Published July 5 (EP); June 29 (WO)

Akzo Nobel WO 00/37650

Hepatitis Y virus

Arnhem, the Netherlands

Hepatitis Y virus, genes, and encoded proteins, cells for growing the virus; for making vaccines.

Albert Einstein Coll. Med. WO 00/36910

MSH5 transgenics

Bronx, N.Y.

Transgenic mice having ablated MSH5 gene expression; for identifying contraceptive agents.

American Home Products WO 00/37681

Estrogen receptor modulators

Madison, N.J.

Assays for identifying modulators of estrogen receptor-a and -_ using reporter molecules.

Amsterdam Univ. WO 00/37678

Human CMV diagnostics

Amsterdam, Netherlands

Detection of human cytomegalovirus (CMV) nucleic acid sequences using amplification techniques.

Boyce Thompson Inst. WO 00/37609

Oral cholera vaccine

Ithaca, N.Y.

Orally immunogenic bacterial enterotoxins from Vibrio cholerae expressed in transgenic plants; for vaccines.

Boyce Thompson Inst. WO 00/37610

Oral hepatitis vaccine

Ithaca, N.Y.

Orally immunogenic hepatitis B surface antigens expressed in transgenic plants; for vaccines.

Brussells Free Univ. WO 00/37493

Bordetella vaccines

Brussells, Belgium

Virulence genes from the pathogen Bordetella pertussis, encoded proteins; for vaccines.

California, Univ. of WO 00/37612

Ablated prion genes

Oakland, Calif.

Somatic cells with an ablated PrP prion gene; for making transgenics and studying neurodegeneration.

California, Univ. of WO 00/37680

Detecting specific sequences

Los Alamos, N.M.

Efficient detection of specific nucleic acid sequences by reporter molecule synthesis on the target sequence.

Cell Therapeutics WO 00/37655

Lysophosphatidic acid acyltransferase

Seattle, Wash.

Mammalian lysophosphatidic acid acyltransferase, encoding gene sequences; for diagnostics and therapeutics.

CNRS (Natl. Ctr. Sci. Res.) WO 00/37607

Adipocyte production

Paris

Production of adipocytes from non-differentiated fibroblasts that are confluent and express _3 adrenergic receptor.

Chiron WO 00/37494

Chlamydia vaccines

Siena, Italy

Chlamydia trachomatis proteins that are immunogenic in humans; for vaccines.

Corixa WO 00/37643

Colon tumor immunotherapy

Seattle, Wash.

Colon tumor proteins, immunogenic portions, encoding gene sequences; for diagnosis and immunotherapy.

CuraGen WO 00/37634

Polypeptides

New Haven, Conn.

Polypeptides, encoding gene sequences, antibodies, recombinant production methods.

CuraGen WO 00/37685

Psychotropic agent identification

New Haven, Conn.

Identification of psychotropic agents not inducing motor side effects by using differential gene expression methods.

Cytoscan WO 00/37616

Neural disease therapy

Seattle, Wash.

Administration of ion-dependent cotransport antagonists; for treating epilepsy and other neural diseases.

Daiichi Pure Chemicals WO 00/37632

Apolipoprotein antibodies

Tokyo

Monoclonal antibody to apolipoprotein A-1; for treating lipid metabolism diseases.

Develop. Res. Inst. WO 00/37673

Malarial diagnostics

Paris

Identification of Plasmodium falciparum using genomic DNA amplicons having RAPD markers; for malarial diagnostics.

DSM WO 00/37671

Cephalosporin production

Heerlen, Netherlands

Improved in vivo production of cephalosporins using transformed bacterial strains.

Eli Lilly WO 00/37094

Apoptosis modulator

Indianapolis

FLINT protein that binds Fas ligand, encoding gene sequences; for modulating apoptosis and inflammation.

Eli Lilly WO 00/37492

Human HDGFh

Indianapolis

Human HDGFh, encoding gene sequences, antibodies, chimeras, transgenics, production methods.

Eli Lilly WO 00/37615

_-lipotropin production

Indianapolis

Gene sequences, host cells, and fusion proteins for producing _-lipotropin.

Evotec WO 00/37628

Electroporation microsystem

Hamburg, Germany

Microsystem for cell permeation and cell fusion using miniaturized electrodes for electroporation.

Felder, S., et al. WO 00/37683

EST mapping

Tucson, Ariz.

High-throughput system using repeated arrays of probes that maps expressed sequence tags (ESTs).

Genencor Intl. WO 00/37658

Improved specificity enzymes

Palo Alto, Calif.

Chemically modified enzymes having multiple charged moiety variants on thiol side chains; for improved specificity.

Genentech WO 00/37502

VEGF antagonists

S. San Francisco

Vascular endothelial cell growth factor antagonists such as VEGF antibodies and receptor fusions; for stroke therapy.

Genentech WO 00/37638

Growth inhibitors

S. San Francisco

Methods for finding growth inhibitors, identified inhibitors, encoding genes; for cancer therapeutics.

Genentech WO 00/37640

Cancer expressed proteins

S. San Francisco

Proteins that are overexpressed in cancer cells, encoding genes, antibodies; for diagnostics and therapeutics.

Genetics WO 00/37938

Drug screening system

Zurich, Switzerland

Drosophila modified to be sensitive to particular biochemical pathways; for function-based drug screens.

Genetics Inst. WO 00/37630

Secreted proteins

Cambridge, Mass.

Secreted proteins, encoding gene sequences, production methods; for diagnostics and therapeutics.

Genset WO 00/37491

Secreted proteins

Paris

Secreted proteins, encoding cDNAs; for protein expression and making antibodies and vectors.

Guss, B., et al. WO 00/37496

Streptococcus vaccine

Uppsala, Sweden

Fibronectin binding protein from Streptococcus, encoding gene, recombinant production methods; for vaccines.

Hall Inst. Med. Res. WO 00/37636

Cytokine regulators

Parkville, Australia

SOCS-box peptides that interact with intracellular molecules, encoding genes; for cytokine regulation.

Hesch, R.D. EP 1 016 730

Breast tissue proliferation

Konstanz, Germany

Gene expression assay for diagnosing cell proliferation in breast tissue [in German].

Imp. Cancer Res. Technol. WO 00/37677

Cancer diagnosis markers

London

Human chromosome 16q tumor suppressor gene, variants; for cancer diagnosis.

Incyte Genomics WO 00/37639

Lymphocytic membrane proteins

Palo Alto, Calif.

Lymphocytic membrane proteins, encoding genes, antibodies, modulators; for diagnostics and therapeutics.

Interleukin Genetics WO 00/37679

Sepsis susceptibility assay

San Antonio, Texas

Methods for detecting polymorphisms predictive of the susceptibility to sepsis.

Isis Innovations WO 00/37676

Antimicrobial screens

Oxford, UK

Bacillus subtilis regulatory sequences of essential genes linked to a reporter gene; for finding antimicrobials.

Isis Pharma EP 1 016 715

Herpes virus inhibition

Carlsbad, Calif.

Oligonucleotides having a conserved G4 core sequence flanked by a sufficient number of nucleotides to inhibit HSV-1.

Janssen Pharma WO 00/37613

Cancer therapeutics

Beerse, Belgium

Human Akt-3 protein, encoding gene sequences; for finding modulators and cancer therapeutics.

Janssen Pharma WO 00/37641

VEGF-X angiogenesis modulation

Beerse, Belgium

Vascular endothelial growth factor (VEGF)-X, encoding gene sequences; for modulating angiogenesis.

Kris, R.M., et al. WO 00/37684

EST measurement

Tucson, Ariz.

High-throughput assays using repeated arrays of probes and measurement of ESTs by mass spectrophotometry.

Lab Molec. Biophotonics EP 1 016 731

Target nucleic acid detection

Shizuoka, Japan

Labelled target probes attached to a solid phase; for detecting a target nucleic acid by hybridization.

Lafon Labs WO 00/37499

Topoisomerase II inhibitors

Maisons-Alfort, France

Peptides that act as inhibitors of topoisomerase II; for antitumor therapeutics.

Ludwig Inst. Cancer Res. WO 00/37025

Truncated VEGF-D antibodies

New York

Antibodies to truncated vascular endothelial growth factor (VEGF)-D; for angiogenesis diagnostics and therapeutics.

Lutz, H. WO 00/37672

Pathogen analysis

Rudingen, Switzerland

Quantitative PCR using a one-tube fluorogenic real-time detection system; for high-throughput analysis of pathogens.

MRC (Med. Res. Counc.) WO 00/37611

Stem cell selection

London

Sox gene expression as cell lineage markers in embryogenesis; for selecting pluripotent stem cells.

Medimmune WO 00/37105

Streptococcus vaccines

Gaithersburg, Md.

Streptococcus pneumoniae proteins, immunogenic fragments; for preventing infection and making vaccines.

Merck WO 00/37104

Hepatitis B vaccines

Rahway, N.J.

Recombinant hepatitis B surface antigen having greater antigenicity; for more effective vaccines.

Merck WO 00/37487

aV_6 integrin inhibitors

Darmstadt, Germany

Peptide ligands for aV_6 integrin that have a common structural motif; for receptor inhibitors.

Microscience WO 00/37490 & 37646

Streptococcus vaccines

London

Streptococcus outer surface proteins, encoding gene; for making vaccines.

ML Labs WO 00/37102

Xenograft tolerance

London

Immunization with a B cell epitope derived from pig polypeptides; for inducing immunotolerance to xenografts.

Myriad Genetics WO 00/37483

Alzheimer's drug screens

Salt Lake City, Utah

Protein-protein interactions in Alzheimer's disease, antibodies to these complexes; for drug screening.

Nanogen WO 00/37163

Cell separation chips

San Diego

Dielectrophoretic separation and characterization of cells and their expressed genes in microfabricated chips.

Neurotech WO 00/37111

Transfected cell therapeutics

Orsay, France

Mammalian cell preparations that are transfected with a therapeutic gene and injected into patients for therapy.

Neurotech WO 00/37112

Immortalized endothelial cells

Orsay, France

Endothelial cells transfected with a gene helpful in angiogenesis diagnostics and therapeutics.

Nippon Gene EP 1 016 729

Full-length cDNAs

Tokyo

Methods for synthesizing cDNAs having the 5'-terminal sequence of full-length mRNAs from sample mRNAs.

Ono Pharma EP 1 016 714

Cancer therapeutic

Osaka, Japan

Plasmid containing a reporter gene and a gene encoding a protein that acts against cancer or autoimmune disease.

Pasteur Univ. WO 00/37659

Non-viral transfection

Strasbourg, France

Non-viral transfection vector having a nuclear localization sequence[ for gene delivery.

Pfizer WO 00/37504

Antibodies to T cells

Groton, Conn.

Human monoclonal antibodies to human cytotoxic T cell antigen 4, other antibodies that act as antagonists.

Pharmacia & Upjohn WO 00/37620

Bone disease therapeutics

Stockholm, Sweden

Crystalline form of active tartrate resistant phosphatase; for designing therapeutics to treat bone disease.

Promega WO 00/37682

Augmenting protein production

Madison, Wis.

Augmenting expression of foreign genes by cotransfection with a bHLH protein gene; for protein production.

Raven Biotech WO 00/37503

Cell type antibodies

San Carlos, Calif.

Methods to generate monoclonal antibodies that bind to antigens from specific cell types.

Regeneron Pharma WO 00/37642

Eph receptor fusion ligands

Tarrytown, N.Y.

Fusion peptide ligands that bind the Tie or Eph family receptors, encoding genes; for improved affinity.

RIKEN WO 00/37633

Longer DNA sequencing

Saitama, Japan

Polyamines used as RNA polymerase transcription promoters; for sequencing longer DNA molecules.

Roche Diagnostics WO 00/37618

Thermostable polymerase

Mannheim, Germany

Thermostable E. coli polymerase having 3'-5' exonuclease, but not 5'-3' exonuclease, activity.

Rubin, J.S., et al. EP 1 016 716

Keratinocyte-like growth factor

Rockville, Md.

Human keratinocyte-like growth factor, encoding gene sequences, production methods.

Rutgers Univ. WO 00/37686

Nucleic acid stability assay

Piscataway, N.J.

Methods for determining the thermodynamic stability of nucleic acid duplexes and single nucleotide polymorphisms.

Sci. Invest. Council WO 00/37498

Cancer therapy

Madrid, Spain

Proteins that suppress c-jun and c-fos gene expression; for cancer therapy.

Searle WO 00/37617

Aminotransferase enzyme

Chicago

A human aminotransferase enzyme, encoding gene sequences, homologs, fragments; for identifying modulators.

Shionogi EP 1 016 867

Gamma-BNP assay

Osaka, Japan

Immunoassay for gamma-BNP derivatives using two antibodies that can be labelled and immobilized.

Sloan-Kettering Inst. WO 00/37608

Calcicheamicin synthesis

New York

Micromonospora echinospora gene cluster encoding the biosynthesis of calcicheamicin and resistance to it.

SmithKline Beecham WO 00/36920

G protein-coupled receptor

Philadelphia

Rabbit G protein a 16, encoding gene sequences, recombinant production methods; for diagnostics and therapeutics.

SmithKline Beecham WO 00/37113

HIV-1 infection therapy

Philadelphia

11cby genomic gene sequence, probes, polymorphic markers, transgenics; for treating HIV-1 infection.

SmithKline Beecham WO 00/37495

Antibacterial screens

Philadelphia

EF-Tu polypeptides, encoding gene sequences, recombinant production methods; for antibacterial screens.

SmithKline Beecham WO 00/37675

ob protein modulators

Brentford, UK

Identification of ob protein modulators using transfected endothelium-derived cells.

Subsidiary No. 3 WO 00/37635

HIV-1 suppressors

Wilmington, N.C.

Genetic suppressor elements isolated from the HIV-1 genome; for AIDS therapy.

Takeda Chemical WO 00/37637

Sodium bicarbonate transporter

Osaka, Japan

Sodium bicarbonate cotransporter, encoding gene sequences, antibodies, transgenics; for identifying modulators.

Tennessee, Univ. of WO 00/37648

Streptococcus vaccines

Knoxville, Tenn.

Group A Streptococcus protective antigen that induces opsonic antibodies; for vaccines.

Texas, Univ. of WO 00/37653

Nitric oxide synthase modulators

Austin, Texas

Three-dimensional structure of nitric oxide synthase and its variants; for identifying modulators.

Transgene WO 00/37664

Posiplex gene delivery

Strasbourg, France

Methods for preparing stable posiplexes, homogeneous preparations; for nucleic acid delivery.

Victoria Univ. WO 00/37674

Nucleic acid sequencing

Manchester, UK

Nucleic acid sequencing using amplification techniques and eximers or exiplexes as labels.

Virginia, Univ. of WO 00/36919

Bone tumor gene therapy

Charlottesville, Va.

Bone sialoprotein gene regulatory and control elements; for toxic gene therapy for calcified tumors.

Wisconsin, Univ. of WO 00/37629

Lovastatin production

Madison, Wis.

Increased production of lovastatin using bacterial strains transfected with the biosynthetic enzymes.

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