00/52155
Recombination modulation
Redwood City, Calif.
Modulation of recombination of insertion modified nucleic acids; for use in nucleic acid shuffling procedures.
McGill Univ. WO 00/52205
Tetrahydrofolate reductase phenotypes
Montreal, Que.
Human methylene tetrahydrofolate reductase cDNA, probes, encoded protein; for detecting phenotype mutations.
Merck WO 00/52175
Histidine protein phosphatase
Darmstadt, Germany
Histidine protein phosphatase, encoding gene, homologs, variants, antibodies; for diagnostics and therapeutics.
Merck WO 00/52187
Adenoviral vector construction
Rahway, N.J.
High efficiency construction and production of adenoviral vectors using recombination methods.
Millennium Pharma WO 00/52022
Secreted proteins
Cambridge, Mass.
Secreted proteins, encoding genes, antisense, antibodies, transgenics; for diagnostics and therapeutics.
Millennium Pharma WO 00/52047
Dickkopf-related protein
Cambridge, Mass.
Human Dickkopf-related protein, encoding gene sequences, antibodies, transgenics, production methods.
Millennium Pharma WO 00/52164
Potassium channel proteins
Cambridge, Mass.
Potassium channel proteins, encoding genes, antisense, antibodies, transgenics; for diagnostics and therapeutics.
Mosaic Technol. WO 00/50644 & 50870
DNA purification
Boston
Electrophoretic methods and devices for DNA purification using a medium having immobilized capture probes.
NIH (Natl. Inst. Hlth.) WO 00/50643
Radiation exposure assay
Bethesda, Md.
Nucleic acid microarray hybridization for detecting biological effects of radiation exposure.
Nexstar Pharma WO 00/52207
Taq polymerase ligands
Boulder, Colo.
High-affinity ligands for thermostable Taq and other polymerases; for finding inhibitors.
Novartis WO 00/52202
Fungal pathogen detection
Basel, Switzerland
Detection of the fungal pathogen Monilinia fructicola using PCR-based assays.
Orchid Biosciences WO 00/50871
Biological assay microstructures
Princeton, N.J.
Microstructures made of siloxane polymers; for surface-based biological assays such as medical diagnostics.
Orntoft, T.F. WO 00/52204
Bladder cancer diagnosis
Aarhus, Denmark
Gene expression analysis of normal and cancerous bladder cells; for cancer diagnosis and therapy.
Oxford Biomedica WO 00/52188
Retroviral vector production
Oxford, UK
Packaging and producer cell lines for temperature regulatable production of retroviral vectors.
Pacific Northwest Res. Inst. WO 00/50900
Carcinoma diagnosis
Seattle
Determination of soluble mesothelin related antigen; for carcinoma diagnosis.
PPL Therapeutics WO 00/51424
Genetically modified somatic cells
Roslin, UK
Somatic cells genetically engineered in vitro by gene targeting; for making genetically modified animals.
Regeneron WO 00/52167
Angiopoietin-related protein
Tarrytown, N.Y.
Angiopoietin-related protein, encoding gene, antibodies, production methods.
Sci. Applications & Res. Counc. Soc. WO 00/50636
Protein function assay
Paris
Screening databanks for nucleotide sequences that encode proteins believed to have a desired function.
Scripps Res. Inst. WO 00/52192
Catalytic DNA
La Jolla, Calif.
Catalytic and enzymatic DNA molecules that contain modified nucleotides that can cleave RNA in a site-specific manner.
Shanghai Biorigin Gene Develop. WO 00/52200
Large-scale cDNA cloning
Shanghai, China
Methods for large scale cDNA cloning and sequencing by circulating subtraction hybridization.
SmithKline Beecham WO 00/51430
Fatty acid synthase
Philadelphia
Human fatty acid synthase, encoding gene sequences, production methods; for diagnostics and therapeutics.
SmithKline Beecham WO 00/52024
Organic anion transporter
Philadelphia
Human organic anion transporter, encoding gene; for modulator screens and developing therapeutics.
SmithKline Beecham WO 00/52025
Antibacterial screens
Philadelphia
Bacterial Q16 polypeptides, encoding gene sequences, production methods; for antibacterial screens.
SmithKline Beecham WO 00/52042
Moraxella infection diagnostics
Rixensart, Belgium
Moraxella catarrhalis polypeptides, encoding gene sequences, production methods; for diagnostics and therapeutics.
Stanford Univ. WO 00/52030
RANTES expression activation
Palo Alto, Calif.
Zinc finger transcription factor that activates RANTES cytokine gene expression; for modulating inflammation.
Suntory WO 00/52193
Modified OmpT protease
Osaka, Japan
Modified OmpT protease; for use in controlling the cleavage of polypeptides by this enzyme.
Sydney IVF WO 00/50895
Cytoplasm sampling
Sydney, Australia
Isolation of cellular cytoplasmic fractions without impairing the viability of oocytes and embryonic cells.
Tennessee, Univ. of WO 00/52162
Enkephalin antifungals
Knoxville, Tenn.
Yeast oligopeptide transporter of enkephalins, encoding gene sequences; for antifungal treatments.
Terragen Discovery WO 00/52180
Molecular diversity
San Diego, Calif.
Generation of molecular diversity by recombination of genomic DNA from a variety of organisms.
Texas, Univ. of WO 00/52144
Chemotherapeutic response
Austin, Texas
Manipulation of ABC transporters and ecto-phosphatases; for improving responses to chemotherapeutics.
Tufts Univ. WO 00/51635
Emulsan-based vaccines
Medford, Mass.
Bacterial emulsan or emulsan analog combined with an antigen; for making vaccines.
Van Haeringen Lab WO 00/52206
Detecting microorganisms
Wageningen, Netherlands
Detection and quantification of the presence of multiple microorganisms using PCR-based techniques.
Variagenics WO 00/50639
Genetic sequence variation
Cambridge, Mass.
Determination of genetic sequence variation for the prediction of patient response to therapeutic treatment.
Variagenics WO 00/52210
RNA function modulators
Cambridge, Mass.
Methods for identifying structural and sequence targets in RNA; for finding modulators.
Vialogy WO 00/51056
Mutation signatures
Altadena, Calif.
Identifying mutation signatures in a biochip using a dot spectrogram to extract tessellation parametrics.
Warner-Lambert WO 00/50889
Differential gene expression
Ann Arbor, Mich.
Data processing system for managing and presenting information derived from differential expression of genes.
Yissum Res. Develop. WO 00/52181
Foreign protein production
Jerusalem, Israel
GCN4 transcription factor promoter linked to a heterologous coding sequence; for production of foreign proteins.