Published April 26 (EPO); April 20 (WO)

Akzo Nobel EPO 995 799

Coccidiosis vaccines

Arnhem, the Netherlands

Hydrophilic Eimeria polypeptides, encoding gene sequences, fragments; for making coccidiosis vaccines.

American Home Products WO 00/22125

G protein-coupled receptors

Madison, N.J.

G protein-coupled receptor-like proteins, encoding genes, production methods; for diagnostics and therapeutics.

Arena Pharma WO 00/21987

Modulating receptors

San Diego

High-throughput assays for measuring cellular responses to putative modulators of cell surface membrane receptors.

Arena Pharma WO 00/22129

G protein-coupled receptor assay

San Diego

Non-endogenous, constitutively-activated human G protein-coupled receptors, encoding gene; for receptor assays.

Attomol WO 00/22163

Matrix-based amplifications

Lipten, Germany

Amplification reactions using matrix-bound DNA; for direct detection of nucleic acid sequences.

Aventis WO 00/22120

Oncogenic p53 binders

Antony, France

Polypeptides capable of interacting with oncogenic mutant forms of p53.

Avigen WO 00/22152

Adeno-associated virions

Alameda, Calif.

Compositions and methods for producing recombinant adeno-associated virions in large amounts or high titers.

Behan, D.P., et al. WO 00/22131

G protein-coupled receptor assay

San Diego

Non-endogenous, constitutively-activated human G protein-coupled receptors, encoding gene; for receptor assays.

Biogen WO 00/21558

Lymphotoxin-_ pathway blockade

Cambridge, Mass.

Reversal of viral-induced systemic shock and respiratory distress by blocking the lymphotoxin-_ pathway.

Biotech Res. Inst. EPO 995 795

Binding mesenchyme

Braunschweig, Germany

Human recombinant cell for bone and cartilage binding with undifferentiated mesenchyme [in German].

Biotech Res. Inst. WO 00/22139

Antibiotic synthesis

Braunschweig, Germany

Genes encoding enzymes for the synthesis of polyketides and heteropolyketides; for making epothilone antibiotics.

Brigham & Women's Hosp. WO 00/22127

Cardiac hypoxia diagnostics

Boston

p53 isoform associated with cardiac hypoxia occurring during heart attacks; for diagnostics.

Brown Univ. WO 00/22171

Sequencing by hybridization

Providence, R.I.

Use of gapped probes in hybridization reactions for gene sequencing methods.

California, Univ. of WO 00/21362

Prion protein transgenics

Oakland, Calif.

Transgenic animals having chimeric prion proteins; for studying neurodegenerative diseases.

Canji WO 00/21575

Apoptosis enhancement

San Diego

Calpain inhibitors combined with p53; for administration to enhance apoptosis

Canji WO 00/22124

Killing tumor cells

San Diego

Compositions for killing tumor cells and concomitantly mobilizing dendritic cells; for antitumor immunoresponse.

Canji WO 00/22136

Cancer cell lysing vectors

San Diego

Recombinant E1A-deleted adenoviral vectors; for replication and lysis in cancer cells.

Canji WO 00/22137

Selectively replicating vectors

San Diego

Recombinant viruses that replicate intracellular using a pathway-responsive promoter that inhibits viral replication.

Cell Activation WO 00/22160

Complement activation assay

San Diego

Methods for measuring complement activation by measuring mannan-binding serine protease activity.

Children's Hosp. WO 00/22095

In vivo electrotransfection

Boston

Apparatus and methods for in vivo gene transfer by electrotransfection.

Chiron Behring WO 00/22135

Ulcer vaccines

Marburg, Germany

Outer membrane proteins from Helicobacter pylori, encoding genes, antibodies; for ulcer vaccines.

Chiron WO 00/22130

Metastasis risk assessment

Emeryville, Calif.

Metastatic breast and colon cancer-regulated genes; for determining metastasis risk.

Chiron WO 00/22430

Meningitis vaccines

Emeryville, Calif.

Neisseria meningitidis B genomic sequences; for obtaining immunogenic proteins for vaccines.

Chugai Molec. Med. Res. Inst. WO 00/21999

G protein-coupled receptors

Ibaraki, Japan

G protein-coupled receptors from human testes, encoded protein; for regulating immunoresponse and hematopoiesis.

Cleveland Clinic Fdn. WO 00/22093

Interferon-modulated genes

Cleveland

Interferon-stimulated and -repressed genes, methods for identifying such genes.

Clontech Labs WO 00/22172

Oligonucleotide arrays

Palo Alto, Calif.

Arrays of oligonucleotide spots stably associated with the surface of solid supports.

Colorado, Univ. of WO 00/21552

Oligosaccharide antigens

Boulder, Colo.

Hapten oligosaccharide structures added to proteins, antibodies to these structures; for inducing immunity.

Columbia Univ. WO 00/22128

Fluorescent protein reporters

New York

Linked nucleic acid segments encoding a protein of interest and two green fluorescent proteins; for use as a reporter.

Cornell Univ. WO 00/22101

ATPase-driven microfluidics

Ithaca, N.Y.

Nanofabricated devices having ATPases as molecular motors; for light-activated microfluidic devices.

Curie, Univ. Pierre & Marie EPO 995 802

Hematopoietic cell transfection

Paris

Delivering gene sequences to hematopoietic cells in vitro or ex vivo using recombinant retroviral vectors.

Dynavax WO 00/21556

HIV therapeutics

Berkeley, Calif.

Immunostimulatory polynucleotides combined with HIV antigens; for HIV therapeutics.

Eli Lilly EPO 995 759

Angiopoietin-related gene

Indianapolis

Angiopoietin-related gene sequence scarface 2, fragments, encoded proteins; for modulator screens and therapeutics.

Eurona Medical WO 00/22166

Cardiovascular status genes

Uppsala, Sweden

Polymorphisms in cardiovascular status-related genes; for diagnostics and drug screens.

Fuso Pharma EPO 995 800

Bacteriodes diagnostic probes

Osaka, Japan

Specific DNA probes isolated from Bacteriodes fragilis; for diagnostics.

Genencor EPO 995 801

Stabilized enzymes

Nienburg/Waser, Germany

Process for stabilizing enzymes through mutations in their gene sequences; encoded stabilized enzymes [in German].

Genentech WO 00/21996

Antitumor agents

S. San Francisco

Methods and compositions for inhibiting tumor growth; screening methods for identifying these agents.

Genetics Inst. WO 00/21990 & 21991

Secreted ESTs

Cambridge, Mass.

Secreted expressed sequence tags (ESTs) isolated from a variety of human tissues.

Genset WO 00/21984

Human CIDE B protein

Paris

Nucleic acids encoding human CIDE-B protein, polymorphic markers, encoded proteins.

Genset WO 00/21985

Olfactory receptor genes

Paris

Genes encoding olfactory receptors, biallelic markers, encoded proteins, antibodies; for diagnostics.

Genset WO 00/22122

CNS disease genes

Paris

Genes associated with central nervous system (CNS) disease, biallelic markers, encoded proteins; for diagnostics.

Genset WO 00/22164

Painting chromosomes

Paris

Fluorescent probes for multicolor in situ hybridization methods for painting chromosomes.

Georgia, Med. College WO 00/21997

Dopamine receptor modifier

Augusta, Ga.

D-1 like dopamine receptor activity modifying protein, encoding gene; for drug screens and therapeutics.

Georgia, Univ. of WO 00/22112

Stabilized bioactive peptides

Athens, Ga.

Intracellular system for identification and selection of stabilized randomized recombinant bioactive peptides.

Geron Bio-Med WO 00/22098

Pig transgenics

Roslin, UK

Pig oocytes with improved developmental competence after in vitro or in vivo maturation; for making transgenics.

Harbron, S. WO 00/22165

Hybridization assay

Berkhamsted, UK

Hybridization assay using solid supports and allowing destruction of excess probe.

Harvard Univ. WO 00/21555

Contraceptive Wnt antagonist

Cambridge, Mass.

Administration of a Wnt antagonist to female primates to inhibit oocyte development; for contraception.

Harvard Univ. WO 00/22110

Protein proteolysis targeting

Cambridge, Mass.

Targeting cellular proteins for proteolysis by association with ubiquitin protein ligases.

Helix Res. Inst. EPO 995 797

Nuclear transport proteins

Chiba, Japan

Mutant transcription factor gene bound to another gene; for finding nuclear transport proteins.

Hoechst Marion Roussel WO 00/21998

BMP antagonist

Puteaux, France

Bone morphogenic protein (BMP) antagonist derived from the mature protein; for therapeutics.

Horiuchi, T. WO 00/22107

Gene amplification

Aichi, Japan

Amplifying foreign genes using recombination hot spots and autonomously replicating sequences.

Incyte Genomics WO 00/21986

Matrix-remodeling genes

Palo Alto, Calif.

Matrix-remodeling genes, encoded proteins, antibodies, modulators; for diagnostics and therapeutics.

Incyte Genomics WO 00/21988

Ankyrin family protein

Palo Alto, Calif.

Human ankyrin family protein, encoding gene sequences, antibodies, modulators; for diagnostics and therapeutics.

Incyte Genomics WO 00/22143

Protein kinase homologs

Palo Alto, Calif.

Protein kinase homologs, encoding genes, antibodies, modulators; for diagnostics and therapeutics.

Ingene WO 00/22113 & 22114

Single-stranded DNA synthesis

Overland Park, Kan.

Vectors with necessary signaling instructions and enzymatic functions for in vivo synthesis of single-stranded DNA.

INSERM (Natl. Inst. Hlth. & Med. Res.) WO 00/21553

Motor neuron survival

Paris

Nucleic acid constructs that regulate gene expression in motor neuron genes; for cell survival.

Interpharm Labs WO 00/22146

IL-1 receptor antagonist

Ness-Ziona, Israel

Expression and secretion of interleukin (IL)-1 receptor antagonist type II; for therapeutics production.

Isotechnika WO 00/22000

Cyclosporine antibodies

Edmonton, Alberta

Methods for the production of antibodies to specific regions of cyclosporine and cyclosporine metabolites.

Janssen, J.W.G. WO 00/22117

Tumor protein

Heidelberg, Germany

Tumor protein, encoding gene, antibodies, production methods; for cancer diagnostics and therapeutics.

Julich Res. Ctr. WO 00/22096

Protein production cells

Julich, Germany

Chinese hamster ovary cells having separated growth and production phases; for recombinant protein production.

Kansas Univ. Med. Ctr. WO 00/22094

Oxidative modification prevention

Kansas City, Kan.

Methods for preventing the oxidative modification of low density lipoproteins; for preventing atherosclerosis.

Kennedy Inst. Rheumatology WO 00/22097

Cells for gene therapy

London

Peripheral blood mesenchymal precursor cells; for gene therapy or tissue engineering.

Kentucky, Univ. of WO 00/21370

Cancer therapy

Lexington, Ky.

Lactone forms of camptothecins stabilized by complexing with oligos, for combined gene therapy and cancer chemotherapy.

King's College WO 00/21995

Inflammation therapeutics

London

Immunoglobulin heavy chain binding protein, derived peptide; for diagnosis and treatment of inflammatory disease.

Krebs Res. Ctr. WO 00/22151

Parvovirus vectors

Heidelberg, Germany

Parvovirus vectors, production methods; for use in gene therapy and vaccines.

Leicester Univ. WO 00/22158

Cytochrome P450 assay

Leicester, UK

Electrochemical systems, apparatus, and methods for assaying cytochrome P450 catalytic activity.

Ludwig Inst. Cancer Res. WO 00/21551

HLA-B35 binding peptides

New York

Isolated peptides that bind HLA-B35 molecules; for recognition and lysis of cytolytic T cells.

Ludwig Inst. Cancer Res. WO 00/21560

Flt4 receptor kinase

New York

Purified Flt4 receptor kinase polypeptides, fragments, encoding gene sequences, antibodies; for tumor imaging.

MA Bioservices WO 00/22168

Carcinogen assay

Rockville, Md.

Differential gene expression assays for determining patterns characteristic of carcinogen treatment.

Mass. Gen, Hosp. WO 00/21976

BMP-induced genes

Boston

Bone morphogenic protein (BMP)-induced genes, encoded proteins; for diagnostics and therapeutics.

Max Planck Res. Inst. WO 00/22118

Glutamate receptor

Berlin

Non-sensitizing AMPA-type glutamate receptor, encoding gene sequences; for diagnostics and therapeutics.

Max Planck Res. Inst. WO 00/22134

Lyme disease vaccines

Munich, Germany

Borrelia antigens and antibodies; for Lyme disease diagnostics and vaccines.

MRC (Med. Res. Counc.) WO 00/22111

Generating antibody diversity

London

Antibody-producing cells capable of directed constitutive hypermutation of specific nucleic acid sequences.

Medimmune WO 00/21989

Lyme disease therapeutics

Gaithersburg, Md.

Decorin binding proteins, encoding genes, antibodies; for preventing and treating Lyme disease.

Merck WO 00/21557

Fatty acid desaturase

Rahway, N.J.

Delta 6 fatty acid desaturase, encoding gene sequences, recombinant production methods; for finding modulators.

Microgenomics WO 00/22170

Metabolic pathway selection

San Diego

Metabolic selection methods used for screening novel enzymatic pathways.

Millennium Predictive Med. WO 00/22109

Agranulocytosis susceptibility

Cambridge, Mass.

Genes differentially expressed in clozapine-treated bone marrow cells; for predicting agranulocytosis susceptibility.

New Mexico, Univ. of WO 00/22169

Foreign organism detection

Albuquerque, N.M.

Detection of foreign organisms in samples using probes for Snz and Sno genes and their encoded proteins.

Novimmune EPO 995 798

MHC transcription factor

Geneva

MHC class II gene transcription factor, derivatives, inhibitors.

Novo Nordisk WO 00/22103

Reduced allergenic proteins

Bagsvaerd, Denmark

Modified polypeptides having reduced allergenicity that can be linked to polymeric molecules; for immune therapeutics.

Ono Pharma WO 00/22156

Neurodegenerative diagnostic

Osaka, Japan

Glyceraldehyde-3-phosphate dehydrogenase antibodies; for diagnosing neurodegenerative diseases.

Onyx Pharma WO 00/22142

Cell signal regulators

Richmond, Calif.

Isolated SRK polypeptides, biologically active fragments; for regulating cell signaling.

Perkin-Elmer WO 00/21974

Primer extension methods

Foster City, Calif.

Nucleotides and nucleosides having a rigid linker; for primer extension using mutant polymerases.

Princeton Univ. WO 00/22173

Array hybridization patterns

Princeton, N.J.

Quantitative analysis of hybridization patterns and intensities in oligonucleotide arrays.

Rudolph, R. WO 00/22119

Active _-NGF

Halle, Germany

Methods for obtaining active _-nerve growth factor (NGF) from pro _-NGF in prokaryotic inclusion bodies.

Sanofi-Synthelabo WO 00/22001

Potassium channel

Paris

Potassium channel of the erg family, encoding gene; for neural dysfunction diagnostics and therapeutics.

Shanghai Second Med. Univ. WO 00/21992

FK506 binding protein

Shanghai, China

Human FK506 binding protein, encoding gene, recombinant production methods; for diagnostics and therapeutics.

Shanghai Second Med. Univ. WO 00/21993

PTD010 protein

Shanghai, China

Human PTD010 protein, encoding gene, recombinant production methods; for diagnostics and therapeutics.

Shanghai Second Med. Univ. WO 00/21994

PTD011 protein

Shanghai, China

Human PTD011 protein, encoding gene, recombinant production methods; for diagnostics and therapeutics.

Shanghai Second Med. Univ. WO 00/22116

MDG1 protein

Shanghai, China

Human MDG1 protein, encoding gene, recombinant production methods; for diagnostics and therapeutics.

SmithKline Beecham WO 00/22159

Coumarin derivatives

Brentford, UK

7-alkoxycoumarins as substrates for cytochrome P450; for therapeutics.

South Carolina, Med. Univ. WO 00/21559

Treating immune disease

Charleston, S.C.

Administration of an inhibitor of Factor B; for treating complement-mediated immune disease.

Statens Serum Inst. WO 00/21983

Tuberculosis vaccines

Copenhagen, Denmark

Antigens from Mycobacterium tuberculosis, B- and T-cell epitopes; for tuberculosis diagnostics and vaccines.

Stratagene WO 00/22147

Electroporation methods

La Jolla, Calif.

Methods for electroporation using sugar-containing non-ionic solutions; for nucleic acid transfer.

Sumitomo Pharma WO 00/22106

Adenoviral vectors

Osaka, Japan

Cells expressing Cre recombinase in the presence of FLP recombinase; for making recombinant adenoviral vectors.

Sumitomo Pharma WO 00/22123

Cancer cell growth inhibitor

Osaka, Japan

WAR-1 protein that inhibits cancer cell proliferation, encoding gene, antibodies; for diagnostics and therapeutics.

Texas, Univ. of WO 00/22115

p53 alterations

Austin, Texas

High-throughput screening assays for identifying functional alterations in the p53 tumor suppressor.

Toyo Kohan WO 00/22108

Carbon-immobilized DNA

Tokyo

Carbon-based supports for immobilizing DNA for replication by amplification.

Univ. College WO 00/22121

Neuromodulator screens

London

Non-selective cation channel vanilloid-like receptor, variants, encoding gene; for neuromodulator screens.

Ventana Med. Systems WO 00/21975

Gene translocation detection

Tucson, Ariz.

Detection of reciprocal gene translocations using multiple probe sets spanning breakpoint regions in chromosomes.

Xgene WO 00/22167

Transcription factor activity

Burlingame, Calif.

Methods for determining transcription factor activity using site-specific strand cleavage.

Zymogenetics WO 00/22126

Follistatin-related protein

Seattle

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