Published April 26 (EPO); April 20 (WO)
Akzo Nobel EPO 995 799
Coccidiosis vaccines
Arnhem, the Netherlands
Hydrophilic Eimeria polypeptides, encoding gene sequences, fragments; for making coccidiosis vaccines.
American Home Products WO 00/22125
G protein-coupled receptors
Madison, N.J.
G protein-coupled receptor-like proteins, encoding genes, production methods; for diagnostics and therapeutics.
Arena Pharma WO 00/21987
Modulating receptors
San Diego
High-throughput assays for measuring cellular responses to putative modulators of cell surface membrane receptors.
Arena Pharma WO 00/22129
G protein-coupled receptor assay
San Diego
Non-endogenous, constitutively-activated human G protein-coupled receptors, encoding gene; for receptor assays.
Attomol WO 00/22163
Matrix-based amplifications
Lipten, Germany
Amplification reactions using matrix-bound DNA; for direct detection of nucleic acid sequences.
Aventis WO 00/22120
Oncogenic p53 binders
Antony, France
Polypeptides capable of interacting with oncogenic mutant forms of p53.
Avigen WO 00/22152
Adeno-associated virions
Alameda, Calif.
Compositions and methods for producing recombinant adeno-associated virions in large amounts or high titers.
Behan, D.P., et al. WO 00/22131
G protein-coupled receptor assay
San Diego
Non-endogenous, constitutively-activated human G protein-coupled receptors, encoding gene; for receptor assays.
Biogen WO 00/21558
Lymphotoxin-_ pathway blockade
Cambridge, Mass.
Reversal of viral-induced systemic shock and respiratory distress by blocking the lymphotoxin-_ pathway.
Biotech Res. Inst. EPO 995 795
Binding mesenchyme
Braunschweig, Germany
Human recombinant cell for bone and cartilage binding with undifferentiated mesenchyme [in German].
Biotech Res. Inst. WO 00/22139
Antibiotic synthesis
Braunschweig, Germany
Genes encoding enzymes for the synthesis of polyketides and heteropolyketides; for making epothilone antibiotics.
Brigham & Women's Hosp. WO 00/22127
Cardiac hypoxia diagnostics
Boston
p53 isoform associated with cardiac hypoxia occurring during heart attacks; for diagnostics.
Brown Univ. WO 00/22171
Sequencing by hybridization
Providence, R.I.
Use of gapped probes in hybridization reactions for gene sequencing methods.
California, Univ. of WO 00/21362
Prion protein transgenics
Oakland, Calif.
Transgenic animals having chimeric prion proteins; for studying neurodegenerative diseases.
Canji WO 00/21575
Apoptosis enhancement
San Diego
Calpain inhibitors combined with p53; for administration to enhance apoptosis
Canji WO 00/22124
Killing tumor cells
San Diego
Compositions for killing tumor cells and concomitantly mobilizing dendritic cells; for antitumor immunoresponse.
Canji WO 00/22136
Cancer cell lysing vectors
San Diego
Recombinant E1A-deleted adenoviral vectors; for replication and lysis in cancer cells.
Canji WO 00/22137
Selectively replicating vectors
San Diego
Recombinant viruses that replicate intracellular using a pathway-responsive promoter that inhibits viral replication.
Cell Activation WO 00/22160
Complement activation assay
San Diego
Methods for measuring complement activation by measuring mannan-binding serine protease activity.
Children's Hosp. WO 00/22095
In vivo electrotransfection
Boston
Apparatus and methods for in vivo gene transfer by electrotransfection.
Chiron Behring WO 00/22135
Ulcer vaccines
Marburg, Germany
Outer membrane proteins from Helicobacter pylori, encoding genes, antibodies; for ulcer vaccines.
Chiron WO 00/22130
Metastasis risk assessment
Emeryville, Calif.
Metastatic breast and colon cancer-regulated genes; for determining metastasis risk.
Chiron WO 00/22430
Meningitis vaccines
Emeryville, Calif.
Neisseria meningitidis B genomic sequences; for obtaining immunogenic proteins for vaccines.
Chugai Molec. Med. Res. Inst. WO 00/21999
G protein-coupled receptors
Ibaraki, Japan
G protein-coupled receptors from human testes, encoded protein; for regulating immunoresponse and hematopoiesis.
Cleveland Clinic Fdn. WO 00/22093
Interferon-modulated genes
Cleveland
Interferon-stimulated and -repressed genes, methods for identifying such genes.
Clontech Labs WO 00/22172
Oligonucleotide arrays
Palo Alto, Calif.
Arrays of oligonucleotide spots stably associated with the surface of solid supports.
Colorado, Univ. of WO 00/21552
Oligosaccharide antigens
Boulder, Colo.
Hapten oligosaccharide structures added to proteins, antibodies to these structures; for inducing immunity.
Columbia Univ. WO 00/22128
Fluorescent protein reporters
New York
Linked nucleic acid segments encoding a protein of interest and two green fluorescent proteins; for use as a reporter.
Cornell Univ. WO 00/22101
ATPase-driven microfluidics
Ithaca, N.Y.
Nanofabricated devices having ATPases as molecular motors; for light-activated microfluidic devices.
Curie, Univ. Pierre & Marie EPO 995 802
Hematopoietic cell transfection
Paris
Delivering gene sequences to hematopoietic cells in vitro or ex vivo using recombinant retroviral vectors.
Dynavax WO 00/21556
HIV therapeutics
Berkeley, Calif.
Immunostimulatory polynucleotides combined with HIV antigens; for HIV therapeutics.
Eli Lilly EPO 995 759
Angiopoietin-related gene
Indianapolis
Angiopoietin-related gene sequence scarface 2, fragments, encoded proteins; for modulator screens and therapeutics.
Eurona Medical WO 00/22166
Cardiovascular status genes
Uppsala, Sweden
Polymorphisms in cardiovascular status-related genes; for diagnostics and drug screens.
Fuso Pharma EPO 995 800
Bacteriodes diagnostic probes
Osaka, Japan
Specific DNA probes isolated from Bacteriodes fragilis; for diagnostics.
Genencor EPO 995 801
Stabilized enzymes
Nienburg/Waser, Germany
Process for stabilizing enzymes through mutations in their gene sequences; encoded stabilized enzymes [in German].
Genentech WO 00/21996
Antitumor agents
S. San Francisco
Methods and compositions for inhibiting tumor growth; screening methods for identifying these agents.
Genetics Inst. WO 00/21990 & 21991
Secreted ESTs
Cambridge, Mass.
Secreted expressed sequence tags (ESTs) isolated from a variety of human tissues.
Genset WO 00/21984
Human CIDE B protein
Paris
Nucleic acids encoding human CIDE-B protein, polymorphic markers, encoded proteins.
Genset WO 00/21985
Olfactory receptor genes
Paris
Genes encoding olfactory receptors, biallelic markers, encoded proteins, antibodies; for diagnostics.
Genset WO 00/22122
CNS disease genes
Paris
Genes associated with central nervous system (CNS) disease, biallelic markers, encoded proteins; for diagnostics.
Genset WO 00/22164
Painting chromosomes
Paris
Fluorescent probes for multicolor in situ hybridization methods for painting chromosomes.
Georgia, Med. College WO 00/21997
Dopamine receptor modifier
Augusta, Ga.
D-1 like dopamine receptor activity modifying protein, encoding gene; for drug screens and therapeutics.
Georgia, Univ. of WO 00/22112
Stabilized bioactive peptides
Athens, Ga.
Intracellular system for identification and selection of stabilized randomized recombinant bioactive peptides.
Geron Bio-Med WO 00/22098
Pig transgenics
Roslin, UK
Pig oocytes with improved developmental competence after in vitro or in vivo maturation; for making transgenics.
Harbron, S. WO 00/22165
Hybridization assay
Berkhamsted, UK
Hybridization assay using solid supports and allowing destruction of excess probe.
Harvard Univ. WO 00/21555
Contraceptive Wnt antagonist
Cambridge, Mass.
Administration of a Wnt antagonist to female primates to inhibit oocyte development; for contraception.
Harvard Univ. WO 00/22110
Protein proteolysis targeting
Cambridge, Mass.
Targeting cellular proteins for proteolysis by association with ubiquitin protein ligases.
Helix Res. Inst. EPO 995 797
Nuclear transport proteins
Chiba, Japan
Mutant transcription factor gene bound to another gene; for finding nuclear transport proteins.
Hoechst Marion Roussel WO 00/21998
BMP antagonist
Puteaux, France
Bone morphogenic protein (BMP) antagonist derived from the mature protein; for therapeutics.
Horiuchi, T. WO 00/22107
Gene amplification
Aichi, Japan
Amplifying foreign genes using recombination hot spots and autonomously replicating sequences.
Incyte Genomics WO 00/21986
Matrix-remodeling genes
Palo Alto, Calif.
Matrix-remodeling genes, encoded proteins, antibodies, modulators; for diagnostics and therapeutics.
Incyte Genomics WO 00/21988
Ankyrin family protein
Palo Alto, Calif.
Human ankyrin family protein, encoding gene sequences, antibodies, modulators; for diagnostics and therapeutics.
Incyte Genomics WO 00/22143
Protein kinase homologs
Palo Alto, Calif.
Protein kinase homologs, encoding genes, antibodies, modulators; for diagnostics and therapeutics.
Ingene WO 00/22113 & 22114
Single-stranded DNA synthesis
Overland Park, Kan.
Vectors with necessary signaling instructions and enzymatic functions for in vivo synthesis of single-stranded DNA.
INSERM (Natl. Inst. Hlth. & Med. Res.) WO 00/21553
Motor neuron survival
Paris
Nucleic acid constructs that regulate gene expression in motor neuron genes; for cell survival.
Interpharm Labs WO 00/22146
IL-1 receptor antagonist
Ness-Ziona, Israel
Expression and secretion of interleukin (IL)-1 receptor antagonist type II; for therapeutics production.
Isotechnika WO 00/22000
Cyclosporine antibodies
Edmonton, Alberta
Methods for the production of antibodies to specific regions of cyclosporine and cyclosporine metabolites.
Janssen, J.W.G. WO 00/22117
Tumor protein
Heidelberg, Germany
Tumor protein, encoding gene, antibodies, production methods; for cancer diagnostics and therapeutics.
Julich Res. Ctr. WO 00/22096
Protein production cells
Julich, Germany
Chinese hamster ovary cells having separated growth and production phases; for recombinant protein production.
Kansas Univ. Med. Ctr. WO 00/22094
Oxidative modification prevention
Kansas City, Kan.
Methods for preventing the oxidative modification of low density lipoproteins; for preventing atherosclerosis.
Kennedy Inst. Rheumatology WO 00/22097
Cells for gene therapy
London
Peripheral blood mesenchymal precursor cells; for gene therapy or tissue engineering.
Kentucky, Univ. of WO 00/21370
Cancer therapy
Lexington, Ky.
Lactone forms of camptothecins stabilized by complexing with oligos, for combined gene therapy and cancer chemotherapy.
King's College WO 00/21995
Inflammation therapeutics
London
Immunoglobulin heavy chain binding protein, derived peptide; for diagnosis and treatment of inflammatory disease.
Krebs Res. Ctr. WO 00/22151
Parvovirus vectors
Heidelberg, Germany
Parvovirus vectors, production methods; for use in gene therapy and vaccines.
Leicester Univ. WO 00/22158
Cytochrome P450 assay
Leicester, UK
Electrochemical systems, apparatus, and methods for assaying cytochrome P450 catalytic activity.
Ludwig Inst. Cancer Res. WO 00/21551
HLA-B35 binding peptides
New York
Isolated peptides that bind HLA-B35 molecules; for recognition and lysis of cytolytic T cells.
Ludwig Inst. Cancer Res. WO 00/21560
Flt4 receptor kinase
New York
Purified Flt4 receptor kinase polypeptides, fragments, encoding gene sequences, antibodies; for tumor imaging.
MA Bioservices WO 00/22168
Carcinogen assay
Rockville, Md.
Differential gene expression assays for determining patterns characteristic of carcinogen treatment.
Mass. Gen, Hosp. WO 00/21976
BMP-induced genes
Boston
Bone morphogenic protein (BMP)-induced genes, encoded proteins; for diagnostics and therapeutics.
Max Planck Res. Inst. WO 00/22118
Glutamate receptor
Berlin
Non-sensitizing AMPA-type glutamate receptor, encoding gene sequences; for diagnostics and therapeutics.
Max Planck Res. Inst. WO 00/22134
Lyme disease vaccines
Munich, Germany
Borrelia antigens and antibodies; for Lyme disease diagnostics and vaccines.
MRC (Med. Res. Counc.) WO 00/22111
Generating antibody diversity
London
Antibody-producing cells capable of directed constitutive hypermutation of specific nucleic acid sequences.
Medimmune WO 00/21989
Lyme disease therapeutics
Gaithersburg, Md.
Decorin binding proteins, encoding genes, antibodies; for preventing and treating Lyme disease.
Merck WO 00/21557
Fatty acid desaturase
Rahway, N.J.
Delta 6 fatty acid desaturase, encoding gene sequences, recombinant production methods; for finding modulators.
Microgenomics WO 00/22170
Metabolic pathway selection
San Diego
Metabolic selection methods used for screening novel enzymatic pathways.
Millennium Predictive Med. WO 00/22109
Agranulocytosis susceptibility
Cambridge, Mass.
Genes differentially expressed in clozapine-treated bone marrow cells; for predicting agranulocytosis susceptibility.
New Mexico, Univ. of WO 00/22169
Foreign organism detection
Albuquerque, N.M.
Detection of foreign organisms in samples using probes for Snz and Sno genes and their encoded proteins.
Novimmune EPO 995 798
MHC transcription factor
Geneva
MHC class II gene transcription factor, derivatives, inhibitors.
Novo Nordisk WO 00/22103
Reduced allergenic proteins
Bagsvaerd, Denmark
Modified polypeptides having reduced allergenicity that can be linked to polymeric molecules; for immune therapeutics.
Ono Pharma WO 00/22156
Neurodegenerative diagnostic
Osaka, Japan
Glyceraldehyde-3-phosphate dehydrogenase antibodies; for diagnosing neurodegenerative diseases.
Onyx Pharma WO 00/22142
Cell signal regulators
Richmond, Calif.
Isolated SRK polypeptides, biologically active fragments; for regulating cell signaling.
Perkin-Elmer WO 00/21974
Primer extension methods
Foster City, Calif.
Nucleotides and nucleosides having a rigid linker; for primer extension using mutant polymerases.
Princeton Univ. WO 00/22173
Array hybridization patterns
Princeton, N.J.
Quantitative analysis of hybridization patterns and intensities in oligonucleotide arrays.
Rudolph, R. WO 00/22119
Active _-NGF
Halle, Germany
Methods for obtaining active _-nerve growth factor (NGF) from pro _-NGF in prokaryotic inclusion bodies.
Sanofi-Synthelabo WO 00/22001
Potassium channel
Paris
Potassium channel of the erg family, encoding gene; for neural dysfunction diagnostics and therapeutics.
Shanghai Second Med. Univ. WO 00/21992
FK506 binding protein
Shanghai, China
Human FK506 binding protein, encoding gene, recombinant production methods; for diagnostics and therapeutics.
Shanghai Second Med. Univ. WO 00/21993
PTD010 protein
Shanghai, China
Human PTD010 protein, encoding gene, recombinant production methods; for diagnostics and therapeutics.
Shanghai Second Med. Univ. WO 00/21994
PTD011 protein
Shanghai, China
Human PTD011 protein, encoding gene, recombinant production methods; for diagnostics and therapeutics.
Shanghai Second Med. Univ. WO 00/22116
MDG1 protein
Shanghai, China
Human MDG1 protein, encoding gene, recombinant production methods; for diagnostics and therapeutics.
SmithKline Beecham WO 00/22159
Coumarin derivatives
Brentford, UK
7-alkoxycoumarins as substrates for cytochrome P450; for therapeutics.
South Carolina, Med. Univ. WO 00/21559
Treating immune disease
Charleston, S.C.
Administration of an inhibitor of Factor B; for treating complement-mediated immune disease.
Statens Serum Inst. WO 00/21983
Tuberculosis vaccines
Copenhagen, Denmark
Antigens from Mycobacterium tuberculosis, B- and T-cell epitopes; for tuberculosis diagnostics and vaccines.
Stratagene WO 00/22147
Electroporation methods
La Jolla, Calif.
Methods for electroporation using sugar-containing non-ionic solutions; for nucleic acid transfer.
Sumitomo Pharma WO 00/22106
Adenoviral vectors
Osaka, Japan
Cells expressing Cre recombinase in the presence of FLP recombinase; for making recombinant adenoviral vectors.
Sumitomo Pharma WO 00/22123
Cancer cell growth inhibitor
Osaka, Japan
WAR-1 protein that inhibits cancer cell proliferation, encoding gene, antibodies; for diagnostics and therapeutics.
Texas, Univ. of WO 00/22115
p53 alterations
Austin, Texas
High-throughput screening assays for identifying functional alterations in the p53 tumor suppressor.
Toyo Kohan WO 00/22108
Carbon-immobilized DNA
Tokyo
Carbon-based supports for immobilizing DNA for replication by amplification.
Univ. College WO 00/22121
Neuromodulator screens
London
Non-selective cation channel vanilloid-like receptor, variants, encoding gene; for neuromodulator screens.
Ventana Med. Systems WO 00/21975
Gene translocation detection
Tucson, Ariz.
Detection of reciprocal gene translocations using multiple probe sets spanning breakpoint regions in chromosomes.
Xgene WO 00/22167
Transcription factor activity
Burlingame, Calif.
Methods for determining transcription factor activity using site-specific strand cleavage.
Zymogenetics WO 00/22126
Follistatin-related protein
Seattle