Published July 5 (EP); June 29 (WO)
Akzo Nobel WO 00/37650
Hepatitis Y virus
Arnhem, the Netherlands
Hepatitis Y virus, genes, and encoded proteins, cells for growing the virus; for making vaccines.
Albert Einstein Coll. Med. WO 00/36910
MSH5 transgenics
Bronx, N.Y.
Transgenic mice having ablated MSH5 gene expression; for identifying contraceptive agents.
American Home Products WO 00/37681
Estrogen receptor modulators
Madison, N.J.
Assays for identifying modulators of estrogen receptor-a and -_ using reporter molecules.
Amsterdam Univ. WO 00/37678
Human CMV diagnostics
Amsterdam, Netherlands
Detection of human cytomegalovirus (CMV) nucleic acid sequences using amplification techniques.
Boyce Thompson Inst. WO 00/37609
Oral cholera vaccine
Ithaca, N.Y.
Orally immunogenic bacterial enterotoxins from Vibrio cholerae expressed in transgenic plants; for vaccines.
Boyce Thompson Inst. WO 00/37610
Oral hepatitis vaccine
Ithaca, N.Y.
Orally immunogenic hepatitis B surface antigens expressed in transgenic plants; for vaccines.
Brussells Free Univ. WO 00/37493
Bordetella vaccines
Brussells, Belgium
Virulence genes from the pathogen Bordetella pertussis, encoded proteins; for vaccines.
California, Univ. of WO 00/37612
Ablated prion genes
Oakland, Calif.
Somatic cells with an ablated PrP prion gene; for making transgenics and studying neurodegeneration.
California, Univ. of WO 00/37680
Detecting specific sequences
Los Alamos, N.M.
Efficient detection of specific nucleic acid sequences by reporter molecule synthesis on the target sequence.
Cell Therapeutics WO 00/37655
Lysophosphatidic acid acyltransferase
Seattle, Wash.
Mammalian lysophosphatidic acid acyltransferase, encoding gene sequences; for diagnostics and therapeutics.
CNRS (Natl. Ctr. Sci. Res.) WO 00/37607
Adipocyte production
Paris
Production of adipocytes from non-differentiated fibroblasts that are confluent and express _3 adrenergic receptor.
Chiron WO 00/37494
Chlamydia vaccines
Siena, Italy
Chlamydia trachomatis proteins that are immunogenic in humans; for vaccines.
Corixa WO 00/37643
Colon tumor immunotherapy
Seattle, Wash.
Colon tumor proteins, immunogenic portions, encoding gene sequences; for diagnosis and immunotherapy.
CuraGen WO 00/37634
Polypeptides
New Haven, Conn.
Polypeptides, encoding gene sequences, antibodies, recombinant production methods.
CuraGen WO 00/37685
Psychotropic agent identification
New Haven, Conn.
Identification of psychotropic agents not inducing motor side effects by using differential gene expression methods.
Cytoscan WO 00/37616
Neural disease therapy
Seattle, Wash.
Administration of ion-dependent cotransport antagonists; for treating epilepsy and other neural diseases.
Daiichi Pure Chemicals WO 00/37632
Apolipoprotein antibodies
Tokyo
Monoclonal antibody to apolipoprotein A-1; for treating lipid metabolism diseases.
Develop. Res. Inst. WO 00/37673
Malarial diagnostics
Paris
Identification of Plasmodium falciparum using genomic DNA amplicons having RAPD markers; for malarial diagnostics.
DSM WO 00/37671
Cephalosporin production
Heerlen, Netherlands
Improved in vivo production of cephalosporins using transformed bacterial strains.
Eli Lilly WO 00/37094
Apoptosis modulator
Indianapolis
FLINT protein that binds Fas ligand, encoding gene sequences; for modulating apoptosis and inflammation.
Eli Lilly WO 00/37492
Human HDGFh
Indianapolis
Human HDGFh, encoding gene sequences, antibodies, chimeras, transgenics, production methods.
Eli Lilly WO 00/37615
_-lipotropin production
Indianapolis
Gene sequences, host cells, and fusion proteins for producing _-lipotropin.
Evotec WO 00/37628
Electroporation microsystem
Hamburg, Germany
Microsystem for cell permeation and cell fusion using miniaturized electrodes for electroporation.
Felder, S., et al. WO 00/37683
EST mapping
Tucson, Ariz.
High-throughput system using repeated arrays of probes that maps expressed sequence tags (ESTs).
Genencor Intl. WO 00/37658
Improved specificity enzymes
Palo Alto, Calif.
Chemically modified enzymes having multiple charged moiety variants on thiol side chains; for improved specificity.
Genentech WO 00/37502
VEGF antagonists
S. San Francisco
Vascular endothelial cell growth factor antagonists such as VEGF antibodies and receptor fusions; for stroke therapy.
Genentech WO 00/37638
Growth inhibitors
S. San Francisco
Methods for finding growth inhibitors, identified inhibitors, encoding genes; for cancer therapeutics.
Genentech WO 00/37640
Cancer expressed proteins
S. San Francisco
Proteins that are overexpressed in cancer cells, encoding genes, antibodies; for diagnostics and therapeutics.
Genetics WO 00/37938
Drug screening system
Zurich, Switzerland
Drosophila modified to be sensitive to particular biochemical pathways; for function-based drug screens.
Genetics Inst. WO 00/37630
Secreted proteins
Cambridge, Mass.
Secreted proteins, encoding gene sequences, production methods; for diagnostics and therapeutics.
Genset WO 00/37491
Secreted proteins
Paris
Secreted proteins, encoding cDNAs; for protein expression and making antibodies and vectors.
Guss, B., et al. WO 00/37496
Streptococcus vaccine
Uppsala, Sweden
Fibronectin binding protein from Streptococcus, encoding gene, recombinant production methods; for vaccines.
Hall Inst. Med. Res. WO 00/37636
Cytokine regulators
Parkville, Australia
SOCS-box peptides that interact with intracellular molecules, encoding genes; for cytokine regulation.
Hesch, R.D. EP 1 016 730
Breast tissue proliferation
Konstanz, Germany
Gene expression assay for diagnosing cell proliferation in breast tissue [in German].
Imp. Cancer Res. Technol. WO 00/37677
Cancer diagnosis markers
London
Human chromosome 16q tumor suppressor gene, variants; for cancer diagnosis.
Incyte Genomics WO 00/37639
Lymphocytic membrane proteins
Palo Alto, Calif.
Lymphocytic membrane proteins, encoding genes, antibodies, modulators; for diagnostics and therapeutics.
Interleukin Genetics WO 00/37679
Sepsis susceptibility assay
San Antonio, Texas
Methods for detecting polymorphisms predictive of the susceptibility to sepsis.
Isis Innovations WO 00/37676
Antimicrobial screens
Oxford, UK
Bacillus subtilis regulatory sequences of essential genes linked to a reporter gene; for finding antimicrobials.
Isis Pharma EP 1 016 715
Herpes virus inhibition
Carlsbad, Calif.
Oligonucleotides having a conserved G4 core sequence flanked by a sufficient number of nucleotides to inhibit HSV-1.
Janssen Pharma WO 00/37613
Cancer therapeutics
Beerse, Belgium
Human Akt-3 protein, encoding gene sequences; for finding modulators and cancer therapeutics.
Janssen Pharma WO 00/37641
VEGF-X angiogenesis modulation
Beerse, Belgium
Vascular endothelial growth factor (VEGF)-X, encoding gene sequences; for modulating angiogenesis.
Kris, R.M., et al. WO 00/37684
EST measurement
Tucson, Ariz.
High-throughput assays using repeated arrays of probes and measurement of ESTs by mass spectrophotometry.
Lab Molec. Biophotonics EP 1 016 731
Target nucleic acid detection
Shizuoka, Japan
Labelled target probes attached to a solid phase; for detecting a target nucleic acid by hybridization.
Lafon Labs WO 00/37499
Topoisomerase II inhibitors
Maisons-Alfort, France
Peptides that act as inhibitors of topoisomerase II; for antitumor therapeutics.
Ludwig Inst. Cancer Res. WO 00/37025
Truncated VEGF-D antibodies
New York
Antibodies to truncated vascular endothelial growth factor (VEGF)-D; for angiogenesis diagnostics and therapeutics.
Lutz, H. WO 00/37672
Pathogen analysis
Rudingen, Switzerland
Quantitative PCR using a one-tube fluorogenic real-time detection system; for high-throughput analysis of pathogens.
MRC (Med. Res. Counc.) WO 00/37611
Stem cell selection
London
Sox gene expression as cell lineage markers in embryogenesis; for selecting pluripotent stem cells.
Medimmune WO 00/37105
Streptococcus vaccines
Gaithersburg, Md.
Streptococcus pneumoniae proteins, immunogenic fragments; for preventing infection and making vaccines.
Merck WO 00/37104
Hepatitis B vaccines
Rahway, N.J.
Recombinant hepatitis B surface antigen having greater antigenicity; for more effective vaccines.
Merck WO 00/37487
aV_6 integrin inhibitors
Darmstadt, Germany
Peptide ligands for aV_6 integrin that have a common structural motif; for receptor inhibitors.
Microscience WO 00/37490 & 37646
Streptococcus vaccines
London
Streptococcus outer surface proteins, encoding gene; for making vaccines.
ML Labs WO 00/37102
Xenograft tolerance
London
Immunization with a B cell epitope derived from pig polypeptides; for inducing immunotolerance to xenografts.
Myriad Genetics WO 00/37483
Alzheimer's drug screens
Salt Lake City, Utah
Protein-protein interactions in Alzheimer's disease, antibodies to these complexes; for drug screening.
Nanogen WO 00/37163
Cell separation chips
San Diego
Dielectrophoretic separation and characterization of cells and their expressed genes in microfabricated chips.
Neurotech WO 00/37111
Transfected cell therapeutics
Orsay, France
Mammalian cell preparations that are transfected with a therapeutic gene and injected into patients for therapy.
Neurotech WO 00/37112
Immortalized endothelial cells
Orsay, France
Endothelial cells transfected with a gene helpful in angiogenesis diagnostics and therapeutics.
Nippon Gene EP 1 016 729
Full-length cDNAs
Tokyo
Methods for synthesizing cDNAs having the 5'-terminal sequence of full-length mRNAs from sample mRNAs.
Ono Pharma EP 1 016 714
Cancer therapeutic
Osaka, Japan
Plasmid containing a reporter gene and a gene encoding a protein that acts against cancer or autoimmune disease.
Pasteur Univ. WO 00/37659
Non-viral transfection
Strasbourg, France
Non-viral transfection vector having a nuclear localization sequence[ for gene delivery.
Pfizer WO 00/37504
Antibodies to T cells
Groton, Conn.
Human monoclonal antibodies to human cytotoxic T cell antigen 4, other antibodies that act as antagonists.
Pharmacia & Upjohn WO 00/37620
Bone disease therapeutics
Stockholm, Sweden
Crystalline form of active tartrate resistant phosphatase; for designing therapeutics to treat bone disease.
Promega WO 00/37682
Augmenting protein production
Madison, Wis.
Augmenting expression of foreign genes by cotransfection with a bHLH protein gene; for protein production.
Raven Biotech WO 00/37503
Cell type antibodies
San Carlos, Calif.
Methods to generate monoclonal antibodies that bind to antigens from specific cell types.
Regeneron Pharma WO 00/37642
Eph receptor fusion ligands
Tarrytown, N.Y.
Fusion peptide ligands that bind the Tie or Eph family receptors, encoding genes; for improved affinity.
RIKEN WO 00/37633
Longer DNA sequencing
Saitama, Japan
Polyamines used as RNA polymerase transcription promoters; for sequencing longer DNA molecules.
Roche Diagnostics WO 00/37618
Thermostable polymerase
Mannheim, Germany
Thermostable E. coli polymerase having 3'-5' exonuclease, but not 5'-3' exonuclease, activity.
Rubin, J.S., et al. EP 1 016 716
Keratinocyte-like growth factor
Rockville, Md.
Human keratinocyte-like growth factor, encoding gene sequences, production methods.
Rutgers Univ. WO 00/37686
Nucleic acid stability assay
Piscataway, N.J.
Methods for determining the thermodynamic stability of nucleic acid duplexes and single nucleotide polymorphisms.
Sci. Invest. Council WO 00/37498
Cancer therapy
Madrid, Spain
Proteins that suppress c-jun and c-fos gene expression; for cancer therapy.
Searle WO 00/37617
Aminotransferase enzyme
Chicago
A human aminotransferase enzyme, encoding gene sequences, homologs, fragments; for identifying modulators.
Shionogi EP 1 016 867
Gamma-BNP assay
Osaka, Japan
Immunoassay for gamma-BNP derivatives using two antibodies that can be labelled and immobilized.
Sloan-Kettering Inst. WO 00/37608
Calcicheamicin synthesis
New York
Micromonospora echinospora gene cluster encoding the biosynthesis of calcicheamicin and resistance to it.
SmithKline Beecham WO 00/36920
G protein-coupled receptor
Philadelphia
Rabbit G protein a 16, encoding gene sequences, recombinant production methods; for diagnostics and therapeutics.
SmithKline Beecham WO 00/37113
HIV-1 infection therapy
Philadelphia
11cby genomic gene sequence, probes, polymorphic markers, transgenics; for treating HIV-1 infection.
SmithKline Beecham WO 00/37495
Antibacterial screens
Philadelphia
EF-Tu polypeptides, encoding gene sequences, recombinant production methods; for antibacterial screens.
SmithKline Beecham WO 00/37675
ob protein modulators
Brentford, UK
Identification of ob protein modulators using transfected endothelium-derived cells.
Subsidiary No. 3 WO 00/37635
HIV-1 suppressors
Wilmington, N.C.
Genetic suppressor elements isolated from the HIV-1 genome; for AIDS therapy.
Takeda Chemical WO 00/37637
Sodium bicarbonate transporter
Osaka, Japan
Sodium bicarbonate cotransporter, encoding gene sequences, antibodies, transgenics; for identifying modulators.
Tennessee, Univ. of WO 00/37648
Streptococcus vaccines
Knoxville, Tenn.
Group A Streptococcus protective antigen that induces opsonic antibodies; for vaccines.
Texas, Univ. of WO 00/37653
Nitric oxide synthase modulators
Austin, Texas
Three-dimensional structure of nitric oxide synthase and its variants; for identifying modulators.
Transgene WO 00/37664
Posiplex gene delivery
Strasbourg, France
Methods for preparing stable posiplexes, homogeneous preparations; for nucleic acid delivery.
Victoria Univ. WO 00/37674
Nucleic acid sequencing
Manchester, UK
Nucleic acid sequencing using amplification techniques and eximers or exiplexes as labels.
Virginia, Univ. of WO 00/36919
Bone tumor gene therapy
Charlottesville, Va.
Bone sialoprotein gene regulatory and control elements; for toxic gene therapy for calcified tumors.
Wisconsin, Univ. of WO 00/37629
Lovastatin production
Madison, Wis.
Increased production of lovastatin using bacterial strains transfected with the biosynthetic enzymes.