Published April 12 (EPO); April 6 (WO)
Adv. Res. & Technol. Inst. WO 00/19205
DNA synthesis modulators
Bloomington, Ind.
Assays for altering PAK activation of Raf-1; for identifying modulators of DNA synthesis.
Affymetrix WO 00/18962
Binding assays
Santa Clara, Calif.
Methods and compositions for amplifying detectable signals in specific binding assays using fluorescent labels.
Alabama, Univ. of WO 00/18888
Immunity modulation
Birmingham, Ala.
Gene transfer vectors for genetically modifying dendritic and B cells; for modulating immunity.
American Cyanamid WO 00/18434
Cholera holotoxin adjuvant
Madison, N.J.
Mutant cholera holotoxin; for use as an adjuvant in antigenic compositions that induce an immune response.
American Fdn. Biol. Res. WO 00/18933
Cancer immunoresponse
Rockville, Md.
Truncated forms of cancer-specific or -associated antigens; for gene therapy of dendritic cells inducing immunoresponse.
Amgen EPO 992 579
Stem cell factors
Thousand Oaks, Calif.
Stem cell factors, encoding gene sequences, production methods; for treating blood disorders.
Amgen WO 00/18914
DKR polypeptides
Thousand Oaks, Calif.
DKR polypeptides, encoding gene sequences, recombinant production methods; for diagnostics and therapeutics.
Amgen WO 00/18917
Parkinson's transgenics
Thousand Oaks, Calif.
a-synuclein mutations that accelerate aggregation in transgenics; for Parkinson's disease models.
Antex Biologics WO 00/18910
Moraxella vaccines
Gaithersburg, Md.
Moraxella catarrhalis outer membrane proteins, encoding gene sequences; for vaccines and infection treatment.
Applied Res. Systems WO 00/18957
Sequencing method
Curacao, Netherlands Antilles
Nucleic acid amplification and sequencing using solid supports.
Aventis WO 00/18908
Smooth muscle gene expression
Antony, France
Hybrid promoters having ubiquitous promoter-enhancer elements enabling expression in smooth muscle cells.
Bayer WO 00/18912
Cholesterol activity modulation
Leverkusen, Germany
ATP binding cassette genes, encoded proteins; for modulating cholesterol-driven processes in various diseases.
Biogen WO 00/18428
Cell differentiation modulation
Cambridge, Mass.
Hedgehog and patched antagonists; for inhibiting cell and tissue growth and differentiation.
Biomedica WO 00/19207
ANP antibodies
Vienna, Austria
Polyclonal antibodies that bind to immunogenic peptides of atrial natriuretic peptide (ANP) and pro-ANP.
Biotech & Biol. Sci. Res. Counc. WO 00/18902
Large offspring syndrome
Swindon, UK
Insulin-like growth factor-2 receptor gene expression in transgenics; for diagnosing large offspring syndrome.
Boston Med. Ctr. WO 00/18964
Virulence activator screen
Boston
Finding activators of transition metal-dependent repressor of virulence gene expression in infectious pathogens.
Brigham & Women's Hosp. WO 00/18211
Cochlear gene
Boston
Cochlear gene, encoded protein, fusions, antigenic peptides, transgenics; for diagnostics and therapeutics.
Brussells Free Univ. WO 00/18883
Taxane
Brussells
Taxane and taxane derivatives from penicillin molds, production methods; for making chemotherapeutics.
California, Univ. of WO 00/18429
Bacterial vaccines
Oakland, Calif.
Modified, attenuated Haemophilus somnus strains; for expressing antigenic proteins and making vaccines.
California, Univ. of WO 00/18788
G protein subunit modulators
Oakland, Calif.
Sensory cell-specific G protein gamma subunit, encoding gene, antibodies; for screening modulators.
Chicago, Univ. of WO 00/18966
Differential gene expression
Chicago
Genome-wide identification of differentially expressed genes using improved poly-dT primers anchored at their 3' ends.
Children's Hosp. WO 00/18895
Modulating kinase activity
Boston
Peptide derivatives from the aD region of a protein kinase; for selectively modulating kinase activity.
Chiron WO 00/18916
Human genes
Emeryville, Calif.
Human genes, encoded proteins, probes, antisense, antibodies; for diagnostics and therapeutics.
Chiron WO 00/18921
FGF receptor ligands
Emeryville, Calif.
Synthetic peptides with fibroblast growth factor (FGF) receptor affinity, fusions, oligomers; for therapeutics.
Columbia Univ. WO 00/18884
Neurodegeneration treatment
New York
Motor neuron restricted protein, encoding gene sequence, antibodies, transgenics; for treating neurodegeneration.
Columbia Univ. WO 00/18959
Cancer diagnosis
New York
Tumor necrosis factor receptor-associated factor protein-interacting hereditary multiple extoses protein.
Corixa WO 00/18431
Inflammation prevention
Seattle
Immunogenic oligopeptides derived from chemokine receptor proteins; for preventing inflammatory responses.
Curagen WO 00/18918
Metabolic X syndrome genes
New Haven, Conn.
Genes whose expression is modulated in SHR rats, a metabolic X syndrome model; for diagnostics and therapeutics.
Danisco WO 00/18934
Recombinant protein production
Copenhagen, Denmark
Peptidyl prolyl cis-trans isomerases; for use in assisting secretion of recombinant proteins from production cells.
Diacrin WO 00/18413
Neural cells for transplant
Charlestown, Mass.
Neural cells having modified cell surface MHC antigens; for transplant to treat chronic pain or spasticity.
Diacrin WO 00/18414
Stroke transplant therapy
Charlestown, Mass.
Embryonic pig neural striatum cells having modified cell surface MHC antigens; for treating stroke ischemic damage.
Diversa WO 00/18909
Archeon proteins
San Diego
Genes and encoded proteins from Cenarchaem symbiosum archeons, antibodies, production methods.
Fleischmann, W.R. WO 00/18427
Diseased cell treatment
Galveston, Texas
Ex vivo treatment of diseased cells with interferon-a; for treating infectious disease and cancer.
Gamida Cell WO 00/18885
Growing undifferentiated cells
Savyon, Israel
Expansion of cells in culture while preventing cell differentiation that can be used in vivo and ex vivo.
Glycox WO 00/18891
Diabetes complications diagnosis
Auckland, New Zealand
Assay for fructosamine oxidase in blood plasma; for diagnosing diabetes-associated vascular complications.
HSP Res. Inst. EPO 992 588
Therapeutic production
Osaka, Japan
Vectors encoding Dsb proteins and a therapeutic protein; for production of recombinant therapeutics.
Incyte Genomics WO 00/18915
Membrane organizational proteins
Palo Alto, Calif.
Membrane-associated organizational proteins, encoding genes, antibodies, modulators; for diagnostics and therapeutics.
Incyte Genomics WO 00/18919
Kinesin-like motor protein
Palo Alto, Calif.
Human kinesin-like motor protein, encoding gene sequences, antibodies, modulators; for diagnostics and therapeutics.
Incyte Genomics WO 00/18922
Carbohydrate-associated proteins
Palo Alto, Calif.
Human carbohydrate-associated proteins, encoding genes, antibodies, modulators; for diagnostics and therapeutics.
Incyte Genomics WO 00/18924
Small proline-rich proteins
Palo Alto, Calif.
Human small proline-rich proteins, encoding gene sequences, antibodies, modulators; for diagnostics and therapeutics.
Innogenetics EPO 992 580 & 581
T-cell HCV epitopes
Ghent, Belgium
Immunodominant human T-cell stimulating epitopes of the hepatitis C virus (HCV); for therapeutics.
Inst. Phys. & Chem. Res. WO 00/18426
HIV-derived apoptosis inducer
Saitama, Japan
Apoptosis inducers derived from the protein encoded by the HIV-1 vpr gene; for treating cancer and AIDS.
Isis Pharma WO 00/18784
RhoG antisense
Carlsbad, Calif.
Antisense oligonucleotide compositions for modulating RhoG expression; for treating RhoG-associated diseases.
Isis Pharma WO 00/18785
CD71 antisense
Carlsbad, Calif.
Antisense oligonucleotide compositions for modulating CD71 expression; for treating CD71-associated diseases.
Isis Pharma WO 00/18786
RIP-1 antisense
Carlsbad, Calif.
Antisense oligonucleotide compositions for modulating RIP-1 expression; for treating RIP-1-associated diseases.
Johns Hopkins Univ. WO 00/18903
Epilepsy gene therapy
Baltimore
Electrical silencing gene transfer using adenoviral vectors; for treating epilepsy and intractable pain.
Kansas, Univ. Med. Ctr. WO 00/18430
HIV vaccines
Kansas City, Kan.
Live, pathogenic, modified simian HIV; for HIV infection prevention and vaccination.
Krebs Res. Inst. WO 00/18907
Anti-inflammatory antisense
Heidelberg, Germany
Antisense oligos for inhibiting expression of the adhesion molecule ICAM-1; for treating inflammation.
Kyowa Hakko Kogyo WO 00/18805
Immunotherapy antibodies
Tokyo
Antibodies to a transmembrane matrix metalloprotease; for treating immune system diseases.
Leuven Res. & Develop. WO 00/18436
Stroke treatment
Leuven, Belgium
Compounds that reduce a2-antiplasmin in vivo; for treating focal ischemic strokes.
Lindhofer, H. WO 00/18435
Tumor immunotherapy
Grobenzell, Germany
Time-staggered use of tumor cells in combination with intact, heterologous antibodies for immunization.
Lindhofer, H. WO 00/18806
Immunotherapy antibodies
Grobenzell, Germany
Bispecific and trispecific antibodies specifically reacting with inducible surface antigens on T cells.
Ludwig Inst. Cancer Res. WO 00/18212
PDGF C
New York
Platelet-derived growth factor (PDGF) C, encoding gene sequences; for diagnostics and therapeutics.
Mass. Inst. Technol. WO 00/18960
SNP genome scans
Cambridge, Mass.
Genotyping using single nucleotide polymorphisms (SNPs) to perform high-throughput genome scans.
Max Planck Res. Inst. WO 00/18955
Shotgun clone preselection
Berlin
Preselection of shotgun clones from genomic DNA using specific probes; for more efficient sequence analysis.
Maxygen WO 00/18906
Codon-altered gene libraries
Redwood City, Calif.
Shuffling and recombining codon-altered libraries of nucleic acids; for making new proteins and altered vectors.
Med. Res. Counc. (MRC) WO 00/18941
Artificial chromosomes
London
Autonomously replicating mammalian artificial chromosomes; for inserting useful genes into cells.
Millennium Biotherapeutics WO 00/18800
Immunomodulatory proteins
Cambridge, Mass.
TANGO 191 and 195 immunmodulatory proteins, encoding gene sequences; for diagnostics and therapeutics.
Millennium Biotherapeutics WO 00/18904
Secreted proteins
Cambridge, Mass.
Secreted proteins, encoding gene sequences, production methods; for diagnostics and therapeutics.
Millennium Pharma WO 00/18782
HRPCA 9/10 genes
Cambridge, Mass.
HRPCA 9 and 10 gene sequences, encoded proteins, production methods; for diagnostics and therapeutics.
Millennium Pharma WO 00/18890
Protein phosphatases
Cambridge, Mass.
Protein phosphatases, encoding gene sequences, antibodies, transgenics; for diagnostics and therapeutics.
Millennium Pharma WO 00/18899
ACE homolog
Cambridge, Mass.
Angiotensin converting enzyme (ACE) homolog, encoding gene sequences; for treating blood pressure-related disorders.
Millennium Pharma WO 00/18923
G protein-coupled receptor
Cambridge, Mass.
G protein-coupled receptor family protein, encoding gene, fusions, antigenic fragments, antibodies, transgenics.
Millennium Pharma WO 00/18952
Antibacterial screens
Cambridge, Mass.
Essential genes from Bacillus subtilis and Streptococcus pneumoniae, homologs, orthologs; for antibacterial screens.
Millennium Pharma WO 00/18961
Prostate cancer expression analysis
Cambridge, Mass.
Expression analysis of nucleic acids and polypeptides useful in prostate cancer diagnosis and treatment.
Nebraska, Univ. of WO 00/18239
Liver cells for transplant
Lincoln, Neb.
Reversibly immortalized liver cells, methods of production; for transplantation.
New England Biolabs WO 00/18881
Peptide ligation methods
Beverly, Mass.
Target proteins fused to a protein splicing element; for peptide ligation.
New England Med. Ctr. EPO 992 578
Intracytoplasmic labeling
Boston
Labeling intracytoplasmic molecules using permeabilizing agents to allow labels to traverse the cell membrane.
New York, State Univ. of WO 00/18894
Immunosuppression
Albany, N.Y.
IkappaB kinase that regulates NFkappaB gene transcription, encoding gene, antibodies; for immunosuppression.
N. Shore-Long Island Jewish Res. Ctr. WO 00/18238
Methylation pattern detection
Manhasset, N.Y.
Nucleic acid probes for detecting mutations and methylation patterns in genes; for diagnostics and therapeutics.
Progenics Pharma WO 00/18432
Viral disease vaccines
Tarrytown, N.Y.
Cellular carbohydrates that are overexpressed in viral diseases, molecular mimics; for viral disease vaccines.
Qiagen EPO 992 583
Vector purification
Hilden, Germany
Purifying covalently closed circular DNA using anion exchange chromatography.
Regeneron Pharma WO 00/18932
Cytokine inactivation
Tarrytown, N.Y.
Fusion peptides that bind and inactivate cytokines, encoding gene sequences; for receptor-based antagonists.
RIKEN EPO 992 587
IP3 binding polypeptide
Wako, Japan
High affinity inositol 1,4,5-triphosphate (IP3) binding polypeptide, encoding gene; for affecting cell signalling.
Rockefeller Univ. WO 00/18896
Venom enzymes
New York
Polistinae venom enzymes, such as phospholipase and hyaluronidase; for recombinant production.
Schering-Plough EPO 992 584
Langerhans cell antigen
Kenilworth, N.J.
Purified mammalian Langerhans cell antigen, encoding gene sequences, antibodies; for diagnostics and therapeutics.
Schering-Plough WO 00/18803
Flt3 ligands
Kenilworth, N.J.
Purified mammalian Flt3 ligands, variants, antibodies, modulators; for diagnostics and therapeutics.
Searle WO 00/18905
Circularly-permuted proteins
Chicago
Inserting circularly-permuted genes into a display vector; for producing circularly-permuted proteins.
Seeger, S. WO 00/18956
Sequencing method
Donau, Germany
Nucleic acid sequencing on immobilized supports using laser-related methods.
Seiki, M. WO 00/18900
Metalloprotease inhibitors
Tokyo
Transmembrane matrix metalloprotease, encoding gene sequences; for inhibitor screens.
Sibia Neurosciences EPO 992 585
Calcium channel subunits
La Jolla, Calif.
Human calcium channel subunits, encoding genes, variants; for identifying modulators.
Singapore Republic WO 00/18958 & 18968
Hepatitis B inhibitors
Singapore
In vitro PCR-based amplification assay for human hepatitis B virus DNA polymerase; for screening inhibitors.
SmithKline Beecham WO 00/18437 & 18804
Angiogenesis modulation
Philadelphia
Tie2 receptor agonist and antagonist antibodies; for use in modulating angiogenesis.
SmithKline Beecham WO 00/18797
Antibacterial screens
Philadelphia
Bacterial map proteins, encoding gene sequences, recombinant production methods; for antibacterial screens.
SmithKline Beecham WO 00/18929
Respiratory infection vaccines
Rixensart, Belgium
Chimeric proteins having immunogenic fragments of RSV and other viral proteins; for respiratory infection vaccines.
Southern California, Univ. of WO 00/18240
Gene therapy vector
Los Angeles
Recombinant replication competent retroviral vector encoding a cell-specific ligand; for gene therapy.
Southern California, Univ. of WO 00/18421
Metastasis prevention
Los Angeles
Contortrostatin, variants, fragments, encoding gene sequences, production methods; for preventing metastasis.
Synaptic Pharma WO 00/18438
Neuropeptide FF receptor
Paramus, N.J.
Mammalian neuropeptide FF receptor gene, encoded protein, antibodies, transgenics; for identifying modulators.
Takeda Chemical EPO 992 189
Vitamin D transgenics
Osaka, Japan
Transgenics having the 25-hydroxylated vitamin D3-24-hydroxylase gene; for modeling various diseases.
Temple Univ. WO 00/18802
Polymeric hemoglobin mutants
Philadelphia
Human _-globin mutant polypeptides, encoding gene sequences; for making polymeric hemoglobin mutants.
Ulster, Univ. of WO 00/19208
Bladder cancer diagnosis
Newtownabbey, UK
Assay for 37kDa epidermal growth factor receptor fragment in urine; for diagnosing bladder and prostate cancer.
U.S. Surgical EPO 992 586
Modified matrix proteins
Norwalk, Conn.
Extracellular matrix proteins with modified amino acid residues; for altering their physiological activity.
Urogenesys WO 00/18925
Prostate cancer gene
Santa Monica, Calif.
Gene expressed in prostate cancer, encoding gene sequences; for diagnostics and therapeutics.
Utah, Univ. of WO 00/18965
Multiplex genotyping
Salt Lake City, Utah
Multiplex genotyping using fluorescent hybridization probes and PCR-based amplification methods.
Utrecht Univ. WO 00/18913
Tumor suppressor gene
Utrecht, Netherlands
Chromosome 19 gene, homologs, fragments, derivatives; for tumor suppression.
Variagenics WO 00/18967
Nucleotide variance detection
Cambridge, Mass.
Methods for analyzing nucleotide sequences, including variance detection, without full sequence determination.
Wales, Univ. of EPO 992 582
Schistosomiasis vaccine
Bangor, UK
Recombinant fusion protein with schistosome carcarial elastase and bacterial protein fragments; for vaccines.
Washington Univ. WO 00/18783
Breast cancer therapeutic
St. Louis, Mo.
Mammaglobin, a secreted mammary-specific breast cancer protein, encoding gene; for diagnostics and therapeutics.
Washington Univ. WO 00/18787
Wolfram Syndrome gene
St. Louis, Mo.
Chromosome 4 gene associated with Wolfram Syndrome, mutations, encoded protein, antibodies; for therapy.
Washington Univ. WO 00/18799
Neurotrophic factor artemin
St. Louis, Mo.
Neurotrophic factor artemin, encoding gene sequences; for diagnostics and therapeutics.
World Fdn. AIDS Res. & Prevention WO 00/18433
HIV vaccines
Paris
Use of antigenic complexes of HIV envelope proteins and HLA class I antigens as HIV vaccines.
Zheng, S. WO 00/18911
Intestinal cancer suppression
Zhejiang, China
Gene located on chromosome 14 that is down-regulated in large intestine cancer; for cancer suppression.