Published May 31 (EP); May 25 (WO); May 31 (GB)
Aberdeen Univ. GB 2 344 106
Cell toxin detection
Yeast cells having an inserted luciferase gene; for use as a biosensor for eukaryotic cell toxins.
Akron, Univ. of WO 00/29604
Biological material production
Production of biological materials by microorgansims that simultaneously respire aerobically or anaerobically.
Albert Ludwigs Univ. WO 00/29442
Transcription factor antibodies
Production of antibodies that bind a protein that binds with its coding sequence.
Anticancer WO 00/29589
Methionase tumor therapy
Methionase, encoding gene sequences, expression vectors; for tumor treatment.
Arcaris WO 00/29565
Salt Lake City
Identifying proteins associated with a particular phenotype by screening for interactions using a two-hybrid assay.
Asahi EP 1 004 669
Human delta 2 protein, encoding gene; for differentiation inhibition and growth of undifferentiated blood cells.
AstraZeneca WO 00/29590
IPC synthase inhibitors
Identifying selective IPC synthase inhibitors by using a sphingolipid synthesis assay.
Biomolec. Engin. Res. Inst. EP 1 004 672
Thermostable protein with deoxyribonuclease activity, encoding gene; for resolving intermediates in recombination.
California Inst. Technol. WO 00/29549
Low oxygen cell culture
Promotion of proliferation and reduction of apoptosis in cell culture using lower oxygen concentrations.
California Inst. Technol. WO 00/29550
CNS progenitor cell culture
Low oxygen culture of central nervous system (CNS) progenitor cells; for inducing enhanced differentiation.
California, Univ. of WO 00/29424
Insulin resistance diagnostics
Polymorphic human PC-1 sequences associated with insulin resistance, encoded proteins, antibodies, diagnostics.
Cambridge Molec. Technol. WO 00/29563
Plasmid DNA isolation
Isolating plasmid DNA using organic solvents and denaturization of contaminating genomic DNA.
Canji WO 00/29573
p53 adenoviral vector
Replication competent adenoviral vectors that can deliver highly effective therapeutic levels of p53.
Canji WO 00/29599
Cancer gene therapy
Recombinant viral vectors having a therapeutic transgene linked to a late regulatory element; for cancer therapy.
Cedars-Sinai Med. Ctr. WO 00/29601 & 29602
Methods for depopulating vertebrate testes and inserting transfected male germ cells; for generating transgenics.
Cell Genesys WO 00/29421
Lentiviral vector packaging
Foster City, Calif.
Methods for selecting and generating efficient packaging cells for lentiviral vectors.
Cell Genesys WO 00/29557
Foster City, Calif.
Indicator cell line that transcomplements envelope-defective recombinant virus; for amplifying the virus.
Children's Hosp. WO 00/29588
Respiratory infection therapeutic
Fusions of lysozyme with the carboxy terminal propeptide of surfactant protein B; for bacterial respiratory infections.
Chugai EP 1 004 313
Wasting syndrome therapeutics
Inhibitors that prevent binding of parathyroid hormone-related peptide to its receptor; for treating wasting.
Chugai EP 1 004 667
Cell cycle regulation
Cell cycle-regulating serine-threonine kinases, encoding genes; for identifying modulators.
Chugai Res. Inst. Molec. Med. EP 1 004 666
PDZ domain protein
Protein with a PDZ domain whose expression is enhanced by TNFa, encoding gene; for protein-protein interactions.
Clausen, H. WO 00/29558
Galactosyltransferase, soluble derivatives, fusion, encoding gene sequences; for recombinant production of glycoproteins.
Coastside Bio Resources WO 00/29009
Pentipeptides from sea cucumbers that have anti-cancer and anti-inflammatory activity.
Cortecs WO 00/29432
Helicobacter pylori antigen, encoding gene sequences; for ulcer diagnostics and therapeutics.
Curagen WO 00/29622 & 29623
New Haven, Conn.
Nucleic acid sequences containing single-nucleotide polymorphisms for identified transcribed human sequences.
Curagen WO 00/29846
Peroxisomal proliferator pathway
New Haven, Conn.
Proteins associated with the peroxisomal proliferator activator receptor-a mediated pathway, encoding genes.
Cyclacel WO 00/29427
Modified membrane transporter
Modified and truncated forms of the membrane transport protein penetratin.
Darwin Molecular EP 1 004 675
Progressive HIV mutation
Screening for nucleoside analogs causing incorrect base pairing when incorporated by HIV reverse transcriptase.
Davies, A. WO 00/29551
Obtaining a host cell population from a non-diseased individual; for autologous transplantation therapy.
Eiken WO 00/29571
Periodic psychosis protein
7-transmembrane protein homologous to a calcium channel protein; for diagnosing periodic psychosis.
Euro-Celtique WO 00/29443
Contraceptive antibody vaccines
Antibodies having a complementarity determining region that recognizes a reproductive function-related antigen.
Eurona Medical WO 00/29614
Prostaglandin receptor polymorphisms
Human prostaglandin receptors, encoding gene sequences, polymorphic variations, antibodies.
Genentech WO 00/29584
Higher binding affinity antibodies
S. San Francisco
Antibody variants having extra amino acid residues inserted in the hypervariable region; for increased binding affinity.
Georgetown Univ. WO 00/29600
Systemic gene therapy
Viral gene therapy vector mixed with cell targeting agents; for systemic gene therapy delivery.
Gliatech WO 00/29564
Human glycine transporter type 2, encoding gene sequences; for diagnostics and therapeutics.
Helix Res. Inst. WO 00/29568
Inhibiting DNA label hybridization
Nucleotide spacers having weaker bonding than normal; for inhibition of label hybridization.
Hisamitsu Pharma WO 00/29031
Nucleic acid delivery
Diaminobutyric acid residue-containing proteins for nucleic acid transport with less antigenicity; for gene therapy.
HSP Res. Inst. WO 00/29429
Stress transcription factor
Endoplasmic reticulum stress transcription factor, encoding gene sequences; for regulating chaperone gene expression.
Human Genome Sciences WO 00/29422
31 secreted proteins
31 human secreted proteins, encoding genes, antibodies, production methods; for diagnostic and therapeutics.
Human Genome Sciences WO 00/29435
12 secreted proteins
12 human secreted proteins, encoding genes, antibodies, production methods; for diagnostic and therapeutics.
Icos WO 00/29446
Inhibiting macrophage infiltration
Macrophage infiltration inhibition following spinal chord injury with alpha-D antibodies that prevent TNF-a release.
Immunex WO 00/29581
Human TSLP polypeptides
Human TSLP polypeptides, encoding gene sequences, recombinant production methods, fragments, antibodies.
Incyte Genomics WO 00/29574
Palo Alto, Calif.
Inflammation-associated genes, encoded proteins, antibodies, modulators; for diagnostics and therapeutics.
Incyte Genomics WO 00/29580
Calcium binding protein
Palo Alto, Calif.
Calcium binding protein, encoding gene, antibodies, modulators; for diagnostics and therapeutics.
Incyte Genomics WO 00/29583
Immunoglobulin superfamily proteins
Palo Alto, Calif.
Immunoglobulin superfamily proteins, encoding genes, antibodies, modulators; for diagnostics and therapeutics.
Innogenetics EP 1 004 670
Hepatitis C genotypes
Hepatitis C virus genotypes, encoded proteins, antibodies; for diagnostics and therapeutics.
INSERM (Natl. Inst. Hlth. & Med. Res.) EP 1 004 664
CTL response regulation
Lacadherin or variants, encoding gene sequences; for regulating cytotoxic T lymphocyte (CTL) responses.
Japan Sci. & Technol. WO 00/29436
Cytokine transducer modulator
Protein that interacts with the SH3 domain of the cytokine transducer STAM, encoding gene sequences, antibodies.
Japan Sci. & Technol. WO 00/29572
Postsynaptic structure protein
Protein that to binds S-SCAM and forms part of postsynaptic structures, encoding gene sequences, antibodies.
Japan Tobacco EP 1 004 665
Macrophage scavenger receptor homologs
Macrophage scavenger receptor-like genes from human fetal brain, encoded proteins; for cell death inhibition.
Kieff, E.D., et al. WO 00/29626
Rhadino virus LANA that allows episomal persistence in mammalian cells; for finding modulators.
Kramer, M. EP 1 004 668
Regulatory protein pKe 83 derived from human keratinocytes, encoding gene; for diagnostics and therapeutics [in German].
Kureha Chemical EP 1 004 674
Erythrocyte elevating protein
Protein that lowers leukocytes and thrombocytes while elevating erythrocytes, encoding gene, immunological assay.
LG Chemical WO 00/29445
Autoimmune disease therapeutics
Seoul, S. Korea
Humanized antibodies that bind human 4-IBB proteins; for treating autoimmune disease and suppressing immunoresponse.
Life Technologies WO 00/29000
Enhancing recombinatorial cloning using E. coli ribosomal proteins, cloning vectors.
Long Isl. Jewish Res, Inst. WO 00/29625
Multiple drug resistance polymorphisms
Identification of differentially expressed hypermethylated gene sequences at multiple drug resistance loci.
Mass. Gen. Hosp. WO 00/29033
Gene therapy immunosuppression
Immunosuppression during gene therapy by administering a complement inhibitor with the gene.
MRC (Med. Res. Counc.) GB 2 344 107
Gene that can induce obesity and/or infertility in transgenics; for therapeutics.
Merck WO 00/29423
Leukotriene B4 receptor homolog
G protein-coupled receptor resembling the leukotriene B4 receptor, encoding gene; for finding modulators.
Merck WO 00/29562
Plasmid DNA isolation
Isolation of plasmid DNA by immobilizing microorganisms on solid phase bodies followed by subsequent lysis.
Millennium Pharma WO 00/29438
Epidermal growth factor (EGF)-like proteins, encoding genes, antibodies, transgenics; for diagnostics and therapeutics.
Millennium Pharma WO 00/29577
Capsaicin receptor homologs
Capsaicin/vanilloid receptor homologs, encoding gene sequences, fusions, antigenic peptides, antibodies.
Mira Diagnostica WO 00/29612
Thermostable polymerase inhibitor
Oligonucleotide inhibitor of the 5'-3' exonuclease activity of thermostable polymerases.
NIH (Natl. Inst. Hlth.) WO 00/29556
Identification of glycospingolipids that promote HIV-1 entry into cells; for developing diagnostics and therapeutics.
NIH (Natl. Inst. Hlth.) WO 00/29578
mRNA transcription coactivators
Coactivators of mRNA transcription, encoding genes, binding agents; for treating breast adenocarcinomas.
Neose Technol. WO 00/29603
Recombinant cells transfected with a gene encoding a glycosyltransferase; for oligosaccharide manufacture.
New Mexico, Univ. of WO 00/29032
Heat shock protein-oligonucleotide complex; for transfecting cells during gene therapy.
New York Blood Ctr. WO 00/29559
Endothelin converting protein
Kell proteins having proteolytic activity; for endothelin conversion and vasoactive intestinal peptide cleavage.
New York Univ. WO 00/29608
Protein production in urine
Transgenics with therapeutic genes inserted into their urinary bladder epithelial cells; for protein production.
Nippon Meat Packers EP 1 004 238
Transgenics having human complement regulator expressed in vascular endothelial cells; for transplant tissues.
Nitsch, R., et al. WO 00/29569
Neural disease therapy
Degeneration and cell death protection protein, encoding gene; for neurological disease diagnostics and therapeutics.
North Carolina, Univ. of WO 00/28811
Neurological disorder transgenics
Chapel Hill, N.C.
Transgenics with reduced expression of NMDA receptors; for studying neurological disorders such as schizophrenia.
Novartis WO 00/29548
Adhesive glycoprotein coupling
Process for coupling adhesive glycoproteins to the surface of a bulk material; for making tissue engineering scaffolds.
Novo Nordisk WO 00/29560
Thermostable a-amylase variants
a-amylase variants, encoding gene sequences, methods of variant generation; for increased thermostability.
Oregon Hlth. Sci. Univ. WO 00/29609
Detection of an N-terminally truncated HER-2/neu product; for adenocarcinoma prognosis and diagnosis.
Organogenesis WO 00/29553
Cultured tissue constructs
Cultured tissue constructs having endogenously produced extracellular matrix components and lacking scaffolds.
Osiris Therapeutics WO 00/29002
In utero mesenchyme transplant
In utero transplantation of human mesenchymal stem cells; for treating fetuses.
Osiris Therapeutics WO 00/29552
Alginate layer system for chondrogenic differentiation of human mesenchymal stem cells in vitro and in vivo.
Oxford Biomedica WO 00/29428
5T4 tumor-associated antigen, vector containing the encoding gene; for tumor immunotherapy.
Pacific Northwest Res. Inst. WO 00/29582
Surface receptor antigen vaccines
Cell surface receptor antigens, recombinant expression constructs encoding immune response molecules; for vaccines.
Pasteur Merieux EP 1 004 314
Polio vaccine for previously vaccinated or sensitized populations that minimizes allergic reactions [in French].
Peptor WO 00/29004
Small functional units of antibody heavy chain variable regions; for antigen binding.
Pharmacia & Upjohn WO 00/29437
Hypoxia-inducible factor, variants, modulators; for finding modulators.
Reutter, W. WO 00/29567
Blood differentiation factors
Recombinant human glycoprotein blood differentiation factors, recombinant production methods.
Roche Diagnostics EP 1 004 677
DNA sequencing from mixtures
Direct, exponential amplification and sequencing of DNA from complex mixtures.
Sagami Chem. Res. Ctr. WO 00/29448
Hydrophobic domain proteins
Human proteins with hydrophobic domains, encoding gene sequences, expression vectors, transfected cells.
St. Jude Children's Res. Hosp. WO 00/29434
Pneumococcal infection diagnostics
Pneumococcal choline binding proteins, fragments, variants, derivatives; encoding gene sequences; for diagnostics.
Selective Genetics WO 00/29555
Protein binding partners
Genetic package display methods for detecting and finding internalizing ligands and other protein binding partners.
SmithKline Beecham WO 00/28818
Mouse 7-transmembrane receptor, encoding gene, recombinant production methods; for diagnostics and therapeutics.
SmithKline Beecham WO 00/28819
YfiL peudouridine synthase, encoding genes, recombinant production methods; for antibacterial screens.
SmithKline Beecham WO 00/28820
DnaB polypeptides, encoding gene sequences, recombinant production methods; for antibacterial screens.
SmithKline Beecham WO 00/29447
Proliferative disease antibodies
Antagonist antibodies to human receptor for hyaluronic acid-mediated motility; for treating proliferative diseases.
SmithKline Beecham WO 00/29547
YfiI peudouridine synthase, encoding genes, recombinant production methods; for antibacterial screens.
Statens Serum Inst. WO 00/29561
HIV genetic vaccine
Production of nucleotide constructs with optimized codons for an HIV genetic vaccine based on early HIV isolates.
Sugiyama, H. EP 1 004 319
Wilm's tumor therapy
Inhibition of expression of the Wilm's tumor gene using antisense, mutant genes, and other modulators.
Sumitomo Electric EP 1 004 596
1(3)mbt gene homolog
1(3)mbt gene homolog, encoded protein, antibodies, antisense; for diagnostics and therapeutics.
Sumitomo Pharma WO 00/29598
Adenoviral gene therapy vector
Recombinant adenovirus vector having a recombinase site for inserting coding sequences to be used in gene therapy.
Takara Shuzo EP 1 004 676
DNA amplification methods
DNA amplification methods using nucleotide analogs; for amplifying without preliminary purification steps.
Takeda Chemical WO 00/29441
G protein-coupled receptor, encoding gene sequences, antibodies; for neural disease therapeutics.
Takeda Chemical WO 00/29570
Brain-expressed protein with a PDZ domain similar to the activin receptor, fragments; for identifying modulators.
Tanox WO 00/29431
Allergic disease therapy
Bispecific molecules that crosslink ITIM and ITAM receptors; for inhibiting allergic disease symptoms.
Texas, Univ. of WO 00/29008
Diagnostic methods for determining if an HLA-Cw7-restricted cytotoxic T lymphocyte response occurs in AIDS patients.
Thomas Jefferson Univ. WO 00/29554
Tumor cell vaccine storage
Isotonic, buffered aqueous media with optimized human serum albumin; for preserving haptenized tumor cells for vaccines.
Tolin WO 00/29433
Bacterial glycoprotein polymers
Bacterial glycoprotein polymers; for use as infection vaccines and anti-proliferative agents against tumors.
Virginia, Univ. of WO 00/29618
Ulcer bacteria detection
Amplification of DNA sequences from human stool samples; for non-invasive detection of Helicobacter pylori infection.
Wallac WO 00/29849 & 29850
Spongiform encephalopathy diagnostics
Immunoassay for the detection of transmissible spongiform encephalopathies in mammals using prion antibodies.
Yoshitomi Pharma 1 004 673
Recombinant protein production
Culturing transfected cells in fatty acids and salts; for producing greater amounts of foreign proteins.
Zymogenetics WO 00/29430
Chromosome abnormality detection
RING finger protein family member, encoding gene sequences; for detecting human chromosomal abnormalities.
Zymogenetics WO 00/29575
Morphological development protein
Human Wnt protein, encoding gene sequences; for controlling morphological development.
Zymogenetics WO 00/29576
Lipocalin homologs, encoding gene sequences, antibodies; for use as antimicrobials and delivery agents.
Zymogenetics WO 00/29579
Mammalian chondromodulin-like protein, encoding gene sequences; for diagnostics and therapeutics.